Enhancers | Transcriptional regulation by Enhancers | Enhancer promoter loop

[@jeancorriveau8686]

This video makes me understand better enhancers and transcription factors.

[@animatedbiologywitharpan]

Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

[@MarvinMonroe]

I just learned that my father's cousin (my first cousin, once removed) was instrumental in discovering Enhancers back in the early 80s at Harvard. Julian Banerji, I'm so proud to be related to him. He and his two sisters and his wife and their husbands are all wonderful humans Edit: and Arpan, if you are wondering why I, a white guy in America am related to a Banerji it's because Julian's mother met and married a man in India back in the 1940s. Not sure if she was traveling in India for a summer and met him then or what the story is. Julian's mother and my father's mother were sisters. So my father has 3 first cousins who are half Bengali and I have 7 second cousins who are 1/4 Bengali Im in the middle of reading the account of the discovery, I'll try and link the article here soon

[@animatedbiologywitharpan]

I am also a bengali

[@MarvinMonroe]

@@animatedbiologywitharpan that's cool! I love every Bengali I've ever met. Julian's father, my Great Uncle Sid was the nicest person ever

[@MarvinMonroe]

@@animatedbiologywitharpan I can't post the link but if you'd like to read about the discovery you can search "Julian Banerji enhancer" and you'll find a post that says "happy 40th birthday Enhancer" That post contains the original 1983 paper and a new paper written by the lab director who recruited the team and he tells the whole story. I found it interesting

[@matthiasturcar7329]

Great video that helped me understand Enhancers. Keep it up!

[@animatedbiologywitharpan]

Please share among friends and help me to reach big audience

[@rahulrai3160]

good work bro ..best way to elobrate concept ....thanks

[@animatedbiologywitharpan]

thanks glad that it helped ...share among friends and help them as well

[@ChristianGriffioen]

Where can I find your more detailed videos about enhancers?

[@MercyMburuNyakio]

Literally what I was looking for. The difference between enhancers and promoters really confuses me!

[@animatedbiologywitharpan]

Please share among friends and help me to reach big audience

[@MercyMburuNyakio]

@@animatedbiologywitharpan Okay! Done!

[@alphegedinsijohnmojiun2961]

This could be a subtle subtopic to explain epigenetics since it involves the regulation of gene expression.

[@animatedbiologywitharpan]

Ya

[@ramchandrasuthar2848]

Very nice analysis sir

[@shrutikasansaria8499]

So nicely explained Thank u

[@animatedbiologywitharpan]

Please share with your friends and help me to reach big audience

[@animatedbiologywitharpan]

Subscribe to my other channel kzbin.info/door/4IpyopsGWSjaPACNTZLuqg

[@lidongli-z6d]

Your video is so well done. Can you share the PPT with me? I am eager to

[@animatedbiologywitharpan]

you can buy the ppt @ 2$

[@bili4591]

I need a video who explain me the mechanism of how a unique stimulus allow more than only one gene to be expressed I am confused.

[@animatedbiologywitharpan]

Thanks a lot for this interesting suggestion. I will try to make one video on that

[@bili4591]

@@animatedbiologywitharpan ok i will wait, thanks

[@mgold9999]

At 2.30 the green to the right should probably not be upstream but downstream enhancer right?

[@stephank9172]

yes, it should be a downstream promoter element (DPE)

[@alejandraacevedo-muniz6255]

when an enhancer is bound, it stimulates the transcription of a specific gene? or more genes?

[@animatedbiologywitharpan]

Very nice question ...actually 1 enhancer can influence multiple Gene's and it all depends how enhancer interacts with promoter in 3d

[@animatedbiologywitharpan]

Please share my channel link with your friends and help me to reach big audience .

[@Brainwise889]

Thank you

[@animatedbiologywitharpan]

Please share my channel link with your friends and help me to reach big audience

[@joanne7699]

Hello, could I ask if promoter is considered a regulatory element? Some sources do not consider as regulatory element. Thank you

[@animatedbiologywitharpan]

It is a regulatory element

[@joanne7699]

@@animatedbiologywitharpan thank you for replying! Could I also ask but core promoter element itself Is not a regulatory element right?

[@adelaide4356]

@@joanne7699 no the core promoter is not a regulatory element. Regulatory elements include promoter proximal elements (PPEs) such as the GC box and CCAAT box (upstream of the TSS by ~50-200 bp), and enhancers and silencers. Hope that helps!

[@joanne7699]

@@adelaide4356 thank u

[@nadeemnaniwala164]

Brother i am waiting for your another video on enhancer

[@animatedbiologywitharpan]

It would be uploaded soon

[@nicolealoeyi1842]

approximately how long is an enhancer in base pairs?

[@animatedbiologywitharpan]

From few hundred basepairs to few KB

[@animatedbiologywitharpan]

Please share my channel link with your friends and help me to reach big audience

[@PriyaThakur__.__]

200bp but can show its effect 1000bp upstream or downstream.

[@MegaYumna]

Pictures in the video are blurry, not clear

[@animatedbiologywitharpan]

Please increase the quality settings for better graphics

[@sali359]

inaccurate and please buy a new mic

[@tonowhereofficial]

Why is it inaccurate? Please, explain.