12. Hexose Monophosphate Shunt (HMP Shunt)

Pentose phosphate pathway
Dicken's Horecker pathway
Phosphogluconate pathway
site- Liver, adipose tissue, RBCs etc.
2 phases
1. Oxidative
2. Non oxidative
Clinical importance
synthesis of NADPH and Ribose sugar
Clinical disorder
1. G6PD deficiency
2. Wernicke's Korsakoff's syndrome

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Very very thanks sir.. You are the real Hero of Biochemistry.. Very nice explanation about HMP shunt..

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[@beautyofnature1674]

Thank you sir, Now I understood whole concept of HMP shunt(2 phases, carbon numbers, number of molecules, products obtained, disorders).

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Beautifully explained which is so understanding..it was too helpful...tnq sir...👍

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That's excellent but it's always help if there are mnemonics that help students memorize the names easily because this would be forgotten easily after the video ends

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[@chemistry7554]

Sir is first phase is not non oxidative phase because NADP+ is use in non oxidative pathway???????

[@Rajesh_Jambhulkar]

G6P is oxidized by NADP dependent G6P dehydrogenase and 3rd step is oxidative decarboxylation catalyzed by phosphogluconate dehydrogenase First phase is Oxidative phase

[@IndraneelMazumdar-c9g]

Sir I wrote whole pathway correctly with proper enzymes in proper sequence but I wrote xylulose and after transketolase I wrote Sedoheptulose 5 phosphate will I lose marks or I’ll get full ?

[@factoz0084]

Nice and smooth video but sir if you explain more and take time to explain then it will be benificial and our concept will be overall strong

[@jyotismitanayak5474]

Undoubtedly this vdo made it easier to understand clearly bt plz explain wid structures sir so that it'll b more helpful

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Tomorrow 10am is my exam and today 11 : 42pm watching lecture you are only hope sir

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Thank u sir for such a wonderful explanation...

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Sir can you please upload a class on the topic of the BIOCHEMISTRY OF CANCER? PLEASE SIR

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[@muthyalakapil8743]

TQ so much sir..sir ATP 36 or 35 sir formed in HMP pathway

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No ATP is either produced or used in hmp pathway

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Sir hme structure bhi to banane hote hai n ?? Ug mein ya nai ?

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No need, no extra marks

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Sir how can I find your enotes

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Sir is it haemolytic jaundice or haemolytic anaemia?

[@Rajesh_Jambhulkar]

Hemolysis ultimately causes jaundice

[@pubilc8819]

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Tq so much sir, but please it available in pdf also, then it's more meaningful.

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You teached wonderful sir.. Thanks a lot

[@shreerajpaudel8257]

biological significance of HMP shunt?

[@Rajesh_Jambhulkar]

Ribose and NADPH Ribose for DNA and RNA NADPH - Antioxidant role

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@@Rajesh_Jambhulkar clinical significance?

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[@aimashah8893]

Why in hmp pathway we utilises 6 molecules of glucose 6 phosphate

[@aimashah8893]

Sir please clear the dout

[@proteinengineering007]

@@aimashah8893 It is because : 1. for one cycle under anaerobic phase you need 1 molecule of Ribose 5 P and 2 molecules of Xylulose 5P to synthesize 2 molecules of of Fructose 6P and 1 molecule of Glyceraldehyde 3P (GAP). 2. To have these three substrates of one cycle of non oxidative reactions, 3 Glc6P are needed (as we know one molecule of Glc6P give rise to single molecule of xylulose 5P.) It means you need 3 Glc 6P for each cycle of reactions catalysed by transaldolase and transketolase. 3. Now U must also know that resulted 2 molecules of Frc 6P and 1 molecule of GAP should get converted back to Glucose 6P. But GAP being 3 C compound cant produce any hexose sugar. SO in order to have another hexose sugar from GAP, another cycle of non oxidative reactions are required. SO another GAP molecule generated from second non oxidative cycle will react with GAP from first cycle to produce another molecule of Frc 6P ( reverse of triose phosphate isomerase + Aldolase reaction of Glycolysis). in summary, 6 Glc6P are converted into 6 pentoses, which are converted to 5 frc6P molecules. If u wish to find more details at: kzbin.info/www/bejne/m5eVoamejaZksNU

[@hydrogen7690]

Very nicely explained!!!!!

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How 12NADPH I can only see 10 pls explaın

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Thank you 🥰

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Which book do you refer?

[@Rajesh_Jambhulkar]

Harper, vasudevan etc.

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Sir please it with structures 😓😭

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Very helpful for me