Autonomic Pharmacology | Adrenergic Agonists

[@irfaansaib4846]

Why did i pay for expensive medschool lectures when this guy explains 100 times better!!

[@selo5124]

Because you don't become a doctor by watching youtube videos.

[@eunicenangogo]

🎉

[@lajeona]

In my university, the lecturer explains all of this in a difficult way that only if you have studied everything you will know what he's talking about . Even though we study pharmacology for the first time this year . Nobody gets to the roots of subjects like you do . Thank you ❤️

[@moqaftaofficial5588]

Same here buddy 😂😂😂

[@lajeona]

@@moqaftaofficial5588 I guess they think they're lecturing post graduated students 😂

[@marcosrua7223]

Maybe they lack deep level understanding and deliberately confuses you

[@Emmanuel_Ekes]

It's same everywhere lol. It's actually with my N. Nerd

[@doskevin4882]

That’s because they just read slides and don’t really understand it themselves. Every university is this way

[@toms7782]

Not only are you extremely effective at simplifying and making this content digestible, but you also share an incredible amount of enthusiasm when presenting your main points. I believe this is one of the reasons why people praise your work in every single video I watch. Thank you for that.

[@salvadorhirth2919]

I click on the " like button " even before watching because all of your videos are great!

[@yoelinramos1859]

Thank you so much for all you explain. Many universities don’t have professors with the capacity to explain things the way you do, a way we all understand. drawing is the best source to remember things. Thank you thank you.

[@giorgosvlachopoulos1615]

Thank you for this great lecture! I appreciate much your work. There is one little mistake at 12:00. The adrenal gland's average secretion is 80% epi and 20% NE

[@ekkenaab1310]

Endocrinology | Adrenal Medulla | Catecholamines lecture at 8:24: 80% EPi and 20% NE

[@sujyotsharma]

12:40 yea basically norepinephrine means No-R-epinephrine which is the absence of R or Alkyl group in it. I read about this on reddit.

[@ريناد-د8ت]

Wow!

[@pppie8509]

This channel is a gift that keeps on giving, year after year!

[@blackyrocky7438]

Little bit correction- around 80% epinephrine secreted by chromoffin cells of adrenal medulla and around 20% norepinephrine by adrenal medulla.

[@btsismybias8332]

Thank you for uploading. I have exam in a month , thank you for saving my life.

[@LB76255]

I am actually blown away by your brain and how it can remember all of this info. I am watching your videos in hope they can teach me what my pharmacology lecturer cannot.....however its still way over my head. )-:

[@prasannapriya2185]

The way you explain every detail of these topics helped me to clear my doubts & understand well, Thank you team Ninja Nerd.

[@biybimaryamjoldasbaeva506]

Thank you so much! You are making pharma so easy to understand and fun! Keep uploading sir

[@ayshasumeer6215]

I saw those graphs about adrenergic agonists in first aid .. I couldn't understand anything from those pictures . .. after watching this lecture when I go back to first aid.. I wondered how easy was that.. this is his magic.. full of concepts..thank you

[@doskevin4882]

I bought the member package because you deserve it. It’s been helpful as well to study the lectures you have

[@manalemad1589]

thanks a lot for all the hard work that the ninja nerd team is providing ❤❤❤

[@stephaniewilkinson3637]

Your love of biological sciences really shines through and reminds me of how much I love it too! Thanks for the excellent review.

[@Schmittywerben]

An alpha 2 agonist I’d also add that we use quite frequently in the ICU is dexmetetomidine. We run it as a drip for sedation. Works great for patients who we need sedated but still need a respiratory drive. Definitely see the effect on heart rate and blood pressure at times.

[@BarrelCollective]

It sedates via the locus cereleus on the spine but what’s its mechanism of action on bradycardia? Is it baroreceptor/vagus response?

[@Schmittywerben]

@@BarrelCollective It’s a direct alpha 2 agonist, which inhibits the release of catecholamines from neurons which leads to bradycardia/hypotension. Sometimes quite profound.

[@dr.p.sprasad7600]

super simple explanation! great teacher! blessed are we to be able to hear you!

[@liz-qt6xq]

Thank you so much for this video! Helped me get through my Pharmacology exams! Would really appreciate another lecture with you about NSAIDS and DMARDS :>

[@sallysherwood2201]

Your videos are the best. Thank you!

[@rinc2006]

Thank God for sending Zackh Murphy into this world

[@seeyou5606]

Wish this was uploaded few months back...i had this in my previous sem but thank you sir 🙏

[@rebeccabrown7244]

Honestly, I'm in a class that has NO lecture on pharmacology whatsoever. It's a "read the book and take the quizzes" kind of class. Thank you so much, I would send you my tuition money if I could.

[@kalenced8575]

Right on time! Im struggling on my uni with pharmacology cause lectures are bad and there is not enough study material. Thank you ninja nerd for teaching us everything

[@mpmitul]

"Your videos are absolutely amazing! 🎉 The way you break down complex topics makes everything so easy to understand. Your teaching style is engaging, clear, and super helpful-exactly what I needed! Thanks to you, I feel more confident in my studies every day. Keep up the fantastic work, you're making a huge difference! 🙌📚"

[@dman5909]

Funny thing I just got prescribed guanfacine (a2 agonist) for ADHD. Explanation was superb

[@m_m786]

Thanks 👍💝

[@jordanchung1399]

Bro im convinced you guys are gonna single handedly get me through med school

[@JayneWilson-d1c]

I had a patient in the ICU who experienced intense reflex bradycardia from norepi! BP would increase significantly and then HR dropped into the 40's and occassionally patient would convert into a junctional rhythm! Very interesting to put two and two together!

[@nonyabidness4103]

This is very interesting to someone who has high blood pressure. I found out last year that drinking alcohol reduces my pressure significantly. Couldn't figure out why that is, but watching this video made me think it has something to do with the alpha 2 receptors. Is that right? Does whiskey act like Clonidine?

[@wanahmadamsyarzafrie8080]

That's kinda tricky, there are many variables and unknowns

[@LukaTrenbolon]

Alcohol is a ligand of GABA receptor (much stronger ligand than GABA itself) so it reduces the action potential of the cell, better said it calms you down. I guess the effect comes from that overall sedative effect it has on your CNS and all other subsystems being downregulated. That's my guess.

[@maple7432]

It does inhibit the sympathetic pathway​ that induces vasoconstruction by acting at the alcohol/barbituate binding site on the gaba br@@LukaTrenbolon

[@markjojamietan3016]

Damn the rationale is so good after all these years, these videos are still very useful thank you

[@bilqisnjama1387]

Medicine can be pleasurable with your support You ROCK sir!

[@EntEmpireTV]

Thanks man , please don’t stop and keep making great videos, appreciate it❤

[@rumaisashahid]

Thanks a lot for this video! Great explanation! Please continue making more videos on pharmacology.

[@sedooamase6423]

Thank you really explains everything, thank you for adding the quiz part at the end of the class, really helps with understanding the whole concept.

[@thomaschezik9769]

Love the videos, keep producing this incredible KNOWLEDGEABLE content! I'll be signing up with the ninjas to help support the channel!

[@fikakahle_nzuza]

God sent!!! Thank you so much ! ❤❤❤❤

[@fikakahle_nzuza]

God sent!!! Thank you so much ! ❤❤❤❤ Please make videos on Local Hormones

[@marconeyou]

Amazing class! Thank you so much!!!

[@ChikaodiliFrancisca]

Thank you Chief ❤

[@deepakrtr4840]

Extremely useful lecture bro❤❤❤

[@rajaafrin1259]

great explanation!

[@hasnaahassan4562]

thank you very much you are amazing ❤❤

[@Laibaselflovecorner]

Amazing lecture thankyou so much ❤❤

[@hafsatahir3115]

What would i do without these videos

[@Mayavee617]

🙏 I’m so grateful to meet you sir!!

[@abdalhamedhanona6829]

افضل دكتور يشرح فارما

[@kellykellykelly1850]

I don't know whether to thank you or cry...thank you

[@rifatahmed760]

May Allah bless you. Im in awe to have you.

[@alsharabyalsharaby1483]

Ninja is the best, Thanks

[@8bppantheryt]

Thank you man, my wish is to this on my Language, this is amazing a wanna be Bosnian Ninja Nerd

[@PravinChandran1983]

Alpha -2 agonist are indeed like symphato lytic reducing blood pressure like clonidine being used for hypertensive urgency

[@stephendurling]

Awesome content as always!

[@hootlavendertea]

Thank you so much!!! 💜💟🩷

[@hassanirfan8678]

Ninja nerd❤❤boomm

[@SayBehnam]

One of the best 🔝👌🏻

[@r.0401]

Hi, I think the Adrenal Medulla, at rest, secretes about 80% of Epinephrine not Norepinephrine. Thanky for the good video though!

[@ujjwalrohilla7951]

These videos helps a lot

[@leilaesmailzadeh6998]

I love these lectures thank you

[@parisafarahani7456]

Thanks. You are awesome 😎

[@josephmisana9178]

You're the best teacher I must admit, but at minute 11:53 I need a clarification on the percentages! Here is what I know, "In the adrenal medulla, this reaction goes still one step further to transform about 80 percent of the norepinephrine into epinephrine, as follows: 5. Norepinephrine  Methylation  → Epinephrine" (Guyton and Hall Textbook of Medical Physiology, 13th Ed. 2016). So I think Norepi is the one which at 20% while Epi is 80%

[@NabiShah]

Great description

[@jamalabdi303]

Please feed us more pharmacology lecture !

[@favourchidiebube3967]

Nerd at it again ☺️☺️

[@rayeneboutabba2048]

Thunk u very much for making this easier 😊

[@AD-hs9su]

thank you so much ..,...PLEASE make video on CNS PHARMACOLGY sedatives, alcohol, AUTOCOIDS PHARMACOLOGY

[@BarrelCollective]

I wish you would’ve touched on dexmetotomidine while you were talking about Alpha 2 agonists. I think it’s sedative nature and adverse affects are confused in most people outside of those prescribing it

[@humaakhan7589]

As your video lectures are very very informative Please make video lecture on Oncology topics like Breast Cancer colorectal Cancer Leukaemia lymphomas … highly requested

[@hammbaby]

this video is so good

[@TheMuslimahh1]

Helpful! Thank you

[@Chaotic_hijabi]

Thank for explanation 👍🏻👍🏻

[@leahkaylor3612]

thank you for these awesome videos!!!

[@stephaniegabriel8044]

thank you as always!

[@bunny8352]

Excellent work, I'm in very impressed

[@mohamedamr7817]

Good evening I hope you are doing well Sorry for bothering I wanted to know how many lectures left in pharmacology,thank you for all your hard work

[@talemwarecheal1132]

Thanks so much gor the video it has really helped me i couldn't understand in class

[@KelvinNjoku-p5b]

you never miss 🙌🏾

[@ekkenaab1310]

I have question! On the timeline the event that starts at 1:25:39: Systolic blood pressure going up it's for two effects: alpha-1 receptors on arteries and veins, alpha-1 receptors that are present on veins that's going to increase venous return, increase preload, INCREASE CARDIAC OUTPUT! The other thing is that there's beta-1 receptors and there is little bit of beta-1 receptor effect and you can increase contractility and INCREASE CARDIAC OUTPUT!! How the hack could be at 1:27:40 that CARDIAC OUTPUT HAPPENS TO BE NEUTRAL???? 1:27:56 now we have alpha-1 receptors ONLY on arteries (not on veins anymore?) that increases afterload and if we increase afterload, we DROP CARDIAC OUTPUT???? How could that be?

[@jamalabdi303]

Thank thank thank you ❤❤❤❤❤❤❤❤❤

[@riyanbabar8416]

Thank you so much for this video.

[@ABDURRAHIMRABIU-lg5lq]

Amazing thank you

[@jbstepke3]

How do you do it? I am in awe! Thanks again for another awesome lecture!

[@Derwinlol]

Ur the best.

[@سعيدسعيد-ه3ط]

Amazing

[@reeceyfries8050]

Amazing! Thank you

[@AndrewGreene-hd3ey]

I mean, I'm learning so much thank you

[@juanmartinvillamea378]

goat of medicine nerdd

[@MareimJassim]

Love you ,you’re the best wallah

[@nadiahassan7250]

You are such an angel to me..

[@shayarilyrical]

At 33:20 you said that Blood pressure would increase and at 33:30 you said it is hypotension means lowering of blood pressure I didn't understand it?

[@denisa.mesacruz7358]

Perfect video, amazing breakdown of content. I love your videos. Keep it up please. Thank you for everything you and your team are doing to make our studying more amenable.

[@yuvalabergel8201]

amazing!!!! thanks

[@karmagaming7112]

Love u 3000 ❤️ We are Ninja Nerds 🥷

[@haley3730]

So does that mean calcium channel blockers can affect the release of norepinephrine, via preventing or blocking the action of the vesicle?

[@AkshatDave-qb1pe]

Herrlich und danke!

[@rakeshsreeramkr1675]

Thank you so much

[@Agoraphobia07]

Any videos on Chemo Induced N/V or the Chemo Trigger Zone specifically? ☺️

[@sarahaljefry8149]

Love it💜

[@joanchance2846]

Heaven sent❤

[@mwansakayula34]

Hi Zac, what book do you recommend me to use for this?