Bizarre Newly Found Structures Inside Our Cells Hint at Origins of Life

[@sdw2911]

My grandfather recently passed away from Parkinson’s with lewy, very cool to hear there’s some good work being done that could lead to understanding this better. it’s a truly terrible disease.

[@TheThreatenedSwan]

Medicine is one of those areas where we should be making much greater strides in, but with risk models especially, it's completely plagued by pc nonsense

[@coweatsman]

@@TheThreatenedSwan It's getting harder to make great strides. More PhDs and more money return a diminishing of benefit contrary to all the media hype. Hype aimed at raising funds from greedy gullible venture capitalist or as marketing for old drugs rejigged into new patents and hyped as "breakthroughs".

[@chuckster255]

I admire your ability to distill down technological jargon into information the average non-technical person can understand. Thank you Anton.

[@GD-lv8cc]

A modern-era Carl Sagan!

[@yvonnemiezis5199]

I really agree👍

[@nycbearff]

I'm 73, so I have some perspective on the advances in biology (and the other sciences) in the last few decades. What we know today is mind blowingly different from what we knew when I was young - and what we will know in another 30 or 40 years will make what we know today look extremely primitive. We think we know a lot now - and yes, we do - but it is still just a very small part of all there is to know. Yes, this is fascinating. And there's more to learn about cells and their interactions than we can currently imagine. Whenever you hear someone say "this is how cells work" or "this is how the brain works" - laugh at their hubris, value your own not knowing about these things, and cultivate patience for the results of future research. "We don't know much about that yet" is the most productive attitude you can have about most scientific topics you encounter. People who can't handle not knowing are not suited to any kind of work in teaching or scientific fields.

[@SirCharles12357]

Mind blown again! A new kind of membraneless organelle, which condensates when needed via RNA instruction!!!! Just wow!!

[@nightknght]

just like me ex girlfirend

[@bjdefilippo447]

Wow! This is huge! The promise from this research is impressive. I'd love to know how these organelles function differently depending on the nature and extent of the stress they experience. I almost wish I wasn't retired, but at least now I have time to read the literature. 😊

[@gastgeschenk]

I really love how this connects all of us.

[@daveknight8410]

Merry Christmas all. Don't forget to like Anton's video 😊

[@stevenkarnisky411]

I often "like" Anton's video before I even watch it!

[@markharwood7573]

This looks like a serious leap forward. RNA does stuff that apparently nobody expected. You still have to suspect that there is a whole long way to go before we understand cells.

[@adambarlev8992]

Ok I first heard about stress granules in a talk about influenza infection and how cells decide to either give up and apoptosis or stress granule their mRNA and survive. Also the same time I learned about 'cap snatching'. Look it up... You'll feel violated for sure. Ef you influenza, don't be stealing my caps!

[@justinpyle3415]

A long way indeed.

[@stefanblue660]

AI is massively overrated in this point.

[@TheThreatenedSwan]

​@@stefanblue660 wat. Not at all. Just like AI models are important for accurately distinguishing between different brains, it's very useful when it comes to rna and proteina

[@williammentink]

Perhaps RNA is the core to all enzymes.

[@RobertBrown-i4r]

Thanks again Anton for proving why the sciences matter -- happy holidays to you and your family

[@joetaylor486]

Wow, absolutely fascinating. This feels like a significant leap forward in molecular biology.

[@windfoil1000]

Wow, thanks for wading through all of that, Anton. Super interesting and a bit complicated but you did a great job of it.

[@thachnguyen861]

I loving the way he pronounces 'Hypothesis' I love it!

[@redhedkev1]

Anton, how do you keep on top of all of this stuff? Another great video. Thank you.

[@Alondro77]

Cells are so vastly more complex than anyone even guessed 40 years ago, when I started learning about them!

[@andrerodon3921]

Absolutely fabulous! Our understanding of cell biology has grown incredibly since I was in school studying biochemistry.

[@global_nomad.]

everytime we think we have understood something complex, we discover our idea of complexity was niave, and another scale of complexity lies within

[@mt-mg7tt]

Fascinating video . Merry Xmas, Happy Solstice etc, Anton et al.

[@CucuExploziv]

Thank you for your awesome work!

[@Devo491]

Thanks for another mind-blowing post, Anton! Biology is immensely complex, thanks to billions of years of experimenting, and Science has plenty to work on.

[@anitapeura3517]

Thanks so much for all your work Anton, keeping us well-informed and engaged with science, and showing that science is not the static monolith so many assume it is. You show it at its best! Happy holiday season to you and your family!

[@greggwilliamson]

I had no real concept of how many different living things have made a home in every single cell in my body. I almost feel violated. Alien abduction? Why? just move in here with everybody else.

[@coweatsman]

We are host to everything which give us the illusion of existing.

[@thachnguyen861]

Hello Wonderful People!

[@wayneharrison]

🖖👽

[@stevedrane2364]

Wow . . This is incredible work, thank you for updating us. .

[@forlottelse2]

I love watching your videos. The further you break it down the more complex biochemistry becomes. You’re lending great credibility to the idea of intelligent design. Thank you Anton. Ты просто являешься чудесным человеком! человек

[@pikesplitman]

Very interesting. The condensation process has been known for a while in the physics community. I did related experiments in the 90's at Cambridge. Currently developing new methods for isolating spectral signals from sections of biopolymers for disease diagnosis. This will inspire new research. Thanks for the heads up.

[@BastilsBlather818]

Evolution starts as a condensate cool, great video 🙂

[@jimcurtis9052]

Wonderful as always Anton. Thank you. 🙂

[@leonardgibney2997]

More great info from wonderful person Anton.

[@FuManchu5ltr]

Anton’s Midi-chlorian count is off the chart.

[@jamesleatherwood5125]

He did it! He did it! He said mitochondria without that dadgum other phrase! Woot! Go Anton, Go Anton, Go Anton, Go! Yay! Pioneer the way!

[@jambec144]

What was he saying before?

[@davisje011]

The more of these you have, the stronger in the force you are.

[@woreno]

Another great video

[@SophiaColon-m4j]

Your videos are always so funny and witty! Thank you for your generosity of heart and colorful, hilarious content!🐴🔴🥪

[@john-or9cf]

I’m a very old physicist - the neutrino was the new kid on the block when I was in college - and now that I’m old and a new great-grandfather, I have time to muse: how the hell did we actually get here? Not from the primordial soup but from two cells from two people getting together, multiply in the proper way where one set of newly created cells decides to become a liver, another set becomes a brain, etc, etc. all in the right places and in the right quantity properly interconnected, etc…yeah, I know DNA, genes, but what is the magic that happens under the hood?

[@blakeloh]

That would be God.

[@re11ik96]

​@@blakelohdoes god also makes poo when you go to the loo?

[@peppermintgal4302]

I think that at some point, the loss of rigid cell walls in eukaryotes allowed them to develop strategies where they could fuse to combine genomes. As for the magic that causes the development of the body, there's an emerging field of bioelectricity that studies some of the behavior that structures organs. A lot of the machinery involved is repurposed from cellular sensory apparatuses, mostly the ones that detect ions and electrical activity, that cells would use to figure out where to go when they were single cellular, (to avoid predators, to find food, etc..) I'd also look at the evolution of sea sponges and tunicates.

[@technokicksyourass]

Concentration gradients of signal molecules. It's easier to understand if you take a look at the first couple of generations of cells during embryo development. But essentially the idea is.. the embryo divides into a ball of cells, then chemical signals emitted from one pole of embryo form a concentration gradient, and genes are activated/suppressed conditional on the concentration amount. This triggers cell differentiation + the emission of new chemical signals and sets up new concentration gradients, which leads to more gene activation/suppression.. and so on. It's basically a computer algorithm, but running on biological/chemical substrate.

[@stargazer5784]

There are probably biologists that have similar quandaries about how it is that physicists are able to construct a device, that uses only a few pounds of fissile material, to create an explosion that flattens an entire city. However, I don't know of any biologists that view their function as being something magical.

[@Anthro006]

Damn good reporting! Thank you! I'm wondering if you might be able to connect and explain how this might relate to and support cytoskeletal formation, intrinsic microtubule build and reduce. Seems like seriously close to an explosion of understanding!!!

[@eccoweaver]

At 3:12 when you first mention Intrinsically Disordered Proteins, the visual shown features a molecular truncated icosahedron (like a wireframe model of a soccer ball/football). I find these and related geometrical forms very fascinating and fun to model. What is that shape or form or figure referred to as in a biomolecular setting? Or does it represent a number of possible things, perhaps depending on individual chemistry? Does it/do they have a particular function or set of functions? The same shape appears in another visual at 10:45 Also at ~10:15, the revelation that functional solids can be formed without membranes or other protective elements is a bit mind blowing. Very cool!

[@robertfindley921]

Keep going biologists, geneticists and scientists! Everything you learn through hypothesis, experimentation and peer review is gold. Don't waste your time debating with theologians.

[@sinecure45]

Hello Anton, I mentioned in a comment to another video that I helped organize a conference at the Strathcona back in 1999, together with Dr. Vali, Eddie Chan and Gitta Jensen. One of the people Gitta and I wanted to speak at the conference was a very old biologist named Bernard Grad, who had written his doctoral thesis on the roof of the Strathcona in around 1950. His thesis is that organized life requires a protected environmnent and that such an environment, a membrane, could form under certain chemical conditions. Dr. Grad was too old to attend the event, but one person who was not quite too old was Lida Mattman of Wayne State university. SHe wrote the book on Cell Wall Deficient Forms, taking a somewhat different approach. The conference was titled Pleomorphic Organisms in Health and Disease.

[@thirdeye147]

I have had Huntington's disease for a few years now. Of course my my mother had it. Both me and my older brother have ity sister doesn't have.

[@paulokoeberle6226]

Hey Anton, YOU DID IT !!! You found the beginning!

[@Sesso20]

Its mindblowing how complex single cells can be and even more that all the organelles themselves are as complex as the whole thing. When you said, structure becomes function it made me think quite hard, because we can see this principle in many other places too. Its very fascinating how RNA can protect itself via forming these clusters - I eventually read the paper although I am not a molecular biology major - but this is astonishing - I wonder what the chemo-physical parameters are that make RNA transform itself.

[@stevenkarnisky411]

As we zero in on how life began are we going to start finding instances of life beginning? The right conditions must occur more than once on this planet. Even if new life cannot compete with what is already here and gets rapidly eliminated, the evidence seems to point to multiple recurrences. Thank you Anton!

[@AnnaScotts]

I admire your professionalism and ability to make quality videos. Thank you for your hard work!🍂🔷🍌

[@megret1808]

It never ceases to amaze that after five hundred years of scientific inquiry, we are still discovering things like micro tubes and organelles

[@annemaria5126]

So another super-interesting topic for new students of all sorts to dive in.

[@suecollins357]

Thanks again ❤

[@GadZookz]

The fact of the matter is if I was an organelle I’d insist on my own membrane. Make no bones about it. If you are under stress you don’t want toned up as a condensate. 9:21 No way!

[@dbabdbbbghbb]

Hey I caught this one early today. Love the content. Been watching for years, if I miss a day I always catch back up. You’re legitimately the most dedicated creator on the platform.

[@SpectralDarko]

Quantum-Inspired Fungal Adaptomics (QIFA) explores whether fungi can exhibit behaviors similar to cognitive processes, using quantum-inspired models and stochastic processes. By studying fungal networks, chemical communication, and adaptive behavior, we can model their growth patterns and decision-making processes through dynamic network models and reinforcement learning. This research uses analogies to quantum mechanics-like superposition and entanglement-to describe fungal adaptation, though these are metaphorical, not literal. The goal is to enhance our understanding of complex biological behaviors and potentially inspire new AI models. The interdisciplinary approach also includes collaborations with mycologists, mathematicians, and physicists for empirical and repeatable experiments.

[@georgehilario3544]

Stop trying to convicence yourself that shroom addiction is enlightening 😂😂

[@georgehilario3544]

@@SpectralDarko oh right, you speak woke 4th dimension 😂

[@skizzlezz359]

So what I'm hearing Anton, is that we started out life as a completely different life-form, and slowly transformed and even took over another life-form to become us.

[@Roust7]

If if RNA was precursor of life on earth, there must be a cell that uses RNA as source of genetic information, but so far only some viruses do that. Viruses could not be a precursor of cells because they use cell as a mean for their replication.

[@C_In_Outlaw3817]

There could be a type of RNA-based cell out there we haven’t discovered yet. But the fact of the matter is DNA is a much more stable compound than rna and it’s thought that in the primordial environment of early earth dna life forms that used rna and proteins for complex reactions outcompeted earlier ‘models’ so to speak. Therefore, it’s reasonable to suspect that rna life forms no longer exist since dna life is so much better at thriving. Viruses , yes, are a bit more complicated. We don’t know how they quite fit into the narrative, but there are theories out there. But as far as _cells_ go you can almost think of things from a Darwinian standpoint. But rna world at the end of the day is just a theory. It might be dead wrong lol

[@tohellorbarbados4902]

"Condensate" is not a verb, it's a noun. The verb is "condense". Things condense; water condenses on a window to form condensation, which is a condensate.

[@jengathoughts]

I remember looking at this under a microscope, most fun I had in biology.

[@markmcphee6996]

Small correction: the phase transition is more accurately described as starting from a solvated phase (not liquid) en route to the condensate.

[@nickwilson589]

Perhaps the reaction to stress is a means not to over adapt. Like if you sink your ship and end up swimming for several hrs your cells won't over react by trying to make for some kind of adaptation to prolonged periods in the water?

[@josdelijster4505]

Thank you Anton very very interesting

[@aleksanderpopov5060]

Nice and interesting quick video, большое спасибо тебе бро!

[@janibeg3247]

reminds me of my molecular biology clases. Except back the, a lot of this stuff was Black Box

[@SapienSpace]

Interesting, I think Yoshinori Ohsumi won a Nobel Prize for something similar, when cells are stressed something (lysosomes?) are activated that sacrifice the weaker cells and turns them into food. It is called autophagy.

[@montyskeetch4082]

RNA World!

[@Atok595]

TNA is better 🤫

[@oneeyejack2]

I think it may be a new type of catalyzing : maybe they use crystal structure to force or facilitate certain reactions or molecules configurations... like using the forces involved in a state transition of some molecules to manipulate other molecules trapped inside the crystal... in that case, these formations would only be transitory... like 3D molds forming around molecules to get a configuration or reaction and then the mold dissipate to liberate the results. This is so fascinating ! I also think we should give up this idea of "evolution innovation" when we look at how things are done inside the cell, or at least not confuse our understanding of what "can happen" with the tree of life... everything that RNA can do, as molecules, would probably appear randomly very early in life.. in other words, if this type of reaction or organization mechanism is possible, it always was. Life can invent "new molecules" but laws of chemistry don't evolve.

[@MakerGrigio]

Hello Anton, Long time fan here. Can you please turn on auto generated audio translation? (audio track) I have family in Chile that I would like to send your videos to, and having your voice automatically translated to Spanish would _really_ help them. THANK YOU! Stay wonderful!

[@MCsCreations]

Sweet. When anyone discovers why I'm here... Let me know. 😊 (I mean the existence, not Anton's video.)

[@Briggsby]

Random chance as an emergent property of the universe. You have no meaning, no purpose, no goal beyond what you set for yourself. There's no grand design beyond what we choose, and your choices will ripple throughout time regardless of how small. Your purpose is self-designed, and self-assigned. Choose wisely.

[@MCsCreations]

@Briggsby I couldn't have said better myself. Well done! 😊 (But you realize it was a joke, right? 😬)

[@JeroenvanGutsem-u7e]

Have ocean black smoker vents been sampled for abiotic RNA production ? The smoking vents them selves allow temperature gradient driven chemical reactions and as the growth in height and thickness or branch out different heat and pressure parametres create a very dynamical dear i say evolutionary chemical lab with a lot of test tubes and several million years to cook up something interestin like RNA.

[@JeroenvanGutsem-u7e]

I would like to see black smokers deeply simulated on our modern supercomputers to see what substances they cook in a ten thousand years computed in 20 minutes. Discover feedbackloops etc.

[@frinoffrobis]

nice try, but life started out in space.. its a lot more time

[@C_In_Outlaw3817]

@@frinoffrobis I think the building blocks of life were out there for sure, but I think cells arose on earth tbh

[@roymarsh8077]

This feels like one of Anton's more important posts. Which is already saying something.

[@stopbeingsoweirdstill]

Thank you again for this information. There is so much we don’t know about our own genetics.

[@davidharvey3743]

As we get smarter,we get new questions!

[@mohsin10047]

Thanks!

[@1943vermork]

Wondering if Prions “mad cow disease” are also in the same category of those

[@wmontg7871]

My thoughts exactly

[@C_In_Outlaw3817]

In the same category as these organelle condensates? Not quite. Prions are misfolded proteins that build up in cell structures . They’re countless and aren’t broken down via ubiquitin easily either. They end up building up in neurons and causing diseases like cruetzfeld-Jakob

[@alejandrotroche6381]

Thanks for inspiring and setting the example in hardworking content creation while keeping your humble and wise throughout your journey. And wow you're English is better everyday

[@smizmar8]

This reminds me of how the tardigrade survival mechanism works.

[@paulbork7647]

Thanks. Have a great Christmas.

[@nickwilson589]

Am I the only one who thinks the 3d examples of cells look like a prototype to a theme park?

[@januszlepionko]

So that discovery means that cells are more complex than people thought before.

[@Shivaho]

Everything is Energy & Information ... the Universe Talking to Itself

[@AbbeyRoad69147]

I told my mom the same story about the mess in my bedroom when I was a kid. She didn't buy it.

[@captindo]

Parasite Eve, great game. The second one though, not so much.

[@l3ll5l]

As usual I recommend the book evolution and design logic and evidence by ammar adil it is with academic references and the author made an excellent job. After reading most people would want to share it like I do its only 170 or so pages

[@neilaxe4388]

I can't help but think that I would get a lot more from these talks if I had a little more scientific knowledge and a little less red wine

[@code4chaosmobile]

air bags in the cell!! neat

[@haraldhasyou6214]

Cheers Anton. Wondering how they can justify RNA vaccines without knowing how these chains develop?

[@halverde6373]

Scary thought is the known universe reflects this. We may be in the process of becoming. Chicken and egg analogy. Microcosm / Macrocosm ?

[@bigstickpilot]

If I were entering grad school today I’d choose this field to work in

[@sentientflower7891]

Where did the RNA get sourced? Beginning life with RNA is sort of like the Wright Brothers beginning flight with a jet.

[@philliplamoureux9489]

Super!!

[@Captain.AmericaV1]

*There's a guy with three channels, Roanoke gaming and another 2, he has a degree in biology and thinks a collaboration with you both on some subjects would be great. You both have a lot of knowledge in your respective fields, and many times both subjects cross paths.*

[@TheMaistro2012]

interesting topic Anton, when you see how complex this is, I think it could only evolve like this if it took place in a protected environment for hundreds of millions of years and then I think of hydrothermal springs on the ocean floor, perhaps an idea of ​​how life there now resembles ours. cells I think that's where it started

[@frinoffrobis]

what is not religious name for intelligent design.. it baffles my mind

[@n3cr0ph4g1st]

man your channel is so fuckin good

[@5nowChain5]

This topic is involved in the immune response causing ME/CFS.

[@johningham1880]

Why surround yourself in a membrane when you can surround yourself in… mysteries?

[@kaarlimakela3413]

My 🧠 my🧠!

[@Geosynchronus]

Will have to get my ai assistant to figure it out in a couple of years

[@tinytim71301]

Condensates. Always the condensates.

[@NancyRode-u9i]

anton everyday

[@AndreaValentine-w4o]

We have to open our minds. If we don’t understand something it must be useless???

[@stephenbrickwood1602]

Emergent properties from molecules that can join when the environment brings them together. And join in only a particular way. The joining of protons and neutrons, and then electrons from which atoms emerge and then molecules emerge with relative properties. The joining of oxygen and hydrogen, H2O. And then the joining of many H2O molecules so wet water properties emerge. Gravity emerges from many interactions of the many. The computational theory. Thinking emerges from the coordinated self-assembly of many complex molecules. Our thinking emerges from our life experiences. Our thinking is limited by our life experiences.

[@andycordy5190]

Huge!

[@henrythegreatamerican8136]

These biology vids are more interesting than the physics vids.

[@weegiewarbler]

Are these "Lewy Bodies" as in the dementia (á la Robin Williams)?