Adenylyl Cyclase - cAMP Pathway || Gs and Gi Protein Pathway

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Video Summary:
Under resting state, α, β, and γ subunits of Gs protein are associated with receptor and α subunit is bound to GDP. Activation of the receptor causes the release of GDP and binding of GTP. This causes the release of the αs subunit that activates adenylyl cyclase. Adenylyl cyclase converts ATP into cAMP which activates PKA. Activated PKA phosphorylates various target proteins and modulate their activity. Generally, this leads to an increase in cellular activity. When the external signal is removed, the signal is terminated by GTPase activity of α subunit that inactivates itself and thereby adenylyl cyclase, phosphodiesterase that degrades cAMP and phosphatases that dephosphorylate the target proteins. Gi protein inhibits adenylyl cyclase and prevents all these from happening. This generally decreases cellular activity.
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DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.

[@meifukusha2465]

You made medical concepts easier to understand. More powers to you sir.

[@AshBlanx]

simple yet effective explanation. thank you

[@sidraiqbal2833]

Literally the best video to knw how actually this G protein couples receptors work.. no need to see other videos on ths topic..thanks a dozen

[@NonstopNeuron]

Most welcome. Please share the channel with yours contacts to support us. Thank you. 😊

[@jonathanfargalla5427]

so well explained, we can't thank you enough!

[@LucasFerreira-dv6ol]

I'm stunned how didactic this video is ! Amazing ! Keep the good job dude, I appreciate your effort !

[@NonstopNeuron]

Yes I will. Thank you 😊

[@SalmanKhan-eh4gg]

🤩 I am going to in love with your lecture

[@yo_hunny2663]

Thankyou for the detailed explanation. The animated video made it even more fun to watch and understand better

[@Abbas2003io]

Thanx from Iraq 🇮🇶 Pharmacy student

[@user-zw9ew1gq1k]

راجع جدا ❤ شكرا لك

[@salmahassan7487]

Your videos are really easy to understand, interesting and helpful. Thank you so much for making such amazing videos🤩

[@yasho6711]

Sir Thank you so much for this video. This helped me lot while I was confiused with biochemistry examination. Thank you agin and again.we need more videos♥️

[@syb5009]

Fantastic illustrations and explanation

[@aedejoseph5903]

Thank you so very much, sir. You've helped me to understand this concept really well

[@zakirzak1494]

Thank you, very well explained and had nice animations :)

[@mmuh197]

this is amazing you made it very simple and understandable thanks for your efforts

[@juallee2711]

excellent explanation!!! thank you so much!!

[@easycode924]

I wanted this concept, thanks 🙏😇

[@mr.authorallinone4706]

Great explain about g protein coupled receptors😊😊😊. Thanks sir

[@ammarasattar7809]

Thank you so much this video is so helpful for me to understand the physiology 🧡🔥

[@harryseverusgranger255]

absolutely amazing video!!!

[@darshanbhirud3354]

Thank you what a animation keep doing sir

[@asimzubair55]

Thanks for sharing. Its wonderful video

[@mmmpr2261]

Thank you, so much !

[@eshragaabdallahmohammedahm387]

It's amazing 👏 Thanks so much

[@vitoria96634]

Clear and practical video, thank you so much

[@NonstopNeuron]

Welcome 🤗

[@shiprasingh2143]

It really helped me a lot

[@prathz1065]

Very well made👏

[@wycliffenyandika9017]

Nice! I like the explanation

[@nomeshsahu2816]

Thank you so much for made easy 😁...

[@meifukusha2465]

Thank you so much.

[@amiyodas6908]

Clear understanding ❤

[@uttamghosh503]

Awesome ❤ most helpful

[@tresasebastian9909]

Thank u so much sir.....👏

[@hayaalhassawi7091]

Brilliant 👏🏻

[@FatimaRaja-zf1ke]

❤❤very interesting

[@rinaislam6428]

Awesome!!!

[@keurinrin16]

Your illustrations are sooo cute🤣🤗🤗

[@zainabfarooq5263]

Thank you

[@samsciences5966]

Nice work

[@user-ce9xq7vi8f]

Wow amazing

[@sairaahsan9019]

Amazing video

[@nabeelafarheen8224]

💖💖superb sir

[@shahiimran3365]

Thnq u sir ❤️

[@vaibhavi5469]

Really it's very good 😃😻

[@Gabin._.]

thx u smmm

[@muhammadatif7441]

Amazing 😍 Mashaallah

[@catherinesakeena1099]

Best💯🙂‍↕️

[@virginiayoussef]

Many thanks for your amazing explanation, no one explained it as you did , would you pls allow a transcript to show below the video for more focus , thank you

[@NonstopNeuron]

Captions are added to almost all the videos on the channel. You can turn them on or off as per your preference.

[@galmaankhan8338]

Thank you so much sir.

[@NonstopNeuron]

Most welcome

[@nazaninsherafati3510]

❤📚thanks

[@user-cn9uh6bb7p]

thank you so much my dear god...teach us more

[@mudasirahmad446]

Very helpful

[@liliadriss7944]

رائع جدا شكرا جزيلا لك

[@saragadamramdiwakar8578]

Very usefull lecture And very cleanly explained Thank u sir😍

[@Abhisheksingh_102]

Underrated channel.

[@NonstopNeuron]

I need your support to grow. If you feel this channel deserves more, please share videos to all your contacts.It helps a lot in many ways. Thank you so much.

[@ammu9642]

Sir we need more and more Vedios like this tq so much sir

[@NonstopNeuron]

Yes. I am working on it

[@ammu9642]

@@NonstopNeuron 👍

[@KanuPriya-dn1ul]

Very very useful❤️

[@NonstopNeuron]

Glad it was helpful!

[@funnymanandguy]

Good video!

[@NonstopNeuron]

Thank you

[@abhishekkashyap-iw9ig]

Superb

[@NonstopNeuron]

Thanks😊

[@chancelorhardy9893]

I have a quick question; if the alpha subunit has ATPase activity, what prevents the conversion of ATP to ADP before it can activate the Adenylyl Cyclase?

[@NonstopNeuron]

Hummm... Interesting question. Honestly I don't know the answer. It may be the association with the receptor itself or with beta-gamma complex. Or maybe the activity is intrinsically slower than the speed with which it goes to Adenylyl cyclase and activates it. But as a medical person we don't need further detail to understand other concepts. I have already covered every detail necessary to the best of my knowledge and understanding. So although the question is interesting, I am not excited to find out the answer. I am happy with my assumption 😝

[@NonstopNeuron]

I am also assuming that you are a medical student. If you are a researcher or something, then you might need to go into further detail.

[@louiza2245]

💗💗💗

[@loveall022]

❣️

[@pijushsingha9232]

Sir with the effect of adrenaline and noradrenaline the calcium ions will come out from sarcoplasmic reticul into the cytosol but u just said that it sequesters the ca2+ions into the sarcoplasmic reticulum

[@NonstopNeuron]

Yes, both statements are true. There is no conflict between the two. Under the influence of these hormones the SER becomes more loaded with calcium i.e. more Ca is sequestered in SER. This is at the basal level. And as this sequestered Ca is released during each impulse, more Ca is released. And this, as stated is during impulse. I hope it helps

[@GoodKnight5252]

how does sequstation of Ca into the sER cause increase in myocyte contractility? isn't it the opposite?

[@NonstopNeuron]

With sequestration more calcium can be released in cytosol with each impulse. So the contractility increases

[@saragadamramdiwakar8578]

Sir,small request - Plz make pnemonics to remember drugs🙏🙏

[@NonstopNeuron]

Instead of mnemonics, I try to explain the core concept in a memorable way. You can consider visual metaphors as memory tricks. That being said, I do get thoughts of making mnemonics but if I ever do that, it will be secondary to my main way of teaching.

[@nishantsen6820]

Beta gamma subhunit remain attached to gprotein?

[@NonstopNeuron]

No

[@nishantsen6820]

@@NonstopNeuron okay and one more dobut why receptor use more than one g protein?

[@NonstopNeuron]

To integrate incoming signals. Watch this video: kzbin.info/www/bejne/l3q9gmahmtdjgac You will get the idea.

[@nishantsen6820]

@@NonstopNeuron okay thanks

[@hellyerlolipops5186]

How :0