Blood Test: Immunoglobulin E (IgE) - what does a high immunoglobulin e level mean

Allergic diseases are amongst the most prevalent diseases worldwide.
Food, skin, and respiratory allergies are the most common atopic disorders in children. For the past few decades, the prevalence of allergy has increased significantly in Western countries.
Currently, testing for immunoglobulin E (I G E) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions.
Five immunoglobulin isotopes exist, and immunoglobulin E plays major role in allergy and allergic diseases like: Asthma, atopic dermatitis and allergic rhinitis. I G E also contributes significantly to the body's immune response to parasitic infections, which are more prevalent in third-world countries.
A fraction of I G E antibodies is found in the plasma.
If I G E Level is high in the blood we can suspect on several important diseases:
Allergic rhinitis Involvement of the upper airway can cause many patients to suffer from mild seasonal allergies or allergic rhinitis.
Due to repeated inhalation exposure to pollen and other outdoor antI G Ens, type one hypersensitivity occurs, and mast cell degranulation causes epiphora, rhinorrhea, cough, and other symptoms.
Asthma,
Additionally, the involvement of the lower airway in patients with atopic asthma experience immune response to aeroallergens resulting in airway smooth muscle constriction, increased mucus production, and inflammation that manifests as obstructive lung disease.
Atopic dermatitis.
also known as eczema, is an inflammatory skin disorder, which presents with dry and pruritic lesions on the flexure surfaces of extremities as well as head and neck areas.
There are several hypotheses why allergicv diseases increased last several decades.
This hypothesis commonly are controversial and not definitive. For example. According to one hypothesis lack of antioxidants can cause allergic diseases, according to another, excess of antioxidants can cause allergic diseases.
Other hypothesis include hygiene theory, which means the more hygienic environment is the higher chance that the kid will have allergic diseases.
Another hypothesis: intaking of vitamin d in childhood can cause allergic diseases.
Anaphylaxis is a potentially fatal systemic hypersensitivity reaction. Anaphylaxis carried out by an immunologic mechanism is referred to as allergic anaphylaxis. In allergic anaphylaxis, Fc epsilon RI binds I G E and activates mast cells and basophils.
Food allergy.
Food allergy is most commonly triggered by the I G E-mediated hypersensitivity reaction and presents with local or systemic symptoms that begin minutes or hours after the ingestion of the offending food. The proposed pathogenesis involves I G E production against normal food constituents, such as glycoproteins. I G E binds Fc epsilon RI and triggers the downstream signaling cascade, which leads to the production of increased levels of inflammatory mediators. These mediators, in turn, cause an inflammatory response and lead to symptoms involving the skin, gastrointestinal and respiratory tracts, eyes, and the heart, ranging from a mild to severe fatal anaphylactic response.
1) The total I G E assay which is nonspecific and provides only gross information.
The amount of total I G E was considered in the early studies as the simplest way to identify allergic subjects, but it became evident soon that total I G E levels could not be considered a reliable marker of allergy status.
I G E levels significantly higher than the normal threshold, are usually associated with atopic disorders, but also with other conditions.
On the contrary, low or normal values do not exclude the presence of I G E-mediated diseases. As a consequence, total levels of I G E should be carefully interpreted and not considered as an indication for the presence of allergic diseases.
Serum I G E concentration is largely age-dependent. Very low levels it increases with age up to teen ages. After this it starts slowly decreasing. Total serum I G E then declines from the 2nd through the 8th decades of life.
Very high I G E levels are observed in parasitic infestations.
Rarely in multiple myeloma patients producing I G E, and in some primary immunodeficiencies (e.g., Immune dysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX), Omenn syndrome, Wiskott-Aldrich syndrome, Comel-Netherton syndrome, hyper-I G E syndrome and atypical complete Di George syndrome).
Allergic broncho-pulmonary aspergillosis is the only clinical condition described to date, where the presence of high levels of I G E is strictly related to disease severity.
Increased serum I G E levels can be seen also in a proportion of smokers.
By Department of Pathology, Calicut Medical College - Calicut Medical College, CC BY-SA 4.0, commons.wikime...
By BruceBlaus - Own work, CC BY-SA 4.0, commons.wikime...

[@marifeatienza7604]

I have asthma, allergic rhinitis, and skin asthma but the test turned out 100.6 which is within normal range. Now I don't know if that test is really accurate. Recently I have been suffering from frequent allergic rhinitis and need nasal spray everyday.

[@genrod-gal7265]

My 13 year old is 2056. How can I help him 😢😢😢

[@cb6440]

30 year old male. 1075 is that serious or normal medication and back to normal not much to worry abt.?

[@Life-hg2zt]

Did you get the answer to your question?

[@safiyasiddiqui4133]

Galy m bhi drd hota h kya

[@melissak4661]

Idk if it's true but i read somewhere that allergic rhinitis can cause thyroid issues because of high IgE. It would help a lot if someone confirms this.

[@batenali195]

My immunoglobulin E (IgE) is 3285 what to do please suggest

[@ebymathew7995]

My ige is 1724 .and i have ibs .is it ige is a couse for ibs or vice versa pls reply doctor

[@ByTurkoglu]

hello Is low ige an immune deficiency? I've had pneumonia 4 times, can this be the reason?

[@Dr.Constantine]

Yes it can be correleted with immunodeficiency state but u cant base only ige. Other parameters are much more important. Such as neutrophils.

[@ByTurkoglu]

@@Dr.Constantine Thank you very much for the answer. My IGE value is 1.30 IU/ML when I give a blood test. I have an infection very often. My other immune values seem normal. My lym value is low in general.

[@sabirulislam5591]

How can i reduce high ige level? My ige level is 905.6 ul/ml

[@omgbygollywow]

@@sabirulislam5591 There are drugs that can reduce it. Olair is one, I believe.

[@vanjacalantropo]

Is ige total of 13 considered low?

[@sibongilepelnasithole5821]

My IgE is 336...i am always coughing, had pneumonia during covid delta. I always have tonsilis and flu. How can I manage my condition😊

[@m1000-n8w]

Mine is 460, just dont be a pussy. I am a God of this earth

[@subhashinit550]

Same

[@VikramBajiya-rh2ff]

Same

[@tanvirizaz8665]

My IgE is nearly 400... I get Asthmatic symptoms when I take some specific medication and Normally get Chest pains...

[@lindaelzu4466]

I have the same condition

[@IndiaDigitalNomad]

My IGE value is 2400. I have to take anti histamine daily as im allergic to dust

[@Wipez]

I'm 500, how's your rship with food? I can't eat very much fruit at all. And have trouble with beans and legumes

[@IndiaDigitalNomad]

@@Wipez I’m fine with food, no issues in eating. I did a blood test for allergy where I found I have allergy to only dust and micro mites which are found in mattress or clothes. I don’t have allergy to food as per blood reports. And I take ebastine dc once every 2 day.

[@aCARATwhoisSTAYingatMOAsENGENE]

Mine is 2500+ but idk what are the things I'm allergic to🙂 how do u find what u r allergic to?

[@IndiaDigitalNomad]

@@aCARATwhoisSTAYingatMOAsENGENE allergy blood test

[@aCARATwhoisSTAYingatMOAsENGENE]

@@IndiaDigitalNomad oh ok

[@sg-km6hp]

My IGE level is 54. But i have allergic rhinitis

[@MonroeMarcus-n3p]

William Keys

[@kirubai5585]

My IgE is 91 it's normal?

[@GustavoPizano-n9z]

Jacobson Court

[@randy3223]

I have 1687 ige wat should I do now

[@khanumer2709]

Meet dr Neel mehta

[@KarthicSelvam]

My ige 274 problem in breathing

[@tanvirizaz8665]

My IgE is nearly 400... I get Asthmatic symptoms when I take some specific medication and Normally get Chest pains...

[@NickMonroe-u7f]

Ken Crest

[@RodneyGutierrez-z4z]

Alex Branch

[@ayamore8885]

What is a treatment path for someone whose IGE is bit over 2800?

[@SecondWindStories]

Wow, is that even possible? That's 28x the normal level of 100.

[@malavika898]

My sister had ige level 1964.00 How to control?

[@GOWRISAILESHKOTIPALLI]

Same here what to do

[@ismail56657]

Hello my ige level is 3500..What can I do to reduce this?? Please help me..I'm suffering from skin problems for this...Please help me..Please help me..Please help me..Please help me plz plz plz

[@tvarun]

How to contact with you about this?

[@ismail56657]

@@tvarun Kindly write here what can I do...

[@abhilashnair4343]

How is ur condition now

[@ismail56657]

@@tvarun Which contact app do you want to contact with me? I've all social media apps..I can give you any social id name...Plz help me

[@MuhammadSalman-gb4wi]

If ige leavel is 33 . Confirm copd

[@IncognoCop]

How are you right now? Is everything alright? I have high ige too feeling cough every time, and lot of mucus sometimes hard to breathe while coughing..... How are you right now?

[@thilakparamasivan8409]

is IgE level of 33 high or low ? 0 to 140 is considered normal know?

[@montusachdeva7728]

My ige is 4200 and i have atopic dermatitis

[@truthdream9384]

Hello ab normal h?

[@montusachdeva7728]

Ya

[@RichardHunsaker-i3r]

Bonita Valley

[@addieaddie9792]

What can make this high or low?

[@BlackTrista-y9c]

Gilberto Meadows

[@PinkFlowers365]

ty

[@LorraineRogers-d1c]

Jakubowski Flats

[@DonaldYoung-z8v]

Theo Springs

[@KraigLarive-g6o]

Roosevelt Track

[@mhakash420]

My immunoglobulin igE is 1462

[@FrederickVogt-k7r]

Homenick Road

[@CynthiaHarris-i6w]

Domenick Trace

[@mohammaddhahidhahi4533]

My ige 904 😢

[@BrightHedy-z1o]

Maria Prairie

[@MariaLeila-m8l]

Christiansen Drives

[@BeulahWagner-u2n]

Beatty Ford

[@RobinsonDerrick-u7p]

Hank Streets

[@MichelleChamberlain-e8k]

Hartmann Well

[@RuthEsquivel-h3j]

Krystel Square

[@DorotheaBrian-m4g]

Buford Circles

[@LisaTomberlin-l6b]

Murazik Highway

[@JamesGrubb-u9g]

Lenna Expressway

[@TheKellie890]

My ige is 700 😢

[@CharleyLarry-p5l]

Howe Underpass

[@BrandonKammler-u5f]

Aylin Mall

[@EdithSophia-z4h]

Ernie Mission

[@hariharany9195]

Level is 1816

[@nurfarjana4021]

My ige 1482.2

[@JenniferPena-p8r]

Carroll Heights

[@SamsonHayden-q5m]

Alexandria Drive

[@BlumeBaird-d3h]

Griffin Divide

[@MaloryLeona]

345 Kirlin Village

[@HughSummers-m6d]

Gibson Village

[@RuebenStroebel-r5g]

Luettgen Brooks

[@gordonblare9719]

Gislason Mill

[@WashingtonONeil-z7l]

Sawayn Fork

[@DanielHayden-z7h]

VonRueden Turnpike

[@ZimmermanBoyd-d1l]

Schaefer Mount

[@ManualWhipple-b3r]

Zboncak Stravenue

[@ChrisJacobs-w4j]

Walter Squares

[@RuthLynn-o9j]

30031 Jameson Ports

[@kittylifyyy]

I m 18 yrs old and have 135ige

[@mohakobrachannel2594]

My IgE:6920😢😢😢

[@buchiiig376]

My ige result is 320

[@BlakeLaris-m7p]

Bradtke Club

[@DaltonWade-g6q]

Emard Path

[@CordellShuey-t9t]

Harber Dam

[@CharlesOphelia]

223 Toy Gateway

[@Eternal_Recurrence]

More than 2500😢

[@ummardahiru8115]

Hoeger Lake

[@JonasThill-p6t]

Pollich Corner

[@NatashaNizxcce-ic4qg]

Fahey Track

[@RoseNorma-q5r]

Kuhn Mountains

[@RAYWIPE]

My IgE Value is -> 2791.5 😂

[@aminul_9931]

My 1500

[@StevenVidro-x1e]

Zboncak Via

[@BrentConley-z3p]

Zulauf Squares

[@KarlynWizwer-g3u]

Mayer Shore

[@mr.olive28]

8100+

[@EzekielChristian-r5j]

Ward Junctions

[@LindaTillis-v2b]

Cummings Shores

[@JamalHadi-c7v]

Homenick Club

[@GalenMandino-d1c]

Luettgen Crossing

[@BBoy-br4sg]

8925 my😢😊

[@Devkumar-nb1cr]

Ji immune system is weak

[@DobbinLester-d4f]

Edwardo Viaduct

[@ArnavLagent]

My IgE result is >3200 😢

[@suhanashaikh861]

😢 take care dea

[@suhanashaikh861]

My result is 1200

[@MrStewart-gu7ru]

Mine is 3109

[@kumarrajasekharreddy7998]

Bro mine 4000...how r u bro what happened

[@RoyJones-nx6zi]

How do you feel?​@@kumarrajasekharreddy7998

[@AdamTaggart-k9v]

Quitzon Neck

[@rahman98712]

My ige = 917 😢😢😢