Alessio Fasano - Spectrum of Gluten-Related Disorders: People Shall Not Live by Bread Alone

The cultivation of gluten-containing grains that were the backbone of the agricultural revolution have also brought with them the manifestation of conditions related to negative reactions to gluten. These include celiac disease, wheat allergy and the "new kid on the block" of the spectrum of gluten-related disorders-gluten sensitivity. The autoimmune disorder of celiac disease is the most widely studied condition on the spectrum. It affects approximately 1 in 133 people, a rate that has doubled in the U.S. every 15 years over the past 35 years. An estimate from the Center for Celiac Research puts gluten sensitivity at 6% of the U.S. population. With current interest in the human genome and microbiome, research is leading scientists to examine the relationship between the intestinal microbiome and gluten-related disorders. Currently the gluten-free diet is the only available treatment for gluten-related disorders.
World-renowned pediatric gastroenterologist, research scientist, and entreprenuer Alessio Fasano, M.D., founded the Center for Celiac Research in 1996. The Center offers state-of-the art research, clinical expertise and teaching for the diagnosis, treatment, and prevention of gluten-related disorders, including celiac disease, wheat allergy, and gluten sensitivity. Trained in Naples, Italy, as a pediatric gastroenterologist, Dr. Fasano was recruited to the University of Maryland School of Medicine in 1993 and founded its Division of Pediatric Gastroenterology and Nutrition. Puzzled by the absence of children exhibiting symptoms of celiac disease in the clinic, he resolved to uncover the mystery of missing American "celiacs." His perseverance in the face of skepticism about celiac disease in the U.S. eventually led to his publication of the groundbreaking study in 2003 that established the rate of the autoimmune disorder at one in 133 Americans.
In early 2013, Dr. Fasano was appointed Division Chief of Pediatric Gastroenterology and Nutrition at MassGeneral Hospital for Children. He brought the Center for Celiac Research to Boston, where he heads the Mucosal Immunology and Biology Research Center, based in Charlestown, and is Associate Chief for Basic, Clinical and Translational Research for the Department of Pediatrics at MassGeneral Hospital for Children. He is a Visiting Professor of Pediatrics at Harvard Medical School.

[@Atheria444]

My 87 year old dad found out at 62 that he had Celiac Disease. By then, he was down to 118 lbs., had severe anemia, and prostate cancer. My sister and I don't have official Celiac, but CLEAR intolerance to gluten. One of the super weird symptoms I had was that I developed worse and worse painful, bloody, scabby sores up inside my nasal passages. I think gluten is freaking evil. I have had horrible digestive issues my entire life. I've been off gluten for years now.

[@Atheria444]

I should add that one of my dad's sisters died from ALS/Lou Gehrig's Disease!

[@theantiqueactionfigure]

I was just diagnosed at 70 years old. I'm in for a learning experience again, Lol! But I'm looking forward tackling it.

[@SuzanneCheung]

Oooooo9o

[@SuzanneCheung]

Oooooo9o

[@clarereynolds9607]

I've been through hell with it for 42 years, doctors are extremely ignorant at best..at worst they're abusers of their positions or possibly killers, my mum's died a few months ago weighing 5 stone, my family would/are suffering but won't listen to me, I feel wretched..evil, filthy gluten !

[@bethanhamer.8669]

Ten years ago I was having horrendous pain, saw a rheumatologist who basically humiliated me in front of five medical students . He wouldn’t let my husband with me and I was told to undress to my underwear . He looked said I had appalling posture was obviously depressed and needed to change my job .I left in tears . This put me off ever seeing medics again. As years went by my migraines went in overdrive and became hypothyroid . Hadbeen diagnosed with ibs in the past Roll onto 2021 ; after the covid vaccines I wet numb in one leg and up my torso ,couldn’t walk . Sent to neurologist and from the blood tests found to have among other things one test came back saying I could be gluten sensitive and have more bloods today to confirm , all these years of fatigue ,migraine joint pain ,nausea ,ibs ,low thyroid , shit teeth , low moods ,anxiety and it could be something so simple. Feel let down that nobody ever suspected gluten. Also have high platelets count and vertigo . My mum had hashimotos and ended up with encephalitis and left with myelitis in spine ; wonder if it’s my genes from my mum. Just got to the part about birth ! I was a c section ! and had a c section omg 😳 can’t believe what I’m hearing . Great guy he’s a brilliant lecturer!!

[@josephsmth646]

Do you consume diary and Soy and Vegetable oils? did you by any chance used birth controls?? Because this all trigger auto immune response.

[@bethanhamer.8669]

@@josephsmth646 no I didn’t ever use the pill I’m 54 now so no lol . It was after second vaccine that I had numbness in left side and couldn’t walk, was admitted to neuro and after tests I came back positive for gluten sensitivity. So wether I had it and then the vaccine accelerated the response I don’t know !

[@josephsmth646]

@@bethanhamer.8669 Sorry ,forgot to mention gluten did you consume a lot of gluten based products in your early adulthood? What i have seen doctors saying many people won't react to gluten untill a certain time and than the reaction is triggered.

[@bethanhamer.8669]

@@josephsmth646 I’ve always eaten a lot of bread and rubbish as it’s quick , work in operating theatres so only get half hour a shift to eat . Don’t eat Chinese food anyway because I get migraine with msg

[@laisa.]

@@bethanhamer.8669 you've really been through it 🌹 Do you still have vertigo? Have you been checked by an ENT for bppv (crystals in inner ear) or Menieres if you have hearing loss? Menieres is also auto-immune. I live in this auto-immune world too..

[@mannyrevuelta4070]

As a physician and a Celiac, I can say that this was brilliant. First saw Dr. Fassano in 2006. This is great progress. Hope this continues to get better.

[@adanzeribe4076]

My jaw just dropped...I have been anaemic for all my life and have Chronic Fatigue! I'm angry and happy at the same time. I'm sure you can figure out why!

[@jez770]

Hello Ada, fancy seeing you here, 4 years later!!

[@smudge8882]

Note that Crohn's disease and Ulcerative Colitis can cause the same symptoms! It's best to see a gastroenterologist to figure out exactly what it is

[@noglu106]

​@smudge8882 crohn's or colitis probably won't respond to a strict free diets.

[@martinfeatherstone3508]

Brilliant talk, very very interesting, this is why I went gluten free.

[@giannagiavelli5098]

i have celiac and this was one of the best talks ever on it.

[@martinrose6357]

My doctor didn't want to believe me when I told him I might be Celiac, based on my own research, simply because I didn't have the classic symptoms such as: diarrhea, vomiting or weight loss. But here's this doctor who perfectly says that gluten sensitivity nowadays does not manifest through those symptoms - quite the opposite! I'm confirmed to being dairy/gluten/soy and yeast intolerant one year after that, and yet no doctor believes that I feel fatigued the day after I consume a product that contains any of those. I'm not mad, but just disappointed because even close ones do not believe me. The auto-immune world, unless you're living in it, is really an unthinkable place and a concept to grasp by the non-autoimmune people, so I refuse to blame them, but doctors however...

[@genericx2347]

Your lucky YOU figured it out.I also was fortunate to find this info. Dr.s have let us down.And people don't listen either.Good for us.if i eat a crumb of gluten i have pain for a week.

[@DurgeshBailoor]

Yes very true, Gluten and highly processed food, both are causing major metabolic diseases in modern times. DM, HT and PCOD are just a small sampling

[@lisamarie2353]

What were your symptoms? And what tests did they do to find that you actually have celiacs disease? I have terrible brainfog, swaying dizziness and always tired...

[@martinrose6357]

@@lisamarie2353 I've had various symptoms for over 8 months and there was a different symptom every week. Then it would disappear but would come back again after few weeks or so. I was petrified the whole time, and I suppose the more gluten I consumed, the more my body couldn't take it and new cracks (symptoms) would start to appear until I couldn't take it anymore and had a more major symptom. I was never confirmed a Celiac. I first got diagnosed with all those intolerances because of my own request for a simple food intolerance blood test. This is how I had my doubts confirmed. Then, I started the gluten free diet on my own after a month or so, and since I didn't know my doc would refer me for a Giladin Antibody test, I tested negative because I'd been eating clean already for the past two months. But I also heard that test sometimes doesn't show you have celiac simply because they only test you for IgA and another one ( I forgot the name) and there's researches that show there are like tons of other antibodies, which you may test positive for, but there still aren't tests for those. I never had a biopsy cause in my third world country they told me to come back after 6 months, during which I consumed gluten as I had been told, only for then to inform me the biopsy/endoscopy would take place without anesthesia. I told them goodbye, and I just started the diet on my own. I only ate gluten-free bread, but I had to throw potatoes, rice (which I already ate on my gluten-free diet) due to developing insulin resistance. Once you're intolerant to gluten, etc. you're basically screwed in the long run. I probably have diabetes now no joke.

[@martinrose6357]

@@lisamarie2353 fatigue is the biggest symptom. I also felt dizzy whenever I ate. It didn't matter how much I ate, I always felt dizzy almost every second day even after the smallest amount. It wasn't dizzy, dizzy, but if I kept eating, I knew I'd be sick. Which was weird cause I was hungry and starving, yet food would make me feel repulsed by it. I also had terrible itch on my forearms and on my scalp, which woke me up from sleep several times. Just get a food allergy blood test first. It would confirm definitely. If my third world country tests can pick up sensitivity to sunflower seeds and beef (lol), then your tests would definitely pick up any intolerance you might have. I didn't even know I'd be intolerant to yeast too ffs

[@geribrewster9055]

a must for everyone to review as so many autoimmune diseases are being expressed

[@SmogenParadise]

+Geri Brewster It drives the immune system incredibly folish for good.

[@martinrose6357]

Last night I dreamt of Red Reddington from the Blacklist, and today I discover this doctor upon searching for information about Celiac Disease, who happens to have the same eyes as him and talks as eloquently.. Life is so weird!

[@SiegfriedEmme]

Thank you . That was an amazing presentation

[@alfredrice4863]

I hear many people have a gluten intolerance maybe up to 85 percent of Americans , a minor aspect of gluten allergy but still detrimental on our health because if we can’t digest vitamins and minerals it may lead to disorders and diseases.

[@alfredrice4863]

Can I give two thumbs up

[@danmcdaid]

This guy is a delight to listen to

[@mwest0894]

Staying away from gluten has resolved my nerve pain and diverticulitis. I will stay away from gluten from now on.

[@noglu106]

I take it you were not officially diagnosed. If that is so, I applaud your intelligence. You suspected the problem and applied the treatment. Congratulations.

[@jonathandelgado8253]

Dr. Fasano, one word: Glyphosate. It saturates our wheat AND is a patented antibiotic. 🤔

[@Drivenwithambition]

Glyphosate is sprayed on other grains that is gluten free and people don’t get the same bad reaction. Wheat issue is a real thing, non the less glyphosate is straight poison

[@jonathandelgado8253]

@@Drivenwithambition The less toxins and antinutrients the healthier, my friend. 3 years strict Carnivore diet, with experimentations to see what foods cause what reactions. Turns out, less is more.

[@aa.4639]

@@Drivenwithambition True. That's why all grains are shit.

[@alomaalber6514]

I hear ya, let's say BOTH, in science it can be BOTH. The pesticides and the wheat, the med problem is not new and more diagnosed now, but I agree with you on the chem you note ALSO. Med school teachs it 'can be ticks AND fleas" the rich man at the race track knows he can order "surf AND turf" regular folks are taught one OR the other, hope this helps in ALL things, best to you.

[@noglu106]

This is best way to diagnose if you suspect Celiac. First, go strict GF to see if symptoms improve, then reintroduce to see if symptoms return. If that is the case, then test for it. If the diet doesn't work, then there are only 2 possibilities either you have refractory Celiac or something else. This gentleman who I saw almost 20 years ago explains it the best.

[@mspinchey]

Sad that my doctor nor my mother could see the obvious!

[@concernedcitizen3476]

Great lecture...thank you

[@alidalouisa4462]

he is amazing! Very interesting and very funny!

[@lindseyburrow9772]

Brilliant. 👏🏽

[@Lennythewinner]

20:30 I thought he was going to say that in ancient Egypt, wealth was measured by the total amount of gold in all their dental fillings after the carb had rotted their dental enamel away.

[@desireefielder2154]

This is amazing information . Todah,,,, much thanks..

[@martinswells1987]

Hello Desiree, Merry Christmas I hope you're safe over there and I hope this year brings happiness, prosperity and love to you as well. I would love to be a friend, where are you from?

[@joaocoelho7331]

He, pretty much, is talking about what I learned from the book Wheat Belly, by Dr. William Davis. He is the first one I learned from, about the dangers of wheat and grains. I would recommend his videos, too.

[@violamena8165]

Joao Coelho : William Davis gives credit to Dr Allesio, because Allesio revolutionized the gluten theory

[@violamena8165]

In fact that’s how I’ve learned about this doctor, from Dr Davis interview

[@aliriozavarce2358]

This is great information. Thank you, Dr. Fasano. We’re not supposed to eat wheat because we, humans, don’t have the enzymes needed to breakdown gluten into individual amino acids. Gluten is toxic to everybody. So if you eat it, and get sick, you get tagged as a Celiac or with any of the other non-GI “disease” names. Don’t eat wheat or anything with gluten. Period. This is not a genetic problem. This is a nutritional problem. If you eat something that you’re not designed to eat, you’ll get sick. Your body doesn’t like it. Simple. It is hard for me to believe that “evolution made a mistake.” SMH.

[@Nick-cp3sr]

“Gluten is like a bacteria.. But very few on us lose the battle and very few of us will get in trouble with gluten over time..” Dr Fasano. We are constantly having immune responses to foods.. Does mean they are all negative or will have any significant effects on human health..

[@juliametcalf2660]

Think lots of these issues will trace back to the seed oils used in cooking & eating ...

[@dianaalexdaniel]

I found your Video to be Amazing, thank you for sharing it with Me, just plain - Awesome, have a Wonderful Day, I am Gluten Sensitive, thank you again, Diana Lipski. May People all Around the World see the Truth and Get Better - Mind and Body Wise.

[@herbladie]

Amazing info…thank you!

[@martinswells1987]

Hello Marilyn, Merry Christmas I hope you're safe over there and I hope this year brings happiness, prosperity and love to you as well. I would love to be a friend, where are you from?

[@thatslena]

I am waiting for Dr. Fasano to give clear guidance on hashimotos. If he says ni gluten then i am off of it completely.

[@lauradean3207]

why are you waiting, what do you have to lose. many autoimmune diseases respond to removing gluten, dairy etc. Although I don't have Graves disease I bought a book by Dr Amy Myers "The Autoimmune Solution" and followed an initial 1 month exclusion diet and have had great results. Most of the autoimmune diseases are thought to be caused by what we are eating, and it is removing certain foods from out diets. I have had life changing autoimmune conditions from being a child, I have now developed another one and I am therefore continuing my own research into diet, buying certain books that make sense to me. The pain and disability is what drives me. If you have a condition that completely alters your life you would take action, if you have one autoimmune disease it means you can get others as well. Just stop eating our western junk food. I repeatedly hear people say that if such a food was harmful they would not be allowed to sell it, how can anyone be so naive as to trust people with their health, the food industry makes money out of putting rubbish in our food, look at the what is put into it that is so removed from what is natural. Look what people put in their shopping trolleys. So much processed and junk food, no wonder everyone is fat and getting ill, no one looks healthy any more. Read the labels and help yourself. Forget about eating and making cake etc, why do people allow themselves to get caught up in whatever is trending. In the UK, the cookery programmes on TV are portraying foods that are full of eggs, sugar, wheat and dairy etc and people are copying them. Look at those doing the shows, the cooks and chiefs nearly every one of them is fat. Use your eyes, read, and draw your own conclusions. Who wants to get these terrible life changing, life shortening if they can be avoided by what we eat. We are wasting the money and time we spend on harmful foods that are making us ill. How unintelligent and plain ridiculous it that. Good luck.

[@thez33k]

What do you have to lose if you went gluten free for a few weeks?

[@thatslena]

@@thez33k I wouldn't think a few weeks would help with symptoms. However, I've done so many tests for gluten since posting this comment and also a dna test which says I don't have the gene :/

[@Hashi.2]

“The best way to predict the future is indeed to create it” That’s right 👍🏽

[@DaJoker1]

Very informative, Thank you so much! But what about oatmeal or buckwheat?

[@kwasiAsareBoye]

Whereas I agree that the total environment has been compromised, this study: www.ncbi.nlm.nih.gov/pubmed/24521561?dopt=Citation suggests that "... products (bread, pasta, biscuits and crackers) made from ancient as against modern wheat significantly reduced symptoms due to IBS etc."

[@KarenPendergrass]

Probably because we artificially selected for higher gluten content in cultivating modern grains, so that makes sense ^^

[@EugeniaLoli]

They have less gluten, but they still have some. And if they also become a staple, they will create problems too.

[@LucianPTeatfatgetlean]

That study is set-up to promote the "ancient" wheat and funded by a company which sells this wheat. If the researchers wanted to answer the question comprehensively they should have included a 3rd group: no wheat group! maybe they would't got the funding if they did that.

[@sundarex]

Karen Pendergrass Yes, modern wheat is very different from traditional/Biblical varieties like spelt in terms of gluten content. One critical factor is that ancient breads were fermented... but modern bakery products are quick fix stuff. My baker friend who got trained in Paris says that the wheat dough should be fermented for 3 whole days before it enters the oven!!! Fermented dough or soughdough reduces the offending gluten but remember that some will still be there. The upper limit of daily consumption of gluten is set at 10-12 parts per million for gluten sensitives. Gluten cannot be destroyed thru' sprouting hence bread made with sprouted flour doesn't help.

[@IBNancy1]

DawnHinz

[@acefalcon100]

grazie

[@abdulrashid1041]

I am a patient of ankylosing spondylitis for last 2 decades. My whole spine has fused with miserable pain. Can gluten free diet help in pain relief and reversal of changes. Second...Is gluten free wheet floor is considered gluten free. Third if insidently I consume gluten by mistake, my whole hard work is spoiled?

[@user-rl4yw4ys9x]

19 years for me to get a diagnosis.

[@tonnibeck]

+Lisa Purcell I still have you beat! My symptoms started as a child, hospitalized first at 8 yrs old. Was not diagnosed until I was 49! So now, I frequently go into crisis. Have to be hospitalized, even have been placed in long term care for months at a time! Celiac has done damage to all of my organs (most have been removed) . In fact I just got out of the Hospital 2 days ago after a 2 week stay - and 3 calls for a Crash Cart! ALL WHILE LIVING GF!!!!

[@SmogenParadise]

+Tonni Beck I am an easy prey in front of any gluten invasion. i have endured a lot. I avoid wheat barley and rhey. I feel way better.

[@SmogenParadise]

+Lisa Purcell I am so sorry.

[@deejay9868]

That's quick! Mine took 51 years 🤨

[@helenroscoe1124]

I fear I've been misdiagnosed for years too ......unwell during childhood......symptoms since now 46 starting to think Celiac 😢

[@phylenejanousek2740]

Just no more bandaids plez Cure appears to be a totally clean balanced diet. No rice grains soy fillers natural flavored etc. It’s work but worth it👍

[@alomaalber6514]

the wheat is a total no for me, but the soy is not my friend either.

[@1yogachris]

But something else needs to be factored in; the effects of antibiotics and other medications on the gut. Antibiotics kill off the beneficial and essential gut bacteria, allowing the harmful ones to proliferate. These also damage the lining of the gut and give rise to Leaky Gut Syndrome. So some people will acquire sensitivity to gluten (and to a whole range of other foods and beverages).

[@nicoled7949]

What about those with selective IgA deficiency that blood test negatively!? That's a paradox. And then scopes come back negative but have all the classic symptoms and show anti gladian in stool test and genetic tests show celiac genes. How would you meet the 4 in that situation!?

[@Liberty1111]

SAME with me. Noone cares abt us.. haha. Do u feel like shit after eating gluten? that's our answer I guess???

[@hyacinthdsouza1663]

God bless

[@cholakicha]

hey, great content greatly delivered!

[@olekike72]

I hate it when the speaker towards the end, starts rushing and skiping subjects.

[@bonniestrait9138]

I enjoyed listening to your video very much! I have celiac s i was diagnosed with it age 50 by a stomach empting test! I ate a half of peanut butter and jelly on whole wheat 17 hours prior to test and when they took pictures of stomach contents it was still in my stomach! Looked like i just ate it! I believe the way wheat is harvested today is bad for you! The part thats poisonous to us is mixed in! Back in Biblical days they knew and threw that part out!

[@bencyber8595]

wait , let us find out

[@mspinchey]

Thumbs up on the beer comment!

[@dawnemoore6484]

can't hear

[@jennalovecraftreeves9679]

I cant break it down inside, my body wont process it. Its like pooping rocks.

[@telepetenowheat5342]

Paradise existed here on earth before the advent of agriculture. Wheat. The forbidden fruit. Did you really believe that it was an apple? 18 Thorns also and thistles shall it bring forth to thee; and thou shalt eat the herb of the field; 19 In the sweat of thy face shalt thou eat bread, till thou return unto the ground

[@54321Truth]

Only a dumbass thinks Eve was given SEXUAL punishments for eating fruit or wheat. Eve had sex with the fruit of a forbidden FAMILY TREE. God hates those who destroy his creation through RACE MIXING. Adam and Eve were of one race with Trees of their Kind to eat from but the Sweet talking serpent of another Family Tree talked Eve into having sex, then was born two different kinds of kids, where the Serpents kid murders the Adamic Child. Diversity and Race mixing are a sickness that create conflict and destruction of families and nations. Race mixing is destroying Gods Creation.

[@spaceghost8995]

Oh fuck off with the bible bullshit. You can make the bible say anything you want it to.

[@Aharon_I]

The root cause is salt deficiency