Signal Transduction Pathways (G-Protein, Receptor Tyrosine Kinase, cGMP)

[@DirtyMedicine]

The mnemonic for G-Protein Coupled Receptors could be improved by writing "Go to AC for Craps and Poka". Poka (as opposed to Poker) helps remember PKA even better! Credit to Meryl Braun for the idea!

[@Mohamedyasar1234]

Super explanation sir

[@David-ys1dt]

you da man God bless bro

[@balkiszaitoun3051]

or just read it in a british accent haha

[@Sweetlynah]

I just noticed Dopamine wasn't included as a GPCR! It affects Gs (b1), Gi (a2), and Gq (a1) as well as D1 and D2 receptors. I'm still trying to understand more of its effects though

[@مُجاهِدْ-ز2د]

"any financial support will help but if you dont donate im still going to make free videos anyway. ", this guy is legend

[@DanielaHernandez-wr3cl]

I SPENT AN HOUR TRYING TO UNDERSTAND THIS USING MY PROFESSORS LECTURE AND NOTES AND BY THE END I WAS STILL CONFUSED. BY WATCHING THIS VIDEO I UNDERSTOOD RIGHT AWAY. THANK YOU SO MUCH FROM THE BOTTOM OF MY HEART REALLY

[@anianoelle7033]

i literally just decided i was going to take the Ls on these questions, and then BOOM! Dirty saves the day 🥳bring on the signal transduction q's IM READYYYYYY 😤

[@Be1smaht]

Why take an L on anything dude?

[@Be1smaht]

Get those pts. You know like 20 questions is the difference between like 50 points lol

[@Be1smaht]

This is game day baby! Stay hungry

[@cytozy6809]

The amount of joy it brings me when I look up a concept on KZbin and see that you have a video on it is immeasurable. I just know that a concept that I was struggling with is going to suddenly become way more understandble 💖

[@hehateme1187]

I just spent a half hour looking at this page in First Aid completely lost. I could kiss you right now. you had NO business going this hard 😩🔥

[@laurabou1244]

omg where on the FA (page/ FA year)?

[@hehateme1187]

@@laurabou1244 They barelyyyy talk about it. It's ridiculous. Page 337 in the 2020 edition.

[@MoeKyawThu86IM1]

Thank you for your clear explanation. Just for the fact, i like to point out that MAP-kinase-kinase-kinase is called Raf, MAP-kinase-kinase is called Mek and MAP-kinase is called Erk. (You mentioned MAP-kinase-kinase-kinase controls Raf and so on at time 13:20 to 13:27).

[@dannyd9964]

You didn't talk about non receptor tyrosine kinase (the Jak/stat) which is driving me insane. Please help

[@babahuusain9828]

See medicosis Perfictionalis he explained this top clearly…. JAK GET PIG😂

[@Zehra-s3e]

Cytokine → Receptor → JAK → Phosphorylated STAT → Gene Regulation.

[@tatius2457]

Oh my god, I was just stating how I wish there was a video on this, thank you so much step in 4 weeks!

[@tatius2457]

came back, 1.5 weeks. prayers please

[@CXY96]

How did it go? Any surprises?

[@michaelekun3175]

Hello! Thank you very much Mr dirty for this video it really helped me break down this complex topic uno something easily understandable with extra learning and I am hoping to see a topic on : apoptosis and necrosis on day arigatou go sai ma su and may God bless you😁

[@mutazomer9143]

it is important video for medical student, it,s help full and give good idea about signal transaction.

[@prestigehilary]

I don't comment on videos often, but damn.... thanks, man!!! ❤

[@hamzaanees2811]

The only video on this topic that I like

[@prestigehilary]

15:45 so you end on a high note and feel like you dominated this video 😂😂. Reminds me of Yuval Harari's book, Homo Deus and all the talk about our biochemistry there. Thanks for the great video ❤

[@AnaH-qu1eh]

BLESS U FOR MAKING THIS!!!! my exam is in two weeks!

[@KinzaHussain]

Wow I've been needing a mnemonic for thisss! Thank you!!! Do you have a video on the Heme synthesis pathway & porphyrias? I haven't found it and I can't think of a mnemonic! I always forget the steps for this pathway!

[@DirtyMedicine]

Not yet, but it's one of the videos in my queue that should be coming soon. I've already done some of the slides

[@Womanhu]

He does now baby!!!

[@alvarosoria8787]

just what i neeeded!!! thank u

[@rufinamenezes7712]

Thank you very much for your video. It was very helpful

[@nived8476]

His Mickey Mouse-sounding impression of us is spot on lol

[@savepalestine408]

The great dirty🙌:Tells mnemonics to memorize the pathways Meanwhile dirty:forgets to tell mnemonics to memorize the hormones 🥲 Bold of you to assume that we can memorize that ourselves 🤐

[@cardiocosmos]

Thank you! Very helpful!

[@duruemmanuel-up2hh]

Awesome video...❤ ...BUTTT!!!!!! Why didn't you just save us the stress of checking the abbreviations 😢 However...10/10

[@anglaismedical5573]

We should call you Dr Big Picture! Thanks a million! I can never thank you enough for simplifying what seemed un-understandable

[@Painsurb]

Thank you so much 😊

[@sparkles2345]

OMG Thank you!! What my professor couldn't teach me in 1 month you taught me in 17 minutes!!

[@kikithepupper6774]

when I can't remember the Gas activates the Adenyl Cyclase pathway, I think of that song GAS GAS GAS I'm gonna STEP ON THE GAS, which gets the adenyl cyclase pathway going...

[@fatimasuleman1980]

Thank you so much

[@PS-pr5py]

all killa no filla! thanks!

[@t-alimichael3363]

..and my Phd professor making 6 figure income couldn’t explain it in 2 hours lecture-shame. Bless you Sir!

[@nabimanyaconrad9811]

thank you so so much🙏

[@xaaboopinkly]

Huge thanks sir!

[@carolinaferraz255]

awesome video!

[@aevrynmcalister8800]

As a nursing student, I watch a LOT of educational videos, but this is the first that led me to actually comment. Very solid video, very helpful. You made a lot more sense than my professor explaining this topic, and I find your mnemonic memorable. Thank you!

[@alvanhamisi8271]

thank you😊

[@mohammedalrubaiaan9138]

a mnemonic for the substrates was literally layed out for us, I dont know if he didnt mention it because it was obvious and everyone knows them or if it was seriously missed. its the first letter of all substrates in the same order he had in the video for G protein coupled receptors Gs and Gi the substrates are: FLAT CCHHAMP GG. or FLAT CHAMP cggh (pronounced sugah) the 2 Gs can remind you that its Gs AND Gi and the theme of things in pairs of 2 should remind you that its H2 and ADH V2 for Gq: GOAT HAG , there is only 1 goat so its linked to V1 and H1 for RAS: remember its associated with growth and insulin is an anabolic peptide + Growth factors. letters are random IIPFE cGMP; its associated with dilators as he mentioned. NO ANP BNP and Endothelial derived RELAXATION factor are all dialators

[@toobashoukat4959]

I’ll donate my first month salary to you soon promise

[@monisiay]

I love this video

[@areejkhatib9095]

Great one!

[@dikshantjha]

Thank you!!!!!

[@parisarezvani4012]

Thanks for this great video, but as a question,Angiotensin2 signaling doesn't work through Gs?

[@kim_398]

Any video on cytokine receptors and jak/stat pathways

[@AgustinaArce-ne2lt]

I wish i could make my own medical school and hire you as a professor

[@BellaVevo08]

You are amazing

[@grahampankratz2243]

Step in three days. Perfect timing, Dirty!

[@paulakuper6998]

Hey! Thank you for your biochemistry videos they helped me a lot last semester. I wish you could do more videos like this one because it appears now in my molecular biology course and only you can save me from this awful course 🙏🏻🙏🏻🙏🏻

[@aleenamasroor436]

Thank you so much. I never understood this for first two years of med school. Finally today I needed to understand this for pharmacology and YOU somehow sprinkled sense into it. THANKS A LOT ONCE AGAIN.

[@afrahnaseerhussainmohammed1664]

CAMP...FLAT ChAMP Can Grow His Glucose Ip3... His GOAT Ate Gas

[@priyankarait3733]

Ras is activated by grb+sos Gdp - gtp is used in gpcr but in rtk it's different 😬😬

[@oduahkeren3724]

How to I cite "Dirty" Medicine I'm my Paper. Phewww

[@bartoszszwed5200]

Bajajajajajajajajjjojojojojo

[@tariqtariq3208]

thanks you. do you have any good way of remembering the hormones related to each pathway

[@actionman4593]

For IP3 mediated: GOAT HAG:- GnRH, Oxytocin, ADH V1, TRH, Histamine H1, Gastrin For cAMP: FLAT CHAMPs CHuGG:- FSH, LH, ACTH, TSH, CRH, Histamine H2, ADH v2, MSH, PTH, Calcitonin, hCG, Glucagon, GHRH

[@koushikkarthikeyan156]

@@actionman4593 legend

[@vidhu999]

For ip3 - Goa ghat

[@adeelsajid995]

OMG this is god sent!! Was in dire need of this!

[@renjuraju6054]

super

[@yourfuturedocburenbeiya]

Love your channel & you deserve a million+ followers!! I couldn't thank you enough!!

[@sm4887]

thank uuu

[@danjbro]

But Diiiiiirty! I love it - great work! 😆 🤣 😂 ⚰

[@vibe.check_failed]

This is the only video on transduction I have found so far that ACTUALLY talks about everything we're studying. Thank you!

[@Afterburningyou]

Also, keep in mind everyone that: - increased levels of GTPase = decreased Gq/Gs/Gi activation. - if they talk about activation of a G-protein followed by a phospholipid cleavage = Gq pathway

[@Ag_paul]

I love dirty ☻😎🧠

[@سكينة-ض7ت]

10:30 RTK

[@asisababun7543]

Thanks!

[@markme3259]

…much of what you teach has to do with Medical Pharmacology..and is taught extensively to PharmD students, as well as Med Students…

[@TheZFHaters]

YES KING

[@luiseldulcimente6633]

Wow I like me a lot this one video.i am pharmacist especiallized in Pharmacokinetics

[@babahuusain9828]

For Non Receptor Tyrosine Kinase pathway(JAK STAT) see Medicolis PERFICTIONALIS

[@josephenricdy4552]

Thanks!

[@lukehumphrey1911]

I thoughts ras was activated by GEF which is activated by SOS bound to grb2 which is bound to the rtk

[@hoang9682]

It's comprehensive ! Thanks a lot

[@Zoologywaala-y1n]

Anyone biology students here

[@openyourmindtomedicine]

"That is a defeatist attitude" :')

[@Be1smaht]

Flat champ

[@JPlus-qm8je]

I thought ERK is MAP Kinase? So MAP kinase kinase controls the phosphorylation of ERK because it is the kinase for MAP kinase.

[@proghostlee2795]

Wow! This is my tomorrow exam's test content!

[@joshuagonzalez4933]

Great video

[@ambreensabah3758]

Thank you so much....you are blessing👍😀

[@pallavir4822]

Thank you so much sir . It was very helpful video 🙏🙏

[@Soriyou3]

Thank you so much for this video. Can you please make a video on genetic/molecular markers for cancers? Also a video on general immunology would be helpful. Thank you.

[@rahulsadhumbbs5124]

Best taught by najeeb sir

[@wex_0098]

Do beta blockers block the Gs pathway preventing it from occurring? Or do they somehow activate the G inhibitory pathway? How does the cell know if the alpha subunit is supposed to activate Gi or Gs?

[@3catsand3humans]

Thanks a million… you just saved my brain😂😂

[@ethelinda8439]

thank you soo much. now I can say I hateD this topic😁

[@osamaal-faqeh3462]

thanks

[@مصطفىمحمد-ب8س9ن]

I wish I could understand English well

[@khushwindersingh5244]

Yesss!!!!!

[@srushtipatil6739]

Thank you so much! It really helped!

[@lightdarkequivalent7143]

3 years later and your video unironically made me enjoy this lmfao

[@jaehaerys9194]

I am a chemical engineering applicant who has never studied biology in my entire life, but i want to do pharmaceuticals, why the hell am i torturing myself...

[@UBUYoga-pq2yx]

Thanks!

[@youssefhamdy6008]

I promise I'll donate frequently once I get a job

[@__-lo7yt]

OMG thank you sooooo much！！！ Really appreciate your help.

[@YourIMGguru]

but what about janus kinase receptors? Jak-stat?

[@vidhu999]

For camp pathway - camp cgh flat gh

[@drkaymd]

Saviour saviour 💕💕💕💕💕💕💕

[@solsoblue2297]

Dirty, T_TI love you so muchhhhhhhhhh. You save me from a mess!!! finally!!!

[@USMLE_Mastery]

There's absolutely no errors, in this video and the entire content of this video is relevant in (May 14) 2024, right?

[@USMLE_Mastery]

Because I'm ready to memorize this for Step 1

[@kokocipher]

finally a video that connects Ras w/ Receptor TK.

[@outofsquare8692]

sene halaldi yetka, opurem seni

[@kellyquiroz1595]

this was the clearest explanation!

[@-REYO-]

Thank you that is greaaaaaat

[@obioraokafor831]

still doesn't get old. thanks