Neuroscience - Long-Term Potentiation

[@CoWsGoNeighh]

It's funny to think that by watching this video I learn how memory works, and by doing so, the exact mechanisms that are displayed in this video IS HAPPENING IN MY HIPPOCAMPUS RIGHT NOW AS WE SPEAK, I CAN FEEL THE GROWTH OF NEW SYNAPSES BY THE INFLUX OF CA2+ IN THE POSTSYNAPTIC CA1 CELL. THE ACTION POTENTIALS ARE AT A ALL TIME HIGH RIGHT NOW.

[@anni98dftba]

I thought the same thing and actually laughed out loud at this lmao

[@CarolRobertsonPsychosensory]

Hi Paolo, you might love Havening Techniques :)

[@kutilkol]

you're high

[@happiestbeing77]

haha love it

[@zhiyubu1723]

It’s not a mechanism tho

[@annieslice2268]

How is it that when one person (or three!) explain this it makes absolutely no sense and this makes it seem so super simple! I don't understand how people passed exams without google and youtube!! thank you so much!! xo

[@CarletonUvideos]

Thanks for the feedback, Annie. Glad it was useful!

[@cindyo6298]

Lol, they read good textbooks.

[@42MapleTree]

I've watched a lot of videos about neuroscience. A lot are good, some are great, this was magnificent!

[@stevenk113]

3:26 Well thanks for reminding me while I'm studying for my exam today.

[@Tphransis]

Being able to visualize this helps so much more than just reading and looking at pictures in the textbook. I don't think I'll ever forget this now, thanks !

[@Urreasteve]

Wow! I can't express how glad I am that I found this video. My book was not able to explain it as clear as this presentation, my understanding of this subject just expanded because of this video. Thanks!

[@DerRebellTraumer]

The person or persons who created this video know exactly what they talk about - if anyone is doing psycho-biology this is a really helpful source since it explains simply - but in depth - what LTP is. For sure I am coming back for more, keep on doing these videos.

[@zenzaiL4D]

I'd like to thank all the people involved in making this very informative video. LTP is a rather complex process and you have managed to make a video that explains the phenomenon in a precise way which makes the concept easier to comprehend. Thank you!

[@DraugSatan]

Brilliant! Dale Purves' "Neuroscience" offers some really in-depth stuff, but generally fails at mashing in small nails with big mallets, which we sometimes need when cramming. Succinct and precise, and gorgeously presented. Kudos!

[@LiudmilaGlav]

our teacher recommended this video. It is impossible to make it clearer than here. thank you

[@dannichols6261]

Kudos to the speaker, who speaks VERY clearly and at a good pace! It can be frustrating to watch a video on complex material and not be able to understand the speaker, or hear a speaker to talks too fast to follow well.

[@HannahNguyen1995]

My professor should just show us this video instead of the 20 page incomprehensible power point slides. I was able to piece everything together so easily with this video. Great video!

[@estebanvenegas89]

This is what my teacher took an hour to explained, but explained very good in 8min, thanks!!

[@shantanusinha3609]

My primary interest and major is in Computer Science but I have very strong interest in Neuroscience, as well. I had difficulties understanding the working of synapse and neurotransmitters for memory. This video is very informative! My question has been successfully answered :)

[@alejandrarincon452]

I'm studying this the night before of my exam. I understand I'm screwed.

[@Ai-ChingChen]

I'm studying this a few hours before my exams lol

[@billipta3573]

me too 😅

[@LesbianDrag0n713]

I'm studying this 26 hours before my exam

[@Psnowdog7]

A great deal of long-term depression happened while I was watching this

[@pallavisamaira1018]

😂😂😂

[@saikumar802]

the best lecture with extraordinary explanation of the physiology of memory tq so much for your help and support..............

[@hannahmendelsohn8893]

By far the best video I've seen! thanks

[@micaelabazan3869]

This was even better than reading Purves. LTP memorized in 8 minuts. Great!

[@eileenhay5697]

this video gave a clear and concise explanation of memory making it possible to remember!!!

[@court7694]

Seriously this video was so awesome!!!! It was so helpful to see the representation of the long-term potentiation and hear the very clear explanation of what was happening. Definitely recommending this video to people in my class. Thank you!

[@luciferin22]

i have exam tomorrow and this is more clear than some of my lectures. THANK YOU

[@yeebygee5517]

+luciferin22 same!

[@ShinigamiDui]

+luciferin22 Same!!

[@onso]

Same here

[@akhilkrishna9581]

The memory of this memory is saved in my brains memory !

[@WTFudgeFTW]

THANK YOU! This was awesome! I've breen struggling to understand LTP for such a long time! I'm giving a presentation about memory and plasticity in a few days and now I think I finally understood this!

[@Gourmetfetisch]

doing the same in 2024 haha

[@hanihighest]

Wow, this is an amazing video. I when to lecture, read the notes carefully and read the chapter in Neuroscience book and was still not fully understanding this. After the video I understand it fully. Thank you.

[@Siliceous0oze]

Gr8 video! Besides the misspelling of the AMPA- receptor (thumbs up!)

[@nadhirahbaharin.]

Just had my neurosciece lecture about long term potentiation and depression this week. I wasn't able to focus in class. Glad I found your video it is super helpful! Love from Sheffield

[@Bidia280795]

Thank you for your explanation! Made an hour long lecture much more understandable and bearable!!

[@likeyou3317]

Best explanation I've come across so far. Gr8 animation!

[@HENRYYYYYQQ]

Really good video. Excellent animations and commentary. Beautifull!

[@InceptionSolver1]

There is one more part of the early phase of the LTP that also strengthens the synapse. Part of the protein kinase cascade includes the movement of AMPA receptors from the base of the dendritic spines to the tips of the spines, allowing for a greater chance of contact with glutamate in the synapse. The video mentioned new AMPA receptors being installed from storage, but this facet of the LTP is just movement of previously installed receptors away from the cell body and toward the synapse.

[@justinabagger8330]

This video changed my life

[@vasiolast6824]

It's 7 years later, but still. It's a great explanation of the LTP. Thank you!

[@snoopysweethrt7]

This was so much more clear than my professor was!

[@halimaiqbal8664]

concise yet detailed description. thanks. now to study LTD

[@Daniel-er9mc]

This si what i already needed, You' re the best

[@rebeccataylor973]

absolutely brilliant video - thank you so much! My lecturer couldn't explain this properly and through one video i've got it!

[@gotit7628]

Very good video. Made the topic very easy to understand

[@TheSick83]

This was great!! I wasnt logged into my account, but i did after watching this video just so that i could "LIKE" and Comment on your video :)

[@CarletonUvideos]

TheSick83 Thank you! We appreciate it! :)

[@bws7532]

AWESOME VIDEO!! excellent explanation and one of the best voice over's I've ever heard! Great voice! And great explanation. Helped me understand it so much better!! Cannot thank you enough for this.

[@FREDERICklkwokab]

Very beautiful and helpful Animation

[@janellem3821]

excellent! very clear explanation for a very confusing topic! thanks a lot

[@guilhermemorais8898]

It's perfect. Thanks from Brazil.

[@TravisKearney]

Will an intake in Sodium, Protein, or Calcium give increased cognitive performance in any way?

[@jaybyers8550]

Wow. Thank you for this video! My textbook really was not explain this in a digestible way (could be that there were no helpful diagrams and I’m very visual), but you guys made this very comprehendible! Seems as though many other people’s textbooks are also not very clear as well, which is interesting because after watching this it seems like a fairly straightforward concept. Could be that reading NMDA (especially when your brain registers it as MDMA because you watch to much Joe Rogan), AMPA and glutamate over and over gets a bit overwhelming and distracting from all of the actual concept of the function.

[@กรกนกแรมลี-ฆ8ฒ]

This VDO is very helpful. Thank you so muchh

[@Gymdesde__012]

Muchas gracias concuerda con mi libro de fisiología que no entendia nada pero gracias al video lo comprendi al 100

[@daniel88165]

I feel so much better about taking this biopsych final now! Thank you!

[@XreemeoX]

THANKS SOOOOOO SOOOO MUCH, this helps a heck of a alot!!!! i can not thank you enough for making this clip!!!

[@tobeij237]

great video! explained it better than my book thank you!

[@sharonkende4774]

Thank you for this awesome explanation of LTP. Now I can finish my paper (as soon as I figure out how to give credit in a citation of a youtube video). (:

[@tomtang2639]

jeez, much more concise than my lecture of 2h duration

[@LesbianDrag0n713]

This video summarises the process really well and is super helpful in revising for my test

[@Jonnyiswhatweaimfor]

3:30 so how many times should I watch this video?

[@discordant8543]

Jonnyiswhatweaimfor Ideally, not many, you should check out other videos on the same topic too, read chapters from a textbook, maybe have someone create a test on the material for you to take.

[@user-rr2gk9ds4i]

this was brilliant, and saved me from having to wrack my brain over written notes. thank you!

[@amaliaprat3685]

Thank you for the video! Is very clear and understandable, it has been a great help for me!

[@isabello1906]

Very useful information provided by this video !

[@paolagotelli107]

Una maravilla este video! Increíble!

[@aipenglew3493]

Concise yet well explained!

[@nazeeraharmanza]

his is a good video! hi from neuroscience enthusiast here!

[@Trilost24]

Dehydration causes sodium to be elevated. So If someone was dehydrated often would that cause LTP Vs LTD? Thank you for any response.

[@Daemon_intellectualis]

i would like to have handy some of the missing references, concerning the LTP leading to production of growth factors for example. Really good video.

[@mattewsmith638]

Thank you so much for making this great video! It finally makes sense (although I may need to watch it one more time to strengthen the connections, haha).

[@valeskacidjofre3109]

Thanks!! Really good video, perfect for understanding the mechanism. Cheers from Chile

[@tima67]

V helpful for my exam tomorrow, thanks!

[@OilersLBA]

Fantastic video, thank you very much. This hopefully was part of the LTP in my studying and the forming of new AMPA receptors which hopefully will last a long time!

[@abcaimeex]

I LOVE THIS VIDEO IT SAVED MY ESSAY AND THUS MY LIFE

[@court7694]

+abcaimeex YAS

[@heavyraindrops4750]

Brilliantly explained, thank you! :)

[@rajsekhar4212]

great... helped me in understanding the concept... Thank u.....

[@giorgosgranitsiotis]

it was just superb u sir are a legend and im not indian

[@NephilaClavata]

Very clear explanation, thank you.

[@imagination7710]

Slowest action potential I ever saw XD

[@Dangineering]

I don;t know why this made me laugh.

[@KimHellemans]

Thanks everyone - so glad this video has been helpful! :)

[@zephir]

Thanks! It really helped :)

[@codyharrington8263]

Great video! thanks for making and posting.

[@RebDalmas]

Yet, it is well known that correct FOCUS can open a natural learning ability, the kind young children have. Long term study is memory building, direct interaction as physical learning can bring in information faster. The use of fear, warps information, the pavlovian dog movement, and as such, slows down processing as it blocks that direct seeing that is that degree/pressure/movement of absolute focus. If we practice one " tempo" that acclimates and resonates, making it difficult to see through the " smoke and mirrors of inner resonance. Yet, that shows us to ourselves. Improvement in absolute focus, disperses that shadow, because it cannot withstand such exposure.

[@Wiggyify]

Really enjoyed and benefited from this. Please keep them coming!

[@jaybestemployee]

Great video on the topic! Better if links to videos of related topics are provided to form a playlist of the subject. Keep it up!

[@kyleadelaide]

Thank you so much. It's much clearer now

[@nesbertkagonda2447]

awesome, clear and concise

[@Psychologielernende]

Great Video! Thank you very much

[@jkhotrod360]

Very informative and efficient. Thank you!

[@21eny]

Thanks for the video! It is a helpful supplement for studying for a test I have to take.

[@sarahbenkirane9459]

Thank you! This video was so helpful, like the person under me, I felt the need to create an account just to say thank you!

[@domenicomaddaloni7955]

Thank you! This is fantastic!

[@annettepers9138]

Nice video! Some points that need ti be mentioned though: 1. Coincidence detector refers also to the binding of glycin or d-serin next to glutamate and the depolarisation through ampa. 2. It is misleading that there are more calcium and sodium intracellular after the depolarisation as in the video. Even a small amount is sufficient to cause an electrical depolarisation.

[@Shadow155]

Great video. I would suggest adding some text during the video to reiterate a few points, though.

[@CarletonUvideos]

Shadow155 Thanks for the feedback! We are passing on suggestions and feedback to the video's creators.

[@CrystalFaye]

I agree- text would be good for those who cannot spell very good. (I make notes while watching these videos)

[@alexandra-stefaniamoloiu2431]

I'm taking notes too, using the subtites. Great explanations, thank you so much!

[@dannichols6261]

Adding a TRANSCRIPT to the 'show more/show less' under the video would help too, as would true script-based closed captions. What I presume are computer-generated closed-captions are in this presentation pretty good, but not, I think, totally accurate. Where the cc says 'internal cortex' ~ 1.01 (sending signals to HC), I think he actually said 'entorhinal cortex', maybe?

[@srussifordwilliams]

Tell the creator they are doing an amazing job! With Shadow155's addition, this could be the most educational seven minutes and 59 seconds of my entire life.

[@hjyssg]

Great video! really helping me understand the concept.

[@MOHITKWATRA]

Amazing informative video of LTP

[@beatrizmassis]

This video is great and very didactic! It helped me a lot, thank you!

[@dannyholley]

Brilliant video. Thank you!

[@veenatripathi3264]

Thanks for the video! This was clear and informative. I would recommend this video to students of neuroscience!

[@shreyaray5500]

This was super helpful, thank you!

[@Muuip]

Please note: at 2:07 "AMPA" not "APMA"

[@syed9576]

so, practice doesn't make perfect, but makes magnesium get out of the way?

[@jamshedfbc]

Thanks to the writers and animators and whoever made this video possible.

[@charlottephilipp1030]

That was really helpful, thank you soooo much

[@allaboutclinicalpsychology]

Very nicely explained

[@lindaruschenschmidt7941]

Thanks for saving my Biology final exam

[@rokanmoschus1564]

Thanks a lot ..plz more videos of biochemistry

[@joaorachel4114]

Excellent! Great video, it helps me a lot!