Anti-inflammatory drugs (NSAIDs and steroids)

[@ravenholbrook2353]

I'm in nursing school, and this video was so helpful for PathoPharm! You have NO IDEA how much I appreciate the work you put into these vids!! Thank you Dr. Mike

[@Imkenyx]

I wish my university teachers were as clear as you. Thank you!!

[@Imkenyx]

@@joewaylon9559 reported for spam :) Just insecure guys hack their girlfriends to spy on her back. Loser...

[@ghazanfarnoorzaie7701]

Man, you are just killing it !!! I love your lectures, and they are to the point, clear and life saving. Keep it up. I would like to tell everyone who is here, to keep on watching your videos and I promise they will learn a lot.

[@Manhii]

This is the best explanation I’ve ever had- you really make it sound so simple and intriguing at the same time. Thank you very much indeed.

[@stephgalway2548]

I sat looking at textbooks for 2 hours revising for my P+P exam -- this video in 20mins has cleared my mind and I'm understanding it! Life changer and life saver!! Thank you

[@Onyxandfriends.4467]

Let's throw all the text books away!!! Just kidding, but you made everything so clear and interesting. I love it so much! Thank you, thank you Dr.!

[@mamasitaaxoxo]

This was amazing!! You are awesome. I'm studying Pharmacology in nursing school and this breaks everything down and clarifies so much. Looking forward to more!

[@DrMattDrMike]

mamasitaaxoxo thank you!! I am so happy that it helps!! Best of luck with exams 🤗

[@tannerpeebles1249]

Found my new favorite channel for med school. Amazing!

[@siroussarmadi1614]

This is the best lecture I ever saw in my life regarding NSAIDS! Appreciated!

[@majidrepublic7164]

man,seriously i had a big issue to understand NSAIDs clearly , you made it a piece of cake ,,thank you so much

[@DrMattDrMike]

Majid Republic thank you Majid 🙏

[@josecolon3194]

Jose Colon 1 second ago In nursing school; a very helpful lesson. I like how you start at the beginning of a process and make your way to what we see in practice, thanks.

[@anthonyjmunoz]

Excellent! Thanks for posting. This is such a big help with my pharm class.

[@hobbesip1]

Brilliant. I have many autoimmune issues, and this break down explains why they are so careful and, sometimes reluctant, in their practice and how to proceed. It's more complicated than I thought.

[@zakariamohamed9815]

only teacher i go to when it comes to pharmacology . thank you very much

[@luketwaits5998]

The most clearly explained NSAIDs vid yet! Cheers!

[@DrMattDrMike]

I am very glad it helped Luke!!

[@mrglasswindowwashing]

Can prednisone be used for the Coronavirus

[@joiezkomorebi172]

This guy is a complete package: teacher, gym endorser and matinee idol. :)

[@seedsofhope8643]

I learned from u than the whole 2 semesters in my collage .. thank u so much

[@anneochana782]

An excellent presentation. You broke NSAIDs down and helped to make sense of the pathway.

[@mellozz91]

Would love more pharmacology and meds videos please!

[@jonesaffrou6014]

I'm in high school and understood every single thing. You're a magician.

[@madeleineemilyfaydavis1383]

Thank you this is one of the best videos you have done. Excellent detail and context to help build the full picture

[@melz0512]

Thank you for explaining something that was a bit confusing to me in a very simple and easy to understand way.

[@autumnrose3943]

Very well presented. Thank you so much. Very helpful for a nursing student. You are the best.

[@y.p.2528]

the way you break down the information is outstanding. thank you. so much clearer. The subject becomes interesting.

[@mattisfahani6021]

thanks mate , not only for the amazingly practical and easy to follow contents but also for your talks . the reason I emphasise on it is that many international health workers who try to do the exams only have access to non-Australian videos and speech. Even though, they are very good too , but hearing it from someone within the system is very helpful. thanks again

[@elizabethfox5277]

amazingly clear and thorough and your teaching style is superb!

[@SM-io6fp]

Man he's the best teacher out there and thus channel is the best at that regards

[@lookingsober]

Very clear and detailed explanations, thanks so much, please keep doing what you're doing! They help so much

[@aurorablair5194]

You are amazing! Preparing for my pharmacy licensure examination, big help to review basic pain meds.

[@toulakranitis6924]

Awesome presentation, you explain everything so well, I could read a text book over and over and still not absorb this information. Really you make it so much easier to understand well done, love your work.🤩👍

[@farfromhome4842]

That was agreat video .well explained.Thank you somuch. looking forward for more lessons

[@blondie9318]

This video is off the chart!! Thank you!!!

[@Drmaryamoffical]

thank you so much sir, seriously your way of teaching is great

[@osamaemran100]

The greatest pharmacological video i've ever seen

[@gbb5112]

You guys are amazing!!! Thank you so much for taking the time to help me pass my FNP program :)

[@lapharmacie98]

so yesterday I was studying physiology of pain and I got a MASSIVE headache, I took an aspirin and it wasn't helping, and I started thinking about how it was affecting nociceptors and..well everything is clear to me now. I love pharmacology.

[@DrMattDrMike]

Haha! That’s great!

[@ranita899]

Thank .you so much for explaining so well and easy this topic which i found very difficult to understand in other lessons or videos. You are an amazing educator

[@wechulivictor312]

Great work Doc, you make complex stuff look so easy. Thanks

[@af_co8413]

Thank you again for another great lecture! please keep posting more videos 😊

[@unnatikumar9074]

Great video! it's nice to learn pharm with clear concepts :)

[@suma333]

Thank you!! This really help me understand pharm lecture better and pass my pharm exam

[@bencawley853]

legendary explanations as always, thanks guys!

[@marinavl685]

Very helpful explanation! Thanks ! -A previously confused nursing student ;)

[@gwynthegnome2050]

Quick correction: Tylenol (acetaminophen, also called paracetamol) is NOT an NSAID. Mentioned at 11:30. Maybe u were thinking of Aleve (naproxen), which is a common NSAID sold over the counter right alongside ibuprofen. Otherwise, great video! Thanks for this, mate :)

[@DrMattDrMike]

Gwyn the Gnome that’s correct. I clarify this statement at 15:03 (ie NSAID-like with poor anti-inflammatory properties) and thanks!! 😊

[@ahmadalsharif8119]

Watched 3 videos but none like your lecture. Thanks soo clearr💕

[@redredwine1277]

Excellent presentation, Thank you for sharing, very helpful info. 🌼🌺🌸

[@DoctorSandia]

Dude thanks. I didn´t learn pharma that much on my classes and you make it so easy.

[@nareshkumar-sg8tn]

The best method of making clear.thanks a lot for this. From Indian students

[@James-cu1qw]

Matt/Mike. Why is it beneficial to reduce inflammation if it is an important protection/repair/regeneration process?

[@DrMattDrMike]

James Conlan Great question! Inflammation is like an unexpected guest. It’s okay for a short period of time (actually beneficial), but if it stays around too long it becomes detrimental. Should be regulated by negative feedback, once the stimulus (e.g. cut) is healed it should disappear. When we use NSAIDs to mitigate pain, it only suppresses the prostaglandin based effects of inflammation. Many other chemicals will still be involved.

[@khawlahahmed5499]

Thank you so much Dr matt I have learnt alot from you than my lectures In school may God bless yo work

[@BNDPSTUDIOOFFICIALD]

Awesome lecture sir love 💕 from india 🇮🇳

[@Mitpat46]

amazing video but I confused on what this means Prostaglandins Derived from Arachidonic acid via COX1, 2 and 3.

[@tyler4975]

Iv never seen such a high sub rate for the view count on your videos, i think you guys will really take off at some point.

[@briangpratt]

Nice video. Not an easy topic, but you broke it down quite well.

[@alisonross1217]

So great at explaining it. Thank you Dr Mike

[@osamawaqar3034]

Understood the concept, liked and subscribed, turned the notifications on, and also saved the video in my youtube playlist ✅ 👌

[@connoresterhuizen6608]

Thank you for the very detailed explanation!

[@michalatkins5055]

What a fantastic presentation! Thank you!

[@genesisdelrio1523]

You're literally amazing, thank you for this !

[@danielduffy5640]

Thanks, you are a wonderful teacher! Very helpful.

[@maria11172]

Thank. very helpful. find it hard with several concepts but broken down well.

[@gasofthepeople]

Excellent video, thank you so much!! High quality education for free, you guys are amazing.

[@hooriyahsethi414]

i didnt get your point at 1:50 to 2:15 how the endothelial constriction is occurring why and what it does can you elaborate a litte please?

[@DrMattDrMike]

Hi hooriyah! When pro-inflammatory chemicals are released (ie histamine) one of the roles they play is to tell the cells that line the walls of the blood vessels (endothelial cells) to contract. In doing so, the gaps within the capillary walls get larger and promote more plasma and blood cell loss to the damaged site.

[@hooriyahsethi414]

Oh thankyou for this elaboration I got it now

[@hooriyahsethi414]

Biological Sciences if you don't mind can I ask what sources do you use I mean you didn't mention any reference .. are you a doctor? sorry if you mind any question

[@anniemurphy9857]

He's a researcher and educator at a university

[@neiviramos8748]

I cannot thank you enough, very easy to understand :)

[@beatlover3802]

Great explanation sir... May god bless u always ❤️

[@migueltacos1610]

Holy CRAP! I can't believe how much fun that was to learn!!

[@mohammedahmed2360]

it makes sense !!! thank you very much, greating from Africa!

[@jessicaftw9564]

UGHHH THANK GOD NURSING STUDENTS HAVE YOUUU ❤️

[@fitafanatomy3359]

I took naproxen 1000mg slow release last night and today I feel so tired. I never take medication but thought I'd try... I think I'll stick to my natural anti-inflammatory route.

[@farookchotu11]

excellent explanation sir... thank you so much.....

[@江寒刀风乱]

According to Harvard Pharmacy Book, NSAID can also increase the risk of strokes. Does it because it makes the plagues travelling in the vascular system? Yes you have explained in the video, those are cox2 blocker. Thanks

[@user-ei1kt]

Thank you! Amazing and helpful explanation :)

[@marium1583]

Just cleared all my concepts....thanks alot Dr. Mike✨

[@christinaforsberg5514]

Great video, easily explained and made me understand things better :)

[@atheer1485]

Thank you so much, the video was very helpful for me.. and your accent is very clear to me as Arabic girl Thank you 💞🤙🏻

[@AndyThomasStaff]

This is great! I'm surprised you didn't talk about the dangerous fluoroquinolone antibiotics, like Cipro and Levaquin. On their own, these antibiotics are well documented to cause irreversible full body damage, but when administered with CORTICOSTEROIDS, they are much more likely to disable the patient. Why didn't you talk about this relationship?

[@DrMattDrMike]

Hi Andy! Time constraints and this vid was an intro for my students. Hope all is well! - Mike

[@rumaisashahid]

Thanks a lot for breaking it into chunks.

[@Nicole-iy1ps]

You are a great teacher!

[@sholjas13]

Brilliant, thank you. Incredibly refreshing listening to straight talk. Much easier absorbtion into the intelligence 😄🙏 🙋‍♀️

[@nxqqi3290]

You just earned a sub. Thank you so much sir!

[@sameeds.8270]

Hi Dr.Mike, lately i was going through an article from American College of Cardiology. In which they have said that combining Misoprostol with NSAIDS can lower risk of heart attack by 44%, 34% lower risk of Renal Injury and 24% lower risk of Stroke. My question is how misoprostol can do that in the absence of prostaglandins?

[@sameeds.8270]

I am really looking forward for your comments here. Thanks

[@peterphiri6373]

Doing BioMedical Sciences,and this topic is giving me pressure... Thank you for the explanation

[@DrMattDrMike]

Thanks! 😊

[@hiwot28]

Thank you!!! you made it easier for me to understand!

[@SarkisKlinik]

What is the longest duration of time and dosage that we can give acetaminophen and NSAIDS for elderly with chronic pain ?

[@ree6461]

Excellent explanations, great charts. Thankyou so much!!

[@christianethomas3896]

Briiliant!!!! Concise but so informative.

[@sidach7135]

Complex subject made simple to understand; well structured and penetrating presentation. Well done!

[@DrMattDrMike]

Thank you, Si Dach! I'm glad you liked it! 🤗

[@rajnithomas510]

Brilliant !! Great explanation.

[@LazarKosticdonickoce]

There are several factors in exercises cure joint pain. One resource I discovered which succeeds in merging these is the Mackyns Nature Guard (check it out on google) it's the most incredible blueprint i've seen. look at all the extraordinary information .

[@amiraali818]

Can you please explain asthma and the relevance of arachidonic acid, allergic pathway (atopy) and non-allergic pathway

[@shvonned.burkemsncrnpagpcn619]

Asthma is MIB! 💕 Never looked at it that way.

[@cynthiaavly7562]

Thank you. Helps a lot ! Great explanation

[@timblackburn1593]

Brilliant...can anyone help with the names of the cox-1 & cox-2 promoted prostaglandins?

[@shamusapkota]

I have a question, sir. Inflammation is protecting our body from injuries. Then why are we trying to reduce it?

[@MariosLasagna]

Is it right to assume that turmeric and black pepper will have basically the same process as a NSAID?

[@maxwellnkulumo5546]

you kill it Mike you are a genius

[@elchiniorl849]

Holy sh!t mate thank you for helping out a MS1!

[@DrMattDrMike]

elchinio RL glad it helped!!

[@mellozz91]

This was so helpful!

[@mahakamal1481]

This video was really good. Thanks A lot :)

[@lisareed9296]

So how does decreasing synovial fluid help? Wondering what the long term effects would be.

[@hooriyahsethi414]

here you are saying that aspirin inhibits both Cox 1 and Cox 2 .. cox 1 increase platelet aggregation and cox 2 decrease platelet aggregation so if its working on both how will this be effective in cardiovascular diseases???

[@ellybana]

Aspirin more selective to cox1 activity. It act more upon the thromboxane

[@smitk90]

Platelet inhibition process is more potent therefore overall effect decreases clotting ability.

[@pharmacist8035]

actually aspirin irreversibily inhibit cox2 in platelets which means new platelets will be required thus anti-platelets action

[@ahmadameer366]

No all ur answers are wrong guys , we give low dose aspirin ( 75 mg ) to prevent platelet aggregation because the low dose aspirin will inhibit only cox 1 and will decrease txa2 production , but in high dose aspirin ( 325-1000) it will inhibit both cox 1 and cox 2 .

[@paragus100]

U are right Ahmad