Anti Aging with Nutrition | Dr. Matt Kaeberlein

[@iaminkaland]

TIMESTAMPS 00:00 Intro 00:00:25 Anti Aging Trends 00:04:00 Anti aging, longevity, and healthspan 00:11:50 Healthspan and Biology of Aging 00:13:27 Healthspan and Biology of Aging 00:14:35 Health in Organs 00:15:50 NAD, Health Decline, and Optimal Age for Anti aging 00:17:40 Reversing Aging Damage 00:19:20 Anti Aging Nutrition Research 00:21:10 Caloric Restriction, Calorie Restriction, and Protein Restriction 00:26:00 Risks of Extrapolating and Inflammation 00:28:30 Caloric Restriction, Reproduction and Hormonal Health 00:32:00 Can Ketogenic Diet Increase Lifespan 00:32:50 Genes, Keto diet and Health Benefits 00:35:20 Tool: Blood Test, Labs, DEXA, Vo2max, etc 00:37:15 Biological Age Tests 00:38:20 Human Nutritional Strategies for Anti Aging (Anti Aging diet) 00:39:00 Non-Diet Factors 00:39:40 Sugar, Protein, Continuous Glucose Monitoring, Processed Foods 00:41:20 Mediterranean Diet, MIND Diet, Alzheimer’s Disease 00:42:45 Alcohol 00:43:21 Extreme Diet and Carnivore Diet 00:44:45 Inflammation, Food Intolerance, Immunity, Allergy and Aging 00:50:00 Biological Mechanisms of Aging 00:53:00 IGF-1, mTOR, and cancer 00:54:40 mTOR and Rapamycin, FGF21 00:58:30 Dr. Matt Kaeberlein Longevity Protocol 01:04:00 Anti Aging in Dogs: Dog Aging Project

[@paulfiedler9128]

Inka looks like she's 24 to me. Very young and healthy looking. We should be interviewing Inka, also. Matt is great, but Inka really seems to know her stuff, too.

[@iaminkaland]

Thank you for the kind words, I appreciate it. I'm also only 32 chronologically, so that helps :) Glad to that you find the content valuable.

[@skincraftorganicsllc8537]

Excellent conversation, thank you!! I so agree about the tracking!! I've been using Cronometer religiously (virtually every morsel that goes into my mouth) for over 3 years and LOVE doing so!! It truly is eye-opening for learning portions as Matt said - plus knowing what I'm getting, both micro & macro, have helped me cut out some supplements because with the info I get from tracking, I know what I may be lacking, and then make an effort to tweak my diet to get those nutrients from food - it's a fun challenge for me!!

[@iaminkaland]

Thanks for sharing. I use chronometer too! The vitamin / mineral tracking is so useful!

[@susymay7831]

I love your fabulous timestamps ❤

[@iaminkaland]

Glad to know they are helpful!

[@Fitsoccerqueen]

Veggies caused my rosacea and acne. As soon as I got rid of them and upped my fatty red meat, skin cleared and also became more plump. I glow now and I'm 35. Also, my PMS and insomnia went away completely. So I'm basically doing the opposite of what this guest recommends 😂

[@iaminkaland]

Same girl.. Plants mostly make me sick, inflamed, and fatigued. And eating meat usually solves it.

[@Fitsoccerqueen]

@@iaminkaland many have said the same! Glad you figured it out. 🥰 you look amazing!

[@iaminkaland]

Aw, thank u angel. You too. Your skin is flawless 😭😍

[@Scottlp2]

As someone who had a decade of antibiotics from age 3-13 and am still fixing my gut, I would suggest that you gut is messed up. Fixing it would improve your overall health and likely allow to you tolerate plants (which have benefits for many).

[@Fitsoccerqueen]

@@Scottlp2 My gut is perfection now. I'm going to keep doing what I'm doing. I also don't miss plants lol

[@ItsTheJourney24]

Could you please make a video on ADHD and how it correlates with food addiction and binge eating? Just found you page and love your videos!

[@iaminkaland]

Hey, what a coincidence - I have an interview coming up next week about dopamine and food addiction. We don't discuss ADHD but it's relevant for that, too! And this topic is great. I'll add that to the list. Thanks for the request, and have a great day 😊

[@maiaallman4635]

Maybe autism as well please, because ADHD and High Functioning Autism often go together.

[@Tom-ye5dn]

I have ADHD a no carbohydrate diet works wonders.

[@iaminkaland]

@@Tom-ye5dn, what diet are you on? lion or carnivore? This is interesting.

[@Tom-ye5dn]

@@iaminkaland Carnivore diet. I think it has something to do with the brain running more on ketones rather than just glucose alone

[@StraitjacketFitness]

Looking forward to this one. (Posted 09:22 May 29, 2024)

[@iaminkaland]

Hey. This one was good. Can't wait to release and u to watch it.

[@wonderdr1]

I would be interested if he also addressed longevity/lifespan effects of multi-day fasting.

[@iaminkaland]

I've understood there's not much difference between daily TRE vs. longer fasts. But could be wrong.

[@peterz53]

On CR vs fasting suggest research from Lamming Lab (and ARDD talks). Seems that they overlap but also affect different genes. My view is that very mild DR combined with TRE makes sense as there are other lines of study which suggest TRE improves various health parameters. Dr Courtney Peterson is an expert on TRE having done research in this area over a number of years. She would be a great guest.

[@iaminkaland]

I agree with you. DR seems to be necessary. But I also think that the general nutritional recommendations require a massive update. They're just mostly off... TRE makes logical sense, considering the light pattern and hormonal cycles. Thanks for the tips - I'll check everything out!

[@paveldrobnych]

My favourite anti-aging Doc interviewed by the alluring host. Great interview. What about Dr Valter Longo ?

[@iaminkaland]

Dr. Kaeberlein is great. Thanks for the comment.

[@hadiama5793]

very interesting ... i enjoyed it :) thanks

[@iaminkaland]

Glad to hear! Thanks for the comment

[@eliasorbon450]

Nice interview!

[@iaminkaland]

Glad to hear you liked it!

[@eliasorbon450]

@@iaminkaland Looking forward to your next one.

[@Roberto-cg2gr]

What is the effect of very low visceral fats in health spans

[@orion9k]

Regarding skin creams, everytime I have skin rash or something that looks like fungus, it's cured after a single day with using either olive oil or black nigella seed oil, so it's really not that complicated to cure skin issues in many instances.

[@iaminkaland]

Good share - thank you.

[@dinomiles7999]

She's AMAZING, her knowledge floores me along with her skill to communicate ❤. Eyes mind heart and soul wide open. NO FEAR !❤. Decentralization is coming ❤. !

[@janinaeggers6059]

Thank you for bringing up the caloric restriction for female hormones...because He wouldnt have brought this Up right?

[@Roberto-cg2gr]

What is the effect of low GKI in health span

[@iaminkaland]

Low GKI has beneficial effects, especially in cases of cancer. I have an episode coming out about this today!

[@Roberto-cg2gr]

@@iaminkaland Other than Cancer. Prof Seyfried is targeting GKI of less than 2 for cancer

[@iaminkaland]

@@Roberto-cg2gr sure. Autophagy, cell renewal, immunity benefits, reversible etc. but it’s not necessary to be high continuously for a healthy individual.

[@iaminkaland]

@@Roberto-cg2gr and brain benefits- cognition mood NAD

[@Roberto-cg2gr]

@@iaminkaland Is GKI of less than 2 the marker for Autophagy? I water fasted for 72 hours and my GKI is 1.15

[@250txc]

After watching hours of these types of videos, it comes to light that the human body is too complex to truly understand. Do not eat man-made foods, keep sugars down, including fruits, to a low number, and exercise to some degree. That's all we can do folks... lol

[@helios4425]

How come athletes or bodybuilders who exercise and eat high protein diets do not see increase in cancer ? Goes to show you that acute bumps in mtor doesnt equal long term side effect.

[@iaminkaland]

I think it's the frequency of eating more than the amount or protein you eat.

[@250txc]

@@iaminkaland lol ... They eat like hogs every day ..

[@timwilliams9100]

Any comments on the TRIM Studies where Rejuevanting the THYMUS may lead to Longevity benefits? They were able to replicate the impressive results from the first study and have more studies planned. seems to dovetail with your topic of immune system and longevity .

[@iaminkaland]

That's interesting. In this study, they indeed reversed several aging markers in humans, and they observed an increase in FGF‐21 levels, which Dr. Kaeberlein also mentioned. However, they used Metformin (calorie restriction mimetic) and DHEA too. www.ncbi.nlm.nih.gov/pmc/articles/PMC6826138/

[@newdata]

mtor is technology from 20 years ago. should do interview w Dr Sinclair who work w yamanaka factors that really turn back the clock.

[@iaminkaland]

Thank you for the comment. While mTOR (mechanistic Target of Rapamycin) research has been around for some time, it continues to be a a key protein and pathway in the human body that regulates cell proliferation and survival - hence the key role in aging. I'll definitely keep featuring diverse experts for a broader perspective.

[@BillyBob-fh5he]

Sinclair is such a fraud!

[@newdata]

@@iaminkaland is just glorified fasting

[@dinomiles7999]

This guys info is SO YESTERDAY . 😢SAD ❤.

[@250txc]

Stupid RU!

[@peterz53]

On diet in humans you might look at work of long term researchers Gary Fraser and Walter Willet.

[@iaminkaland]

Thanks for this.

[@MichaelEdwardWright1]

Matt, you say that we know that whole vegetables are good for health. What is your scientific basis? I have demonstrated that eating vegetables is derogatory and contra-indicated.

[@250txc]

Stupid RU!

[@vgloveforlife]

Check out Dr. brooke goldner. She puts people on a strict 100% raw plant diet for one month focused on omega 3 (chia or flax), leafy greens, cruciferous and water - that's it - and she reverses diseases within just one month.

[@dinomiles7999]

Nature's Source Code ❤! Love, light, water and magnetism. ❤ Mind , body , spirit ❤ ! Its synergistic ! There is no one GOD molecule or bullet ❤

[@nicholaslui2239]

Too wordy

[@feedmehamburgers]

Wow... She looks like an elf from Lord of the Rings or an angel 🥲