Dom D’Agostino - Achieving Therapeutic Ketosis

The science and application of ketogenic diets and ketone metabolic therapy is developing rapidly and moving into human clinical trials for a diverse range of applications. The presentation will focus on past, present, and emerging research on nutritional and supplemental approaches to achieve therapeutic ketosis. These metabolic-based therapies are successfully used to treat neurological disorders, and many common diseases that are linked to poor metabolic health. Metabolic-based therapies, including diet and supplementation, can alter systemic physiology, brain metabolism, cellular bioenergetics, and even gene expression. In addition, the lecture will cover important cardiometabolic biomarkers that should be measured and discussed with your doctor, but that are not typically associated with routine exams. These biomarkers and measurement tools help to advance personalized medicine and are important for enhancing longevity and metabolic health. Normal ranges of these biomarkers will be discussed as well as methods to achieve ideal ranges that are associated with disease prevention and metabolic health optimization.
This lecture is part of the IHMC Evening Lecture series.
www.ihmc.us/li...

[@svs7138]

I have been type 1 diabetic for almost 50 years. I have been in ketosis for 17 years. I can do that because I know what I'm doing. I'm much more helthier than ever in those years when I eat "normal diabetic food". I lost ~100 pounds and everything is in good condition. Thank you for this information! 🙏

[@PiujuqInuitArt]

Good job!

[@m-hadji]

I diagnosed as T2D in 1996 and I did whatever I could. But everything went south until nov2021. I put my first CGM on at this time. I discovered amazing stuff about effects of food and activities. It was life saver. I discontinued 7 meds including two insulin injections. My BP normalized and I don’t use CPAP anymore. Oh I forgot to say I lost almost 50 lbs.

[@gabriellorinczi4386]

So you were in ketosis when this changes happened? After how long? Thank you

[@m-hadji]

@@gabriellorinczi4386 I never check my ketones. I just stopped eating with white carbs. Rice bread pasta you get the idea. My only fruit is berries. I have a cup salad. I never separate the fat from my meat. And never buy fat free anything. I thought myself how to read and act my CGM data. I walk 6 miles a day no matter what. I had my last slice of pizza at thanksgiving 2021 and I didn’t miss it at all. I hope it helps. What works for me might not work for everyone. Find your way.

[@PiujuqInuitArt]

Good job!!! ❤❤

[@PiujuqInuitArt]

@@m-hadjii stopped eating white things in 1972

[@m-hadji]

@@PiujuqInuitArt❤❤

[@CashMoneyMoore]

What an excellent talk. Anyone considering medical ketosis should watch

[@monnoo8221]

that was pretty comprehensive, appreciate it, indeed. I would like to comment on 2 biomarkers, the HbA1c and LDL. A1c is dependent on the MCV and RDW, which together reflect the average age of RBC. That age can vary in a range of 15% around the "3 months" average. Actually there are very few studies having determined the age of the RBC at all, because it is very difficult. Add to this a higher MCV, which can be caused by chronic folate deficiency, yu easily get a range of variation of 25% of a hypothetical value. 12.5% of 5.5 mmol in either direction yields 4.8 or 6.2. Without an estimation of the age via MCV, MCVC and RDW ithe A1c is anything but reliable. It should be handled carefully. . Second about LDL, Yes you mentioned the LMHR,. Yet you still advocate ApoB. LDL AND ApoB are surrogates based on a deeply inappropriate theory.Hence they are both crap. What is critical is oxidized LDL, which can be measured by size distribution of LDL, and partially the VLDL particles. Talking about "Bad LDL" is like the tale of the inherited sin, aka all people are bad. Neither people (that is an assumption) nor LDL are apriori "bad" as a global group. There is a precise mechanism, and a precise measurement, so every professional, at least those, should stop talking about "bad" LDL. LMHR people have to care a lot about there oxidative capacity in the blood, and have to keep it as low as possible.

[@kindedge]

Love Dom. Willing to be relevant & yet data-driven.

[@awesometulips9427]

This is a superb talk, packed with all kinds of practical information on how to improve metabolic health. Where can we find the pdf with the slides for this talk? Dr Dom mention to email him but that would be my last resort. Thanks to all for making this video available 😃❤

[@ruthdella37]

Can we get together regarding FAKE KETO FOODS and sue them to stop selling fake stuff? The only way to get companies to change is by suing them for false advertising. The money received from the lawsuit can be donated to more Keto research.

[@andrewrivera4029]

You’ve read my mind although I rant and rave about it all the time in youtube comments sections!

[@cgoodiefunk]

keto bars with 12g carbs and seed oils lmaooo

[@RC-qf3mp]

Or just learn how to read food labels and take responsibility for what you put into your body.

[@mpoharper]

Not every food affects people in the same way. There are foods that don’t affect glucose spikes in some but do in others.

[@andrewrivera4029]

@@mpoharper correct, seed oils in KETO snacks cause oxidized LDL but doesn’t spike glucose.

[@marynayna6327]

MCT oil in my morning coffee with a tablespoon of butter.👍

[@salvatorefazzino5697]

This is a great lecture, very educational, I have been on ketogenic diet for the past year, it has saved my life… However, I have been very attentive to other physicians and podcasts, I think you should investigate the fasting insulin test, it will give you a different perspective and insight about diabetes, insulin resistance, and how ketosis plays a major role on reversing metabolic syndrome…..

[@jeannelocke8852]

Thank you so very much for this generous video. My family and friends send respect, appreciation and love.

[@domenicrutigliano2511]

Excellent Dom. Alot Of New Useful Information.

Knowledge about ketosis changed my life. Since 2017 low carb....although not always strict, although not obese, having not any serious illness before but anyway it changed my life healthwise.

[@dinomiles7999]

Dr. Dom is a WIZARD ! ❤

[@wocket42]

My lab report shows B12 should be in range of 197 to 771. I had 2000+, though. Before I was eating meat, it was more like 800.

[@lf7065]

What kind of meat are you eating? How much?

[@eileenromps9266]

Dom, you are such a wealth of knowledge!! What issues arise from high ketones and what symptoms should I look for? I’m a high ketone producer and have been keto for 3 years. I measure ketones and bg. My average ketones for the last 3+weeks has been 3 and bg in 80’s.

[@RC-qf3mp]

That’s not “high” ketones. Ketoacidosis is high. That’s up around 8. And the scale is logarithmic, so you aren’t even close to high.

[@cattleprods911]

Fantastic! Thanks Dom!

[@Athenaikos]

I have a new appreciation for Dr. D Agostino . Very profesional and thorough presentation.

[@PiujuqInuitArt]

My mom if she was still alive she'd be so proud of you. She always said if you have your health you have everything. It's the most important thing in life. I am proud of you too! 😊❤️

[@esoteric.breadcrumbs.]

1:02:02 I really appreciate knowing about psychological stressors and hs-crp influences. That’s quite illuminating.

[@peterz53]

Thanks for blood work details. I'm WFPB. Eat brown rice and potatoes too. But no junk food and very little alcohol. Only animal food is a small amount of wild fish. Last hsCRP was 0.3 and HbA1c was 4.9. ApoB of 67, so need a little work to get < 60, my goal. B12 is ~ 700, but supplement. Age 69. Don't check insulin. long term 16/8 TRE.

[@lf7065]

It's important to check fasting insulin levels!

[@karend.9218]

Also bone density, plant based people lose bone mass faster than others. Google studies.

[@BeefNEggs057]

Look up the toxins in potatos. Oxylates damage the brain and eyes. Don’t eat roots in general. Nightshades are bad business.

[@ct8689]

F/45/TX currently awaiting biopsy and accepted at MD Anderson as a patient. They're great so far, lots of diagnostic testing and already scheduled for surgery due the mass and thrombosis. Sadly, no talk of nutrition while awaiting surgery. The internal medicine Dr shot me down the first day when I mentioned metabolic therapy. After researching on my own, I've done water fasting and using my keto mojo several times a day. I've maintained high level therapeutic ketosis on my own. MRI done again last night. Hoping to see progress. If it didn't cost money, I would seek out another dr to assist in testing.

[@savatryramsaran1877]

Can you please share the food you eat.

[@karenohanlon4183]

I get b12 shots methocobalimn. Every 2 months. A week before its due I feel so tired and weak its as if my body knows its due Even on keto I still need the shot. Its so essential and cheap as chips

[@wanderingheart9447]

Trying to find someone who does the methylcobalamin shots near me south of Tampa….didn’t think it would be so challenging to find.

[@PiujuqInuitArt]

Nick Norwitz and Dave Feldman talk about lipids. Apparently I am fine. No one should like statins. They cause diabetes heart disease and dementia. I will try to email you. I want your slides. I can also arrange for you to go hunting caribou seal etc in the high Arctic if you'd like. I heard in Florida there you hunt and eat the local wildlife. Thanks so much for sharing your knowledge!

[@bobcocampo]

Please have a research on effects of 🥑🥓🥚🧀 keto in kids 👶👧🚼 and students 👩‍🎓 on learning, memory and Intelligence

[@OIOnaut]

I had neuropathy. Went on keto and got rid of the symptoms. They come back even from a small concentration of dietary glucose. Been on keto now 10 years of which last 5 on carnivore. I have searched the literature for an explanation and found it from the realm of bio quantum mechanics. Deuterium content elevation has so far been a strong indicator. Structured water, electron and photon resonance driving redox signalig in mitochondria is a huge factor that is underpinning all the molecular jargon I had to stand during the ten years of struggle and learning. My fortune is that I already understood physics better than chemistry. Since I have got that part too. Deuterium depleation and semiconducting water as a solar radiation collector thus the driving force of life itself.

[@JuliePeterson-12345]

I wish I understood what you were saying bc I think it could be very helpful to me as I deal with neuropathy. Any suggestions of who I could listen too and study? Jack kruse is over my head

[@savatryramsaran1877]

I wish I understood what you just said as I think it can truly help me.

[@OIOnaut]

Perhaps Sara Pugh or someone like Max Gulhane could help with that. My point is that the learning curve is so steep. Otherwise it is like faith on others. It hardly ever works. Knowledge builds one brick at a time. Time is all we have so learn well.

[@yelenaboyko273]

Where is a practical, actionable advice promised

[@petercyr3508]

Fundamentally, ketosis is REQUIRED, not theraputic. Like saying breathing is theraputic. Yeah, kind of obvious Navy Seals need to be in ketosis. Also little old grandmas, children and well anyone... Just dont block it by constantly eating starches and sugars.

[@PiujuqInuitArt]

Yes yes Peter but it's hard for the general public to take that I yet. Keep talking.

[@yoso585]

Nonsense. Only the metabolically unhealthy need the diet.

[@mom2artists]

@@yoso585so like 88% of the population of the USA? lol (I'm one of them)

[@andrewrivera4029]

I’ve been doing low carb for 6 years, fasting started carnivore January 1st, I’m a metabolically healthy 58 years young male but I’m not in ketosis. I’m burning fat and building muscle and feel great so is continued ketosis really REQUIRED? FYI when I fast I get into ketosis.

[@backfru]

Required for what? How is a metabolic state that is basically strarvation, "required" for grandma, children, and anyone? If a specific diet that eliminates entire food groups, and is abolished by eating some fruit, is "required", then it sounds like you're pushing some personal agenda and have no business suggesting anybody but yourself should follow this way of eating

[@PiujuqInuitArt]

So if you got thyroid and adrenal and ovarian failure what happens to your blood sugar if you water only fast. Or if you water only fast and add dark roasted organic coffee with ketones added?

[@Roberto-cg2gr]

Is GKI an indicator of Autophagy? Is insulin levels an indicator of Autophagy? If insulin is low is MTOR down. regulated? How do we know if MTOR is down regulated? Is ketone levels an indicator of Autophagy?

[@Selahree]

My doctor founded the metabolic psychiatry clinic at Stanford University - and coined the term. :-)

[@wocket42]

If you are in nutritional ketosis, can you still have elevated insulin? Or does the ketone meter replace the fasting insulin test in this case?

[@PiujuqInuitArt]

To know your insulin levels best to get a fasting insulin done but however if you glucose ketone ratio is 2.0 or less your insulin is likely not too high

[@SurviveFromCancer]

Hi, I'm a stage 4 Cancer Survivor since 5 years. I would like to speak with you to share my story. Pr. Thomas Seyfried gave me your name years ago but sorry I neglected to reach you. Sorry Guy Tenenbaum

[@PiujuqInuitArt]

Hi Guy. Keep going good work

[@bobcocampo]

Any research on healthy students taking MCT OIL before examination?

[@savatryramsaran1877]

@SurviveFromCancer Please share your protocol some of us will benefit from your journey.

[@jaktao6044]

Dom is a cool guy.

[@BeefNEggs057]

No one who is metabolically well should control cholesterol. Let the body control it. Your body produces what it needs. Otherwise this is a really good presentation. The cholesterol part seems like he’s playing it safe. The science says if your trigs are low and your hdl is high your “risk” is low. LDL is a useless measurement in every way.

[@PiujuqInuitArt]

So how much raw steak to I need to eat to optimize my B12. I don't want any kind of above the neck atropy thanks! ❤

[@BeefNEggs057]

Daily beef and eggs is best. Replace those toxic vegetables.

[@OIOnaut]

About ApoB you should talk about LMHR studies in context of HDL ApoA and TG

[@OIOnaut]

Again deuterium content matters and shows that ApoB should be elevated too!!! LDL con still rules IMO.

[@mikeward9870]

Check out the recent book "Ketogenic: The Science of Theraputic Carbohydrate Restriction in Human Health"

[@monroemusicnz]

There is no “bad cholesterol”.

[@BeefNEggs057]

Cholesterol shouldn’t be monitored. Let the body produce what it needs and focus on metabolic health. Triglycerides is much more important as a heart disease predictor but is ignored by many doctors. HDL should be high and trigs should be low.

[@monroemusicnz]

@@BeefNEggs057 Agreed.

[@dreamervanroom]

I’m almost at the hour mark and I know one test is high. The doctors give everyone so if my fasting blood sugar is high I know I need help and I don’t need to take and spend money on all these other subtle test. I was just there for people who want to make sure their Everything is good. Once something is bad you know you need help. I think that he’s going to suggest the keto diet for everything.

[@PiujuqInuitArt]

Perlmutter and Lustig talk about uric acid

[@mikerudd4943]

Dave Asprey and Dr. Veech talk about uric acid from 7 years ago. Potassium can be needed to help with the kidney in ketosis

[@mariejones7136]

Well im out of keytosis after being in for 2 weeks..0nly 0.3 ketones and 80 glucose so I'm fasting until tomorrow and i hate it lol..i do use exogenous ketones but not everyday..i do intermittant fasting but not enough to stay in ketosis along with keto diet..i get kicked out of keytosis fast .

[@lf7065]

Once you're fat adapted, the body uses the ketones and you will not register as high or barely at all. That does not mean you're not in ketosis - if you are eating high fat and using time restricted eating, you will be in ketosis. 🙂

[@RC-qf3mp]

Eat more fat, fewer carbs and protein. Yeah, fasting works too. But so does bacon and egg yolks.

[@mariejones7136]

​@@RC-qf3mpI'm so afraid to eat bacon ..I don't like eating pig lol

[@RC-qf3mp]

@@mariejones7136 to get into deeper ketosis you can 1) eat higher fat, lower carbs, 2) fast, 3) EXERCISE. Works like a charm - do Zone 2 endurance training for at least 20 min a day, 3x a week. Doing it in a fasted state would be even better. Go for a walk after each meal.

[@eugeniebreida1583]

I’m not hearing the downsides for many (women especially) wherein sustained higher ketones affect/raise cortisol and other sleep destroying hormones as time goes on. Dom: Should a 110lb 5’2” 65 yrs woman add (?) carbs to balance things out in favor of lengthening sleep/raising quality of sleep? Help? (naturally lean, athletic, low thyroid… and desiring (carnivore?) keto diet to turn down psoriatic arthritis.

[@PiujuqInuitArt]

Don't add the carbs. You do not need carbs to live. In fact I seem to have a carbohydrate intolerance

[@aniccadance13]

I'm the same weight, height and age as you, I've been on a keto diet ( under 20g of carbs a day) for about 8years and my blood works is excellent and also I feel great. Sending love❤️

[@eugeniebreida1583]

@@aniccadance13 But do you suffer from serious insomnia as result? May I ask what form your ltd. carbs come in, each meal?

[@eugeniebreida1583]

@@PiujuqInuitArt I seem to def. require some carbs… or no can sleep. (A major health destroyer, in real-time)

[@RC-qf3mp]

Eat animal fat- which is what helps form and regulate hormones.

[@gratefulagoraphobe]

I have been carnivore for a while, practice time restricted eating and exercise. My ketone levels are still low. I don't understand it. I want to be in therapeutic ketosis for mental health issues and Dr Palmer says ketones should be 1.6 to 2 to see benefits. I can't get anywhere near that. Also, I used to take Mct oil, did nothing for my levels. Any idea why they could be still so low?

[@JuliePeterson-12345]

A theory to look into is that a high protein diet could be causing gluconeogenesis where your body is turning protein into glucose and keeping your bs higher and out of ketosis. I’m not a doctor but believe this was my issue with super high protein diet

[@gratefulagoraphobe]

@@JuliePeterson-12345 I eat high fat and check my glucose, which is great so that's why I'm not sure why my ketones are so low. It's confusing. Maybe I should stop obsessing about it 😂 but I'm worried that if I'm not in therapeutic ketosis I'm not getting full effects of this lifestyle

[@JuliePeterson-12345]

@@gratefulagoraphobe I know all too well how obsessing about these things can drive us nuts😂. When I started carnivore my bs actually went up and it made me crazy. I had to stop obsessing about it so much. I’m sure you’ve been doing this a long time and know more than I do but wanted to mention something I noticed for me…even though I was super low carb I struggled to get into ketosis at the beginning. It took me 48 hours of fasting to finally get into a low level of ketosis-then it was easier able to maintain it and get into. Just a thought:)

[@gratefulagoraphobe]

@@JuliePeterson-12345 I have thought of it, and tried omad and they went up slightly. My problem is that I am doing this because of extreme anxiety. Not eating isn't an option for someone like me bc it spikes anxiety. I'm hoping that it's just my metabolism still in the process of repairing and that eventually it will be ok. I'm on day 44 of carnivore, was keto for a month before that, so I'm new to this 🙂

[@JuliePeterson-12345]

@@gratefulagoraphobe that totally makes sense. I think just avoiding processed carbs and sticking with carnivore rather than hitting ketosis is more important to reducing anxiety. Keep doing what you’re doing! I hope you are and start feeling better!

[@WORKOUTSOLUTIONS]

❤️‍🔥🕊️💪🥗🙏✝️GOD BLESS ✝️🙏👨🏻‍🌾🥇🚀

[@karenohanlon4183]

Does virgin coconut oil have mct?

[@lf7065]

A little

[@OIOnaut]

Omega3 is tied to Melanin and DHA. Quantum electronics.

[@dinomiles7999]

MCT oil and DDW !

[@bobcocampo]

Please discuss improvement in intelligence with keto diet 🥑🥓🥚🧀for students

[@georgewright1093]

That guy is obviously smart as hell and he gave a lot of great information but I just can't take anyone named Dom seriously. So I'm going to stick with my jelly donut and chocolate chip cookie diet.

[@allencrider]

There's nothing therapeutic about ketosis.

[@PiujuqInuitArt]

Explain please?

[@daynawest3707]

You are mistaken

Yes, because it's the natural state. Not being in ketosis is pathological.

[@backfru]

@ How is it a natral state? You 'enter' it when you're starving, to provide fuel for the brain to keep you alive So by that logic, strarvation is our natural state , and we should tweak the system to mimic a state of starvation all the time? Not being in ketosis can easily be achieved by eating some potato, or fruit, honey, dairy products Damn. So in order to achieve this "natural state", you just have to follow a specific diet, avoid entire food groups, and rely on a backup fuel system to ensure you don't die? Sounds totally natural to me I can walk down the street and pick an apple off the tree. Oops, I'm pathological now.

[@RC-qf3mp]

Tell that to people use ketosis to successfully treat epilepsy.

[@60secondmuscle]

Most confusing brabbling I have EVER heard in this topic. Learn to be spesific in giving steps that can be practically followed. Pathetic

[@monag.769]

Maybe it is just too much information for you? Dr. D‘Agostino is one of the most knowledgeable persons on this planet when it comes to ketogenic diet and its therapeutical applications, and his conferences are chock full of serious scientific information. Maybe if you watch the conference several times you can process it better.

[@RC-qf3mp]

You can just ask AI for those steps. The presentation was to show the science , not provide a how-to manual.

[@farmer_donny]

If you're not prepared to learn enough science to understand what he's saying, you'll just have to wait till somebody brings out a picture book to explain it.

[@elkiton]

Sorry you found it so..... To me it is a well presented but complex subject matter, interesting and comprehensive. Thought provoking. No its not a "do ketosis" cookbook, there are plenty of 10 minute videos on that, ie superficial knowledge level for those who want to practice the basics without needing to know the background theory.

[@roachums123]

It's a scientific talk, not a clinical how-to manual.

[@PiujuqInuitArt]

So I can use my hsCRP as a proxy for my insulin levels? My GP has waist size close to 60 inches and his grey matter is inversely proportional to his white matter volume to be tactful and here in Ontario our very metabolically ill government can not see its way to attracting competent MDs to Ontario so I'm stuck with one that unfortunately does not know more than me Appears to know less than me.

[@aniccadance13]

I love Dom, he's amazing..Thank you uploading❤

[@donchigazola8886]

I've been following a Keto diet for 5 years. I notice that when I'm in ketosis, my sleep is disrupted and I commonly wake at 3am with an inability to go back to sleep. Is this common?

[@BeefNEggs057]

It’s temporary- it passes - lots of transitory problems go away with persistence and consistency.

[@mariejones7136]

My boyfriend has Parkinson's but he cant do keto because he loses too much weight...Hes afraid to eat red meat because the protein interferes with his medication..what can he do??

[@thecolonel-truesoutherngen2230]

keto is not a weight loss diet see Dr Ken Berry's vids on Proper Human Diet. you don't restrict eating. eat until you are comfortably stuffed. your body will find its correct weight.

[@mariejones7136]

​@@thecolonel-truesoutherngen2230..he thinks if he eats meat etc he will clog his arteries..I give up