Are Turmeric And Black Pepper Bad For Health?

[@mjs28s]

Debunk was already done as soon as I saw it was Paul Saladino

[@conqueragingordietrying123]

I didn't set out to debunk Paul-I would've posted the data even if it worked against me...

[@user-cr4pz5yg7y]

​@conqueragingordietrying1797 we all know paul is a pick me. He talks loud and looks around when speaking so he knows everyone knows he is talking. He is a talker, not a doctor. I agree with very little he says.

[@stx7389]

​@@user-cr4pz5yg7y he is flat earther anti science 🤡

[@monnoo8221]

yes, that's a perfect demonstration of the superiority of science over bro science, abbreviated B.S., and perhaps an eye opener for those vulnerable to click-baiters and gossypers

[@singularity6761]

I don't think it will be an eye opener for the mentioned group, because this folks don't watch channels like this.

[@nicklam66]

Perfect? From a study of n=1? Really?

[@monnoo8221]

@@nicklam66 it's not an experiment targeting a population, no generalisation onto the population level is intended, nor possible... For that the N would be =1, sure. However, here we have a time series analysis, with enough data points to calculate associations, and for some key components he also performed recently repeated On/Off experiments. Those allow conclusions on the level of causality, which often are not possible for simple RCT. In fact, time series are the only type of experiment that unequivocally allow to talk about causality. Of course, it would be nicer if everything he is doing would include 11+ other people. Then it would start to be possible to have generalisation to population level

[@willnitschke]

​@@monnoo8221keep dreaming 😅

[@monnoo8221]

@@willnitschke nothing to say to a guy not knowing anything, have a good rest....

[@viracocha2021]

This is awesome. I wish we had this kind of analysis for the rest of nutrients :)

[@grugnotice7746]

Soon enough we will have a "scientific AI" into which we can dump all of the data and it will spit out a total analysis like this.

[@ChessMasterNate]

@@grugnotice7746 Or it will just make up stuff. I was trying to get the percentages of kinds of sugars in various fruits and berries. And it completely fabricated the numbers. So, some time when I have 6 hours, I guess I will have to do it myself (I was trying to reduce fructose intake, but still have enjoyable fruit).

[@grugnotice7746]

@@ChessMasterNate That's first gen large language models, not 2nd or 3rd gen models hand crafted for scientific analysis.

[@ChessMasterNate]

@@grugnotice7746 I was just emphasizing that they are not ready, not that they will never be. Clearly, they are improving rapidly.

[@monnoo8221]

@@grugnotice7746 that are LLM, first, and second, handcrafted means, there is no AI, just an automation of the limited understanding of the programmer. Thus those meta algorithms are not able to do scientific work for the foreseeable future==some 200 years

[@myrrhsolace5875]

My biggest question about turmeric is: why does nobody pronounce the first “r”?

[@manolisgledsodakis873]

It's an American thing.

[@philmartz]

Gotta buy you a coffee! Excellent, as always! Highly instructive! I'm following closely, as always, even though my optimal diet is far different from yours. Considering the large number of t-tests you are doing, I appreciate you applying here and in the future additional advanced statistics of FDR and multiple linear regression to remove false discovery and confounders. Much thanks!

[@conqueragingordietrying123]

Thanks @philmartz, and I appreciate your support!

[@adamesd3699]

Be careful with large amounts of black pepper. I tried a similar experiment where I gradually increased my intake of black pepper. I ended up taking too much and got heartburn that took months to go away. I still like black pepper, but now know to have it in low amounts.

[@hvglaser]

In many eastern countries they use a lot more spices than we do in the west. 1,3 grams is quite low compared to someone from a culture that use more spices, so it would be interesting to see the numbers from that.

[@conqueragingordietrying123]

Yep, definitely. The data currently suggests that I can go higher for both, too-maybe there's an upper limit for potential health effects

[@agy3504]

Very quality analysis 👏 Thank you for all your efforts and sharing your very rigorous journey

[@conqueragingordietrying123]

Thanks @agy3504!

[@ttfan3257]

@James-ke5sx 1 day ago I am 74 years old and in perfect health and I haven't been to a doctor since 1972. I eat black pepper and turmeric in every single thing from salads and eggs to meat. No problem.

[@allurbase]

I don't know if you take them together, like how big is the correlation between pepper and tumeric, but it's interesting that they show the same correlations.

[@conqueragingordietrying123]

I take them together, albeit in slightly different amounts.

[@jamesgilmore8192]

@@conqueragingordietrying123 Its worth taking them together because of the increase in curcumin bioavailability.

[@allurbase]

@@conqueragingordietrying123 wonder what happens if you measure correlation of one independent on the other.

[@natfat9064]

I have seen women who had to come to the ER for vaginal bleeding that won’t stop. All of them were told to stop turmeric by the doctor

[@avibhagan]

Anything in excess is bad for you. Even water. Yes, overconsumption of water can kill. Does the few cases of people dying from overconsumption of water mean that water is bad for your health ?

[@johnvanderpol2]

It would be great to run all the data through a Data mining AI to find all the correlations, you did not notice yourself yet. Also good you checked against body weight. It would be great to have this kind of detailed open data research done by many people, to get away from the N=1.

[@nuovoaccount998]

@@quantifiedmax What makes you think that these correlations are generated by randomness after 30 blood tests?

[@DBMMMMM]

What is also not taken into account is longterm use, for example oxalatecrystal buildup. Even when uric acid goes down, kurkuma is still very high in oxalates. Longterm use could lead to more permeable colon lining?.....

[@conqueragingordietrying123]

Up-to 6 years of biomarker data in the video... There would be a pattern in the biomarkers of that, i.e. higher uric acid because of decreased kidney function, or increased inflammation with a more permeable gut lining. There's no evidence for that being true in my data atm...

[@DBMMMMM]

@@conqueragingordietrying123 oxalate build-up effects I think depends on our Microbiome... True?.. Oxalate build-up may become an issue after a very long time just like cancers.. But hey i highly appreciate your videos... It's just an idea I had

[@jamesgilmore8192]

@@conqueragingordietrying123 Maybe when you have a couple more years of data you can split the analysis into first 5, last 3 and see if the same relationships hold across time. Or alternatively add a variable of total curcumin intake over time and see if anything shows up.

[@skincraftorganicsllc8537]

Most curcumin supplements are made with turmeric extract, and therefore extremely low in oxalates.

[@DBMMMMM]

@@skincraftorganicsllc8537 I press my own organic kurkuma as 1000mg per capsule caps, mixed with black pepper 20:1 ratio, ingest it with fish oil caps mostly. Its high in oxalates

[@bhut1571]

Thanks for the info. Wish I had your statistical smarts. I'm 78 and started using a small amount (say 1/2 to 1 tsp) of turmeric to me morning oats some 30 years ago when my companion "Arther" was bothering me knees. I then started adding a snort of black pepper some 15 years ago. Now this is just and "n" of 1, but my blood lipids are great, great H1ac, no statins or drugs and Arther hardly bothers me. However I have had a tad of afib over the last year. It probably all depends on one's genetics, for example if one is a kidney stone former one wouldn't want to put turnmeric on their beets.

[@James-ke5sx]

I am 74 years old and in perfect health and I haven't been to a doctor since 1972. I eat black pepper and turmeric in every single thing from salads and eggs to meat. No problem.

[@Mikolas649]

Does it affect your iron level,like lower it?

[@Michael_RareZebra]

@@Mikolas649He won’t know because he hasn’t been to a doctor since 1972.

[@SafeEffective-ls2pl]

@Michael_RareZebra Seems like he's pretty healthy

[@andymilkowski7682]

Awesome advancement of this discussion. Good for you and your work.

[@conqueragingordietrying123]

Thanks @andymilkowski7682!

[@fluffyheed9166]

I know you showed your inflammation markers were reduced but were the reductions significant? Were your inflammation levels ever high?

[@conqueragingordietrying123]

3x higher than now at its peak, about 2x higher than now (< 0.3 mg/L for 17 consecutive tests) on average

[@mannmstorm]

Regarding turmeric and platelets: At what platelet count would you reduce or stop your turmeric supplementation? I am already low on platelet count (usually right at the lower range 150),

[@conqueragingordietrying123]

Below 200 for platelets, as 200-300 is associated with lowest ACM risk

[@yeoyeodere1]

Why does tumeric and black pepper affect RBC and platelet count?

[@conqueragingordietrying123]

@@yeoyeodere1 They're correlations, I can't say if it's causation, but it could be that higher levels of both may be too high, and slightly lower levels may be a more healthful profile. If/how that happens, beyond the correlation, not sure

[@tunneloflight]

It would be interesting to look at ternary plots of the data (age corrected) for Turmeric and Black Pepper versus each parameter. Visually, real correlations should jump out. And any threshold effects or compound effects should as well.

[@glutenfree4713]

I'm wondering if some of the red arrows was because your levels were already too low or too high? For example, an adaptogen can increase or decrease a biomarker depending on what is optimal for you.

[@conqueragingordietrying123]

Yep, that's definitely possible-arguments can be made that both platelets and RBCs are actually green, but to play it by the book (age-related changes), they're technically red.

[@christiancrafoord]

this video is much appreciated, a lot of turmeric controversy going on(or more specifically curcumin), thx!

[@abdelilahbenahmed4350]

Great analysis as usual.A Moroccan tagine would be tasty even if it includes only 3 spices, turmeric,black pepper and ginger.And even if Prof.Lustgarten is not a fan of olive oil, adding some of it in the tagine makes the spices more bioavailable and increases their préventive , anti-aging, and maybe healing power as we can see through the decrease in hsCRP, glucose and RDW 😊.

[@conqueragingordietrying123]

Thanks Abdelilah. Note that I'm generally anti- all oils, not just olive oil-I prefer whole foods instead, including olives...

[@iotanb1772]

Im 40 yrs old. My Lymphocytes have always been slightly high for the last 15 years 42-46%, with everything else normal. Recently they were 64% with limit being 40% with 4,500 to max of 3000. No symptoms. Should i get further testing or nothing to worry about?

[@jamesgilmore8192]

The bioavailability of curcumin makes this all quite interesting. The use of turmeric powder + black pepper means you are probably targeting the GI tract and liver (e.g. CRP is made in the liver) with the GI effects hard to measure. Some of the more bioavailable formulations, which reach higher circulating concentrations, could better target the brain and other body systems, although you'd need to go the supplement route.

[@conqueragingordietrying123]

The bioavailability of turmeric (or not) is somewhat over-popularized. What isn't absorbed can be metabolized by gut bacteria, potentially also benefitting health.

[@jamesgilmore8192]

​@@conqueragingordietrying123 My take on the bioavailability science was ground turmeric or curcumin extract powder itself are useful even if not well absorbed as they collect in GI tissues more than the high bioavailability supplements. If however you want high circulating amounts, then using something like Theracurmin is a reasonable choice. However these high bioavailability supplements seem to have more pronounced side effects in some people. Its a shame they don't have clear use cases with associated biomarkers.

[@DBMMMMM]

I used kurkumapepper daily before, and changed to only use it whenever I have flu or Covid, inflammation etc, it's extremely powerful like antibiotics but it needs a pretty high dose. Say some 3000 mg minimum. But since it could interact with several other nutrients/supplements, and to raise effectivity in case of inflammation/viruses, only use when necessary. Definitely not on daily basis.

[@mindcache5650]

I take a daily teaspoon of 12 ground spices and herbs per day ( including turmeric and black pepper). Cloves and have an incredibly high anti oxidant score. But all spices are hundreds of times better than blueberries in terms of antioxidants.

[@AnonMedic]

The only negative with Tumeric is its oxalate content for people with oxalate toxicity or issues with oxalates.

[@ailfawka6278]

Both black pepper and tumeric appear to be anti-androgenic (eg. Dihydrotestosterone inhibitors/blockers), anything that interfers with my anndrogens gets heavily reduced or completely avoided.

[@32GaugeSlug]

But at the same time, Turmeric has been shown to block the action of highly estrogen substances like Bisphenol-A.

[@BitZapple]

you don't need much DHT as an adult It's not Finasteride or Saw Palmetto Very weak and insignificant DHT inhibition

[@loungezinger]

Is there a way to analyze the data with weights attached, not just an overall 'net' positive or negative? If something drops by a small amount relative to what the correlative studies have shown, shouldnt it be less 'valuable' in evaluation vs something that has a huge impact and needle move?

[@conqueragingordietrying123]

Good question-I've experimented with summing the actual correlations, but I'm not sure that's a better approach

[@ChessMasterNate]

Recently, I saw a video where an expert said that fructose creates a lot of Advanced Glycation End-products in the body. I am fully convinced that AGEs are bad news, and I have engineered my diet to reduce the intake of AGEs and engineered my supplement stack to reduce their formation in the body. The diet adjustment is already difficult, cutting out fructose would add additional difficulty and reduce diet satisfaction. Could you use your data to see what it says about the various sugar forms and their associations with your biomarkers? I just want some evidence before I upend my life.

[@conqueragingordietrying123]

I'm not sure if it's because of AGE products, but I track fructose intake, which has a -7 correlative score with these 26 biomarkers. To follow the correlation, my current intake is about half of my highest, and I'm working on bringing it lower.

[@ChessMasterNate]

@@conqueragingordietrying123 Thanks. -7 sounds pretty bad. It probably is the AGEs. They stiffen tissues and are thus associated with just about every negative condition common in aging. Obstruction is probably also a factor, slowing hydration, removal of wastes and oxygenation. The effects probably overlap with amyloids, as they both are useless proteins that build up, the body has difficulty getting rid of. I found an interesting study: : "Advanced glycation end-products, measured as skin autofluorescence, associate with vascular stiffness in diabetic, pre-diabetic and normoglycemic individuals: a cross-sectional study." Bryan Johnson has one of those arm gadgets. He rarely mentions it, so I am curious where it puts him. Heck, I want to know where I am at. I have been reasonably good the last, almost 6 years, regarding consuming AGEs. But when I was a kid and in my 20s, and 30s even, I was not so good. I did not eat fried stuff and BBQ every day, but I liked buffets, and ate a lot of Hometown Buffet, which cannot have been good. I even did their breakfast a few times and ate mounds of bacon. One pile of that probably adds up to a year of AGEs. I figured the only issue was the saturated fat. I did not know anything about AGEs. I focused back then on getting every nutrient my body might need, and exercise. I exercised, including weight training, from 1984 to 2007. Crap happened in 2007, and I haven't completely put things together. I am hoping they are wrong and glucosepane actually can be removed from the body, just very slowly. Then, there is every reason to think decades of being good will enhance my health rather than just slowing decline. Reducing AGEs in the diet, improved my kidney function dramatically. GFR of 72 brought up to 108 (111 a few months back). Oh, that albumen pill did increase my albumen, but some other numbers went backward. I don't know if that is connected, though. I am moving too many variables at the same time.

[@ComeAlongKay]

Turmeric I’ve heard can chelate iron, a thing you may already be getting a lot of without high iron foods as it’s fortified in stuff.

[@friedux2065]

For someone like me who has intolerance to oxalates due to a dearth of oxalate degrading bacteria after antibiotic use I tend to avoid turmeric and black pepper as both are high in oxalate, white pepper less so.

[@MPM6785ChitChat]

To help with oxalate removal / allievation - eat organic cheeses , butter, yogurt from Goats, Ewes/ Sheep. Avoid dairy from Cows. Cows eat grass - in nature they dont eat any grains which causes them terrible health issues , rhe inflammation contaminates their flesh and milk. If l eat beef its in small amounts and always Aberdeen Angus or Bovines that are feed ib grass from start to finish of their lives.

[@chris-lk4ml]

After watching the half of the video, I have had a strong feeling that I just need a tumeric-drink with 2g black pepper, 12g tumeric powder, 10g cocoa, 30g almonds and oats milk. I think I should adjust it a little bit more for the tast.

[@user-yl7kl7sl1g]

I can't wait for your bodyweight video. I've suspected a lower bodyweight would slow aging.

[@jamesgilmore8192]

I think Mike has already discussed some of that in a previous video...lower body weight is generally beneficial if your preserving muscle mass, but there seems to be a limit of CR beyond which some important marker start to decline like strength, muscle mass. Also reserves become limited which is something else to consider.

[@andrewtaylor9799]

Nice analysis. Maybe I'll start taking tumeric again. The thing that bothers me is that its mechanism is reportedly stressing the cell. Good to see vascular health in the scores.

[@barbiekat6352]

Could you please state more about its (turmeric) “mechanism stressing the cell”? Where could I find more info? What terms to search? 🙏 Thank you!

[@andrewtaylor9799]

@@barbiekat6352 Google "tumeric oxidative stress"

[@consciousnessawake505]

Amazing work, congratulations! Would you mind to give the links for the data in each body marker ?

[@conqueragingordietrying123]

Thanks @consciousnessawake505. i'd start by searching the YT channel for each biomarker What you don't find I can send

[@Icarianbrother]

Paul Saladino- "We've been told that vegetables, nuts and grains (aka plant leaves, roots, stems and seeds) are essential for optimal health. I strongly believe that these parts of the plant are a net negative for humans, and that the only part of the plant we should be eating is the fruit." Paul Saladino is a national treasure. His information is part of a eugenics program to improve the genetic quality of America's population through dolt reduction.

[@conqueragingordietrying123]

Don't get me wrong, i appreciate Paul. But, the point of the video is to objectively assess whether turmeric or black pepper may be bad for health by tracking one's own biomarkers over a long time period.

[@Icarianbrother]

@@conqueragingordietrying123 I'm just kidding. Thank you for another great video!

[@sabincioflec8413]

Turmeric is probably good IF you have a good microbiome that deals with the oxalate content, just like most vegetables. Also it's a known chelator and lowers the availability of iron to be absorbed so depending on iron status it can be good or it can be bad for you.

[@conqueragingordietrying123]

Watch the video?

[@sabincioflec8413]

@@conqueragingordietrying123 I've watched it, can you direct me to the minute where you talk about iron or microbiome and the interaction with turmeric? Just a boring video where you hide behind "data" and think that tells the whole story, in most double blinded randomized controlled studies you will see people that have very good response to the intervention and people who have very bad, including low carb, high carb or other nutrients. I believer it's called a waterfall plot. That's why that is science and this is playtime. If you have a good microbiome you will have the good response, like you do here with a lot of biomarkers but if we take 50 people and do the same controlled diet/turmeric diet you will see people having 10 negative markers and 1-2 good. This is perfectly exemplified in the stanford microbiome studies where people with low diversity have more inflammation with more fiber and people with high diversity have less inflammation and more benefits.

[@matttee1319]

I watched the video also. I'd love to get the positive benefits the data revealed, but I'm personally at greater risk for the negatives, possibly..? Snarky(?) replies to viewers' comments aren't helpful. Taking the comments seriously is an opportunity to advance the conversation for everyone. That said, great video. Bad reply.

[@conqueragingordietrying123]

@@matttee1319 I'm not trying to be snarky, but your comment, "Turmeric is probably good IF you have a good microbiome that deals with the oxalate content, just like most vegetables" has nothing to do with what's in the video, which is an objective, data-driven analysis.

[@lauchlanguddy1004]

well i have Hemochromatosis, hope it lowers iron. Im 71 and platelets etc low...

[@JohnDoe-os3mc]

my concern with turmeric is affecting telomerase in healthy cells, and black pepper increasing gut permeability

[@conqueragingordietrying123]

Some of the correlations for turmeric were with a longer telomere length, not shorter, and if black pepper increased gut permeability, I'd expect to see increased systemic inflammation, but that's not the case based on the associations in the video.

[@jamesgilmore8192]

To clarify you are using ground turmeric, not the curcumin extract powder (95% curcumin) that is commonly available?

[@conqueragingordietrying123]

Hi James, yep, ground turmeric, mentioned in the video at 1:45

[@colinvankeith4814]

After developing idiopathic pulmonary embolism (PE) and deep vein thrombosis (DVT) I suspected turmeric and black pepper that I had added significantly to my diet believing it to be highly beneficial. I dropped the turmeric and black pepper and have not had a recurrence of the symptoms, however I have also been on low dose blood thinners so that is a confounder. Now that this case study shows that both turmeric and black pepper lower platelets so 16:19 this lends credibility that the combination of turmeric with black pepper were responsible for the increased risk of the blood clotting problem leading to PE and DVT. In my case the adverse effects were potentially life-threatening and far outweighed any possible improvement in other bio-markers.

[@DCGreenZone]

Liposomal curcumin sourced from India with the liposomes stabilized with fenugreek seed galactomannan fiber gel has a half life of 7.5 hours instead of 15 to 18 minutes as does standard curcumin. I read that somewhere.

[@drlorishemek]

What a wonderful presentation! Thank you for all you do. What is your feeling about curcumin the active compound in turmeric?

[@conqueragingordietrying123]

Thanks @drlorishemek. Potentially positive based on the turmeric amounts in the video, at least in my case. I'd encourage others to test biomarkers in conjunction with any supplement addition, to see if it's detrimental, neutral, or potentially a positive for health

[@erastvandoren]

Weird, scientific literature says turmeric increases the platelets count.

[@conqueragingordietrying123]

Interesting, can you please post that link? Platelets decline during aging...

[@monnoo8221]

it does a lot of things... for instance, it makes macrophages hungry, such that they are cleaning waste more effectively

[@user_375a82]

My experience with turmeric and black pepper is generally negative, turmeric is oxalic acidy imo & notice no good outcomes with black pepper. Its just my n=1 personal tests.

[@hereticsaint100]

That's a phenomenal level of tracking!

[@conqueragingordietrying123]

Thanks @hereticsaint100!

[@btlmail1969]

Great work but, you did nit address the issue of the amount of turmeric per day, which is what you initially presented and never returned to.

[@conqueragingordietrying123]

Hi @btlmail1969, current turmeric intake is at 1:51

[@yeoyeodere1]

Why does tumeric affect .RBC and platelet count adversely?

[@conqueragingordietrying123]

They're correlations, I can't say if they're causative, but one possibility is that both were too high, and lowering them may be a part of a healthier systemic environment.

[@jamesgilmore8192]

Mike, maybe for videos like this you could list the correlations of say e.g. turmeric intake with other dietary changes over the same time period. That might indicate to viewers there could be some other potential factors. I'm not sure what the data looks like, but it could be messy I suppose.

[@conqueragingordietrying123]

Hmm, thanks James, I'll have to think about how to present that, as It could get messy with even more data

[@HarryJensen-kr4qz]

Been hearing a lot about melatonin lowering dementia risk. Your video covering sws 5 months ago confirmed importance of sleep, js.

[@user_375a82]

Someone told me in a cafe "don't take stains, they give you dementia". She seemed an intelligent 65 year old.

[@lauchlanguddy1004]

@@user_375a82 statins are vary scary with very very little benefit but high profitability,

[@elizabethezell8749]

​@@user_375a82 I don't know about dementia, but they sure make your body hurt. I had a heart attack they put me on Lipator , I had a second one, they asked are you taking your cholesterol medicine? I said yes why, well you had a burst of cholesterol to clog your artery. Why am I taken it if it doesn't do it's job......I haven't in roughly 2 mths

[@darrenparis8314]

What is the correlation strength of your daily black pepper intake with your daily turmeric intake?

[@conqueragingordietrying123]

Great question, very high over the 6yr period: r=0.92, p=4E-15

[@bixinho199]

​@@conqueragingordietrying123 So it could be a possible confounding? Did you adjust for it?

[@jamesgilmore8192]

Its tricky here regarding confounding as its well known pepper increases the bioavailability of curcumin. One analysis would be to analyse pepper and turmeric together see what is stronger, maybe in a combined endpoint. Other experiments are supplements without pepper and taking pepper and turmeric at different meals.

[@jamesgilmore8192]

​@@conqueragingordietrying123 It would be worth checking mediation with back pepper here.

[@OnlyKaerius]

I see a weakness in the methodology, both consumptions closely match, so the data points for them are the combined effect of both, you haven't isolated them individually.

[@main___name___main___name]

Thanks for the meta-analysis - however the assumption is that these source investigations are being reported after performing due diligence and adherence to strict laboratory protocols - which may not always be the case. The data could be unreliable..

[@conqueragingordietrying123]

Meta-analysis? That's not in the video

[@bosman6456]

thanks for the detailed analysis. Most people would consider lower platelets to be a good thing as it keeps blood from clotting ?

[@conqueragingordietrying123]

Thanks @bosman6456. There's a U-shaped curve for platelets in terms of all-cause mortality risk, with < 200 and > 300 associated with increased risk. In my case, is closer to 200 or 300 better? An argument could be made that the platelet associations could be green, as lower within the 200-300 range is associated with more biomarkers going in the right direction vs wrong.

[@decimusmeridius88]

Thnx for the work and the vid. Weren't there lots of other aspects of your lifestyle, besides bodyweight, that you improved besides turmeric during this period as well that could have contributed to the beneficial outcomes on the different markers? As in, couldnt there be more confounders you didnt adjust for?

[@conqueragingordietrying123]

I'm not sure what the other confounders could be, but a lower body weight seems to have the largest impact on these biomarkers.

[@HiloBoiz808]

This video reminds me of when I ate a vegan diet, over complicated.I now eat a carnivore diet for over a year and am never looking back.Starting to eat a carnivore diet has greatly simplified my life when it comes to eating and preparing meals not to mention huge improved health.

[@conqueragingordietrying123]

That's great, it doesn't have to be my way, there may be many roads to optimal health.

[@zardoz7900]

Turmeric and black pepper are high in oxalates. Especially black pepper. That's why they tell kidney patients to avoid black pepper. I'm really surprised you didn't mention that.

[@conqueragingordietrying123]

For the 3g of turmeric and 2g of black pepper that I eat per day, that's 81 mg of oxalate, which is a very small amount when compared to 1oz of spinach (325 mg). Oxalate binds to calcium, followed by their excretion, so it's essential to ensure a far higher calcium intake. In my case, I aim for at least 600-700 more calcium relative to oxalate.

[@KTPurdy]

gotta love the power of statistics

[@williamhoffer9277]

Great, comprehensive presentation.

[@conqueragingordietrying123]

Thanks @williamhoffer9277!

[@earx23]

You are totally methodical. This is awesome. I like Kurkumapepper, but I've heard that it inhibits muscle growth?

[@pimacanyon6208]

excellent analysis and video! thank you.

[@conqueragingordietrying123]

Thanks @pimacanyon6208!

[@frankfeather8548]

Great presentation - would love to see the link you mentioned about the markers that increase/decrease with aging.

[@conqueragingordietrying123]

Hi @frankfeather8548, I'd start by searching for each biomarker on the YT channel. What you can't find, I'll send

[@gabri.mac3]

Do you track anti-nutrients intake? If yes, which ones?

[@conqueragingordietrying123]

Nope, I don't track that

[@adhizzle9985]

Where can you get these spices WITHOUT heavy metals?

[@ttfan3257]

Nepal, Bhutam India and Sri Lanka have among the lowest cancer rates in the world. And they eat curry 2-3X daily Curry contains Turmeric + BlackPepper. Is PS saying , India has been doing it wrong for 100+ years?

[@Sammyli99]

try 5,000 years way ahead of other nations in natural cuisine and herbs, but never min I am sures Gates and Bros, will have the west eating soylent green, blue and yellow before long.

[@johnmclean8643]

Gates bought Braggs ……UG!

[@johnsyoutube23]

Amazing... this is the way healthcare work should be done.

[@wjjansen6393]

As always the quaility analysis of Dr Lustgarden!

[@conqueragingordietrying123]

THanks @wjjansen6393!

[@slainiae]

Are you considering doing a red-light trial to see if it impacts on any key biomarkers?

[@conqueragingordietrying123]

Not yet, but red light therapy is definitely on the to-do list in terms of potential experiments. Which biomarkers it will improve, if any (in my case) is debatable.

[@jamesgilmore8192]

@@conqueragingordietrying123 Probably measures of skin health, recovery and possibly detoxification markers, Although you could argue each of those has higher priority interventions, and some of markers are hard to measure.

[@glorgau]

It seems to me that it's very difficult to get a control on dietary intake. Perhaps there should be a study on an incarcerated population - there you could really control the intakes.

[@conqueragingordietrying123]

Not for me-I weigh all my food

[@bowmastah5169]

What about oxalate content from turmeric?

[@conqueragingordietrying123]

Oxalate is a potential problem, but based on the data in the video, the net effect of turmeric is potentially positive.

[@lauchlanguddy1004]

@@conqueragingordietrying123 i take high long term curcumin and pepper with no oxalates problems yet

[@32GaugeSlug]

@@conqueragingordietrying123 Surely Oxalate isn't a problem in an extract?

[@willnitschke]

Why did you add ground turmeric to your diet to begin with? Anti inflammatory?

[@conqueragingordietrying123]

For the purported benefits, yep

[@markr5132]

This works for me considering I looked up creatine and in increases red blood cells/platlets quite a bit so a little creatine might work out the total in my mind.

[@ATT935]

but is responding to lidl liver king really even worth?

[@conqueragingordietrying123]

It's not about Paul, it's about the idea-in my case, there's no evidence that either turmeric or black pepper may be bad for health

[@ATT935]

@@conqueragingordietrying123 based and blue pilled

[@conqueragingordietrying123]

@@ATT935 lol, blue vs red pill is a false choice

[@ATT935]

@@conqueragingordietrying123 no worries is just meming... we are all longevity pilled here no cap on a stack 👍

[@adhizzle9985]

@@conqueragingordietrying123 it burns my throat and causes gerd for me. is that a way of being healthy? feeling like shit? lol

[@ulthien]

fascinating attempt BUT: you didnt test them TOGETHER as the main point is the synergy effect eh eh👎

[@conqueragingordietrying123]

While black pepper can help with absorption, the other side of the equation is that turmeric can be metabolized by gut bacteria, which can also be beneficial...

[@domagojJugovic]

Turmeric, mybe good , as anti-inflammatory Black Pepper, very very bad, agravates gut, if you have leaky gut stay away It's not important do you trust me, if this info makes you wonder try to avoid black pepper and see are your skin symptoms better. (Leaky gut is seen as eczema, psoriasis etc)

[@whatthefunction9140]

Video idea. Interview someone who is over 100 who is there because they have tried to optimize their health. Every old person I have met is just there seemingly by chance

[@conqueragingordietrying123]

Yep-I don't know anyone who's 100 and had to science the sh** of it o get there. I'm open to suggestions...

[@whatthefunction9140]

@conqueragingordietrying1797 I've watched all the interviews of the current (at the time) oldest persons. Only thing I've noticed is that they don't give a shitt about anything. Maybe super low anxiety is a key factor...

[@matttee1319]

I'm torn about this. I'm low on rbc's but i like the other positive effects

[@jamesgilmore8192]

Its hard to know if the lower RBC is important or casual. For example, the reduction in CRP could mediate the reduction in RBC through reduced inflammation. Directly increasing RBCs would be worth exploring.

[@matttee1319]

That's an interesting take. I don't know why I have lower rbc's. I'm tempted to add the turmeric and see if my labs change.

[@jamesgilmore8192]

@@matttee1319 You have your answer then -- figuring out the why is the most important thing, for rbcs its usually related to iron intake, b vitamins and membrane substrates (saturated fats etc). Make sure you measure hsCRP and consider 3-4g/day turmeric equivalents (e.g. like Mike above with turmeric(3-4g)+black pepper(~1-2g), or bioavailable supplements) and consider it as an "intervention" otherwise you'll be needing to measure over and over again to form a linear model.

[@conqueragingordietrying123]

The only way to know is to do the experiment...

[@monnoo8221]

@@matttee1319 you may take a few days into the mountains, above 3000m altitude, and do a zone 2 training. Or you restrict breath while doing exercise, by increasing air\breathing resistance. Or you can do breathwork with extended holds

[@dbpook]

Seems like I'd need an advanced mathematics degree to be able to do this for myself - we need an AI that can crunch all the numbers for us, just feed it lab reports and it tells us what to eat for optimal health.

[@conqueragingordietrying123]

I don't have an advanced math degree, so if I can do it, anyone can. I agree about AI

[@juliawigger9796]

As soon as i saw the word saladino🤣🤣🤣🤣🤣

[@sooooooooDark]

once u find this channel u realize how low quality the other """scientific""" channels truely are 😂 that awkward moment when N=1 is more thorough than a whole sector of government 😒

[@monnoo8221]

if you are honest, you do proper science, otherwise you engage in meta analysis and crappy epidemiology. Michal is not doing N=1.... that's a paper tiger or straw man argument. He has enough data points, usually>20 to check for associations. Since everybody is an individual, it is anyway practically impossible to find anything interesting using a generalized approach on the population level via epidemiological studies.

[@jamesgilmore8192]

There are pros and cons to all methodological approaches. The key is to understand the limitations and not inflate the evidence. Those are tough skills to acquire, and even well respected scientists misunderstand the nuances of results on first pass, and it sometimes takes multiple peer reviews to sort things out.

[@sooooooooDark]

@@monnoo8221 reading cherry picked paper isnt science science requires scientific method, not spoonfed (often times cherry picked) data (to justify one's world-view), michael is doing very very well with the way he does it, i wouldnt do it much different if i had the funds to do all the testings 😂ive to rely on intuition more (less reliable/slower, but teaches u intuitiveness in everyday life as well so its got its merits too i guess)

[@monnoo8221]

@@sooooooooDark you probably misunderstood it before, i am quite scepticaal against meta analyses, cllecting large N, but neglecting any important details. (using "you" in the earlier post was not the personal pronoun, it was the generalizing one) I completely agree, what you are saying here

[@sooooooooDark]

@@monnoo8221 meta studies r good if u cant measure it urself like michael does it tho xD, im not claiming that it will yield the best possibly results... but its better than nothing 😅

[@blackfam972]

Did you get the covid19 shots?

[@sabasalih5514]

wow ... Awesome science!

[@Sammyli99]

GOLD

[@dabig_guy2204]

Benefits of science

[@lincolntrewethey]

TUHR' muh rik, not TOO muh rik.

[@dms8504]

Dr Paul Saladino...lmao

[@Seeker_of_sense]

Interesting.

[@daves2624]

Be safe... DON'T EAT ANYTHING.

[@russianprincess3673]

FAKE NEWS FAKE REPORT ♥️

[@Sheena1234ization]

Love Saladino

[@conqueragingordietrying123]

I appreciate Paul, too

[@wmp3346]

Stop listening to Paul and Fox noise

[@conqueragingordietrying123]

Great ideas can come from anywhere, it's important to keep an open mind

[@MorningClarity]

Hasn't that Dr. P. S. been misguided or done multiple about-faces multiple times? 🤣 Nothing wrong with learning and correcting course, but at some point ... 🙄

[@conqueragingordietrying123]

I don't see it like that-I appreciate Paul. We can't always be right-I've had plenty of hypotheses that have fallen flat on my face (grape seed powder, fish oil to increase NAD). But I think the takeaway is doing the experiment, rather than relying on opinion, to find the truth...

[@squarz]

Another Saladino bs

[@conqueragingordietrying123]

In my case, perhaps, but I'd encourage others to track their own data to see if it's true, or not...

[@denmar355]

TuRmeric

[@conqueragingordietrying123]

www.reddit.com/r/Cooking/comments/10elhpa/turmeric_do_you_pronounce_the_first_r_or_not/

[@rickspalding3047]

Have you ever heard of Bryan Johnson who spends millions to try to live "forever"? Integrated in your thoughts

[@conqueragingordietrying123]

Yes @rickspalding3047, of course, Bryan and I have chatted a couple of times. I appreciate Bryan being in this space, shining the spotlight on living long enough to live forever.

[@blue-gx5tm]

I originally blocked physionic's channel because the advice was consistently terrible... but now I follow him and do the opposite of whatever he recommends. I've never felt better!

[@frostar701]

I can debunk that BS with one word: “India”

[@darkpatches]

Tumor Rick!

[@Mrwan13]

You’re part of the conspiracy too !!! 😜

[@smarzig]

Your such a cool 😎