Autonomic Pharmacology | Adrenergic Antagonists

[@jhonklan3794]

You are quite literally the greatest educator that has ever graced the planet earth. You have a PhD+ level of understanding of every topic you cover, yet you know how to communicate it succinctly and simply. You were born to teach.

[@desleykakoulidisgallaway3382]

I agree he’s incredible - a genius for sure... not taking anything away - however, Jesus is the greatest teacher On earth ever in fact he is still teaching people worldwide how to live with purpose 🙏🏻

[@lik_doyaya]

​@@desleykakoulidisgallaway3382 yeah, but Jesus didn't teach me anything about alpha-1 antagonists in the Bible

[@saurabhtripathi9665]

😊😊

[@jaygala9420]

It was due to your teaching I passed my 1st Year MBBS with 75% and got 2nd Rank in my College. All set to ace 2nd Year with your lectures Dr. Zach. You deserve all the respect and love from all the students all over the world. A big THANK YOU to you!!!!!

[@perpetualifemazi6287]

Just a lil correction, the adrenal medulla produces or pumps out 80% epinephrine and 20% Norepinephrine (4:1 ratio) Thank you for your beautiful work😍

[@angusmack.2202]

I love how no matter what level of understanding you are at, you can always keep up with the video and clear your concepts. Thanks u Soo much!!!

[@tarunb6914]

at 29:13, shouldnt it be urine retention instead of urinary incontinence?

[@inazfaisal5051]

Your videos are literally among the best in the medical field! You made pharma so much easier to understand!

[@blackfoxmp5]

Great lecture overall, but one mistake at 9:48: the adrenal gland secretes epinephrine and norepinephrine at a 4:1 ratio. Thus, 80% of secretion is epinephrine and 20% secretion is from norepinephrine.

[@teamdiver8911]

you're my lifesaver. I could not get through my nursing career without you.

[@pachino11839]

An interesting fact about beta blockers is that they can be used as a doping agent on healthy elite sportsmen. During training beta blockers maintain a reasonable cardiac output and muscle perfusion increasing performance as a conditioning agent. During training under normal conditions an increased cardiac output will increase blood pressure only to a threshold where the ventricles need enough time to fill their chambers with blood. If the heart rates increases beyond the threshold the ventricles will fail to pump the 125 ml per contraction. This will reduce tissue perfusion due to a lower mean BP. The beta blockers can keep the heart rate below the threshold effectively during training. This is why beta blockers are banned in competitive sports and considered a doping agent by the IOC.

[@mariakara4848]

I am guilty in being addicted to ur lectures ，no words can describe how much I am grateful for ur hard work and fab lectures😘

[@GregariousGalaxy]

The bestest way of understanding. Sir please make videos on microbiology too

[@jyothiuddandravu3835]

There is no words to say who u are how u are and what you are u r demigod u ur patience your hardwork and your teaching style words cannot describe how I felt like u know everything every topic we r blissed to have u tq so much 🙂👍🤗

[@Nikosmentis]

Best pharmacology lectures on KZbin

[@KathleenSethFarillon]

You'll be the reason why I'll pass my pharmacology subject. THANK YOU SO MUCH

[@manalemad1589]

u deserve all the best I hope this channel hits the 10 million subscribes , lots of effort and time spent while constructing it every time I meet my other medical student friends I tell them about this channel so I can help growing up this amazing work ,I hope I could help in more THANKS ALOT ❤❤❤

[@citytrak]

Zach - when you are talking about Alpha1 antagonist drugs on the bladder with BPH (e.g. the -osins), don't you mean the indication is urinary RETENTION (2ndary to BPH) not incontenance? I though the idea was with BPH, we get relaxation by the A1 Antagonists, allowing relaxation at the prostate and internal sphincter, which allows for easier urination...

[@davideserboni]

you're right

[@saidafirouzi3417]

You are the savior of me and many students out there!

[@muslimgirl6179]

Thank you, sir, ❤❤❤ you are the best teacher❤❤❤

[@hpinheiroa]

I already was passionate by phisiology and pharmacology - but u guys u made me head over heels about it. Congrats in everything you do. Helped me see things in such a easier way - even though really detailed

[@ubongenoch8841]

I thank you sir for your spectacular and remarkable lecture I must confess u are a legend

[@ghandigharaibeh9323]

I discovered Zach's only weakness ( he spells the most famous Beta Blocker as Propanolol) ... he does not pronounce it as PropRAnolo) or even spell it. The imperfection that proves his legend.

[@lamaaldarwish5095]

Thank you so much without you I would fail every pharmacy exam I've ever had❤️❤️❤️😭😭😭

[@lissaizzy4927]

I always find your videos interesting and I like how you describe things keep up the good work

[@cristinajaramillo3778]

I have no words to express my gratitude to you! You are amazing!!!

[@tobaccocancer2635]

My understanding level after watching your videos 📈

[@videosapien]

Sir, The Great Prof, Zach Murphy ❤

[@riomacapanas2196]

Thank you so much Dr. Zach for your very informative videos,bcoz of your channel I passed the Veterinary Licensure Exam just now🥰u were such a great help to my basic understanding of physiology and pharmacology😊. I will surely share your channel with the future examinees of VLE.THANKS AGAIN AND GOD BLESS😇😇

[@saidafirouzi3417]

I cannot express my gratitude and admiration, you are amazing!

[@SitaraDreams]

Thank you all as always for all of your great work and effort. I have a question, wouldn't alpha blockers be treating urinary retention/obstruction in case of BPH and not incontinence ?.

[@rajavignesh6749]

Yes ..same doubt ,it should treat urine retention

[@fusionhypnotic]

You made this course right when I took pharmacology. You are amazing my friend thank you

[@nachi7066]

Preparing for prometric exam and very very useful

[@shreyagite8225]

@29.03 min you said urinary incontinence..it should be urinary retention due to bph?

[@j.b.3543]

He made an honest mistake, and you are right, it helps in urinary retention because it relaxes the internal urethral sphincter and thia causes urination

[@ahnaf_akif_mbbs_bd_ksa]

huge airdrop in my medical base May you be rewarded sir 👌🏾🔥

[@sajadphbaaaj4102]

Thank you so much. I passed my exam today, depending on you. Thank you, professor

[@Cottntale321]

A "lil break"?! LOL You came back with a fresh cut and everything!! Love it !! Great Video!!

[@antoniocuestarepice786]

Bro said "had to take a lil break" = returns with different haircut. LOVE THE VIDS, all the way from SPAIN. I watch your vids at 2x to get a quick recap

[@seenaoommen5137]

Sir you are amazing. Can't thank you enough for your teaching. Inspiration!

[@garrylasaga1550]

Still the BEST lecturer in KZbin

[@adrianaquirogavelasquez9452]

Thank you so much! Awesome explanation. Just an observation/question : Are alpha 1 blockers used for incontinence? Aren't they used for retention instead?

[@calloftruth]

i think alpha 1 inducers retain the urine other hand alpha 1 blockers blocks or stops the activity to treat retention.

[@davideserboni]

you're right

[@user-sp8mf1vx6d]

UNBELIEVABLE HELPFUL!!!!! THANKS A LOT IS THE MINIMUM ...CONGRATS

[@zainab7036]

🤩🤩🤩thank you so much , i love you Channel . Keep going . May God bless you and your team ❤️

[@Arsalan_umar]

Thanks ❤

[@nelsonomondi5941]

Nice one

[@slowbro-]

Marvellous! Absolutely Marvellous!

[@SadiaZaman-tw7si]

Really thank you!! You are the savior ,Sir 😊😊

[@noornoora688]

Thank you so much for this great explanation

[@lourock_]

Thanks this helps tremendously

[@spudman3275]

love your content bro, you are a wonderful human being. thank you.

[@user-ey4hy3le8h]

Hello and thank you for explaining everything so well. I was wondering how NE and E affects the receptors if they ever do overcome their natural affinity?

[@BarrelCollective]

Where would you fit demetotomidine and clonidine?

[@14_usmanarshad32]

awesome lecture, 28:21 our cute little sphincter muscle 😂

[@EntEmpireTV]

God bless you and gives you all you want , see you at 10 millions subs❤

[@Muzzamilgola]

You never Disappoint.. keep it up man ❤❤

[@BarrelCollective]

Getting me ready for CRNA school interviews over here

[@amine6005]

splendid we need more pharmacology

[@shohinsadiev177]

fantastic lesson

[@lennonbruney8591]

Amazing video! Extremely helpful

[@mutee6136]

beautiful

[@doreenm2160]

Thankyou Ninja Nerd

[@lamachi.i8458]

My pharmacology exam is Thursday👀 Great work keep going 💙

[@Sunshine-wc7td]

Was of great help. Thanks nerdy

[@brendaomana8553]

Muchas gracias por sus videos ❤

[@user-sm1hc1gl4n]

We dont prefer alpha 1 blockers forHTN bcz it decreases BP markedly on working at urinary bladder sphincter by micturition is it right concept so we should prescribe it when HTN+ BHP together

[@rouaaabdeldaim1920]

Life saver fr, bless you man

[@layaglynandu.548]

Thanks!

[@doskevin4882]

Best videos out there

[@iamsufyanali]

Sir, you made a mistake at 9:41 when you tell that NE is the 80% released by Adrenal Medulla while it is the other way around. It is 80% EPINEPHRINE that is released by ADRENAL MEDULLA.

[@Maya-uy6fb]

Thanks

[@rafaelandrade8586]

thank you a lot

[@emmanuelmarychinecherem6320]

Awesome!!

[@karmagaming7112]

Love u 3000 ❤️ We are Ninja Nerds 🥷

[@aleyasha3112]

Thank U Boss for Everything ❤❤❤

[@samarestephan2485]

You are intelligent. Thank you ❤

[@vanish3886]

Thank you guys

[@junaidusmany636]

ninja , you are the best . I wish I could be your direct student.

[@sandiarajpoot2302]

well explained!🙏

[@GISdaily]

great sir

[@amandabentley9128]

Thank you!

[@sumaiyaparna1056]

Can you please 🥺 upload more lecture on pharmacology..

[@plamenferdinandov5083]

having the pathogenesis of pheochormocytoma in mind, why don't we use alpha-1 antagonists and but 1+2?

[@Md76iran]

You are fantastic

[@TundeEszlari]

You are a very good videographer.💯❤

[@mahzadarjmandi3585]

Very good

[@CharDavies33]

Im on Labetalol for hypertension as mine spikes above 180/120 regularly, currently on 9 tablets aday and have to take extra when I have a hypertensive crisis, I also have Intracranial hypertension and am on Topiramate. Still being investigated for causes Im only 32 though do have multiple endocrine problems, possible Pheochromocytoma or pituitary tumour.

[@rizgarali4609]

YOU ARE THE BEST :)

[@lobarita]

Would you hold an A1 blocker if the patient has BPH but is hypotensive?

[@lobarita]

good question

[@rahilpatel9686]

Give bethanecol (muscarinic agonist)

[@charlenemeats7701]

You may be what gets me through school.

[@parmidaeelani5719]

You are great ! 🤍👏🏻

[@RainMist89]

Hello! Love your videos! I think the notes on the website and the written values on the video might include a typo. In lecture and web searching we are given EPI and (80%) produced and NE (20%) in a 4:1 ratio not flipped as shown in the video. Also the notes you give on the website also show NE being produced by the adrenal medulla twice. Not a huge deal but just wanted to give that feedback. There were some other things with other lectures I have noticed (minor details), and if there is a better way to inform about these please let me know!. Great Stuff all in all though!

[@meimei9057]

Hey Thanks dear!Please teach us Biostat also !

[@theresasunkutu9935]

God bless you for me

[@BigShaz_]

We love you Keep it going❤

[@myriambelaiche6907]

ur the best!!!!! med-1 student here:)) i literally skipped all my pharmacodynamics classes to follow along with you, and it was the best decision I ever made!

[@shafaqsyed4290]

Thank you, but u didn't cover the B2 blockers in this video. Are u going to prepare another video for this?

[@nicholaskinoti1127]

the video was so long Zach had to get a haircut😂😂😂

[@deepakrtr4840]

No words bro❤❤❤

[@user-pu8ow2ky9u]

ZACHHHHHH THANK YOU SO MUCHH. ITY AINT ENOUGH HERE'S A NON EXISTENT OSCAR FROM ME TO YOU.

[@pzahtisham5944]

Zack came back after a hair cut 🌚😁

[@sagarkhatri7890]

can you make some on anti-depressant

[@bushramohammedsiddiquebush6640]

Sir is Harrison principal of internal medicine 19th edition is good for study medicine ? .... I mean I'm unable to buy 20th and 21st edition .... So is it okay to study from edition 19 ? ... Is there any major difference in these editions ?

[@joshuafrommohiini4219]

happy teachers man