Pharmacology - Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

[@armandohasudungan]

🎥 DON'T JUST WATCH, LEARN ACTIVELY! TRY THE QUIZ! 🤓 youmakr.ai/test-playground/questionnaire/673d3bec859b9c170836ecc3

[@wem3121]

One more information: Specific COX2 inhibitors (Coxibs) are avoided in recent MI (Myocardial Infraction) due to its thrombotic properties. Since the medicament inhibits PG synthesis thus reduce vasodilation, and it also spares the function of thromboxane A2 thus raise platelets aggregation, the overall result would be causing a high risk of thrombosis. :D

[@sandyananjegowda9435]

👌👌

[@salonijoshi4481]

Thanks ❤️

[@petermalmgren1207]

Sounds like you are following the standard

[@rain3369]

Makes since thank you

[@keithl8300]

so don't cox block too often

[@XavierValencia21]

Thanks!

[@nihalsachdev5847]

This guy's going straight to heaven. Absolute lifesaver!

[@Chantal_o]

Nihal Sachdev like seriously he is going straight to heaven. My teacher explained this to me yesterday and it felt like I was doing calculus 😄 but after watching this video, it’s safe to say I have an idea 💡 of the topic and just need to read a little more. 🤍🤍

[@noexp7710]

If he accepts Jesus and turns from sin that is very likely. That said our good works are like filthy rags to God.

[@thetechrefurbchannel]

I'm a nurse at an orthopedic surgery center and your video helped me a lot in remembering the way most painkillers work, such an amazing and simple way of explaining such a complex subject. Thank you for this quick lesson! (Paracetamol in Portugal is commonly called "Benuron")

[@RonnieTeeSmith]

I can only imagine how big your head is with all this knowledge lmao. You've been saving me since undergrad, and now continue to do so in dental school!

[@MigraineScienceCT]

Great work, Armando. In the US, paracetamol is called acetaminophen aka Tylenol.

[@nmda9578]

That's true. Good catch.

[@قناةالحمدلله-ق6ه]

👍

[@Lucky_25]

In Pakistan it's called panadol But here in India It's common brand name is Dolo Or sometimes In short we says PCM

[@mevideym]

@@elliotrazor6696 No, Paracetamol also is a generic name used in most of the world

[@elliotrazor6696]

@@mevideym you're correct! Both paracetamol and acetaminophen are shorthand for N-Acetyl para-Acetaminophenol. The reason for 2 names is because of the different naming system rules in the U.S.

[@jeffsperla3972]

Such an enjoyable lesson..These days, is anything that simple and straight to the point anymore? A breathe of fresh air.

[@rhijutapokharel8206]

You have absolutely no idea how grateful I am to you...

[@sudha-]

Yes, here i am too... Thankuuuu.

[@rhijutapokharel8206]

@@sudha- all the best maya

[@jacobl5488]

You saved my medical career. -pain/spine doc

[@ridaculous2]

I have an exam and this video saved my butt from failing!!! Thankyou

[@rizabalwenardgabrille7429]

Thank you for your videos. Please continue doing these kind of videos. Millions of students need them.

[@dayapreetsinghsodhi7658]

Thanks a lot armando ! I’ve been watching a lot of youtube channels for last two years. But trust me , you are the best. You literally expalin it very simply and i remember these for a long time, but i dont understand why you get low video views. We all know you put a lot of time in your videos , you deserve atleast a 2 mil. Subscribers by 2020. I rank the channels as 1.Armando 2. Osmosis 3. Khan academy 4. Dr. Najeeb (takes a lot of time) 5. Others

[@mullahateeq9801]

But...... Najeeb sir also explains well

[@sathiyaperumal9240]

what about ninja nerds ??

[@feralbluee]

there are not that many people who even begin to understand this. although you’d think the thousands of students who need to know biochemistry would want to listen!! how can we increase awareness?? 🧬⚗️🔬🥼🧪👩🏻‍🔬👨🏽‍🔬

[@ritikapatil2289]

Sir, no one can be better than you cause your knowledge and concepts as well as your explanation is unbeatable really thankyouuu

[@moonemonne2318]

Thank you so much! Was watching this for last-minute revision and it actually saves my GPA THANK YOU!!! It was very understandable because you explain in a clear and simple way. Thank You SOOOOO MUCH

[@ayimessien6246]

I only hope you'll be able to see this message and know how much I appreciate your video. Thanks a lott.

[@shanganwar7726]

I like how your way of explaining stimulate my brain 🙂

[@ameer090788]

I have to say that you are the best teacher ever I wish you were my pharmacology professor.

[@muzammilpattekhanavar2934]

Extraordinary video... Very helpful for medical students... Great job...❤❤❤❤

[@OscarGonzalez-vg3cp]

It was the most brilliant explanation about how things work, sadly I lost my beautiful prostate, with all this drugs they doctors give me. God bless you good man.it was super interesting. Looking to see more videos.🙂

[@Chilli2pt0]

This guy knows so much information. So cool. Thanks for sharing.

[@ayshadalieva9929]

I want to say big thanks to you! May God bless you more, because you bless many!

[@samuelhamujamba628]

Armando, man you are good, you just summarized this topic in 15 minutes

[@dr.sanket]

i have never seen such a awesomely explained video about NSAIDS. Thanks a ton. Subscribed and shared.

[@tummyfull8824]

Ya you right

[@Lostpanda123]

You are literally a lifesaver!!! Thanks!

[@edthoreum7625]

@7:00 Cox1(physiology)/cox2(inflammation)

[@MG-zo9ve]

Perfect. Thank you. Could you maybe zoom out to show the end-summary/ big picture of all the things you wrote on this sheet? That would be great :)

[@anasaash8514]

Thank you a lottttttttttt I have final exam soon in pharmacology and this video helped me a lot

[@ouiemfrs4373]

watching this while applying my anti-inflammatory creme :")

[@khushboosharma8682]

I really like your lecture it make topic more interesting .....thanks for making video

[@alyaghina1108]

you save my college life, BIG THANKSS

I love your drawing style

[@nafijakamerii160]

same do i

[@spicefaith7419]

Ciência Desenhada its si clear

[@rekhamalhan7859]

You made it so simple to understand sir...ty sooo much

[@saratakkoush6109]

This was so beautifully drawn ! Amazing job!

[@terabaap4491]

youre amazing, just regretting i dint find you during my first year

[@aldozakhour2228]

Great Video. However, Inhibiting PG in stomach does not really increase acid production, but reduce the protective layer around the stomach wall which makes the acidity of the stomach more harmful to it's wall.

[@minabish1783]

Hold on, ithought prostaglandins produce the lining of the stomach, also cox 2 causes vsodilation in addition to producing prostacycline which inhibits platlet aggregation

[@hamiltonv.pisanoetal6769]

Thanks, Armando. A lot of info packed into a short video.

[@ahmadansari7760]

Thank you very much for this awesome knowledge And your way of explaining in amazing Thanks once again

[@diamn2828]

Thank you so much❤❤❤. Thank you. Just what I needed.

[@giridv9303]

I was expecting some explanation about action of macrophages, neutrophils and other such immunity chemicals in this pathway. May be I am wrong in my understanding (since I am a non medical person).

[@el34glo59]

I cannot believe how complicated this is over a small injury and treatment. I will never understand how the body and mind became so complicated, so advanced, all on its own.

[@godlessheathen6425]

By evolution of course. If you follow the evolutionary course you would actually appreciate how this complex body evolved.

[@mowunmi7189]

It didn’t become that on its own. It was designed that way

[@dkannikakamali8575]

Nice drawing skill and wonderful explanation 😊

[@feralbluee]

Holy Hell - i know a bit about biochemistry, but this was mind blowing. i had to look up some of the terms. i knew body chemistry was complicated, but this was mind boggling. i understood a lot of it, but was learning most of it, so i’m going to have to listen again and take freaking notes. thank you so very much though. this was fascinating and i needed the visuals to understand at all. what i want to know is - how in the hell did they ever find out about this extremely complicated system!? Geniuses!!!! i just found out about histamines and why fanitidine works for GERD. now i have to find out how Prilosec works and if i should just take fanitidine. and why does butalbital/ acetaminophen/caffeine work, when acetaminophen/caffeine does nothing for my headaches at all??? so thanks so much - your videos are fantastic. i have to concentrate as much as i do when i listen to prof. Sapolsky at Stanford. i love learning like this!! inane smile :) LOL have a great day 🌷🌿🌼🌱🌷

[@bablus4052]

Respect from India❤

[@dr.andrewjonesmdms1814]

Definitely well explained! This video dispels the myth that NSAIDS are bad for COVID-19 patients.

[@mehakchopra5005]

Great explanation and your diagram explanation Is like cherry on cake

[@Masruba06]

Thank you so much 💚💚

[@princesjasmyn]

I always thought that any NSAID that inhibits COX1 would decrease platelet aggregation but through reading, many sources have said that NSAIDs may cause clotting... I don't get it. I understand COX2 inhibitors causing an increase risk of thromosis, but why COX1?

[@sarahbrandao6028]

Perfect as always. Thank you so much.

[@maxo.2035]

great video, but I think you should have talked about the increased cardiovascular incidents with coxibs compaired to nonselective NSAIDS. Only a minor thing, but in the video coxibs are depicted to be without side effects, which is simply not true.

[@shanzanadeem8655]

Thanks a lot! Your videos help me a lot

[@samiha6265]

Awesome thanks dearooo love this video now i m able to understand it more clearly and bcoz of u able to score highest marks.

[@metricquack12]

Hai doctor, My mother is allergic to some medicines : Diclofenac, Indomethacin and Ibuprofen. Is she completely allergic to NSAIDS? Can you pls answer 🙏🙂

[@40sakshimaru15]

Excellent Video... 👍👍👍

[@nefelibatasessiz7643]

Why NASIDs are contraindicated in asthma what’s the mechanism??

[@santoshprasad.8004]

I am from India... I used to watch ur videos

[@Pizaerable]

Wooow perfect!!! My exam is tomorrow and this video was released at the right time :DD

[@souvikkar4175]

Thank you sir i had no idea about these drugs but now it is really crystal clear it really means a lot as a student to understand something so easily i pray u have huge success sir

[@nottodayspringday1761]

Thank you very much , you dont know how this is so helpful for medical students

[@n.x6085]

Perfect explanation! Very smart person 👍

[@mrvyildiz]

Questions to me then what is the difference between ibuprofen and asetaminofen And if there's an inflammatory in body we choose ibuprofen right

[@osmanawad3977]

My best Chanel

[@CliveReyes]

Thanks for a fantastic video.

[@ramanmalepati7574]

you told selective cox-2 inhibitor causes less side effects but the drugs like rafecoxib and valecoxib which are selective cox-2 inhibitor causes serious heart problem .. can you explain this ???

[@Givemecolors]

COX-1 produce thromboxane (TXA2) which is aggregant, COX-2 produce prostacyclins (PGI2) which are antiaggregants. When you selectively inhibit COX-2 you don't produce prostacyclins to counteract thromboxane. Also, some studies shows that contrarily as we previously thought, COX-2 might be constitutive of some tissues. Finally some large phase IV studies point out that intestinal bleeding is not that much reduced with coxib. The selectivity is not as hight as we thought (but enough to increase risk of CV events).

[@falconlover5990]

Givemecolors great explanation 👍

[@Scott_Raynor]

Can you use NSAIDs to actually reduce swelling?

[@PrankishoreDeb]

Very comprehensive video... enjoyed it..Thank you

[@farahnaz9764]

Best way of explation

[@cancelled_user]

So why don't we only use selective COX-2 inhibitors??

[@mennaashraf4410]

Kyle Butler it can increase risk of cardiovascular risks as inhibition of COX-2 only will exacerbate COX-1 mediated TXA2 which increases platelet aggregation

[@noahkristoffersen6710]

It is not know if the cardiovascular risks are only associated with COX-2 inhibitors, as traditional NSAID's may also be associated with increase risk of cardiovascular sideeffekts. as always more research is needed.

[@U2FanSanFran]

I have severe migraines more than 15 days a month and even Naproxen and Sumatriptan doesn’t help. What else helps?

[@mutazalqadre4385]

Thank you very much ❤️❤️

[@josephputz2964]

Did you get all that?

[@alexanderrudolph6069]

This is amazing.. Thank you!!

[@parimehr88]

your channel helped me understand pain mechanisms and its pharmaceutical aspects 🩵

[@dr.vibhasuhane4293]

very helpfull videos..please upload cns and cvs drugs pharmacology videos

[@ماهرصبري-ك2خ]

Thank you 👏👏💚

[@karishma-0921]

Thank you so much sir for such amazing explanation!!

[@harijishnu6594]

You are a real saver bro 🙌

[@dr.shreyaslokhande8070]

Amazing video. Thank you so much 👍

[@shaggbaby]

Coming from a DNP, your videos are excellent. Keep it up👍🏼

[@cristinagouveia762]

Your videos are awesome! Thank you for your great job!!

[@susannelson5021]

Why are nsaid not used in the management of asthma

[@talhakhan-op4cj]

Very well explained mashallah ❤

[@Kiran.2020]

You are the best ❤️

[@ClinicalTalks]

Great work

[@ushnar9346]

Is there any effect of NSAIDs on neurotransmitters' release & metabolism?

[@douniacats]

THANK YOU VERY MUCH IT WAS SO HELPFUL THANK YOU THANK YOU THANK YOU

[@saacidsamakaab9997]

Thank you very interesting lecture

[@drpritisanghavi3341]

Excellent job

[@eclkt]

Thank you for your education.

[@hafidhotulilmillah4139]

thank you for the video armando! please make a video about uterotonic for next.

[@prikwilson]

This video is really helpful..the style of explaining things is interesting. It doesn't make the audience feel boring

[@miatarisa1314]

thank you so much 😄

[@avarbrar763]

Thanks for the video❤️

[@hassco1928]

Thank u very much💯

[@اسماءعبدالباسط-د3ه]

thank you very much .that is very great ,interesting videos .please can I download it and use in my course in Arabic ?

[@ananielee]

Love it!!!! A big thank!

[@sarangthacker4748]

brilliant - thank you so much!

[@awaladam4888]

great work, people like you make studying much easier tnx

[@rajithadhanu4181]

Thank you very much. Another great video.