"ATP" by wehi.tv (2021)

Two examples of how ATP provides energy for molecular activity inside your living cells:
Ca2+/H+ ion channel
DNA helicase enzyme.

[@Preacher_.]

To be able to physically see the molecular machines that exist within every one of our trillions of cells is truly awe-inspiring.

[@paulsass4343]

we are not "seeing" them- these are much smaller than the wavelengths of visible light, and these pictures are very detailed imaginings of general operations of the structures, each of the "dots" in the representation is, of course a quantum structure and has the associated fuzziness.

[@paulsass4343]

the deep time in which these various molecular characteristics accreted and the enormous numbers in which they interact...it may be impossible to figure everything out, but the astounding human patience and dedication to "understanding', even one corner of a little bit of reality is one of the reasons to be proud of humanity.

[@entranceexit1763]

Dude, absolutely! 👍

[@Chris.Davies]

It is possible the human brain is the most complex structure the universe has ever seen.

[@paulsass4343]

@@Chris.Davies it may be the case that the time needed to gradually build up processes that resulted in the switching circuits that human brains instantiate, is this much! i myself am ok abandoning victorian definitions of "meaning" and "purpose" not that there aren't- just the old definitions are inappropriate category errors...

[@regulate.artificer_g23.mdctlsk]

@@Chris.Davies I'd argue it's the elephant's brain that is the most complex structure

[@lordofthecats6397]

@@regulate.artificer_g23.mdctlsk I'd argue the human brain is better. Now will any elephant brains come forward and disagree with me? (Jokes aside, elephants are pretty darn smart)

[@BlackEyedGhost0]

I knew about ATP and DNA helicase enzymes, but I had never seen how helicase is powered by ATP. Phenomenal animation, thank you.

[@l.m.892]

Excellent presentation! You are pioneers in microbiology education. Thank you for the lesson.

[@tesina21]

Amazing work as always! Absolutely love the audio/sound effects!

[@blastum]

I can watch these animations forever.

[@uninsulatedshrimp5518]

Every time I watch these molecular machine videos I have an existential crisis

[@6B26asyGKDo]

dude, same

[@PotionsMaster666]

Same.... But after that I proceed to watch some memes and everything's back to normal lol

[@joeschmoe5583]

It's funny because the exact opposite happens to me - I have an existential crisis UNTIL I watch these videos - and then feel so much better that everything indeed does have a rational explanation.

[@immanuel829]

Every time I watch these molecular machine videos I am even more in awe of our Creator :)

[@marianbuduroi6463]

WOW that DNA separator mechanism is awesome

[@margueriteoreilly2168]

Unbelievable this process happens in everyone of our Cells....i enjoy ur wee movies 🎬 so much Belfast Ireland 🇮🇪

[@Chris.Davies]

I was going to comment "UNREAL!" But that could have been taken the wrong way. I pronounce adenosine differently, but you are allowed to, I decided. :) Love WEHI!

[@vector7938]

It's beyond incredible that any of this even exists, and is programmed to work so precisely.

[@xtratub]

they motivated by death

[@regulate.artificer_g23.mdctlsk]

It's like saying water is "programed" to flow downward

[@vector7938]

@@regulate.artificer_g23.mdctlsk A program is a set of steps, which when executed in order, achieves a certain result. Seeing these molecular machines repeat their working steps over and over again, this is the only comment you were capable of posting??

[@regulate.artificer_g23.mdctlsk]

@@vector7938 No. Proteins - and, by extension, metabolic systems - don't work like programs, unless you strictly mean Everything that does a process in a repeating series of steps is a "program". Then does that mean my respiratory system is a program, because it performs respiration in a set of steps? You have to keep in mind that proteins, like any other molecules, don't have will/a mind of its own; they just behave according to the laws of physics just like water. They aren't "programed", and they certainly do not behave like one; they just do the things they do because of the environment that allows it to - change that and you change the protein's activity or even it's properties. You know that proteins aren't stuck to doing just one specific process, right?

[@quote.d]

@@regulate.artificer_g23.mdctlsk they are "programmed" by their genes tho and could be "reprogrammed" by generic engineering. I think you may be conflating "programmed by a rational designer" with "capable of executing some program that benefits the system as a whole and therefore was selected for naturally". Also, yes, respiration (reproduction, cell cycle, etc) can be regarded as programs.

[@Lexoka]

Some base pairs have 2 hydrogen bonds, but others have 3. So if one ATP molecule is always consumed to break a base pair, is energy wasted when helicase uses it for a 2-bond base pair?

[@B.Mega.D]

Good question..?

[@shaikrehanaparveen8862]

Really great question. Id love to know the answer

[@Gelatinocyte2]

I think the ATP is used to power the mechanical movement of the helicase, not so much to the breaking of base pairs individually or specifically, so I'd say... No?

[@muralitharan6409]

Wonderful animations molecular scale in high resolution , thank you.

[@svenskaapologetiksallskape527]

amazing! fascinating ! inspiring! thx!

[@hanyanglee9018]

Yeah, great animation. Great illustration. Molecules inside the body are so busy. Any slower animation? I can not even see what they do .

[@sparky5584]

I think you can slow the video down using the setting control on the bottom right - looks like a gear or wheel.

[@hanyanglee9018]

@@sparky5584 True. KZbin feature actually does part of the thing for me. But I would like to see some more. When I was in university, I majored in computational chemical. I did experiments on a software called Gaussian. It's addictive to see the atoms shake and move to another position over and over again.

[@dvl973]

This is so uncomprehensibly tiny, so impossibly reliable and so insanely sophisticated, it literally looks like the work of a god. Against all odds, life found a way to resist entropy.

[@xtratub]

The way is simple as circle - just use energy to get more energy

[@ClipsNSnips]

It is pretty incredible, the closer you look the more it looks that way 😅

[@regulate.artificer_g23.mdctlsk]

Well, they're not really "impossibly* reliable". Where do you think those genetic diseases come from?

[@aliburakyanar3325]

Thanks

[@PotionsMaster666]

How in the *actual hell* did they figure out this ? It's not like they could see molecules under microscope......oh wait...isotope labelling ? Is that it or are there any other methods ? Plz help, I'm super excited about this Thank you

[@regulate.artificer_g23.mdctlsk]

There are many other methods, actually. There's Electron Microscopy, Electron Crystalography, X-ray Crystalography, Neutron Diffraction, Nuclear Magnetic Resonance...

[@arturok4209]

this is amazing, ty

[@Apchenail]

Maybe one of your best.

[@mersilvaureus1525]

*energy*

[@jonicley2254]

I'm curious how can we maintain a youthful state indefinitely

[@jonicley2254]

@@gregoryt8792 Jesus knew about chemical machinery. The last verse of John talks about how there were so many more things Jesus had done that the world couldn't contain the books that could be written.

[@entranceexit1763]

All this shaking, of trillions and trillions of molecules such as this, somehow doesn't make my body noisy?

[@z-beeblebrox]

Since air carries sound, and is also made of molecules, their shaking is at too small a scale to disturb the air. But it does disturb photons, which get bounced out in the form of heat energy. In fact, that's what ATP excels at

[@andresconrado]

@@prototype2889 That's a very dismissive and lazy way of answering a simple question, and a wasted opportunity to elevate somebody's curiosity. For a person who seems interested in science, this attitude is not very effective nor constructive. Are you OK?

[@blastum]

It happens very rapidly, so it's ultrasonic.

[@proton.....shafiultutorial3833]

Fine,,,,,

[@FrozenLabRat]

I understand more, but Ive got even more questions.

[@glz1]

Life

[@danielcaraj]

+1

[@margueriteoreilly2168]

Omg.....I love 💘❤💕♥💖💗💘❤💕♥💖💗💘❤💕♥💖💗💘❤💕♥💖💗💘

[@mgciniwata5115]

Its hard to picture or even consider Evolution from nothing when you watch these videos.

[@Chris.Davies]

You mean "much easier" of course. What you are viewing here is nothing but physics and chemistry at the molecular level. Once you understand it's nothing but chemicals and physics, and that the individual molecular interactions are very simple, but very reliable, and totally relentless, provided you are not denied air for three minutes, water for three days, or food for three weeks! The food you eat is used to create ATP, which powers practically all your cells' internal processes. Chemicals react according to physics. And now you have seen the incredible rate at which chemistry takes place inside every cell in your body. Helicase, for example, when it unzips a DNA strand spins the DNA at 10,000 rpm - or about as fast as a jet engine! With chamistry happening at this speed, in trillions of quadrillions of locations on Earth, over billions of years, it is easier to understand how evolutionary forces create complex life. Bad chemistry inside a cell almost immediately kills it. So, failures in reproduction which do not lead to a reproducing lifeform, is the driving force of evolution.

[@mgciniwata5115]

@@Chris.Davies I still cannot grapple with the "nothing but physics and chemistry" part. Now yes I agree that is what we see now. But to think that all this complexity and systems on top of systems of even simple molecular interactions as you put it, coming and immerging out of nothing is close to magic for me, even with a dash of eons of time added. There has to be something underlying, something we are missing

[@sparky5584]

@@Chris.Davies Well said. I especially liked the speed/location part. That's how I see it and watching these animations makes it even more wonderful.

[@regulate.artificer_g23.mdctlsk]

Y'know, atoms are essentially made of mostly empty space; so the idea of "created from nothing" being sort of technically true is funny to me.

[@kuhatsuifujimoto9621]

imagine believing in abiogenesis after seeing this video

[@mnm8818]

yeah its a mind boggling/ impossible concept both ways... though it would be more easy if things didnt need to follow physics or any laws eg a cube planet or dna just magically copies itself without any chemical influence... would make the case of non abiogenesis more... with this vid, its easy to continue it and just need certain chemicals to create chain reactions and increase in complexity through adding/ bumping into other chemicals, as we are all made of chemicals just like all the other 'dead'/not alive things in the universe. its a mystery to solve.

[@dcolb121]

Fascinating