Anti-seasickness drugs for longevity | Peter Attia & Rich Miller

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This clip is from 281 Longevity drugs, aging biomarkers, and updated findings from the Interventions Testing Program (ITP) with Rich Miller, M.D., Ph.D.
In this clip, Peter and Rich discuss:
- FDA approved drugs as anti-aging remedies
- Meclizine’s impact on lifespan in mice
- Rich’s research with these drugs on lifespan in mice
- And more
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About:
The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 70 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.
Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.
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[@MillicentSquirrelHole]

For consideration regarding taking meclazine: The American Geriatric Society (AGS) has placed meclizine on the Beers list of medications in patients over 65yrs of age to avoid because of the strong anti-cholinergic properties resulting in increased risk of confusion, falls/fractures and mortality. Meclizine is not recommended for patients with glaucoma. Do the necessary research substantiating that the above information is valid and applicable to one's situation.

[@bill9989]

Thank you. And in addition to the immediate risks (drowsiness, risk of falls, etc) it also may increase the risk for dementia, including Alzheimers in older adults. So definitely NOT for anti-aging unless you want to be the longest living person with Alzheimers.

[@gstlynx]

Anticholinergic meds are problematic for cognitive health.

[@tommydinob]

First thing I thought about when I saw the title. Been a pharmacist 30 years.

[@SilverFan21k]

Ty peter for covering life extension

[@abc_cba]

I have been prescribed Meclizine for my migraines and now this just made me smile.

[@bill9989]

Be careful if you are over 65. It may increase the risk for dementia.

[@abc_cba]

@@bill9989 Hi, i am just 33 years old, thanks for the warning though, i'll use your warning as a caution and do my research.

[@kenwin5845]

It really helped my kidneys, it is a fascinating compound.

[@rexthompson847]

If the drugs under consideration are in a class called anti-cholinergics (including meclazine), then there are numerous studies that suggest these drugs are linked to dementia. Perhaps more work is needed to differentiate drugs that support longevity AND reduce the risk of dementia.

[@sharknadofartquake2449]

But there's a guy with a 7 second memory span living(maybe still alive) in England. His herpes broke through the blood brain barrier and attacked the part of the brain that does the memory thing. He's still married and so isn't he happy and if he is how is dementia a bad thing?!

[@bill9989]

​@@sharknadofartquake2449 too serious for humor. Time and place.

[@sharknadofartquake2449]

@@bill9989 That is a serious question...

[@gregsLyrics]

Miller's dose of Fisetin, 600ppm, turns out to be about 3mg/kg in mice -waaaaaay off target of published literature. Dr. Kirkland's dose of Fisetin is 20mg/kg. The equivalent in mice would be around 2.5gm, NOT 3mg. source: kzbin.info/www/bejne/f3WymmOFecqqoKc

[@themacso4157]

Im so into this stuff...

[@londonmcdougal]

Meclizine in the ITP fed the mice a human equivalent dose of about 730mg of Dramamine per day for a 70kg person. Meclizine is often dosed at 25 or 50 mg for motion sickness. However, Meclizine is often used as a street drug. You can buy a bottle for a few bucks and by taking anywhere from 10-20 you can feel "drunkish" to hallucinate for hours on end. I can not see Meclizine dosage even remotely close to 700mg. After halucination wearoff around 8-16hrs later, you have short term memory loss for a few days. This is often accompanied by hearing voices and having body aches/tingles.

[@jactac838]

🚨Transcript needs corrected regarding all the correct spelling of drugs mentioned.🚨

[@keng7758]

It’s automated by Google…

[@SuperMrgentleman]

​@@keng7758people upload non-automated transcripts

[@AlexandreOliveira-sy1bh]

Quercetin and azithromycin also act as senolytics

[@JT-di3bl]

what about ondansetron?

[@tonipieleanu]

Anyone else thinking that Rich's voice sounds very similar to Bret Contreras? 😮

[@5kribbles]

He doesn't believe in senescent cells?? I didn't know this was a controversial concept.

[@natalicarolina4544]

please, i need the name of the last drug at 6:45

[@keng7758]

Fisetin…I’ve taken it but I’m not sure it really works…

[@hershlstern]

How do you spell the name of the second drug he mentioned?

[@jimdandy8996]

Meclazine

[@Hasan-jf7by]

Meclizine Astaxanthin

[@user-qo3mk1ck7h]

Meclizine

[@hershlstern]

Astaxanthin is the second drug mentioned. It might protect cells from damage. Astaxanthin might also improve the way the immune system functions. People use astaxanthin for many purposes, including Alzheimer disease, athletic performance, aging skin, muscle soreness from exercise, and many others. (WebMD)

[@fitchmultz]

I take meclizine for migraines and motion sickness. Please don't buy all this up and make the price go up.

[@arlisskowski]

Too late

[@timskolnik3819]

On my way to the store as we speak

[@bill9989]

​@@timskolnik3819 I did too. Got a batch from the big A but now it's going down the toilet. Don't use this stuff. It is linked to dementia.

[@USASMR-o2c]

Dramamine?

[@richardfischel9565]

Hmm, maybe your lack of sea sickness can be attribied to a vestibular issue 😵‍💫