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@rollinstn93779 жыл бұрын
DUDE, SERIOUSLY, your videos are the best. Thank you for all the great work, If I could subscribe more than once, I'd do it. You just saved me pages and pages of studyin in a 9 minute long and clear video. Thank you.
@123jackiez5 жыл бұрын
We have been screaming to be heard for my daughter's MS related symptoms, and your video explains so much that we can now take to our deficient doctors. Thank you to taking a very complex issue and explaining in a way that we could learn it. Amazing!!!
@abranisdz344 жыл бұрын
Can you help me with some informations plz
@sarahjoyce7692 жыл бұрын
Wondering just what your daughters issues are? I’m recently diagnosed and having digestive issues that let me to this video after months of research. Wondering if vitamin b is the issues, hcl, pepsin OR none of the above.
@leximohamed95322 жыл бұрын
Please help us
@sarahjoyce7692 жыл бұрын
Well, I, personally got my b12 results back (actually saw a hematologist to make sure I’m actually absorbing the b12 I’m taking) and my b12 is good so has to be something else. What are your daughters issues. I know she has ms but my symptoms appear to be TOTALLY unrelated. Docs response….well, you have ms. Still digging! Look @ Epstein Barr. That’s where I’m headed. Good luck to you. Your daughter is in my thoughts.
@floridamolina3193 Жыл бұрын
Hi po itanong ko lang po kung pwede 2x day ang vitamin Bcomplex
@mandeepbedi41323 жыл бұрын
Excellent presentation...crisp ..clear...a visual treat and much more than textbooks...simply amazing appreciate the skills...
@xDomglmao6 жыл бұрын
Comment from a different video, copy-pasted: "I'd like to add something about the weird terminology here, just details but might help someone: 1) haptocorrin = transcobalamin I (and I think formerly aka transcobalamin III) = cobalophilin = R-protein = R-factor = R-binder ("R" stands for "rapid electrophoretic mobility"). 2) The intrinsic factor receptor in the terminal ileum is also called "cubilin"; the receptor in the kidney that's responsible for the B12 reabs. is the same like the one in the terminal ileum (it is also cubilin!) with the small difference that megalin was added to this receptor (which means this receptor is more "elaborate" than the one in the terminal ileum). Also, in order for cubilin to work, you need a membrane protein that will make cubilin stay put (and will help in the endocytosis, once B12 bound), this protein being called "amnionless". 3) A mutation in cubilin or amnionless (autosomal recessive) leads to the Imerslund-Gräsbeck syndrome (syn.: defect of enterocyte intrinsic factor receptor, enterocyte cobalamin malabsorption, megaloblastic anemia 1, juvenile pernicious anemia with proteinuria due to selective intestinal malabsorption of vitamin B12), 1:200k in Finland/ Norway --> patients will have problems with both, B12 abs. AND reabs (remember, cubilin/ amnionless is present in both organs). 4) B12 bound to transcobalamin II (the transporter in the blood) is called "Holotranscobalamin" ("active B12"). 5) Haptocorrin is also produced in the stomach, not only by the salivary glands; and, as said in the vid, haptocorrin can bind 80% of the B12 in the blood making it unavailable for use." If you want to add/ correct something, feel free to do so
@xDomglmao3 жыл бұрын
@sanju b I don't have my notes next to me but paper says "[...] Intrinsic factor is produced by the gastric parietal cell. Its secretion is stimulated via all pathways known to stimulate gastric acid secretion: histamine, gastrin, and acetylcholine [...]" pubmed.ncbi.nlm.nih.gov/1775933/
@xDomglmao3 жыл бұрын
@sanju b I am assuming you have a "regular" B12 deficiency (i.e., due to your diet), in that case don't worry about increasing IF, just take the supplements your doc prescribed you and you will be fine
@xDomglmao3 жыл бұрын
@sanju b it may take up to 1 year, depends on many factors
@KuMaR-fn7hu Жыл бұрын
Sir, how to reback our digestive system to intrinsically absorb b12. Please kindly suggest me
@xDomglmao Жыл бұрын
@@KuMaR-fn7hu This depends on the reason your B12 absorption is insufficient. Is it due to IF deficiency? Inadequate intake?
@baleees6 жыл бұрын
YOU ARE AMAZING! I'm such a visual person and all of this... what you're doing... Everything just stays in my brain after one time of watching! No Kidding! THANKS!
@youlisted12379 жыл бұрын
Hello “Armando Hasudungan”. You have been added on YouListed under the categories : 1) Sciences : Medicine and Biology 2) Sciences : Chemistry
@miladsh67798 жыл бұрын
You're a great artist and also a great teacher. thank you so much for all of your works.
@nickush75122 жыл бұрын
Superb presentation, just what I was looking for. Clear, concise, great graphical support to your commentary... Very many thanks.
@garystanton99668 жыл бұрын
Another great video. One major cause of B12 deficiency which I was surprised you didn't mention is alcoholism. I will assume this is due to alcohol damaging the illium and preventing adequate absorption. Additionally alcoholism generally goes hand in hand with poor diet/malnutrition which also accounts for the deficiency.
2 жыл бұрын
I'm the illest
@randomoverpopulatedworldid3286 Жыл бұрын
and b1
@lynserkawi4704 Жыл бұрын
normally the liver stores 5mg to 12mg vit b12. thats 10yrs b4 you deplete it
@garyjamesstanton414 Жыл бұрын
@@lynserkawi4704 yes, it does indeed take years to deplete stores of b12. 10 years is more in the realm of a theoretical maximum depletion time, but in practice the depletion time is around 2-4 years. In a liver damaged by alcohol, it cannot store as much b12 as a healthy liver so this is a factor as well. Interestingly, serum b12 levels can appear normal in those with severe alcoholic liver disease as the b12 can be "leaked" by the damaged liver which masks the otherwise low serum b12.
@TRyanBenoitMusic8 ай бұрын
Wish alcohol was my issue. Haven’t drank in 9 years. Would produce headaches, etc after 1-2 drinks.
@randomoverpopulatedworldid3286 Жыл бұрын
also i heard that Prilosec stops b12 absorption so what if someone takes Prilosec for 2 years? are you b12 deficient? I've stopped taking it now and try to eat eggs everyday, but still have some anemia... i don't eat red meat and only dairy and egg and sometimes chicken. is that enough or do i need supplement?
@Shamsanus9 жыл бұрын
Thank u so much !! Iam really waiting for ur book .. Good luck !
@Mkhan-tl3yx6 жыл бұрын
Kindly if book available of lacture
@yvettemorris11877 жыл бұрын
Thanks Armando.. you are amazing! Can you please think about posting a video of absorption, function and deficiency of vitamin B1
@ayeshahameed28597 жыл бұрын
Thank you so much . everything you explained was crystal clear and you explained in such a way that my mind was able to retain it just by seeing your video once. Best of luck for future and stay bless
@farisalshboul9989 жыл бұрын
excellent step by step illustration as always , thanks very much Armando
@anhenovember80437 жыл бұрын
Armando, you are amazing ! It is so easy to understand all those topics you tackle through your excellent drawings and explanations. Also you have a nice humble way about you. I hope you get into teaching as doctor! Your students will thank you!
@popoyoy137 жыл бұрын
So the transcobalamin I-B12 complex remains in the bloodstream? What happens to it then? Also, transcobalamin I is also in the bloodstream?
@3DHDcat4 жыл бұрын
It get pissed out
@michaelconnors88014 жыл бұрын
American Academy of Neurology: People with inflammatory bowel disease may also be at risk for developing nerve damage and other neurological problems, according to research that will be presented at the American Academy of Neurology’s 59th Annual Meeting in Boston, April 28 - May 5, 2007. Inflammatory bowel disease includes digestive disorders such as ulcerative colitis and Crohn’s disease that cause swelling and/or bleeding in the intestines. For the study, researchers compared 103 people with Crohn’s disease and ulcerative colitis to 51 people with other digestive disorders, such as irritable bowel syndrome, gastritis and chronic heartburn. The researchers found that those with inflammatory bowel disease were about four times more likely to develop neuromuscular conditions, including carpal tunnel syndrome and small fiber neuropathy, which causes pain and lack of feeling in the feet. Those with bowel disease were also more than six times more likely to also have a disorder called sensorimotor polyneuropathy, a nerve disease that can cause weakness, pain, and numbness. These diseases were more common in women with bowel disease than men. “Inflammatory bowel disease patients commonly suffer from several other medical conditions, like B12 deficiency and glucose intolerance. These nerve conditions we have reported are often not diagnosed by their primary care physicians,” said lead study author Francisco De Assis Gondim, MD, MSc, PhD, Professor of the Federal University of Ceará in Ceará, Brazil, and a member of the American Academy of Neurology. “People with inflammatory bowel disease who develop new symptoms, such as pain or numbness in the feet, should see a doctor.”
@gzlee23007 жыл бұрын
loves all our videos. it's really helpful in understanding and all our drawings are really good. keep it up the good work
@DrAarka20195 жыл бұрын
Thank you so much. MR Armando ,I would like the hand writting more clearly
@sajidkhanmahmood4 жыл бұрын
what is the advice for someone on omeprozole for ulcer issues and also metformin for diabetes. Will b12 supplements be adequate or will b12 have no effect because of lack of stomach acid needed for b12 to work effectively.
@salmanSalman-ll3ss2 жыл бұрын
Haldi Malathi sonf For Ulcers.Best Results
@payalas9 жыл бұрын
Wow this was very helpful and wonderful drawings! Thank you so much
@Shiraz3214 жыл бұрын
I have been taking 2000 mcg vitamin B12 and my blood test results shows higher and what is the reasons?
@simpl6775 Жыл бұрын
The most complex vitamin on Earth. thanks it helped a lot :)
@cowesmoooovers71722 жыл бұрын
This is the best interpretation of cobalamin absorption I’ve seen.
@pietrocantuccini55844 ай бұрын
There better ones with animated videos!
@Samq6669 жыл бұрын
How about folic acid metabolism , im courious in blood-brain barrier also
@lagunafishing Жыл бұрын
This guy likes to draw nice easy to follow illustrations.
@fitybux46643 жыл бұрын
5:30 What if I have a Transcobalamin deficiency? (My blood test reads as half the lower range of reference interval.) I do have some TCN2 gene variants, but I can't seem to find anything online about these specific variants. Is Transcobalamin supplementation a thing? My serum B12 is normal to high, depending on how much I supplement.
@ChrisirvinAlcubilla5 ай бұрын
Why vb12 didn't bind with the intrinsic factor in the stomach? Or some of it did? Just curious. Thanks
@beckiwildeman60011 ай бұрын
I have blood cells trying to kill off my thyroid is this on the same thing track that you are speaking of?
@latty19626 жыл бұрын
Hi and thank you for this video. I just got my blood work back and my B12 level is 1500. My doctor didn’t think it was a big deal. But I do. I have been exhausted lately with this annoying itch on top of my skull my elbows and knees. I am otherwise a healthy 55 years old woman athlete. I do not eat meat or poultry. It sounds like I am storing my b12 without getting it out to the rest of my body. This itch is unstoppable! Please help me.
@beckiwildeman60011 ай бұрын
Well seeing this post was 5 years ago did you find out it may have to do with Folate deficiency?
@TRyanBenoitMusic8 ай бұрын
Hey, were you able to find a diagnosis and resolution? I’m showing similar serum levels. Lots of symptoms of deficiency, which I believe is malabsorption.
@Ullimately5 жыл бұрын
Anything about how B12 exactly works inside the Body? and where it works, mechanisms.
@evagold52219 жыл бұрын
Thank you, its very nice always :) Results are not only anemia, but other cells (blood, etc.) loss too.
@michaelgershon90776 жыл бұрын
U know what....I give you golden buzzer
@User-to7nb5 жыл бұрын
i appreciate you so much that words cannot express
@beingbenign2685 Жыл бұрын
I recently discovered you can buy B12 with intrinsic factor. Just started taking it, 🤞. Hoping it helps me and others.
@pietrocantuccini55844 ай бұрын
Sounds like a waste of money. From any supplement your body can absorb ca. 1% of your intake [ if your ileum is intact].
@jj30119 ай бұрын
Can you please provide the pdf for the drawing that you do in your videos please?
@kartarsingh91912 жыл бұрын
I have been talking suprdyn and folic acid daily since long as then deficiency was noticed.some shots were given and then d above medicine. It was 346 in August but in Nov. It is 1052. What should I do Sir.
@babakgholian34676 ай бұрын
I have to watch this video again .
@angelanguyen86029 жыл бұрын
superb quality!! thank you for such great work :)
@Jellilol013 жыл бұрын
Don't forget about people with terminal ileal resections for things like Crohn's, this is also a cause of B12 deficiency
@1219javier6 жыл бұрын
very complex topic, explained easily!
@shelly198two7 жыл бұрын
Love all your videos. This one was especially helpful. Thank You
@ebonyharris113 жыл бұрын
I wish the diagrams I drew in my notes looked this nice lol! Great video!
@AreejFatima2963 жыл бұрын
Hi my b12 level is 88 I recently feel very low and disturb walking so i give a sample but the question is do menstruation periods cause b12 low level bcz i eat all type of animal origin food then why my level is too low
@patmclean4163 жыл бұрын
This just showed up on my UTube. I have a vit b12 deficiency. Explains a lot. Thanks.
@pee29133 жыл бұрын
if i happen to have ulcerative colitis would b-12 activate a flare? since there’s a chance of inflammatory with b-12
@elliotwindle-hills18569 жыл бұрын
you never disappoint thank you
@toksec85884 жыл бұрын
Super awesome illustration... 👏🏼
@aysh_illustration_stage2 жыл бұрын
Will you please tell me the point you told at 3:06. I am a bit confused at that point.
@marappags20024 жыл бұрын
Sir you have very good knowledge. Pl help me over come this deficiency.
@Xrrrr987844 жыл бұрын
This video is fabulous and very helpful! Thanks a lot!
@tomprovan50 Жыл бұрын
what a great video the h+/k transporter is interesting. Possible low potassium may have effects as well?
@xeebot4 жыл бұрын
Cannot recommend your channel enough. Thank you!!!!
@createspaceone2 жыл бұрын
Cant the intrinsic factor be added to b12 in capsule form for people who don't have it? anyone?
@ayeshaiman95183 жыл бұрын
your explanation and diagram is best
@foruzankarimi2515 жыл бұрын
Thanks. .Armando. ..your videos helped me so much. ..
@nnamdinwadialo81185 жыл бұрын
Thanks... Best teacher ever
@maryam0000028 жыл бұрын
you're smart and talented. thank you so much :)
@dinawahidah35165 жыл бұрын
This video is sooo interesting! Thank you for your explanation:)
@gina3334 жыл бұрын
Please somebody help me. I’ve just realized the reason I have b12 issues is stomach acid related but I also have extremely high cobalt which is toxic obviously because my body hasn’t been working the way it’s supposed to. How do I take b12 and absorb it without the extremely high cobalt happening?
@brendadrumm97083 жыл бұрын
Cobalt what's that word never heard it before thank you
@casey6174 жыл бұрын
Just found this video. It ended too abruptly. I was recently diagnosed with PA and after a year of weekly B-12 injections I still suffer. My doctors don’t understand the science behind it so they keep passing me around from one specialist to another. I’m only 58. There must be more that can be done for me then just B-12 injections. Anyone else feel the same way?
@rosieoberon30184 жыл бұрын
Vegemite, nutritional yeast, lozenges with b12, you need good gut bacteria too I think. Wikipedia: b12 is good reference
@dct12382 жыл бұрын
Join the B12 group on FB. You need co-factoes as well. I self inject daily. Once a week isn't enough with PA.
@beckiwildeman60011 ай бұрын
What type of Cobalamin are you using? If its Cyanocabalamin stop that and go to Hydroxocabalamin or Methylcabalamin.
@punthenuts6 жыл бұрын
Great description and easy to follow along!
@yogeshpardeshi96694 жыл бұрын
Hi sir my b12 Level is 230 ph/ml is it fine?and I am a vegetarian... Please reply...
@abia15172 жыл бұрын
Great Video! Thanks AGAIN for helping me understand a topic with ease! :)
@Igaluit5 жыл бұрын
Makes you wonder what purpose Transcobalin 1 could serve by binding so much of the vitamin.
@dimitrijejovanovic30489 жыл бұрын
Exellent stuff mate! Just keep on going. Surely one of my favorite medical channes on YT. Could you please do review on Vitamin B1 and also its deficiency? Cheers :)
@brianalvey54534 жыл бұрын
Adds greater understanding - or should that be interesting facts which take even more understanding , patience, digesting and much more familiarity ( Ha! well so be it )
@leximohamed95322 жыл бұрын
Check out DR Berg B1 difeshencyncy
@mem1701movies3 жыл бұрын
If you can’t absorb b12 from food can you absorb from pills? Or do you have to take shots or sublingual?
@omarel-nemr65062 жыл бұрын
Thanks
@UltraPvnk9 жыл бұрын
thank u for taking from your time
@dondamishitha4684 жыл бұрын
Really gud explanation This video helped me a lot
@tonypowell2503 жыл бұрын
So which is the best brand and type of b12 ?
@daygumnazar9 жыл бұрын
Excellent very nice job Can you put link for images?
@cindyfowler28872 жыл бұрын
Great explanation. Thank you.
@wajihazulfiqar44355 жыл бұрын
amazingly described, thankyou so much
@lemonsvlog47623 жыл бұрын
Nothing to say Best❤️❤️
@aasemahsan10 ай бұрын
7:06 Pernicious Anemia & B12 deficiency
@borisbenedetti3874 жыл бұрын
Thx you really a lot! Your videos are amazing ! ❤️
@dibyanshusekharmohapatra99293 жыл бұрын
What is the source of transcobalamin 1 in blood
@patriciaslice18984 жыл бұрын
Where is the Intrinsic Factor produced?
@mayarmshmsha957 Жыл бұрын
💚 Thank you so much
@solimanabdo21134 жыл бұрын
thank you for help my and we wite more video
@MBridge47 жыл бұрын
What about metabolism of B12? Can you do one on that?
@smitshah80743 жыл бұрын
Thank you sir
@fathimamarwaabdulaziz1044 жыл бұрын
thank you Godbless 😊
@adrianar.r.4247 жыл бұрын
Amazing videos!!! Thanks for sharing ;)
@chewy26329 жыл бұрын
I read the letter I wrote out Please write clearly or not. But thank you very much :)
@safemoonholder2635 Жыл бұрын
GREAT EXPLANATION!!!!
@danirofoo7 жыл бұрын
this is amazing! thank you
@deepun90915 жыл бұрын
're supplementation, which , oral or lypsomal?
@clifftom34416 жыл бұрын
Brilliant as usual
@aldasilva4423 Жыл бұрын
Armando , this is very helpful. I had high levels of homocysteine and have been taken the formula for years. Now I have high level of Vitamin B12 which came as a surprise. Could you make a video addressing this situation? 🙏🙏
@beckiwildeman60011 ай бұрын
What formula are you speaking of?
@anwesha_ks5 жыл бұрын
Very well explained
@poojajoshi40136 жыл бұрын
Folic acid metabolism...????
@fannyparadise80893 ай бұрын
very nice
@bnrvines23803 жыл бұрын
On a serious note how do you draw so well
@meemaa84517 жыл бұрын
That’s very good video thanks
@majoodb92539 жыл бұрын
You are awesome man ❤️
@Muuip9 жыл бұрын
Fantastic! Many thanks!
@raziamehmood64515 жыл бұрын
Excellent .
@sunvavachi9 жыл бұрын
I LOVE your videos...you should teach seriously. Too good.
@aidanloewen27129 жыл бұрын
Sunethra K don't you see? he is teaching right now! I think the future of education is this. If you look at people like Armando Hasudungan, Sal Kahn, Paul Anderson (Bozeman Science), they are providing a new outlet for educating the world, and it is NOT limited to students. Anyone can see these videos, and that's a really beautiful thing.
@sunvavachi9 жыл бұрын
I am aware of that. I meant also in the classroom setting it would be fantastic to be infront of such a great person listening.