Pyruvate is converted to LACTATE via lactate dehydrogenase under anaerobic conditions. This is not a waste product, nor does it cause muscle acidosis or fatigue. Lactate can be moved to the liver and used for gluconeogensis through the Cori Cycle or it can be used at the level of the muscle as substrate for continued contraction via the Lactate Shuttle. Acidosis occurs coincidentally at the same time (due to increase work) but is caused from the hydrolysis of ATP rather than 'lactic acid'. The conversion of pyruvate to lactate + NAD+ is critical in continued fuelling of glycolysis (NAD+ used at step 6).
@cameronharkness54239 жыл бұрын
You have just saved me. Thanks you ;)
@kyleboyek28507 жыл бұрын
The information in this video is horribly inaccurate. how can you 'put off' using glycolysis for energy metabolism?! absolute nonsense
@trainingmadefun42926 жыл бұрын
Why is that nonsense? It is absolutely correct. The longer you can go at higher speeds and stay aerobic, due to significant training at higher intensity aerobic levels, the longer you can "put off" reaching the anaerobic threshold. Makes perfect sense.