Autonomic Pharmacology | Adrenergic Agonists

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You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
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Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Adrenergic Agonists within our short series on Autonomic Pharmacology. We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:07 Adrenergic Agonists Introduction
1:06 Adrenergic Neurons and Receptors
19:32 Adrenergic Target Organ Effects
30:34 Alpha 1 Agonists
39:38 Alpha 2 Agonists
47:48 Beta 1 Agonists
51:42 Beta 1 + 2 Agonists
56:19 Beta 2 Agonists
1:02:47 Beta 3 Agonists
1:04:07 Alpha + Beta Agonists
1:13:17 Epinephrine + Dopamine
1:22:30 Norepinephrine Graphical Representation
1:29:48 Epinephrine Graphical Representation
1:34:49 Isoproterenol Graphical Representation
1:39:11 Adrenergic Agonists Practice Problems
1:45:20 Comment, Like, SUBSCRIBE!
Supplemental Lecture: Neurology | Adrenergic Receptors -- • Neurology | Adrenergic...
Pharmacology Source:
Whalen, Karen. Lippincott Illustrated Reviews: Pharmacology (Lippincott Illustrated Reviews Series). Wolters Kluwer Health. Kindle Edition.
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#ninjanerd #pharmacology #AdrenergicAgonists

[@lajeona]

In my university, the lecturer explains all of this in a difficult way that only if you have studied everything you will know what he's talking about . Even though we study pharmacology for the first time this year . Nobody gets to the roots of subjects like you do . Thank you ❤️

[@moqaftaofficial5588]

Same here buddy 😂😂😂

[@lajeona]

@@moqaftaofficial5588 I guess they think they're lecturing post graduated students 😂

[@marcosrua7223]

Maybe they lack deep level understanding and deliberately confuses you

[@Emmanuel_Ekes]

It's same everywhere lol. It's actually with my N. Nerd

[@doskevin4882]

That’s because they just read slides and don’t really understand it themselves. Every university is this way

[@irfaansaib4846]

Why did i pay for expensive medschool lectures when this guy explains 100 times better!!

[@toms7782]

Not only are you extremely effective at simplifying and making this content digestible, but you also share an incredible amount of enthusiasm when presenting your main points. I believe this is one of the reasons why people praise your work in every single video I watch. Thank you for that.

[@salvadorhirth2919]

I click on the " like button " even before watching because all of your videos are great!

[@giorgosvlachopoulos1615]

Thank you for this great lecture! I appreciate much your work. There is one little mistake at 12:00. The adrenal gland's average secretion is 80% epi and 20% NE

[@ekkenaab1310]

Endocrinology | Adrenal Medulla | Catecholamines lecture at 8:24: 80% EPi and 20% NE

[@yoelinramos1859]

Thank you so much for all you explain. Many universities don’t have professors with the capacity to explain things the way you do, a way we all understand. drawing is the best source to remember things. Thank you thank you.

[@pppie8509]

This channel is a gift that keeps on giving, year after year!

[@blackyrocky7438]

Little bit correction- around 80% epinephrine secreted by chromoffin cells of adrenal medulla and around 20% norepinephrine by adrenal medulla.

[@prasannapriya2185]

The way you explain every detail of these topics helped me to clear my doubts & understand well, Thank you team Ninja Nerd.

[@sujyotsharma]

12:40 yea basically norepinephrine means No-R-epinephrine which is the absence of R or Alkyl group in it. I read about this on reddit.

[@doskevin4882]

I bought the member package because you deserve it. It’s been helpful as well to study the lectures you have

[@btsismybias8332]

Thank you for uploading. I have exam in a month , thank you for saving my life.

[@seeyou5606]

Wish this was uploaded few months back...i had this in my previous sem but thank you sir 🙏

[@biybimaryamjoldasbaeva506]

Thank you so much! You are making pharma so easy to understand and fun! Keep uploading sir

[@sallysherwood2201]

Your videos are the best. Thank you!

[@EntEmpireTV]

Thanks man , please don’t stop and keep making great videos, appreciate it❤

[@Schmittywerben]

An alpha 2 agonist I’d also add that we use quite frequently in the ICU is dexmetetomidine. We run it as a drip for sedation. Works great for patients who we need sedated but still need a respiratory drive. Definitely see the effect on heart rate and blood pressure at times.

[@BarrelCollective]

It sedates via the locus cereleus on the spine but what’s its mechanism of action on bradycardia? Is it baroreceptor/vagus response?

[@Schmittywerben]

@@BarrelCollective It’s a direct alpha 2 agonist, which inhibits the release of catecholamines from neurons which leads to bradycardia/hypotension. Sometimes quite profound.

[@nonyabidness4103]

This is very interesting to someone who has high blood pressure. I found out last year that drinking alcohol reduces my pressure significantly. Couldn't figure out why that is, but watching this video made me think it has something to do with the alpha 2 receptors. Is that right? Does whiskey act like Clonidine?

[@wanahmadamsyarzafrie8080]

That's kinda tricky, there are many variables and unknowns

[@LukaTrenbolon]

Alcohol is a ligand of GABA receptor (much stronger ligand than GABA itself) so it reduces the action potential of the cell, better said it calms you down. I guess the effect comes from that overall sedative effect it has on your CNS and all other subsystems being downregulated. That's my guess.

[@ayshasumeer6215]

I saw those graphs about adrenergic agonists in first aid .. I couldn't understand anything from those pictures . .. after watching this lecture when I go back to first aid.. I wondered how easy was that.. this is his magic.. full of concepts..thank you

[@rebeccabrown7244]

Honestly, I'm in a class that has NO lecture on pharmacology whatsoever. It's a "read the book and take the quizzes" kind of class. Thank you so much, I would send you my tuition money if I could.

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[@liz-qt6xq]

Thank you so much for this video! Helped me get through my Pharmacology exams! Would really appreciate another lecture with you about NSAIDS and DMARDS :>

[@dman5909]

Funny thing I just got prescribed guanfacine (a2 agonist) for ADHD. Explanation was superb

[@stephaniewilkinson3637]

Your love of biological sciences really shines through and reminds me of how much I love it too! Thanks for the excellent review.

[@user-nv1qm5tl5l]

I had a patient in the ICU who experienced intense reflex bradycardia from norepi! BP would increase significantly and then HR dropped into the 40's and occassionally patient would convert into a junctional rhythm! Very interesting to put two and two together!

[@kalenced8575]

Right on time! Im struggling on my uni with pharmacology cause lectures are bad and there is not enough study material. Thank you ninja nerd for teaching us everything

[@r.0401]

Hi, I think the Adrenal Medulla, at rest, secretes about 80% of Epinephrine not Norepinephrine. Thanky for the good video though!

[@jordanchung1399]

Bro im convinced you guys are gonna single handedly get me through med school

[@makemoneyonline_888]

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[@PravinChandran1983]

Alpha -2 agonist are indeed like symphato lytic reducing blood pressure like clonidine being used for hypertensive urgency

[@markjojamietan3016]

Damn the rationale is so good after all these years, these videos are still very useful thank you

[@AD-hs9su]

thank you so much ..,...PLEASE make video on CNS PHARMACOLGY sedatives, alcohol, AUTOCOIDS PHARMACOLOGY

[@lucyberger7625]

I am actually blown away by your brain and how it can remember all of this info. I am watching your videos in hope they can teach me what my pharmacology lecturer cannot.....however its still way over my head. )-:

[@BarrelCollective]

I wish you would’ve touched on dexmetotomidine while you were talking about Alpha 2 agonists. I think it’s sedative nature and adverse affects are confused in most people outside of those prescribing it

[@belfastconor8521]

Take Guanfacine for Autonomic Dysfunction. Used to take Clonidine but was changed to avoid rebound hypertension. Autonomic Dysfunction due to removal of bilateral carotid body tumors and resultant vagus nerve damage.

[@rumaisashahid]

Thanks a lot for this video! Great explanation! Please continue making more videos on pharmacology.

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[@sedooamase6423]

Thank you really explains everything, thank you for adding the quiz part at the end of the class, really helps with understanding the whole concept.

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goat of medicine nerdd

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[@SayBehnam]

One of the best 🔝👌🏻

[@hafsatahir3115]

What would i do without these videos

[@osamaaljassem4256]

One mistake professor is that the adrenal medulla secretes 80% Epinephrine and 20% Norepinephrine

[@ekkenaab1310]

I have question! On the timeline the event that starts at 1:25:39: Systolic blood pressure going up it's for two effects: alpha-1 receptors on arteries and veins, alpha-1 receptors that are present on veins that's going to increase venous return, increase preload, INCREASE CARDIAC OUTPUT! The other thing is that there's beta-1 receptors and there is little bit of beta-1 receptor effect and you can increase contractility and INCREASE CARDIAC OUTPUT!! How the hack could be at 1:27:40 that CARDIAC OUTPUT HAPPENS TO BE NEUTRAL???? 1:27:56 now we have alpha-1 receptors ONLY on arteries (not on veins anymore?) that increases afterload and if we increase afterload, we DROP CARDIAC OUTPUT???? How could that be?

[@rifatahmed760]

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[@kellykellykelly1850]

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Thanks 👍💝

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[@marconeyou]

Amazing class! Thank you so much!!!

[@talemwarecheal1132]

Thanks so much gor the video it has really helped me i couldn't understand in class

[@mohamedamr7817]

Good evening I hope you are doing well Sorry for bothering I wanted to know how many lectures left in pharmacology,thank you for all your hard work

[@stephendurling]

Awesome content as always!

[@ABDURRAHIMRABIU-lg5lq]

Amazing thank you

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[@albertagunggozali2569]

I still don't understand why A1R and B2R contradict with the give of NE/E on the blood vessels. like, if there are 2 receptors in blood vessels will it constrict or relax? -thx

[@grumpyowl3166]

If dopamine doesn't have much of a beta-2 activity, how does it cause the decrease in blood pressure in lower doses (alongside with epinephrine)?

[@yuvalabergel8201]

amazing!!!! thanks

[@Mayavee617]

🙏 I’m so grateful to meet you sir!!

[@abdalhamedhanona6829]

افضل دكتور يشرح فارما

[@deepakrtr4840]

Extremely useful lecture bro❤❤❤

[@brittneyrobinson6358]

Ok but if stimulation of alpha 2 and beta 2 causes antiadrenergic effect such as no secretions why does stimulation of beta two cause release of glucose shouldn't it prevent release of glucose?

[@mwansakayula34]

Hi Zac, what book do you recommend me to use for this?

[@ekkenaab1310]

if systolic blood pressure depends from cardiac output and systolic blood pressure increases with Norepinephrine then the cardiac output must increase as well!

[@gNa_0000]

This might be the only lecture that I've left feeling confused about. In the beginning, you noted that norepi caused decreased HR, decreased contractility, decreased CO@ and also decreased SVR and BP, but then in the comparisons it was not the same. Was this ONLY for higher doses of norepi??

[@hasnaahassan4562]

thank you very much you are amazing ❤❤

[@mohammedfawzy4763]

hollow, its written in lippincott the adrenal medulla release 80% epinephrine and 20% of norepinephrine.

[@denisa.mesacruz7358]

Perfect video, amazing breakdown of content. I love your videos. Keep it up please. Thank you for everything you and your team are doing to make our studying more amenable.

[@rayeneboutabba2048]

Thunk u very much for making this easier 😊

[@user-sm5zq7cp7n]

Amazing

[@sepsepful]

Adrenal medulla recieves pre-ganglionic fibers from sympathetic chain ,in the video is indicated they recieve post -ganglionic fiber

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I appreciate your effort very much. But what I am asking is to let us take full picture of your note please leave board fully visible after lecture. Thank you

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[@TheMuslimahh1]

Helpful! Thank you

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[@stephaniegabriel8044]

thank you as always!

[@KT-mi8sg]

Hi, Can you please go over Postural Orthostatic Tachycardia Syndrome (POTS)? Thank you!

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THANK YOU

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[@saradelrusso7790]

Actually, ephedrine and cocaine are still in use. I am training for anesthesia, and we give ephedrine all the time. ENT surgeons will use cocaine to keep bleeding at bay while providing an analgesic effect,

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Amazing! Thank you

[@nadiasosa4211]

isnt it 80% epi and 20%NE?

[@Prince-nm1jy]

Yes it is