Histone modifications (Introduction)

This is an introductory video on histone modifications (Introduction) and how it affects gene expression and chromatin landscape in a context-dependent manner.
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I learned more from this video than I did in my entire genetics semester. Thank you

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[@molecularunity]

Thank you, a really great video. I like the bar code comparison at the end. I think that one of the cerebral challenges to understanding histone and DNA modifications is to recognize, in the first place, why they are necessary and moreover, how they allow so so many genes to be read, written to, read again, erased, written to again, read again, etc, switching genes on or off, or modulated in some way. The mental barrier is because the focus is too close, to see the big picture. If the big picture is explained FIRST, in broad outline, reasons, and underlying principles, then the mind, when focusing on the fine detail can connect it back to the big picture. So for example, if these medications are explained from the outset as 1) allowing the base 'bar codes' of genes to be read to enable new bar codes top to be created and 2) that new bar codes to be read to do the same, then this creates in the listener's mind and expectation of where the details are heading, or where it connects. I hope that makes sense.

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[@animatedbiologywitharpan]

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[@mariyamsiraj3929]

The most comprehensible video on this topic. Thanks so much!!!

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[@VeganLifestile]

Just so cool man! Im a chemist going into this world and for me this is jus freaking spontaniously amazing

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complete and comprehensible, perfect!

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You are really doing great. I am referring your videos to my students. The animation is great to explain genetics. Wish you success. From Kolkata

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[@drnishalpaul]

Thank you so much. I am doing a research to access the level of Histone acetylation in thyroid cancers using immunohistochemistry and image analysis. This helped me understand the basic 🤗

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Very nice... good to hear that it was useful. Please share my channel link in your friends group such that they get help as well...

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Eiii.... people are really learning.

[@azadekiani5479]

I searched for histone modification alot but didn't find anything interesting except this video. You went into detail and I really liked it. Please make more videos that help medical students.

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[@PreetKaur-fk3ds]

I am glad to find your channel. Explained quite well. however, I'm still confused about the part pertaining to Bromo and chromodomain protein. Nevermind will do a bit more research. please keep updating more videoes especially on the molecular biology, it is such a complex component of the medicine.

[@animatedbiologywitharpan]

Please share among your friends and help me to reach big audience........I will post more on molecular biology

[@healthbabe2691]

Hi Arpan. You are one of the best educators in this field. Your thorough presentation has helped me further understand its mechanism in conjunction with my text books. I do have question. For chromo and bromo domains, can you briefly describe their transcription and translation pathways? Thank you.

[@animatedbiologywitharpan]

I will answer your question in a short video....will upload soon. I am away for a conference

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Ma Shaa Allaah....💕💕💕

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Congratulations for the explanation! This helped me a lot!

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[@bindiyabajracharya1463]

Great explaination. Thank you for the video.

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Your explanation is the best! Thanks a lot!

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[@azadekiani5479]

wow! untill you say that the phosphorylated serine or trionine both have negative charge like DNA backbone does and this results in the repulsion between DNA and histone which makes DNA more accessible to transcription factors, I didn't know how phosphorylation and all of these modification methods work. This video was so clarifying.

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Thank you so much, this really helped

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I learned more from this video than I did in my entire genetics semester. Th!

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Thank you very much

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Thanks sir for nice explanation Easy to understand all the points 👍

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Excellent video!!!

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Thank you so much for clear explanation

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nicely explained and illustrated, thank you

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Thank you I was so confused in my class today and this helped a lot

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[@aditiania3846]

Cutely understandable vid ! धन्यवाद

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Lovely

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[@aishafaisal2249]

what kind of effect this combination of multiple bromodomains and histone acetyltransferase in a single complex will have on the spreading of histone marks and what consequences this might have on the structure of chromatin.

[@InquilineKea]

8:58 wow ADP ribosylation is what SIRT6 does. bromodomain recognizes acetylation at one place and methylation at antoher place?

[@cecilegiralt5745]

We can explain the relaxation of DNA when HAT comes, that could be the fact that the acetylation removes the positive charges of Lysine or Arginine then we have less interaction with the negative charges of the DNA's phosphates.

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[@hitaishiboora1104]

Well explained 😊

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[@pawanrohilla01]

Nice video. Please make a video upon Mitochondria & Chloroplast. As soon as possible. As your videos are pretty helpful for understanding. 😊😊

[@animatedbiologywitharpan]

Yes it’s in the list

[@jabrown2011]

Great video. Could you explain histone lactylation and its effect on transcription?

[@animatedbiologywitharpan]

Soon would upload

[@sumonamukherjee1874]

Nice explanation

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too good explaination

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yeah 10 minutes with this helped more than over 25 hours reading textbook

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Thank you

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Sir make a video on Prokaryotic post translational modification

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thank you

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[@MutilManny123]

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good video

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Tooop❤❤

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[@rohitkrishnan7485]

Can you pls explain the importance and role/function of SUMOylation of histones as a histone modification process?

[@animatedbiologywitharpan]

Thanks for the suggestion. I will try to make a video on this

[@basharj7526]

what are the resources you used plz ? thanks for the great explaination

[@animatedbiologywitharpan]

The references could be found in Watson molecular biology of the gene

[@joudihello4573]

Ty

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[@FoxyLobo]

Phenomenal video - thank you so much. I’m researching the potential role of Histone modification to treat substance dependence. Feel free to reach out to me.

[@animatedbiologywitharpan]

Thanks for your comment

[@felicitasbrock9002]

2:35 As far as I can tell, adding an acetyl group is only possible on lys...

[@animatedbiologywitharpan]

According to fundamental textbooks acetylation is possible in both Arg and Lys but frequently lys residues are acetyl ated......I haven't checked the recent literature about this so I would check and answer your question

[@aidaririvera8783]

The last 5 mins of the video you introduced several names and processes not known by me and I felt they were not fully explained.

[@animatedbiologywitharpan]

Thanks for the feedback....I would try to make a detailed video in that case

[@dharshini.d4378]

Sir can you please tell from which book you refer these topics ?

[@animatedbiologywitharpan]

You can follow molecular biology of the gene for the basic understanding but eventually i will make detailed video

[@animatedbiologywitharpan]

For example watch this video kzbin.info/www/bejne/eYOcZmeaipuMl8k

[@majibarrahaman8987]

I have a doubt Why histones are highly conserved ?? Sir plz answer the question

[@animatedbiologywitharpan]

Shabnam Khatoon Any molecule, critical for the survival of the organism, is highly conserved.In evolution An organism with aberration in chromatin will not survive or rather not selected. organisms with mutations in histone coding DNA does not survive. In other words, only organisms with perfect histone structure will be selected and get evolutionary advantage

[@animatedbiologywitharpan]

Shabnam Khatoon this answer is very hand waving and I am not happy with it.

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@@animatedbiologywitharpan thank you very much sir

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[@anikdasad9]

Sir does DNA methylation also cause epigenitic change?

[@animatedbiologywitharpan]

Yes ...there are methyl transferase enzyme who deposits methylation marks on DNA

[@anikdasad9]

@@animatedbiologywitharpan ok sir

[@anikdasad9]

@@animatedbiologywitharpan is the phenotypic change heritable?rather to say epigenetic change

[@mhtmht7922]

Very good explanation, could you sent the ppt file for the lecture please?

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[e-mail]

[@sipras.panigrahi574]

Explained it really well..

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[@sipras.panigrahi574]

Surely Arpan.. But can you tell some instances where histone modifications have resulted in any disease or phenotypic modification in human?

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Sipra S. Panigrahi stay tuned....more video would be uploaded

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[@heavenly3735]

What happens to the histone after death?

[@animatedbiologywitharpan]

Universal Eye like all proteins it would degrade

[@heavenly3735]

@@animatedbiologywitharpan what do u mean by degrade? For u didn't say die. And since the histone is light expressed what happens to that light after death?

[@heavenly3735]

@@animatedbiologywitharpan why do you say the histone is protein when it is not part of the protein chain, nor DNA but feeding everything with light energy?

[@heavenly3735]

@@animatedbiologywitharpan u do not that degrade is not falling in grade, and it is also not death. U do also know that everything feeding on histone (me) doesn't kill histone (me). Each lifeform in the cell has its own light (expressed the all invisible sound). Hence why we are histone. What sustains and expresses histone is sound invisible.

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Brother this channel was name before arpan paricha????

[@pawanrohilla01]

Yes. Name was changed sometime earlier.

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Ya it’s the same person

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Are u from Bnagladesh?

[@animatedbiologywitharpan]

No .. from India

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By the way ami bangali

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