Thank you, Dr. Chaudhry, for this helpful information. I suddenly developed severe skin rashes after many months of lenalidomide. I discussed changing the drug with my oncologist, but your comments have encouraged me to keep trying lenalidomide. After a break, a little cortisone and a few days of antihystamine, I was able to stop all that ... and the rashes disappeared. My body has developed a positive tolerance. I am very happy with this outcome, thanks again!