Activation of Coagulation Cascade

[@orwa9824]

this guy is amazing, he is saving my biochemistry class

[@Dazzletoad]

1. Fibrinogen is NOT an enzyme, it's a soluble glycoprotein. 2. The Factor VIIa/Tissue factor complex also activates factor IX which aids in amplification. 3. It's worth noting that factor Xa has some proteolytic ability similar to thrombin in activating small amounts of factor V - which will aid in forming the inital prothrombinase complexes. 4. It's also worth mentioning that factor VIII circulates in the blood as a complex with von Willebrand Factor. 5. The only zymogen thrombin (FII) activates is factor IX. The other two components activated by thrombin are factors V and VIII. Fibrin polymers and thrombin can activate and amplify the activity of FXIII once the monomers begin to spontaneously self assemble, which is achieved by crosslinking fibrin thus stabilising the plug. 6. You didnt explain the point of exposing the cleaved fibrinopeptide B site, only the attachment of cleaved FP-A to the gamma globular domain. 7. A hugely important part which you missed out is the activation of plasma protransglutaminase (FXIII) and the critical stabilising covalent crosslinking of the D-domains (the globular beta and gamma regions) of fibrin. There is some disagreement on how the covalent crosslinking actually occurs - whether longitudinally or transversely between the D-domains, but experimentation suggests the crosslinking is most likely transverse - a bonding that would confer greater elasticity on the fibrin.

[@zachzouyed1185]

This is an excellent video! Your method of repeating and summarizing key points really helps with comprehension and retention!

[@917monique]

I'm in Med school. YOU ARE A LIFE SAVER! Your video's are detailed, short, and easy to follow. THANK YOU!

[@michaeloh7487]

Kudos to you, you're a lifersaver - A grateful 1st yr medical student

[@vb9490]

I have been watching your videos throughout my biochemistry degree and now into medical school. Thanks so much!

[@Dr.murtadha]

Best physiology doctor I ever seen Thanks so much sir ❤️❤️❤️

[@evagoogle1917]

Thank you so much! I can recall the cascade off the top of my head thanks to you!

[@englishforall6314]

you are a life saver... think all med students will agree!

[@mateovanegas3415]

I'm a big fan of your lectures. Thanks a lot! you're just fantastic.

[@rachaelm5212]

I'm confused between this one and the video from 2014 called "Blood Clotting Cascade" since they seem to have minor differences...are they discussing the same thing? (P.S. Your videos are my saviour.... I started watching them in second year University when I was having trouble understanding my cell bio prof's explanations and they saved me in that class among many others since then...I'm now almost done my degree and hoping to go to vet school, so I'm thinking I will be watching these videos for a while still! No one else explains them as thoroughly and clearly as you and you are exactly how my brain needs it explained, so thank you!)

[@Dazzletoad]

This video contains critical mistakes. See my comment above.

[@sanhitasaxena1542]

YOU ARE AWESOME, THANK YOU SO MUCH!

[@katherineirwin822]

you are a saviour

[@pump.queenz]

Omg thank you I finally understand!

[@circlez3762]

thank you so much ! I appreciate the hard work and how you simplify the information ! I cant thank you enough

[@danielbristow6153]

@ 11:51 I didn't know Elmer Fudd made a guest appearance LOL

[@NDSB1998]

if there was a million like button...thank u

[@hAnumAndAsAm]

Sir u should include Ca,Phospholipids,Factor-lll

[@-farawla]

you are awesome. ty!

[@AKLECTURES]

+Fofo Nono Thanks!

[@rittenbrake1613]

good bro

[@paulhetherington3854]

WD= +- lims 6mg{6,7} = 1(2mg), 1(2mg) carbon copy! OOPs-- factory or firm, license -- comp troller issues. x 4=4mg ,2mg(1 tablet) = {4WDmg two, tablets, 2WDmg One tablet-- anticoagulation!} ESC- Beta blocker! 2WDmg-- is one tablet, 4WDmg two tabs-- lims, protect as, immunity!

[@momentswithangela]

not me trying to distinguish betwwen purple and blue