ACE-I & ARBs | Mechanism of Action, Indications, Adverse Reactions, Contraindications

[@TheOldMayfieldPlace]

You are so clear in your teaching. I wish you had taught pharmacology when I was in pharmacy school. I am really enjoying your videos. After 30 years I've forgotten some of the specifics of MOAs of the drugs I dispense daily. It doesn't really come up when speaking to my patients, but is the stuff I geek out on.

[@aserehtavlis2866]

I really appreciate your time and effort making all these videos. You're truly amazing and genius. You help me with my exams and really understand how things work. Stay safe and healthy.

[@deepakkumarsingh4994]

Really good

[@kimswartz9107]

You are definitely out here teaching me better than the school I pay tuition to... thank you!!

[@loriakelly7969]

Haven't been to college in 35 years and I can follow you easily. Thank you for sharing your knowledge and style of teaching.

[@omdah070]

You're welcome

[@daniellesoileau5234]

I swear I don’t even need to go to class because of you!!!! You truly have a gift!!

[@mohamedfathi4599]

At first, I want to thank you and all of your team for the great work and dedication to make these type of videos that is comprehensive and informative. However, I want to comment on some of the information presented: 1) The Receptor that is responsible for mediating most of the angiotensin II activity is called AT-1 receptor not AT-2 receptor and ARB act by specifically inhibiting AT-1 2) ARB class of drugs ends with the suffix SARTAN like valSARTAN , candeSARTAN etc 3) Continous and chronic elevation of Angiotension has a mitotic activity on vascular SMC and cardiac myocyte and that is why ACEI or ARB are beneficial for cardiac hypertrophy as it lower the progression of this process. 4) Renal effect of these drugs is by mainly antagonize the effect of ANG-II on efferent arteriole which will eventually leads to dilation and decrease intraglomerular pressure. By relieving the stress on glomeruli that is beneficial is case of nephrotic syndrome or kidney disease.Also that is why renal artery stenosis is contraindication as it will cause sever drop in glomerular pressure by decreasing blood flow from afferent arteriole and by vasodilatory effect of ACEI on efferent arteriole. Thank you again for all your efforts. I hope you all the best.

[@jihaneziati3535]

You're right

[@aditiadvilkar2000]

thank you so much sir

[@libertyblueskyes2564]

You have so clearly and specifically answered my questions about the heart failure I experienced and the drugs I am taking. My cardiologists spends about ten minutes with me, not enough time to thoroughly understand. So thank you from the depths of my heart for taking the time and effort to educate all of us.

[@christineb7757]

You need to be more aggressive with your heart doctor and demand more time and better explanations as it is your life, and you are paying for his time. I'm sure he charges for way more time than he is giving you. Be pro-active. He is employed by you. Ask his office manager if he bills by the hour or the visit. Then explain that if the hour, he owes you money. If it is by the visit, the visit isn't over until you say so or you'll find a physician that will take the time to treat you properly. It's your money and your health. You have a right to get your money's worth.

[@paulroberts2511]

Boom! Drop the Mic! Wow, your videos are excellent! I am a DNP and studying for my AANP (FNP) exam. Your content is right on, and your manner of teaching is an extremely effective teaching style for so many types of learners! Thank you, what a great refresher and preparation for my exam!

[@Transcend11111]

My friend you are the absolute king of teaching this stuff! Even though you are not my teacher in school, you're actually my teacher in school! Lol

[@tuilikaandreas4776]

the sound of your laughter as you repeat the process is so comforting and reassuring :)

[@brianedwards5113]

I have been following you for years and I almost passed up on this video for a shorter one because it's really late and I have to be up early in the morning but you woke me up with this video. Absolutely crushed it, man! I LOVE the content that you make because you really know how to perfectly scratch the itch of not just wanting to know that " 'x' does 'y' " but HOW it does it. Thank you so much for your content!

[@christineb7757]

I am so happy I found your channel. I am confident your knowledge and way of explaining the medications along with mechanisms of action, contraindications, etc. will help me greatly in my adv pharm for adv practice nursing. Thank you for your brain.

[@MrAkooanaih]

he is a genius in explaining thinig, im supporting your channel and website thnk you

[@hwasunfiower1769]

It feel like i experience heaven when i found your channel. This really helps me a lot ❤🔥

[@dr.kennethj.sacchetti2765]

Thank you for this indepth explanation of the actions of ACE inhibitors and ARBs. I suffer from Peripheral Vascular (artery) Disease (PVD/PAD) with cyanosis caused by angioedema; and Stage 4 Chronic Kidney Disease. The accepted treatment for PVD indicates administration of statins or ACE inhibitors. From this video I learned to support my original conviction, against that of my cardiologist, to NOT prescribe an ACE inhibitor for myself which could lead to an M. I. (I have already had 5 M. I.'s with accompanying open heart surgeries), and or a CVA (stroke, of which I have already had 3 of rhe ischemic variety).

[@emilyyoung7201]

I love how it’s so easy to follow your videos for my nursing pharmacology class because of my strong A&P 1 and 2 background…that I also acquired through watching Ninja Nerd videos. 😂 Getting me through every part of my degree. 👏 🙌🏻

[@TheEbuitrago]

This dude is way better than my pharmacology professors. Greetings from Panama

[@ajithmampitiya7166]

Sir, I have never across this type of teaching experience. Very interesting. Vast knowledge in short period. Highly appreciated. Never forgotten. Thank you very much. Triple gem bless you.

[@ariespitzfaden6027]

Most thought out and straight forward video on ACE inhibitors and ARBs. Zach, we salute you. I love it when you piece together the mechanisms of these drugs!

[@annabelle9904]

You're the best teacher ever! Thank you

[@yachiapatel]

Loved when he said "you guys will never forget this mechanism " I literally felt blessed enough by knowing atleast I'm gonna be good at questions with ACE-I & ARBs 😂😂❤🙈

[@filippetrovic9823]

I am so grateful for this video, thank you truly. It is so disappointing that there channels on youtube that explain things better than professors in universities.

[@CiaoColeG]

About to start clinical for my MSN in a month and I've been so scared because I'm in pediatrics and don't give BP meds and so many others... Your videos are AMAZING!!? I love your teaching style. It's so engaging I missed my turn while listening and driving yesterday 😄

[@elisa211]

Love your videos. You break things down so clearly in a way that is easy to understand. The visuals are super helpful for a better understanding as well. Youve made my APN education that much more do-able! Thank you!

[@NinjaNerdOfficial]

Glad you like them! - TG

[@Abdullboss89]

Thank you my second teacher ❤️❤️

[@Deadlokd]

My primary teacher :D

[@jonathanrogers1346]

Just found you a few mins ago off the Neurology | Autonomic Nervous System video. your pretty cool and smart going to start watching your videos bro keep up the good work.

[@doctorspencer2846]

It's a 10/10 from me💯👍.....U just simplified what seemed to be hard. Can't thank u enough

[@draqsashaikh2595]

My God. I hated this topic, but now after your lecture it makes sense, and im loving it❤️ ❤️ ❤️ ❤️. Thankyou so so sooo much😭

[@ropz_karambit1494]

No amount of Thanks will do justice to how much i appreciate your work! i'll donate when i can in the future)

[@otmanezogdani]

Thanks

[@dougr2237]

Amazing, made everything so clear and one of the only resources to explain bradykinin-ACEI relationship

[@progressisimminentjasbir8564]

Amazing. RAAS mechanism is crystal clear now.

[@shannonhuntsman7664]

You’re absolutely fantastic at explaining how it all works! Thank you 😊

[@shelbyvanwagoner584]

Thank you for all your videos! I am preparing to take my boards, I just graduated as an FNP.

[@injustice5991]

These pharm videos are so helpful!

[@dranthonyasturi9790]

You ALWAYS make sense. Each and every lesson Zach gives is a performance akin to "I SOLISTI VENETI", an Italian chamber orchestra founded in Padua in 1959 by Claudio Scimone. I was at the time at the U. of Padua learning electrophysiology. My congratulations to Zach

[@bhuvaneshwari236]

You re just amazinggg🤩❤️!!! No words to appreciate ur efforts ✨🔥👏

[@ShiflaBanu-f4x]

I REALLY LOVE THESE LECTURES...I THANK YOU FROM THE BOTTOM OF MY HEART..

[@sunshinejoy1391]

Thank u zach for making me understand this so quickly with ur beautiful illustrations and clear explanation...more love to u❤️❤️

[@arunabhadebnath1894]

The very best of lectures!!

[@meghakadam5404]

Like the way you have explained in details and step by step , it's helpful in understanding complex topics , thank you for the efforts you have put up , look forward to your videos , also like how you show happiness and interest when narrating , it's like you are having fun teaching and comes through to the viewer .thank you once again.

[@ohemaadeyemi5233]

This is the best video honestly. I am dyslexic and the repetition of the RAAS system helps a lot. Thank you! I will be supporting your go fund me, if its still open.

[@psalmina]

You are awesome. I didn't find anywhere this more clearly explained.

[@aidakhan8142]

thank u so much, i know to say thanks its not enough. u r real hero for us. may God bless u always. Ameen

[@josiepearce5389]

Excellent tuition .You explain the subject so Well step by step .I look forward to more of your videos and zi will save them all Thank you From U K

[@raphaellaballa6884]

Honestly May God continue blessing you coz you are a Life Savior 😘🙏🏽❤️lesson well understood

[@kasunrodrigo6592]

One of the best lectures about ACE and ARB's Thank you sir....

[@qazal1116]

I appreciate your help today and always !

[@buhlemdluli9605]

You are the best, I like how you explain things a bit by bit. God bless

[@akps61]

You are an excellent teacher. I really appreciate your work. Your videos make so much sense. Thanks a million.

[@shasha6064]

I made through first year with your help ..nd u r supporting me in second year tooo 😭❤️ thanks for making pharma easy

[@hapsabatuan4661]

Hi, I’m a Muslim Med student from the Philippines. I have no words. Your videos leave me in awe. You’re a med student superhero!!! I’m married but I think I’m inlove again! In millennial Philippines, if we adore a person so much we say “sana masarap palagi ang ulam mo”. Hahahahaha Love you so much!

[@mesfinabebe9572]

This is really an excellent lecture . I am a physician and also hypertensive taking ACE-I inhibitors and helps me for more follow up

[@sherryjenningsjohnson5414]

I appreciate your 3 videos: Hypertension, AutoRegulation, and ACE's, ARB,s. You are the best teacher! Looking for more on bilateral renal FMD and direct renin inhibitor, Aliskiren. Thank you.

[@kendragreen9830]

Your lectures help me solidify everything I learn in class. As soon as I graduate I am going to contribute to your Patreon and to your GoFundMe - it would be awesome if you all could get your own recording studio!

[@kirstielreid]

Same! ❤️

[@EELLmama]

Please come teach in my nursing school. You are an amazing teacher!

[@debislomp1207]

You are an inspiration and have taught me SOOOO much. You make the material interesting and present it in a simple way, making it easier to retain

[@sewndebisdream6953]

Glad to have this info when I go to my doctor.

[@sadiank3909]

I wish i came across this videos while in pharmacy school, i could have been the best in my set, you make learning so easy and interesting

[@robinbentley4982]

Excellent explanation of something that has been so hard for me to wrap my mind around (the RAAS). Thank you for the wonderful videos!

[@0nevergiveup0]

Explained it so well. Love the recapping, i dont think i can forget this now. Thank you for the time, effort and sharing of knowledge.

[@rubendrath2980]

very understandable, it is more perfect, if you can explain slower than then and some words you spell cant understand. except those, rest is perfect, love the illustrations, and your smile too!!! all the best!

[@smileyc2011]

I wish I would’ve seen this while in Hygiene school :/ you make it simple to understand! Glad I found it before my board exam though! God bless you!

[@lilianechick904]

Always a very productive class. I appreciate very much your work.

[@shahabalam3348]

Dr zach is doing a very Good job ❤

[@vall9588]

You are amazing!!!! You are getting me through acute care NP school! Thank you!

[@ShenoudaRouby]

You are a superstar, mate - I am so fortunate to hit your channel.

[@RAAGECAGE]

At 2:42 you write AT2-R for a receptor that Ang II bind but Ang II binds to receptors called AT1 in the arteries. Ang II does bind to AT2 receptors but those are in low levels in adults and mostly play a big role in fetal tissue

[@Cozzie018]

This was brilliant! Thank you!

[@i_reyaa]

Such amazing lectures..!! Finally I can understand medicine

[@faizanraza8820]

But it is pharmacology 😬😂

[@abeikukimani8565]

You are a blessing. keep up the good work. You make pharmacology interesting to learn and understand. Thank You.

[@kaze123ckr]

Really appreciate "the anti-hypertensive agents" series The control of "ADH secretion" 1. Osmolarity (Osomoreceptor in hypothalamus ) 2. Blood pressure (Arteriral baroreceptor) The textbook usually didnt mention the effect of Ang II directly on Hypothalamus it's probably due to the situation Ang II is elevating ,it's usually the situation of Low blood pressure ( through the baroreceptor pathway)

[@futurendeavours1596]

I've never enjoyed a lecture as much as I enjoy this👍

[@lilfefeop5856]

The best explanation overrrr!!!,

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I love your teachings. Your PATHOPHYSIOLOGY is always superb ❤😊

[@iamlegend1624]

You and dr najeeb are best in The world

[@saidasaid9565]

your explanation is the BEST as always! Thank you

[@architasaha8917]

Thank you for your easy way of explaining such a important chapter. Please keep making us rich with your knowledge.

[@ElijahMartin77]

AWESOME, AWESOME explanation!!!!!

[@sheilawhitney7241]

Love your videos! Very informative- thank you!!

[@niazwali8169]

thank u so much for uploading such vedio especially cardiovascular pharmacology plus cardiology

[@cccalifornia7206]

Excellent teaching.... I learned so much!!! Thank you 😃👍

[@alinassib6483]

I grasped everything...this is really awesome

[@ritihembrom2551]

I'm very grateful to you and this video😭😭✌🏽

[@anshumandhingan6277]

Very helpful video. Thank you.

[@luphelelemavuso8594]

Hi, thank you so much for the lecture, really helpful. I have one question though, how do ACEI and ARBS worsen renal stenosis?

[@alanmarshall8850]

Can the concomitant use of an ace and arb be used for hypertensive patients if potassium levels are monitored appropriately..

[@debbiegoodwin5221]

Great video makes everything so much clearer! Starting my nursing soon and have a feeling i will be on you page alot :))

[@abuadams7947]

Very helpful lecture. Thank you zack

[@maryx9723]

you are truly a god sent. thank you so much for making this videos :)

[@MazharHussain-jc9bm]

Love from Pakistan 🇵🇰💖 Love your way of teaching

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your lecture are very interesting ,I am many many grateful to you

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I noticed you're uploading a lot in the last few days, good job!

[@westfield90]

So beautifully explained

[@evaristokunka3144]

great presentation. Much appreciated!

[@Di_Moriarti]

The great job that makes sense. Thank you!

[@a30s]

Best explanation of every topics.Thanks alot.

[@vishakhachourasiya9639]

Thankuu for such great content they are really helpful ❤

[@PhoenixRN]

Great work man, sounds like I'm not alone, also in adv. pharm. with a major test coming up. Thanks for the content!

[@dhirubhansali]

Outstanding outstanding outstanding...