Agonist, Antagonist, Partial Agonist, Inverse Agonist

[@Casey-dy2oo]

You have no idea how much this video helped me understand pharmacodynamics journal articles.

[@ahmedelfaki2526]

Docter How can I contact with you ?

[@midnightvidz7983]

man, my professor made this sound so complicated

[@user-J250]

On the first clip an agonist does not add or create new receptors correct? It just activates all receptors whether they were already active or if they were dormant? So there are no new receptors created correct? And the antagonist will only limit/block the current active receptors from being able to bind therefore leaving them remaining inactive so there’s no depletion or loss of receptors they just remain in a dormant/inactive state is this correct? Thank you

[@methoxeta]

That's correct.

[@methoxeta]

I will add, your body will often times adjust the number of receptors over time, increasing / decreasing based on saturation. I.e. with stimulants like adderall, over time your brain will adapt to constant use by adding more receptors, making you need more medicine to receive effects (this phenomenon is often referred to as tolerance). When you stop taking adderall, over time your brain will recover and downregulate (reduce) the number of dopamine receptors. So while the drug itself won't affect # of receptors, your body may respond to certain drugs by increasing / decreasing the number of receptors. But apart from that, you are correct - the drugs won't add or reduce receptors, just activate / deactivate them.

[@cabecitadezapallo]

I didn´t quite get the inverse agonist. It´s like an antagonist? whats the diference. Are they endogenous? Are there drugs used clinically?

[@Iberium]

Hey! Here are the similarities and differences: SIMILARITIES between an inverse agonist and a (competetive) antagonist: 1) They both lower the amount of possible active receptors. 2) When there is an agonist (so NOT a partial agonist), both will lower the potency of the agonist. DIFFERENCES between an inverse agonist and a (competetive) antagonist: 1) Competetive agonists do NOT have an effect in absence of an agonist. 2) Only inverse agonists deactivate receptors that are constitutively active (in absence of agonists).

[@HerrZimmerman]

Inactive versus active receptors?.... Not a clear presentation unfortunately ..

[@Elixir01.k]

He made receptors a mysterious species.Second graph he just skipped though it was simple to explain

[@almas9229]

Only he understood this

[@lamerebill]

when we add agonist? 55 sec

[@mohammedsalih7486]

Thank you

[@monika246]

Sir diff between efficacy and potency?

[@Iberium]

Efficacy is the maximal effect of a drug. Potency is the concentration of the drug required to reach a maximal response. (EC50 means X concentration of a given drug is required to have 50% of the maximal result that drug can have).

[@sayantanchatterjee9811]

Very good explanation

[@هند-ث4م]

I wash if you translate to Arabic l don't understand so much 😘

[@Elixir01.k]

He is a very bad teacher...made a very simple thing to a very complex one

[@هند-ث4م]

Thank you