can you get all your DNA from one parent??

You hear people say things like ‘I look just like my mother’ or ‘I take after my dad’. Can we really have more DNA from one parent than the other? Take this to its extreme- can we get ALL of our DNA from just one parent? TLDW, because of genomic imprinting, probably not.
written, narrated and edited by April
Information sources:
+Wendy Chao (2011) Handbook of Epigenetics, chapter 22: ‘Genomic Imprinting’
+Priyanka Nakka, et al. (2019). Characterization of Prevalence and Health Consequences of Uniparental Disomy in Four Million Individuals from the General Population. Am J Hum Genet, dx.doi.org/10.1016%2Fj.ajhg.2...
+Tomas Babak et al. (2015). Genetic conflict reflected in tissue-specific maps of genomic imprinting in human and mouse, Nature Genetics doi.org/10.1038/ng.3274
+Valter Tucci et al. (2019). Genomic Imprinting and Physiological Processes in Mammals, Cell doi.org/10.1016/j.cell.2019.0...
+Tatsuya Kishino et al. (1997). UBE3A/E6-AP mutations cause Angelman syndrome. Nature Genetics doi.org/10.1038/ng0197-70
+Kempton JH. (1919) Inheritance of spotted aleurone color in hybrids of chinese maize. Genetics www.ncbi.nlm.nih.gov/pmc/arti...
+Carole Charlier, et al. (2001). The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status, Nature Genetics, doi.org/10.1038/86856
+Thomas Liehr. (2021). Repetitive Elements in Humans, Int J Mol Sci doi.org/10.3390/ijms22042072
+Susanne Bens et al. (2017). Mosaic genome-wide maternal isodiploidy: an extreme form of imprinting disorder presenting as prenatal diagnostic challenge, Clinical Epigenetics. doi.org/10.1186/s13148-017-04...
Image/video credits:
+Picture of pigmented corn: Fang Bai et al. (2015). Imprinting in plants as a mechanism to generate seed phenotypic diversity, Frontiers in Plant Science doi.org/10.3389/fpls.2014.00780
+picture of sheep: www.nature.com/articles/ng100...
+bacteria dividing video: youtube user CellASIC • Cell division of E. co...
Funded by: UPMC Hillman Academy & NCI R25 YES
#science #genetics
Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation, National Institutes of Health or UPMC.

[@AtTheBenchtop]

This brings a whole new meaning to "You're not my real dad!!" 😂😂

[@compsysbio]

Love the jump in!

[@simeons.koikamannil2782]

Informative video.

[@mannyespinola9228]

Thank you for this video

[@PatKellyTeaches]

The video quality and production value keeps on getting better! The video looks especially crispy in this one. New light or something?

[@bioZone101]

😊 thank you! and no same light.. for now lol

[@lokkomotive8153]

No. It’s impossible. You are 50% of each parent.

[@DamianoLombardi]

We must also accept that these are only hypothetical percentages, but we know very well that 30% cannot be inherited from one's mother, it would be an abortion, because that is barely the DNA that can be inherited from grandparents.We must also accept that these are only hypothetical percentages, but we know very well that 30% cannot be inherited from one's mother, it would be an abortion, because that is barely the DNA that can be inherited from grandparents.

[@Skikdii]

I don't have very english but whats the conclusion

[@bioZone101]

you probably cannot get all your DNA from one parent because of genomic imprinting

[@asternoid30]

can you get all of your parent from one DNA?

[@bioZone101]

lol

[@BAbraham99]

Can you have all your dna from only 3 grandparents?

[@bioZone101]

yes apparently it is possible!

[@DamianoLombardi]

It's not possible, it would be an abortion, because in this way the same individual would always be generated, there would be no variability and then your grandfather would also be your father at the same time, so in this way you would have two fathers (and indeed the owner of the sperm would not even be your biological father). Isn't this counterintuitive and unnatural??? It would only be possible in asexual species but not in us sexual cells. It would only be possible in the case of cloning that gamete of one of our grandparents, but the son/daughter would reject it, it would immediately go into apotosis, because our organism, being an intelligent organism, would reject it, because it is impossible for it to contain inside his gonads the gamete that gave birth to him. Then we are a species that when we carry out meiosis we always generate variability through cross-in-over, which would be incompatible with life if it did not occur (because in addition to generating variability, it also allows correct chromosomal segregation) and generates an exponential variability that guarantees the survival of our species (especially in a period like this, where environmental and climatic variations are making themselves felt and we are adequately adapting), without crossing-over 99% of non-viable gametes would be generated and would suffer from aneuploidy . Inheriting twenty-three non-recombined chromatids is so unlikely that it has never occurred (at most there could be two non-recombined chromatids, but all twenty-three copies is so unlikely that it would never occur and would not even pass natural selection and therefore would be a non-recombined fertilization).It's not possible, it would be an abortion, because in this way the same individual would always be generated, there would be no variability and then your grandfather would also be your father at the same time, so in this way you would have two fathers (and indeed the owner of the sperm would not even be your biological father). Isn't this counterintuitive and unnatural??? It would only be possible in asexual species but not in us sexual cells. It would only be possible in the case of cloning that gamete of one of our grandparents, but the son/daughter would reject it, it would immediately go into apotosis, because our organism, being an intelligent organism, would reject it, because it is impossible for it to contain inside his gonads the gamete that gave birth to him. Then we are a species that when we carry out meiosis we always generate variability through cross-in-over, which would be incompatible with life if it did not occur (because in addition to generating variability, it also allows correct chromosomal segregation) and generates an exponential variability that guarantees the survival of our species (especially in a period like this, where environmental and climatic variations are making themselves felt and we are adequately adapting), without crossing-over 99% of non-viable gametes would be generated and would suffer from aneuploidy . Inheriting twenty-three non-recombined chromatids is so unlikely that it has never occurred (at most there could be two non-recombined chromatids, but all twenty-three copies is so unlikely that it would never occur and would not even pass natural selection and therefore would be a non-recombined fertilization).​@@bioZone101

[@DamianoLombardi]

​@@bioZone101In your opinion, is it possible that a child could contain within its gonad a gamete which would be the one that gave birth to it??? Each of us generates our own gametes, through our own genetic material reassorted and mixed in a new way, otherwise we would all be the same as a cookie cutter. The gametes of the same individual are already not identical, let alone the one between a father/mother and son/daughter, it would be a non-existent gamete within my organism because, being a different individual, I cannot have even a single gametic cell from my father. , I generate my sperm and he generates his. My body would identify a sperm from my father as a foreign cell and my body, being intelligent, would reject it and go into apotosis. In this way my father would always generate a part of himself, but my father and I are two completely different individuals, we have some genetic characteristics in common but we are two different individuals and consequently we have different gametes, I cannot have a gamete with only genes of my father because otherwise it would be his and not mine, but since I generate him, this is impossible within my organism. Even if this cell were generated (and it would be impossible) the organism rejects it because it does not identify it as a cell of its organism. So let's assume that from your father you inherited all the genes of his mother, that is, your paternal grandmother, then your father would have formed your grandmother's egg cell and would not have formed a sperm. Your grandmother would then also be your biological mother, but don't you see how senseless it is. This only happens in organisms that reproduce asexually but not for us who reproduce sexually.In your opinion, is it possible that a child could contain within its gonad a gamete which would be the one that gave birth to it??? Each of us generates our own gametes, through our own genetic material reassorted and mixed in a new way, otherwise we would all be the same as a cookie cutter. The gametes of the same individual are already not identical, let alone the one between a father/mother and son/daughter, it would be a non-existent gamete within my organism because, being a different individual, I cannot have even a single gametic cell from my father. , I generate my sperm and he generates his. My body would identify a sperm from my father as a foreign cell and my body, being intelligent, would reject it and go into apotosis. In this way my father would always generate a part of himself, but my father and I are two completely different individuals, we have some genetic characteristics in common but we are two different individuals and consequently we have different gametes, I cannot have a gamete with only genes of my father because otherwise it would be his and not mine, but since I generate him, this is impossible within my organism. Even if this cell were generated (and it would be impossible) the organism rejects it because it does not identify it as a cell of its organism. So let's assume that from your father you inherited all the genes of his mother, that is, your paternal grandmother, then your father would have formed your grandmother's egg cell and would not have formed a sperm. Your grandmother would then also be your biological mother, but don't you see how senseless it is. This only happens in organisms that reproduce asexually but not for us who reproduce sexually.

[@DamianoLombardi]

Then there is always something chemical, external that corrects everything. Even the exchange between sister chromatids, in the sense that if the environment notices that in the right sister chromatids there is little crossing-over and in the left ones more, an exchange could also take place between the sister chromatids and therefore cause the chiasm. Everything must work in favor of genetic variability because without it the individual would not pass natural selection and would be an abortion, because he would not be suitable for the environment. Then, grandparents are our second most direct ancestors, after our parents, and it would be completely impossible not to have inherited any gene from one of the four of them, this would be possible if we went down ten/twenty generations but not the grandparents, they are too many ancestors direct, and if it turns out that I have not inherited anything from my maternal grandmother it is because she is not actually my mother's mother.Then there is always something chemical, external that corrects everything. Even the exchange between sister chromatids, in the sense that if the environment notices that in the right sister chromatids there is little crossing-over and in the left ones more, an exchange could also take place between the sister chromatids and therefore cause the chiasm. Everything must work in favor of genetic variability because without it the individual would not pass natural selection and would be an abortion, because he would not be suitable for the environment. Then, grandparents are our second most direct ancestors, after our parents, and it would be completely impossible not to have inherited any gene from one of the four of them, this would be possible if we went down ten/twenty generations but not the grandparents, they are too many ancestors direct, and if it turns out that I have not inherited anything from my maternal grandmother it is because she is not actually my mother's mother.​@@bioZone101

[@DamianoLombardi]

​​It is impossible both because crossing-over occurs, and it is inevitable that it does not occur (because otherwise the gametic cells would suffer from aneuploidy and would be sterile gametes) and then it can only happen in two chromatids that remain unchanged, not recombined, but not all twenty-three copies. And then do you think it would be possible that your grandmother is also your mother at the same time??? Because that's what would happen, his father would generate the egg cell that gave birth to him. Do you understand that this is a contradiction??? Would his grandmother also be his mother??? Then, the father's organism would reject that gametic cell and immediately go into rejected. It would not pass natural selection because that individual would not be suitable for the environment. My father and I are two different individuals and I cannot generate a gamete with all my father's genes, because otherwise it would be his gamete, but since I am a different individual I cannot generate his sperm and this probable future son of mine it would have my father as the biological father and not me, who is the owner of the sperm, and it is as big a contradiction as a house with a swimming pool in addition. The gametes of the same organism are not identical, let alone those of two different organisms.It is impossible both because crossing-over occurs, and it is inevitable that it does not occur (because otherwise the gametic cells would suffer from aneuploidy and would be sterile gametes) and then it can only happen in two chromatids that remain unchanged, not recombined, but not all twenty-three copies. And then do you think it would be possible that your grandmother is also your mother at the same time??? Because that's what would happen, his father would generate the egg cell that gave birth to him. Do you understand that this is a contradiction??? Would his grandmother also be his mother??? Then, the father's organism would reject that gametic cell and immediately go into rejected. It would not pass natural selection because that individual would not be suitable for the environment. My father and I are two different individuals and I cannot generate a gamete with all my father's genes, because otherwise it would be his gamete, but since I am a different individual I cannot generate his sperm and this probable future son of mine it would have my father as the biological father and not me, who is the owner of the sperm, and it is as big a contradiction as a house with a swimming pool in addition. The gametes of the same organism are not identical, let alone those of two different organisms.​@@bioZone101