I Was WRONG About Artificial Sweeteners? | Educational Video | Biolayne

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Study Discussed:
www.cell.com/c...
Non-Nutritive Sweeteners decrease body weight & improve glycemic control long term:
pubmed.ncbi.nl...
pubmed.ncbi.nl...
pubmed.ncbi.nl...
pubmed.ncbi.nl...
pubmed.ncbi.nl...
pubmed.ncbi.nl...
Butyrate improves glycemic control: pubmed.ncbi.nl...
Propionate prevents weight gain in obese adults: pubmed.ncbi.nl...
Propionate increases energy expenditure & fat oxidation: pubmed.ncbi.nl...
B. Fragilis decreases intestinal inflammation: pubmed.ncbi.nl...
Streptococcus may improve T2D: pubmed.ncbi.nl...
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[@nyguy5370]

As a PhD scientist who makes a living doing medical research, and has more than a passing interest in this subject because I am a type 2 diabetic, and I have worn a CGM, I think this study established nothing more than that by changing ones diet, you alter the gut microbiome. Layne is dead on that this is hard to interpret. It could be good, it could be bad, it could be neutral. There is no data in the study that supports am overall negative effect of NNS, and the authors even caution in the manuscript that based on this data one should NOT abandon NNS for sugar. Water will always be the best beverage, but I think for 100% of humans, drinking beverages sweetened with NNS’ is far better than drinking something sweetened with sugar. Having published in Cell myself, I agree with Layne that as high a profile journal as it is, there is plenty of great research and plenty of crap in the journal as well. This study is well designed on the whole, but its publication in Cell will cause its impact to be far greater than the dataset presented justify, in my opinion. Finally - an anecdotal finding with an N of 1; my pretty healthy 80 year old Mother drank TAB for decades and still uses Sweet-N-low in her multiple cups of coffee everyday. So if you are one of those people who insists that NNS’ are bad, you will likely cite this study, probably incorrectly, as supporting your point of view. If you think NNS is good, this paper does little to change your mind.

[@asherrfacee]

Appreciate the information. Do you know if there any correlation between artificial sweeteners and memory loss or cognitive decline?

[@huddwah]

thanks that saved me from wasting 10 mins... (I have to watch his videos at 2x speed... and wish he had more humility)

[@marcdaniels9079]

@@huddwah Why ? Do you think all the charlatans and influencers are humble? He is debunking BS and more power to him. If you can’t be bothered to watch the extremely high quality videos why not unsubscribe? I am sure he will live with it. 😉

[@BOSSDONMAN]

It's like those headlines that say "X activity causes changes in the brain." Like okay, what is its significance? Does it have any potential predictable capability or insight of observing as such?

[@nomnomnooma]

@@marcdaniels9079 lol at your gate keeping

[@ChristopherMurtagh]

I love how Layne just sticks to the data, regardless of whether it matches his expectation bias and delivers the content with no bullshit. If only the media would report on scientific studies this way.

[@A_Turner]

Layne is such a gift to the fitness industry, begging for a collab between him and Mike Isratel

[@francescafrancesca9872]

That's very true!! Imagine if he was a news journalist....he'd be hunted down

[@ptortland]

As a sports medicine physician, I LOVE these deep dives into the research! I also deeply appreciate Layne’s oft-repeated mantras: 1) Facts don’t care about your feelings 2) That which can be asserted without evidence can be dismissed without evidence.

[@jsmith5764]

Can you explain what you take "that which can be assertive evidence can be dismissed without evidence", to mean? Is that another way of not reasoning about the assertion? To me when I think on it it isn't saying much or wanting interesting. Thoughts? Thanks

[@Counter-Intuitive]

On another note #1 and 2 are perfect defeaters for all religions

[@bobbobson4030]

@@jsmith5764 Me: "The world is run by pink unicorns" (assertion) You: ”What evidence do you have for this claim?" Me: "Nothing, but I promise they exist!" (No evidence) You: "Please stop wasting my time" You haven’t disproven that pink unicorns run the world. But on the other hand these unicorns could also green, purple…maybe they are actually tortoises…or any other one of an infinite list of possible claims. How do we know which is correct? It’s pointless to waste time trying to disprove a claim with no evidence since there are infinite such claims

[@Counter-Intuitive]

@Zog Bot You're correct, arguments like that only convert intelligent people to the default agnostic position.

[@peachcobbler641]

@Zog Bot you never won an arguement In your entire life

[@bastipear2864]

Dude, I am hooked to your channel! I can't wait till you tell me one day if sweeteners are unhealthy or not. Till then, I will blast my system with this stuff

[@jamesk4452]

Coke zero is the peak achievement of the scientific community. FTA.

[@DAatDA]

They should've won a nobel prize

[@jessiel7694]

💯😆😂

[@TheMastermind729]

That stuff is nuts, can’t tell the difference

[@TheCCBoi]

No, diet mountain dew is

[@jamesk4452]

@@TheCCBoi I haven't drank mt dew in 15+ years. I'll give it a shot though.

[@clubmogambo3214]

Been using liquid Splenda for several years and more recently liquid Splenda monk fruit. Never had any problems with yearning for food containing actual sugar as so many claim results from using no-sugar sweeteners. Have lost more than 60 lbs in conjunction with keto and IF. And my last blood and urine test results were the best in a couple of decades. So I'm fine with taking the opinion that no-sugar sweeteners have been a blessing for me.

[@phil4986]

if drinking regular water without the spenda gets uncomfortable, you should get off the splenda. splenda addiction will attack the stomach and intestines. it will take two months for your insides to repair themselves from splenda induced damage.

[@clubmogambo3214]

@@phil4986 Where in my post did I say I was uncomfortable with drinking water? I'll wager a ton of internet money that I drink a lot more water than you on any given day. I only drink Splenda-infused drinks, almost always iced tea, when I'm having a meal. And even then there are times when I drink water only. So why you stated what you did is quite perplexing.

[@louisaklimentos7583]

I lost weight without artificial sweeteners I drink purified water and soft drinks I find too sweet even if they have artificial sweeteners and no sugar . People who have poor digestion should avoid beverages with artificial sweeteners because our digestive system is styled to digest real foods and nothing artificial.

[@clubmogambo3214]

@@louisaklimentos7583 Not an issue for me, but if it is for you, then by all means avoid them.

[@MArixor100]

@@louisaklimentos7583 Ever heard of lactose intolerance? not artificial yet it still irritates the digestive system IF u are sensitive yet people still consume dairy on a daily basis.

[@SpartanWolf222]

As someone who has lost almost 60 lbs within the past 5 months, I can pretty much thank artificial sweeteners for helping me keep myself satisfied with less/zero calorie alternatives (both more natural options like monkfruit and artificial ones like Splenda.) If I had to point to one culprit that made me go up to 300 lbs over the past two years, I think it would have to be the amount of sweet tea I drank on a daily basis. I know this is anecdotal and I can't say definitively that it was as simple as that alone; however, I know I used to drank 30 - 40 oz of sweet tea on a daily basis, and that is somewhere around 320 - 450 extra calories every day that I never considered to be an issue. Once I stopped drinking that stuff and made other low calorie switches to my normal meals--and I even curbed my tea intake to just one 20 - 25 oz just to help with my teeth staining--my weight has been melting off without too much hassle on top of increasing my weekly exercise and portion control.

[@charlesdean640]

That's like a crack addict switching to powder cocaine and thinking they kicked their habit

[@butsirrr]

@@charlesdean640 You seem to know a lot about drugs... hmmm

[@03blaird]

@@charlesdean640 EXACTLY. these people are quick to blame natural sugar for their weight gain instead of I dunno... Maybe not stuffing their faces with garbage in the first place?!? If you're 300 pounds of fat trust me switching to an artificial sweetener won't solve the other fundamental problems that made you gain that much weight in the first place!

[@asyetundetermined]

@@charlesdean640 It’s not really anything like that at all. GTFOH if you’re actually afraid of a packet of Splenda. Get real dude. Let’s not let perfect be the enemy of good.

[@charlesdean640]

@@asyetundetermined did I say I don't consume sugar or Splenda? No I said he kicked one habit for another. Didn't say anything about myself.

[@CNS1908]

Found you on the Huberman podcast and so happy I did. I love the way you think and explain. Appreciate it.

[@coach_chonko]

Every time there is unsupervised work being done by subjects, it turns out that most subjects lie, make up data, forget to do it... In one study I set up, we asked patients if they lied/made-up data/forgot at the end of the data collection, pretending that it wouldn't matter if they did and behaving like bros. More than half did the measurements wrong and made up the data to cover their mistakes. That is huge.

[@dama301]

Maybe you're making this study up? 🤔

[@Francisco-Danconia]

I would believe that entirely. Humans are lazy

[@JKDLIFER]

100% correct. This study dropped the ball in a few very important areas unfortunately.

[@alankuo2317]

I feel like whenever I see the term gut micro biome, I think of how big and vast the ocean on planet earth is, and how little we know, in depth, about all the creatures that may exist in it

[@meredithbrooks2858]

As a person who never liked the taste of diet soda, eating or drinking anything with non nutritive sweetners was a shock to my system - I'm glad I watched this video and have a better understanding of what is happening - thanks Layne for making published research understandable

[@MindPumpShow]

Great breakdown layne

[@Mir-gw6kj]

As someone doing their PhD in microbiome research, I can say for sure that increases in SCFA-producing bacteria is almost always considered a plus. SCFAs, especially butyrate, are extremely beneficial when it comes to intestinal barrier integrity and reduced inflammatory tone.

[@ExsoLam]

I wish more folks would bring SCFAs up when fiber is discussed. I only have a BSc in microbiology and only took one course on host-associated microbiomes, but it made a lot stuff click into place. Fiber isn't calorically neutral, we can yield up to 2.5 cals per gram, because of the SCFAs. An important consideration when counting calories. And fiber being super good for you doesn't make much sense if you think of it as just controlling the consistency of stool. Makes people underappreciate the benefits of fiber (and fruits and vegetables generally). And with the gut being such a major immune hub and with the gut-brain axis being recognized as more and more important, seeing fiber as NOT just this passive bulk is super important imo.

[@maravillin]

Do artificial sweeteners increase SCFA producing bacteria?

[@Mir-gw6kj]

@@maravillin based on the video, it seems like they increase levels of SCFAs (butyrate, propionate, valerate) as well as the abundance of SCFA producing bacteria, although the metabolites were correlated with negative outcomes, which is odd. Other non- nutritives like sugar alcohols may also have some prebiotic effect, as does stevia

[@BigDees19]

​@@ExsoLam so your saying that all fiber on a gram bases does have calories at least 2.5 per gram soluble or not soluble ? Just wondering cus I always heard fiber doesn't get a ostef as energy so it's basically 0 calories or net calories

[@Ryan_DeWitt]

I have been taking in enough artificial sweetener to satisfy an elephant on a daily basis for 17 years now. I am lucky to be alive.

[@BestLifeMD]

Me too!

[@campfit505]

Lol

[@BOSSDONMAN]

Your brain must be turning to mush as we speak!

[@erics2860]

Bro you got cancer running thru your veins🤣

[@Counter-Intuitive]

It depends on what kinds of sugar substitutes

[@Editor_Steve]

18:55 most important part of this video. The study is legit. The interpretation by people with out this sort of critical thinking (aka the media) is what will be dangerous.

[@EvsPersonal]

Well said. Unfortunately, this is the case with MANY media vs. studies with nutrition

[@fl676]

👍🏻

[@SubZero-kb1ir]

Hey, it's Editor Steve. Hello Editor Steve. Fan of your work.

[@Gladiator1972]

The placibo effect reminds me of an experiment a college professor did with his class. One day he told them he was going to break the rules and let them drink beer in class. What the students didn't know was they were drinking non-alcoholic beer (O'Douls). After a little while of "drinking", the student's voices became louder and some started acting buzzed.

[@Counter-Intuitive]

The msm is just interested click bait. I remember when they were attacking Biden for pulling out of Afghanistan when in reality it was a positive thing.

[@midnightblack07]

Thank you so much for this video and for breaking down the facts in such a simple and unbiased way! I've seen so many fear-mongering videos regarding non-nutritive sweeteners in the last few days (especially following the WHO's recent recommendation), so this was incredibly refreshing.

[@Pinkorchid72]

I really love that you break down the science in a way that the average non-science person can understand. I appreciate your perspective and your opinion. Always entertaining and well informed. I feel like after watching your videos that I learn something new all the time. Thanks for all your hard work!

[@neilrasmussen2063]

Not sure if I missed some fact, but it seems like the most emphasis was on the participants potential bias against artificial sweeteners. However around 7:26 in it was stated aspartame didn't affect blood glucose like the sucralose and saccharin, which proves that is not the case.

[@janenuss6]

Thank you for the information and summarizing it in such a straightforward way!!! 🙏🏻

[@robertbaillie2948]

30 years using aspartame, 65 now. Feel great fit as I have ever been.

[@moa3821]

Weve had saccharin for 140 years now. My mom said it was popular in Nigeria in the 60-70s. We should have enough safety data at this point

[@funnygaming2672]

aspartame is the only sweetener that give me heart palpitation ...I prefer stevia and the other option anything but aspartame!

[@phil4986]

@@funnygaming2672 aspartame is poison. Mr.Baillie will find out soon enough but that is his choice.

[@mcfarvo]

A fair summary, critique, and conclusion

[@ibperson7765]

Note on DURATION: 1. If something statistically significantly affects you in two weeks, it does. 2. If not, that *could be* because it’s too short.

[@rredding]

Note on statistically significance: Once the sample size is very large, like over 5000-10000 participants, significance is without any value. It is only statistically significant, but this days nothing about the value of the outcome. 😮

[@anathardayaldar]

Especially for diabetics, sugar substs helps to reduce carbohydrates.

[@hossskul544]

0:17 as soon as you start talking about new studies, the first question that pops into my mind is, who funded the studies?

[@vladimirshterev1988]

Good one!...

[@320csan]

I wonder if the researchers tracked dietary intake outside of the addition of non-nutritive sweeteners. Maybe the groups that were assigned to non-nutritive sweeteners ate differently as a result of knowing they were eating something they identify as "bad", because like mentioned, it's hard to blind here. Just adding my thoughts! Either way, great to know there is finally a human study!

[@jimmymuthami7130]

This has always been my issue with all these studies. They will say meat is bad because a certain group was eating this amount of meat and another wasn't eating. They won't say what else those guys were eating.

[@Ozzy1984_]

​@jimmymuthami7130 in terms of meat and sugar, there have been plenty of studies where the participants are provided all of their food, which removes that risk. The data is pretty solid that meat and sugar are fine provided they dknt create a calorie surplus and you gain a lot of weight. It's pretty much as simple as calories in. Calories out.

[@maxsilbert]

Man, why didn't they include Ace K or erythritol in the study? So much more common in everyday food/drink products than something like sacharrin. The only time I see sacharrin is in toothpaste

[@Doormat00]

Would be interesting if you also mentioned who funded the studies.

[@0s0n3gr0]

Whenever I need clarity on these matters I turn to use @biolayne. You cut through the bullshit and simplify the complex in doses the layman can understand. You also show how the vaguely understood scientific method is actually applied IRL and give it depth and context. Thank you sir.

[@pablov1323]

This study also got my attention, Happy to hear your analysis!

[@arpadnagy1354]

3 months ago, i was still watching Dr Eric Berg videos.. Such a development that i got rid of that clown and now i can learn from a real expert. Thanks Layne for the lots of effort you put in your work!

[@BornToRun.]

Fascinating! Can’t give up my Dew Zero.

[@phil4986]

Of course you can't ....the soda company put a manmade poison in it to addict you to it. They get rich, it makes you sick, the pharma companies get rich ,you die. Everyone wins but you and the family watching you die.

[@steverino474]

When ever i start falling for woo...i rewatch Laynes videos.

[@avivbrina]

Hey Layne, it’s great to finally see someone address this study and you make some great points. There is one minor thing I think you misunderstood about the study: the participants were screened for 6 months of nonconsumption, not ever in their lives. From the study: “We excluded participants who consumed any quantity of NNS-containing foods or beverages in the six months prior to the trial initiation”. This makes the supposition that the participants had unusually negative opinions on NNS far less likely.

[@romac5362]

You rule bro. Big fan here all the way from New Zealand.. Often share and post your content.. especially the bro science, whatever zealot bullshit..

[@mightywind7595]

I use stevia daily and only have a little sugar once or twice a week. I use a teaspoon in my coffee and 1\4 teaspoon in my tea at bedtime. My mom is sure it will kill me because of some studies. I assured her that I would have to consume a bag or more of stevia a day to hurt me. It keeps me away from sugar and to me it’s a good trade off.

[@RogueCylon]

Have you tried monkfruit extract?😊

[@phil4986]

just stay away from aspartame and splenda/sucrolose. Both are man made chemical poisons in foods only because they are cheap and highly addictive.

[@SevenCostanza]

Look on the back. You're actually consuming 99% erythritol

[@edgewound]

even Stevia triggers an insulin response. The trigger is the sweetness on the tongue that triggers the brain to release insulin preparing for the metabolism of sugar. Not good for the pancreas or the liver. Quit added sweetness and let your brain adapt to not needing it. Coffee is better for you unsweetened.

[@ThomasAT86]

Always interesting to hear all the different things that can alter an outcome, influence a study etc!

[@JimGrass62]

My Doctor recommended you.... sure glad he did

[@mattepton5731]

Great video Layne ! Thank you 🙏 !

[@ObliviouslyLucid]

Well done- Thank you for the analysis.

[@robertkraychik1884]

thanks, layne. interesting breakdown of the strengths and potential weaknesses of the study.

[@sorkeror]

Life is turning out to be pretty dangerous, there are literally billions of things that can harm and kill you

[@DP-ye4xp]

Overweight people have more medical issues than thinner or in shape people. Point being that people who for years without a break live in a calorie surplus tend to have the majority of health problems across the board. Not to say there could be something wrong with sweeteners, Just saying being overweight is much worse for your health and more worry some than sweeteners in my opinion.

[@forthelulz8085]

I drink a diet soda for lunch 5 days a week and I can tell you, for me, it keeps me from giving into my sugar cravings. The cravings are simply dulled because my brain thinks it got the sugar already.

[@micacam2684]

We knew all this. Didn’t t need the study. Can you imagine if people waited around for studies to declare if something is poison or not?

[@03blaird]

Crazy right? People today will get shot in the head and say "I'm waiting for a study to tell me if excess lead to my skull is bad"

[@jofortin22]

Great explanation Dr. Norton!👏🙂

[@MrTEHSTUPID]

Randomly happened upon this video and was super impressed by your reasoning. I don’t usually go to KZbin for dietary info, but this was quality content.

[@Sardy540]

Awesome summary and analysis mate! Cheers from Australia!

[@croxmcjames8038]

Always great content from you! Thank you

[@86Dynamix]

This is another great video from Layne. However, I think that something important is not being addressed here. These test subjects started taking sweetener, but what did they replace with sweetener? If these people were comsuming lots of sugary beverages and such before the study and then started taking a sweetener instead, could that possibly mean that the lack/absence of sugar is that actual cause of the change in the gut microbiome and not the sweetener itself?

[@benjaminchapman3924]

perhaps they used the food history data that they got from the participants to determine if they used NNS before and accounted for it in the results? Dont know without reading the paper itself

[@soaringeagle5227]

Great video. Thanks Layne!

[@asiastormy8728]

I am wondering ultimately, with that study even if there is an rise in insulin or glucose, how much of an adverse effect it has on say someone with Diabetes 2? If the raise level is negligible compared to what sugar or carbs does, I am willing to keep using artificial sugar.

[@gamer4ever838]

Its safe. Why? Because products contain maybe 100 mg aspartame. MG. NOT GRAMS. its so little your body wont even notice

[@xMCxVSxARBITERx]

@@gamer4ever838 100mg can be a lot...or nothing, depends on how toxic it is really.

[@xMCxVSxARBITERx]

Diabetes 2 is mostly caused by carrying too much bodyfat... So no matter if there is a rise in insulin or not (short term), it is quite irrelevant, as the best way to combat D2 for most people is losing weight (calorie defecit, not sugar/insulin deficit lol). It can of course be different for those few who are diabetic without being overweight...

[@gamer4ever838]

@@xMCxVSxARBITERx thank you. You are one of the few people that understand CICO

[@xMCxVSxARBITERx]

@@gamer4ever838 Was that sarcasm or was you serious? 😊

[@danielangst7948]

As always very well done 💪🏼

[@zadinal]

I would like to point out that prior to five years ago I had never consumed artificial sweeteners. Not because I thought they were bad I just liked regular sugar and preferred to make most of my own foods so it is completely within a realm of possibility that the participants just didn't consume them for non ideological reasons. Sounds really interesting, I'm going to go check out the article.

[@potatowaffle5653]

You are in the 0.0001%

[@ZacksRockingLifestyle]

Never is a very strong word.

[@Dominasty]

I've been reading your work, Layne, since before you entered into your Ph.D. program. As always, enjoy your content. From your MD days to the KZbin days. Love it.

[@ColinDeWaay]

What a freaking phenomenal breakdown great job dude, killer info!

[@priscillabahaw5673]

Waw colon dewaay won a prize from Layne . How cool

[@ColinDeWaay]

@@priscillabahaw5673 😂🤦🏻‍♂️ dang spam bots

[@Finvarra]

Physique on point: opinion respected.

[@johnnyj5908]

12 years type 2 diabetic here. I stopped refined sugars immediately. I’ve used artificial sweeteners ever since. They have never elevated my blood sugar, and have never made me crave real sugar. I have had many real arguments with endocrinologists about this. Telling me I’m wrong because of studies. I’ve noticed that most of the studies are funded or done by the sugar companies. Or I’ve seen studies by equal against Splenda. Me personally have never read a non biased study. This one seams more legitimate than any I’ve seen. I’ve just went off what my blood glucose monitor says, and a1c. I even wrote down the time of day I would drink a diet my dew or no sugar coffee creamer, etc. And then I let an endocrinologist load my data to prove it, and they still argued with me. Tbh I’ve never met an endocrinologist that I’ve liked 😂

[@Francisco-Danconia]

From the sounds of it, after 12 years you're still type 2 diabetic? IF that's the case, besides weight loss what benefit have you seen from cutting all refined sugars?

[@standardtuning4guitars423]

Yes its nice to pick up whatever is convenient and if it tastes good we should be able to trust them.

[@Ali-kf5bd]

I used to have basically a diet soda addiction and I don't think drinking a 2 litre of soda in a day is a good idea even if it is low calorie BUT these days I will have a single serving of diet soda a couple of times a week and I'm pretty confident that it's not causing me any issues. I'm in pretty good physical health and while I'm still a tiny bit overweight I used to be bordering on obese and I've been able to keep off 30 pounds for 2 years while drinking diet soda here and there. Of course that's just anecdotal but for me at least it doesn't seem to be a problem,especially compared to all the sugary treats I used to overindulge on.

[@phil4986]

this young woman had a massive reaction to aspartame and lost nine pounds in four days when she got off it. kzbin.info/www/bejne/l3Kze4CDgqx2hbs

[@clinthansen469]

The same people who say that artificial sweeteners are bad also say that sugar, coffee, dairy, and non-alkaline water are bad for you. I'm just going to focus on maintaining a healthy body fat level long-term and keep enjoying my diet Pepsi. Also, I think sucralose tastes disgusting, so I avoid it for that reason 😂.

[@Sentinnel]

It does taste worse than sugar.. but when combined with Ace K it's okay.. now aspartame on the other hand.. eww

[@TheScyy]

@@Sentinnel Coke and Pepsi zero would like a word with you.

[@Laiika93]

whaaat I can't see the difference (not like stevia which definitly have a taste) it's funny how different we perceive things ^^

[@phil4986]

if you have legs swelling or need to take lasix, you may want to stop drinking your diet pepsi.

[@tyreecenewton3194]

Thank you for helping me understand, great channel !

[@allisonfalin8854]

Something I have learned wearing a CGM is that if you do not know precisely when to insert the cannula (can't do it when you are dropping sugar or it will be off by a good bit), calibration techniques etc, then the data from it is useless. It was an interesting study to read for sure, but I did wonder how they managed to do some of the data as you spoke to. I will continue with my occasional Coke Zero and motor on. Thanks for the interpretation.

[@williamhauser3686]

Even if artificial sweeteners do raise glucose levels, they raise them far less than normL sweeteners. Even if artificial sweeteners aren't the best for the microbiome, sugar is not good for it either. This study might very well be 100% accurate, but still, relative to regular sweeteners, artificial sweeteners are still a net positive.

[@ExsoLam]

The increase in SCFAs suggests to me that the non-nutritive sweeteners are being metabolized by gut microbes similarly to fiber.

[@batman-sr2px]

so is that bad for the microbes? What is the result of this?

[@ExsoLam]

@@batman-sr2px It's good for some microbes, the ones who can metabolize the non-nutritive sweeteners. Bad for ones that can't, and who need simple sugars. That would lead to the change in composition. The SCFAs they produce are just metabolic waste, like CO2 for us. It doesn't hurt or harm the microbes, but it SUPER helps us. SCFAs are incredibly good for the gut.

[@calloforestis3126]

Thank you layne👍, amazing video you make studies so easy to understand

[@no3rdseat]

I'm trying to quit my nightly wine habit and the only thing I feel blunts the cravings is Raspberry/Lemonaid Crystal Light. I have to think that Maltodextrin, Aspartame and ACE-K are, on balance, preferable to a bottle of wine a night. :(

[@DarthNoshitam]

Resveratrol though 😉

[@no3rdseat]

@@DarthNoshitam LOL! What a load of bullocks that resveratrol nonsense is!

[@shinpaws1014]

sounds like you shouldnt have wine in the house for a while..

[@no3rdseat]

@@shinpaws1014 It's true, everything I had in the house is swimming with the fishes. Going forward, the plan is to just not have alcohol in the house.

[@phil4986]

believe it or not, a small glass of wine a night is good for you. the best answer to your quantity is to add food to your drinking but also to change your wine. American wines can be really awful. I bought a bottle of California moscata sweet wine from Walmart that was clearly cut with water and tasted like it had aspartame in it. It was awful ....almost like a diet soda wine. But I had been drinking a italian wine from a Giant store that was clearly a real wine. Which I went right back too. I never drink wines in boxes...only bottles. Crystal Light is horrifically addictive and dangerous to your health. Ask this woman. kzbin.info/www/bejne/l3Kze4CDgqx2hbs Aspartame and splenda /sucrolose are poisons. stay away from both.

[@Nobody-fr3wz]

Love your content. Much love from London

[@asirbbrisa]

Power of placebo! Great call out! Thank you!

[@Antaios632]

I'm a type 1 diabetic, so I wear a cgm all the time and I have to be 100% conscious of the sugar/carbs I eat and the insulin I put in my body. I guarantee that if I drank sugary drinks, it would raise my blood sugar and I'd have to take more insulin. It just seems obvious when you have to manually/consciously compensate for what a pancreas usually handles silently. Type 1 diabetics talk about being "on the rollercoaster" in terms of blood sugar variability - trying to chase sugar with insulin & vice versa. If you're consuming lots of simple sugars, your body is doing the same thing, you're just not consciously aware of it. For me, it's a no-brainer to use NNS as a tool to make my life easier and avoid the cardiovascular damage big swings in blood sugar can contribute to. Granted, science often challenges or refutes "common sense," but NNS would need to have some pretty big risks and negative effects to make them undesirable - and the science seems to be saying that those risks and negative effects are pretty small and difficult to detect without the kinds of rigid controls that make the studies less naturalistic and applicable to everyday life. And yes, of course I have the option of just not eating or drinking anything sweet at all. Maybe that's ultimately the best option if you can stick to it, but I don't see any point in that level of restriction for such a small and dubious benefit.

[@civilapalyan6253]

I still don't like artificial sweeteners, because they are not supposed to be in/as food, and I keep staying on the cautious side. Though I admit, sugar is the worst.

[@kostas9094]

Interesting study, thanks for sharing. Typically the microbiome tends to return to normal within a month after moderate diet changes. Especially as NNSs are prebiotics I would expect a permanent shift in the microbiome to occur after at least 6 months considering consistent and high use. It would be more interesting to see longitudinal studies in people consuming NNSs. Perhaps they could stratify into low-medium-high users. Also I would be interested to see use of NNSs within people with gut related conditions such as IBS, IBD, etc. How does the microbiome change then and what are the implications. How could we reverse the microbiome to “normal”?

[@batman-sr2px]

what about supplementing with probiotics. If someone needs to live on diet coke or a medication that reduces microbiome for whatever reason, do probiotics actually help balance?

[@ethallial3217]

I am here from Greg Doucette super interesting video thanks. Subscribed directly 👍

[@stephanieilluzzi7355]

WOW. God bless you! I wish you were the head of the FDA. 👏👏👏👏

[@disinformationworld9378]

I would look into all health effects. Corporations also have funded studies so that their products are promoted in a favorable light. So one study is not enough.

[@Joseph1NJ]

"Saccharin and sucralose impair glucose tolerance in healthy adults." In just two weeks? Wow!

[@phil4986]

Aspartame is just as bad. This crap is poison.

[@thepeddle]

Even if there is an initial spike, anything in moderation will not harm anyone. People just over due it and then shit gets vilified. I have one or two cans of diet coke a day and I'm never giving that up.

[@Amyjwashere]

to me, artificial sweeteners are so much better than high fructose corn syrup. if you had to choose, pick an artificial sweetener that your gut can handle and go from there.

[@Francisco-Danconia]

Did you know that regular table sugar is 50% glucose and 50% fructose, while high fructose corn syrup is 45% glucose and 55% fructose? It's really not very different, but demonized much more

[@yesiamsharon]

Thanks for the review and explanation.

[@jeffogrady2065]

People are so concerned about silliness but we have people smoking their brains away and that's fine lol

[@punkandlifting]

All I’m going to say is zero calorie non nutritive sweeteners are a godsend

[@mikepetrilli4686]

Who paid for the study?

[@scottyg5403]

I've lost quite a bit of weight over the years and I give some credit to cutting out a lot of sugar. So even before I watch the video I thought to myself I will still continue to use some artificial sweeteners. But anyway another excellent video thanks!

[@perrygriffin2371]

Use honey

[@perrygriffin2371]

@@The_Real_Grand_Nagus also when it comes to cost why not spend more on nutrition i pay £2 for 300grams of blueberries or £1 for 9 kitkats 🤷🏼‍♂️

[@moa3821]

Everyone waiting for this. should have had sweetner users In a seperate group. Really weird that aspartame wouldn't cause a change

[@phil4986]

tells you who paid for the study.

[@AquarianMan]

notes : non nutritive studies - well powered - within regular intake ranges gut microflora changes with any change in diet glyceimic response - adjusts over time metabolites that were changed - we dont know enough to say its bad - some say bad - others say good b fragilis - some say decreases inflammation when i make recommendations - looking at consensus of the data - they are not metabolically inert - but we dont know if its a bad thing or good thing braodly its ogood for human outcomes - because they are just consuming less calories glyceimia - initial response - the body probably adjusts over time - that could explain the difference between short term and long term data power of placebo can be just as powerful as actual drugs - if you are biased against hard - then you will see it as negative and you will have negative outcomes in physiology - placebo if you have no cravings for sweet - avoid non nutritive sweeteners but if you have

[@melanie4926]

I've been carnivore for 5 months. I had 10 ounces of diet coke and thought I'd die. 3 hours after ingesting, I was doubled over in pain. A month later, I drank 8 ounces of a zero calorie drink. Same thing happened but lasted even longer. Never again!

[@HillbillyYEEHAA]

This will be like the sugar industry in years to come. We will find out that its as bad as sugar and big sweetener has covered it up. Sweeteners mess up my stomach due to ibs

[@03blaird]

All about money. Billion dollar industry doesn't want the profits to stop until the evidence is overwhelming. Might take another 5-10 years but it will happen

[@matthewgalvano7248]

I LOVE telling my weight loss clients that they can basically drink as much diet soda as they want. It's a great jumping off point for talking about smart diet strategies that are NOT about deprivation and self-punishment

[@chewher4171]

Very informative and insightful. Thanks man.

[@subotnai1]

it's not bad... it's a slight difference... although.. I would be curious to see what the effect would be at the nervous and immunological level. track the metabolite throughout the human system. We need to put this to rest.

[@seanthegod4585]

I already knew this about aspartame. I will keep my ripped abs and stick with the diet soda. 💪😎

[@andreslara95]

Facts!

[@scottmitchell1974]

Same.

[@peachcobbler641]

Greg doucette

[@seanthegod4585]

@@peachcobbler641 I'm taller and better looking than the parrot. 😎

[@promo130]

Lost 35 lbs in 12 weeks And drink alot of these sweeteners drinks all day long

[@juhamartikainen3050]

This was just the thing I was interested to know.

[@mrsloth_8820]

Haven’t watched yet. Just finished a Diet Dr Pepper. Am I gonna die???

[@twopintsofmilk]

Absolutely! Not sure how big the bottle was but I'd give you less than 100 years

[@secondthought2]

U just might

[@mrdee2454]

Are you vaccinated than yes

[@qT_p13]

Yes..... eventually

[@UbzUnclemax]

I wonder if he would be so soft on the researchers if they had done a weight loss study with controlling caloric and protein intake, but at the end of 2 weeks letting the participants measure the primary outcome 'bodyweight' at home ...

[@ashishtom]

Should I worry about sucralose in my whey protein isolate? I take 1 scoop a day

[@phil4986]

find one that uses stevia or monk fruit . Sucrolose/Splenda and aspartame are man made chemical poisons meant to addict you to the products they are in. Sucrolose/Splenda attacks the stomach and intestines. There is no human dose that is safe.

[@alexweigelhikes]

I haven't personally done it, but isn't oral glucose disgusting? If it's already drawn up in a syringe, then maybe it's a non-issue. But if it's poured in a cup, then I bet that not everyone is finishing all of it. Do you rinse, swish, and drink? Toss the residue? Lick the cup? I'm with Layne on this one: The task sounds simple, but I don't think it was consistent.

[@h.hickenanaduk8622]

The Placebo Effect may have some response in any study, but it's main role is to measure the standard of error vs. the control group. I hear too many people treating the PE as if it were some magical explanation when a large part of it is just how weak experiments explain or write off large, unexpected deviations.

[@helios4425]

Not buying the power of placebo. The power of placebo only affected glycemic response from sucralose and saccharin groups? How discriminating of placebo

[@scottymackay1801]

Basically if you're someone who consumes a lot of sugary drinks, you're better on artificial sweeteners. If you're someone who doesn't require sweetened drinks or foods, then don't start ingesting them. At best they're neutral on your body, or at worst they're bad for you.

[@batman-sr2px]

what is the bad though

[@Francisco-Danconia]

@@batman-sr2px logically anything that decreases your overall health, lifespan, or quality of life.

[@HerrFinsternis]

I don't think many willing participants who avoid this on a daily basis will be thát concerned over a 2 week trial period. Maybe some, and that might actually have an effect across all groups, but it's often the longterm effects that worry em. If they were as thorough with their screening as you said, they probably took this into consideration. Lot's of probabalies, but that's what happens when you argue like this. Having said I like the "we don't know enough about X" approach you took today. What I don't understand why they didn't have a third control group with people who have been consuming artificial sweeteners and did so during the trials as well. It's not like they had a lack thereof and it's much more representative to how we live. It could have accounted for many of your questions.