8. Ketone bodies- Synthesis, utilization and clinical significance

Ketone bodies
Acetone
Acetoacetate
Beta hydroxy butyrate

[@mohdarman3581]

Sir your lecture is short , and cover all things on that topic , your lecture save our time , thank you so much sir , for supporting students.

[@ananditasingh5370]

Sir, thank you for making these videos... thick books like vasudevan become so much easier to understand once you give a concise overview of the important topics.

[@thebluephoenix1543]

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[@RRR8745-j6r]

Sir , you are such a blessing for us. Thank you , Thank you , Thank you very much for your efforts and for giving us your precious time. Thanks a lot. 😊😊

[@vatsalyatiwarii]

Helps for PharmD students too. Thank you Sir!

[@ramakrishna9466]

Good 👍

[@savemefromKoreanandChineseboys]

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[@hemakongara5303]

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Sir me Pakistan ce hn ap boht acha lecture dety hy hr chez clear ho gati ha

[@druniverse9814]

Thank u so much sir u have eased the biochemistry for us . Whenever I opened the book and got flattered first I have in mind is ur videos . Thank u so much once again

[@ankuranand7516]

I thought ketone bodies is a tough topic but it is very simple... Sir you also teach very nice.. Thanks

[@moshinmohammed7410]

Pregnancy unavallki ketone vosthe how

[@moshinmohammed7410]

How can it slow Positive is vosthe yella chepandi

[@umermukthar4959]

Thank you so much sir, because of u only I was able to get good mark in biochemistry of my University exam

[@noorfatima893]

Excellent lectures on all major topics of biochemistry

[@rajayeducation6581]

Previous year old paper dekhiye kzbin.info/www/bejne/iX7GmqGFaLmAga8

[@zonureen9738]

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[@saulehakhan5833]

Sir your method of teaching is awesome

[@devunair7254]

Simply fabulous lecture sir. Enjoyed and understood fully💯

[@dr.nancychauhan]

Where is 1 ATP utilized ? Why did we substract 1 from 22.5?

[@Rajesh_Jambhulkar]

Activation of acetoacetate to acetoacetyl CoA required 1 ATP

[@dr.nancychauhan]

Oh understood. Thanks sir

[@redowlgaming6168]

Thanks 🙏🙏🙏

[@thescienceelixir3354]

​@@dr.nancychauhan in beta oxidation activation of fatty acids to fatty acyl coA will consume two ATP right ? Then why here one ATP only ??

[@maheshbhaijadav4551]

@@thescienceelixir3354 that are different reactants They are fatty acids And here acetoacetate so Different

[@sumitbajaj5740]

great help as always ,very informative and precise .excellent sir

[@076.tanvimohod8]

Best and precise explanation thank uh sir! Keep going..keep guiding us!

[@divyapratapsingh9303]

Sir where is 1 ATP consumed?

[@drtomboycool5723]

Hmm red

[@aarya2285]

@@drtomboycool5723 where?

[@akifmulla9421]

@@aarya2285 conversation of acetoacetate to acetoacetyl CoA

[@aperson2020]

Beautifully explained 👏 👌 ❤

[@littleinzagi]

Sir could you please explain energy supply briefly....

[@kurianraju3398]

It's simply an awesome lecture sir. Thank you ❤️☺️

[@swalihakhan4248]

Sir you explained it in a very easy way, Made easier to understand Really A Big thanks to you❤❤

[@SKspeaks845]

Where are you from swaliha khan?

[@sayedsajid2529]

Amazing way to elaborate the topic.... Thank you soo much for help ❤️

[@siddarthsavadi]

Doubt..🙋‍♂️-as the liver has Glut-2 glucose transporter....and glut 2 is independent of insulin...then how does the DM causes lipogenisis,where the glucose can be uptaken by liver through a passive process...!!??🤔🤔

[@aanchalsingh9158]

Glucose uptake by liver is possible but other cells of body which transport through insulin dependent transporter can't get sufficient glucose

[@balramsinghparihar3263]

I’m rocking here in russian medical college, Watching your lectures🎉

[@awangroup1353]

Sir I'm Muslim from Pakistan...but really i love your lectures ❤.... Salam from 🇵🇰🇵🇰🇵🇰

[@nainak8699]

@BiochemistrybyDrRajeshJambhulkar sir energetics i didnt understand...1 ATP is utilised where?

[@akshatmodi9014]

Tell about it's regulation...i cant understand regulation.....plz..give answer..sir..

[@ayeshasiddiqua9361]

Who ever is watching this video....... Pay more attention on what sir is speaking than u pay on crush .............. N note down what sir is writing on board....... After 12 min u'll b confident to give even sminar on this topic....... 👍

[@rafiulhussain5515]

Thanks a lot sir ......... Always be a fan of you sir ❤️ .

[@mlt2waqarahmad20]

Sir during utalization of ketone bodies in which step one ATP Are used ?

[@rh2fitness788]

I just became a fan of your teaching sir💖💖💖💖💖💖

[@TheMaxter526]

Very clear explaination.

[@chaitanyareddy6705]

Sir why should we substract 1 ATP from 22.5 ATP in utilization Plss clear my doubt

[@hmh3324]

Activation of acetoacetate to acetoacetyl CoA require 1 molecule of ATP

[@success8598]

Sir if oxaloacetate is depleted and tca cycle cannot occur so acetyl coA is diverted towards ketone body synthesis then how during ketone body utilization can acetyl coA give 20 ATP by entering into tca cycle if tca cycle is not even operating?

[@yasirquershi3070]

Thanks, wonderful lecture...

[@sanskrutisiras642]

Thank you for helping me pass my exams 😭🙏🙏

[@rajayeducation6581]

Previous year old paper dekhiye kzbin.info/www/bejne/iX7GmqGFaLmAga8

[@pravingunjal4999]

Precursor for ketogenesis is acety coA Or acetoacety coA

[@SaurabhKale-se7ju]

Sir I have a doubt At 10.06 u say that 1 ATP is utilised but where?? And when succinyl CoA converts into succinate 1 GTP is formed which inturns form ATP , so why r u not calculating it

[@jgirish6549]

3:40 why there is absence of oxaloacetate

[@___s___8071]

In starvation, glucose in the body is low. So glycolysis does not occur, because there is no glucose to be broken down. So no pyruvate is formed and as a result OAA which is derived from pyruvate by action of Pyruvate carboxylase is not formed. Hence there is insufficiency of OAA and acetyl CoA cannot enter TCA cycle so it goes into ketogenesis.

[@nainak8699]

@@___s___8071 can u please explain the energetics

[@bitaelisha1891]

Well understood Sir. Are there instances when the brain cells catabolyse Ketone bodies to get ATPs

[@megalakarnan484]

Where we utilize 1 atp sir🤔 in 10.12⏳

[@sameentayyab5631]

Sir you are a blessing ♥️

[@JUSTFun-fo7sn]

Excellent sir,,,and thanks

[@adhilasherinkv178]

Sir where is that one ATP utilised in beta hydroxy butyric acid utilization

[@Brown_dentist]

It is used in the activation of acetoacetate to acetoacetyl coA

[@Usbdh1291]

Aceto acetate to B-oh butarate why enzyme dehydrogenase it should be reductase right?

[@user-wk2gp3tu8h]

Thank you very much sir 🙏🏻👍🏻👍🏻

[@mihirpatel5632]

Thank You Sir 🙏🙏Great Explaination 🙂😇

[@salmanrain325]

Sir, during ATP production from Ketonebodies, where one ATP is utilized?

[@subhashkumar-rf1dx]

Krebs cycle me utilise hoga during succinyl coa to succinic acid

[@parthapratimdas07]

Sir awesome video...keep making videos sir ....these videos are helping me a lot .

[@bageriasclasses]

Sir if tca cycle is not happening then how in energetics from two molecules of acetyl coa 20 atp is forming. There is lack of Oxaloacetate and the main reason for ketone bodies synthesis is diversion of tca cycle due to unhandling of acetyl coa by tca cycle?

[@ManojKumars-et9mu]

May be the succinate derived frm activation of acetoacetate produces OAA which revives tca cycle ...... I'm thinking..........?????

[@Ibrahim-ku1lu]

Where 1 ATP is utilised

[@sai2346]

Sir why minus 1 is done from net atp??

[@ajaysinghmankotia2253]

Thank you 😊

[@61-gaanrwangmei60]

Where is the last ATP utilisation occur???

[@112sushmithag4]

Sir you subtracted 1 ATP in ketone body utilization.. Where is the one atp used up in the pathway sir?

[@shamithar5030]

Thank you sir ...... ur teaching is awesome sir🤩

[@Learner_space]

Sir why 21.5 ATP is formed where 1 ATP IS UTILIZED???????

[@Learner_space]

???????

[@uttamanandarout7135]

Excellent video

[@akshitchauhan3506]

Sir exam ke liye asaan kr Diya aapne sb 🔥🔥🔥

[@rajayeducation6581]

Previous year old paper dekhiye kzbin.info/www/bejne/iX7GmqGFaLmAga8

[@kunikachopkar2964]

Ketone bodies synthesis jab glucose level kam rahta tab hota hai but incase of diabetes mellitus glucose level toh increase rahta hai toh k.B kaise synthesis hongi ???plz explain

[@VijayYadav-jv5qx]

Excellent video, but where is 1 ATP is utilized sir

[@hzbofficial6170]

Medical physiology pr bhi videos bnaye sir G...

[@rajayeducation6581]

Previous year old paper dekhiye kzbin.info/www/bejne/iX7GmqGFaLmAga8

[@ayushyadav5321]

10:13 what about succinate will it not enter into tca cycle to produce atp

[@kunikaagrawal6359]

Awsm lectures... Thank u so much sir... ❤️❤️

[@himanimomula3685]

Very clean explanation and short 😀

[@perfectlyimperfect234]

Sir that means we can say in Diabetes Mellitus type 1 there in increase of glucose level outside the cell nd decrease of glucose level inside the cell???

[@rowdyrenu7833]

Where we use one atp sir You minus that one atp🤔

[@OmarFaruk-iz3ju]

I wish i was a student in ur class sir . Very simple method to learn such hard topic . Thank u sir❤❤❤

[@alianafah3631]

Thanks a lot for making this easy..... doctor why oxaloacetate is deficient in diabetes mellitus ?

[@Rajesh_Jambhulkar]

Glucose can't be utilized by cell.because of defective glucose uptake by cells.

[@alianafah3631]

Ok doctor thanks 👍

[@sleepyafbawsawgntz2669]

Thank you so much for this explanation! I am doing a paper on the keto diet's effects on cellular respiration and I notice you mention only starvation and uncontrolled diabetes as conditions that induce the synthesis and utilization of ketones. Is it the same process for someone eating a diet of say no more than 20g of carbohydrates a day to induce ketosis?

[@betterisbest.3905]

Where did 1 ATP is used, To make it 21.5 ATP's?

[@gunjeetdehariya2993]

Your teaching is marvelous sir 🙏

[@basitdftri7055]

Bahot level Hy apka sir g

[@morphineshot9231]

Acetoacetate to beta OH butyrate is occurring in the presence of beta OH butyrate dehydrogenase but there is addition of hydrogen occur but sir you use dehydrogenase , i hope u answer this question.

[@marian6404]

Thank u sooo mch sir❤ It helped us a lot..

[@clipstation3232]

Thank u sooooooooooo much sir 🙏🙏🙏🙏🙏🙏🙏🙏🙂

[@foodielovers6033]

Sir can you plzz explain the keton body formation

[@jemimamathew8339]

Sir why is oxaloacetate needed?

[@sarbanandadoley5564]

Why liver tissue can't utilizes ketone bodies...? Plz reply

[@Rajesh_Jambhulkar]

Thiophorase required for utilisation of KB absent in liver

[@sarbanandadoley5564]

@@Rajesh_Jambhulkar thank you sir

[@aditirattan8190]

Great job

[@aanyakadam4731]

Supperb explanation ❤ thank you sir

[@soumyaranjanswain2263]

Lipid metabolism chapter seemed to be tough to remember. But it is cleared thanks to your explanation. Thank you Sir.

[@drkiran84]

Tysm ❤❤❤❤

[@drchaary7386]

Acetyl coa + acetyl coa = 20 atp y sir

[@krishnabhagam4238]

Sir, You started with TWO acetyl COA molecules and ended up with TWO acetyl COA molecules, already excess acetyl COA leads to ketone production but in the end of the ketone utilization process acetyl COA concentration remains the same , HOW THIS WORKS ?

[@Bro-kq6ox]

I think the Acetyl COA will enter TCA cycle which will break them down.

[@saketpandey3889]

That acetyl coA will enter kreb's cycle further ETC and produce energy

[@01.bhetariyadivya4]

You are great sir great 😃👍

[@noreenkhan8193]

Brilliant JazakaAllah sir stay blessed

[@abhi9973]

Sir, I have a doubt - acetyl coa is the first compound in ketogenesis. Then it can be directly converted to glucose via tca cycle???

[@Rajesh_Jambhulkar]

Acetyl CoA is completely oxidised into 2CO2 in TCA cycle

[@rittikpaul7523]

Thank u sir ......nice teaching 💖💖💖

[@rajayeducation6581]

Previous year old paper dekhiye kzbin.info/www/bejne/iX7GmqGFaLmAga8

[@shubhamaggarwal3801]

Thank you so much sir👍🏻☺️

[@merlinjohn7381]

The concept is so simple and clear….. thank you sir 👍🏻👍🏻👍🏻

[@alone_warrior_29]

Sir please tell where the 1 ATP is used???

[@ishratjahandisha2608]

sir, you explain every topic very simple way, thank you so much sir 🇧🇩

[@i_mermaid]

Sir plzz explain HMP shunt pathways

[@Rajesh_Jambhulkar]

Yes sure

[@i_mermaid]

@@Rajesh_Jambhulkar thanks sir

[@bhavikasharma5691]

where is one ATP utilised ?

[@drsailaja7313]

U can find the answer down in the comments 😊

[@NARSIMHA182]

Sir ...please explain dietary ketosis

[@MassmaharajaRaviteja-t6g]

Sir how 20ATPs are generated and where 1ATP is utilized ,I can't understand sir please clarify me sir

[@udaykiran5100]

Did you find out ?

[@aanchalsingh9158]

Here 2 acetyl coA are produced. Each acetyl coA when undergoes TCA cycle generates 10 ATP. So, 20 ATPs are generated like this and according to sir 1 ATP is utilized to activate acetoacetate to acetoacetyl CoA. Hope it helps..

[@bramaganddaval2519]

Great explanation sir

[@govindmule2629]

Ur very great sir.