You have no idea how much this video helped me understand pharmacodynamics journal articles.
@ahmedelfaki25263 жыл бұрын
Docter How can I contact with you ?
@midnightvidz79835 жыл бұрын
man, my professor made this sound so complicated
@user-J2504 жыл бұрын
On the first clip an agonist does not add or create new receptors correct? It just activates all receptors whether they were already active or if they were dormant? So there are no new receptors created correct? And the antagonist will only limit/block the current active receptors from being able to bind therefore leaving them remaining inactive so there’s no depletion or loss of receptors they just remain in a dormant/inactive state is this correct? Thank you
@methoxeta3 жыл бұрын
That's correct.
@methoxeta3 жыл бұрын
I will add, your body will often times adjust the number of receptors over time, increasing / decreasing based on saturation. I.e. with stimulants like adderall, over time your brain will adapt to constant use by adding more receptors, making you need more medicine to receive effects (this phenomenon is often referred to as tolerance). When you stop taking adderall, over time your brain will recover and downregulate (reduce) the number of dopamine receptors. So while the drug itself won't affect # of receptors, your body may respond to certain drugs by increasing / decreasing the number of receptors. But apart from that, you are correct - the drugs won't add or reduce receptors, just activate / deactivate them.
@cabecitadezapallo5 жыл бұрын
I didn´t quite get the inverse agonist. It´s like an antagonist? whats the diference. Are they endogenous? Are there drugs used clinically?
@Iberium5 жыл бұрын
Hey! Here are the similarities and differences: SIMILARITIES between an inverse agonist and a (competetive) antagonist: 1) They both lower the amount of possible active receptors. 2) When there is an agonist (so NOT a partial agonist), both will lower the potency of the agonist. DIFFERENCES between an inverse agonist and a (competetive) antagonist: 1) Competetive agonists do NOT have an effect in absence of an agonist. 2) Only inverse agonists deactivate receptors that are constitutively active (in absence of agonists).
@HerrZimmerman5 жыл бұрын
Inactive versus active receptors?.... Not a clear presentation unfortunately ..
@Elixir01.k6 жыл бұрын
He made receptors a mysterious species.Second graph he just skipped though it was simple to explain
@almas92294 жыл бұрын
Only he understood this
@lamerebill3 жыл бұрын
when we add agonist? 55 sec
@mohammedsalih74862 жыл бұрын
Thank you
@monika2465 жыл бұрын
Sir diff between efficacy and potency?
@Iberium5 жыл бұрын
Efficacy is the maximal effect of a drug. Potency is the concentration of the drug required to reach a maximal response. (EC50 means X concentration of a given drug is required to have 50% of the maximal result that drug can have).
@sayantanchatterjee98114 жыл бұрын
Very good explanation
@هند-ث4م7 жыл бұрын
I wash if you translate to Arabic l don't understand so much 😘
@Elixir01.k6 жыл бұрын
He is a very bad teacher...made a very simple thing to a very complex one