Base excision repair

Base excision repair is a DNA repair mechanism that removes the chemically modified bases from the DNA. The Enzyme involved in Base excision repair is DNA glycosylases. The DNA glycosylases, enzyme removes the modified base to create an AP site. This site is then cleaved by AP endonuclease and repaired by DNA pol I and ligase.

[@haileyyoung7558]

you've made a seemingly complicated process very easy to understand, thank you!

[@mohamedelafia4956]

i think N Glycolase does not remove the base it just identifies the wrong base. ap endonuclease cleaves the region and the base will be removed from 5 exonuclease than comes polyemrase one with the base and finally dna ligase to repair the cleavage.

[@umbra9029]

That's exactly what happens if I'm not mistaken

[@sameerhussain3709]

no he is correct you guys are wrong..... read books 📚📚📚

[@becheaachi]

You think wrong man...glycosylase breaks the n-glycoside bond between the base and sugar

[@FMshorts17]

It's wonderful bro....now I,m feeling that it,s so easy to understand it

[@cameroonian7]

Now that I see it, I understand. Thank you !!

[@Bidi_acho]

Thank you🥰

[@blueballoon7832]

the animation shows a 3' to 5' DNA pol. but the narration say it was a 5' to 3' DNA pol, so which one is it?

[@allaboutakoo]

dna is always built 5 - 3 prime

[@cygthings]

The overall direction is 5' to 3' but in that instance, the exposed ends are 3'-OH on the left side and 5'-P on the right side.

[@Phoenix-np1iu]

if i understand correctly, each nucleotide has a 5 prime end and a 3 prime end. the new nucleotide is added so that its 5 prime connects to the 3 prime of the one before it

[@songohan393]

thank you

[@arzuhaqverdiyeva4237]

Thanks . L am Azerbaijan💪🇦🇿

[@63554]

Thank you

[@deeptiaditya9133]

Thankyou sir

[@husammatar5543]

Thank you so much you are really goog to explain.

[@quratulain3252]

super helpful thank you

[@alimamstudying9462]

Thank you so much

[@shashios1236]

Very nice 🙏👍

[@Hg80_Jxs]

saved my life

[@alanoodalhouqani7036]

thank you so much

[@bhatti7714]

Excellent 👌

[@Biochemist448]

best video ❤

[@aditimane3349]

Amazing 🤩😍

[@AliKhan-ns2dp]

Weldone

[@sushamabhumbe6296]

It's helpful ☺️

[@iam7405]

❤❤

[@judytoma8733]

Great

[@wolfbaron25]

What does AP Lyase do in this context?

[@anowartheplantbreeder..8660]

When DNA glycosylases remove modified base then already 3'OH nd 5'P site open so AP endoculease what actually did??🤔🤔

[@tanvirahmed-rr7vt]

Nope the phosohodiester bond is not broken as the nucleotide moeity( without the base) still remains at the region..

[@rabiaghafoormalik2026]

Weldone