ACE Inhibitors (Angiotensin Converting Enzyme Inhibitors): Captopril, Enalapril, Lisinopril etc.

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Video Summary:
ACE inhibitors (Angiotensin converting enzyme inhibitors) are group of drugs that target renin angiotensin aldosterone system, an important bodily mechanism involved in blood pressure regulation.
Drugs in this group are captopril, enalapril, Lisinopril etc.
Mechanism of action of ACE inhibitors is inhibition of angiotensin converting enzyme (ACE), which converts angiotensin I into angiotensin II. Angiotensin II increases blood pressure. So its reduced synthesis by ACE inhibitors helps reduce blood pressure in hypertension. Other uses of ACE inhibitors are heart failure/left ventricular failure, myocardial infarction, Prophylactically in patients with high risk of cardiovascular events, diabetic nephropathy and scleroderma renal crisis.
Common side effects of ACE inhibitors are: Hypotension especially after first dose, hyperkalaemia, dry cough, Angioedema, rash, renal failure in patient with bilateral renal arterial stenosis/heart failure, fetopathy, dysgeusia.
Among drug interaction, it should be used cautiously with potassium sparing diuretics due to increases risk of hyperkalaemia and with NSAIDs due to risk of diminishes antihypertensive response of ACE inhibitors.
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DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorised websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.

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