Long-Term Plasticity In The Hippocampus (LTP, LTD, STDP) | Clip

Welcome to Science With Tal!
In this video, we will go over the mechanisms that underlie plasticity in the hippocampus. The hippocampus is a very important region that mediates diverse aspects of memory and many more. The mechanisms that we will cover include long-term potentiation (LTP), long-term depression (LTD) and spike-timing-dependent plasticity (STDP). We will see how these mechanisms behave both on the electrophysiological and molecular level.
This conversation on neurons in the CNS derives from important concepts that are described in two previous full discussions:
1- To watch the first part (Signal propagation in the Neuron), make sure to go to: • Signal Propagation In ...
2- To watch the second (The Neuromuscular Junction as the model of the chemical synapse) make sure to go to: • Neuromuscular Junction...
To improve the quality of my content, I highly value the feedback from the viewer so do not hesitate to give any feedback in the comment section.
TIMESTAMPS
0:00 Introduction
0:17 Hippocampus anatomy
2:11 LTP mechanism at the Schaffer Collateral (& late-LTP)
8:17 Plasticity terminology (Input specificity, Cooperativity, Associativity)
12:38 LTP mechanism at the Mossy fiber pathway
13:58 LTD mechanism at the Schaffer Collateral
15:15 Spike-timing-dependent plasticity (STDP)
18:44 Conclusion & citations
RESOURCES
Here is a list of the resources that I’ve used to produce this video. (Author(s): title resource)
- Dale Purves: Neuroscience (6th edition)
- Eric Kandel: Principles of neural science (6th edition)
- Lodish: Molecular Cell Biology (9th edition)
- Niswender, Colleen M, and P Jeffrey Conn: Metabotropic glutamate Receptors: physiology, pharmacology, and disease
- Bünemann, M et al: Activation and deactivation kinetics of alpha 2A- and alpha 2C-adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents
- Howlett, Allyn C et al: CB(1) cannabinoid receptors and their associated proteins
- Morris, R G: D.O. Hebb: The Organization of Behavior, Wiley: New York; 1949
- Stent, G S: A physiological mechanism fo Hebb’s postulate of learning
To have more information on these resources, you can refer to the conclusion section where a more formal citation is provided.
CREDITS
Writing: Tal Klimenko
Voice: Tal Klimenko
Animations: Tal Klimenko
Drawings: Tal Klimenko
Editing: Tal Klimenko
Introductory jingle: Thierry Du Sablond
Conclusion music: lukrembo - sunflower ( • lukrembo - sunflower (... )

[@Pumiki]

"From the perspective of the weak pathway..." - 12:35 - *heterosynapic* plasticity DID happen. right?

[@sciencewithtal]

Oh, right! Sorry about that, I just verified my narration and my example should be about the case of input specificity. In that case (input specificity), there is no heterosynaptic plasticity in the weak pathway. In the case of associativity, there is heterosynaptic plasticity. Again, sorry for the confusion and thanks for picking up on that!

[@Pumiki]

thank YOU@@sciencewithtal

[@oblomov4580]

I can not describe how grateful I am for this video. Before watching, I spent hours learning the ltd and ltp which i did but COULD NOT grasp the stdp fpr the life of me but after this video I FİNALLY understood it all. Thank you thank you thnak you

[@sciencewithtal]

Awesome! I'm glad the video could help you make sense of that !!

[@alzbetahojsikova]

Thank you for this video! My professors explained it in such a chaotic way that I did not understand anything, but your explanation gave me the much needed clarity on this topic ❤

[@sciencewithtal]

I am glad you found the video helpful! Thank you very much.

[@neurosciencegirl]

Okay you definitely gave me an Ah-ha moment with STDP and backpropagation, you are the first person to mention this! Makes so much sense now

[@sciencewithtal]

My pleasure!

[@rabihanasir315]

this is the best video ... I really understand what LTP, LTD and STDP is Thank you

[@sciencewithtal]

My pleasure to help, thanks for the feedback!!

[@jiaxisun9064]

Thank you so much for this video. I've asked my prof 3 times about how STDP happens cuz I don't understand how AP can go backward. My prof never explained this as clearly as your video. This video saved my life. Please keep on doing more videos related to neuroscience. Thank you very much !!!!

[@sciencewithtal]

Thank you for the comment!! I am glad the video was helpful!

[@giteins7481]

Dude thanks for all yours videos.

[@sciencewithtal]

Thank you !! Im glad you enjoyed!

[@TristanLozito]

Anyone know where camkIV is involved? I know that that kinase is calmodulin Activates it, where it Phosphorylates CREB and MAPK causing Ubiqipuitin hydrolase synthesis/PKA R subunit degredation, and CREB to alter gene activation for synaptic growth. But my professor has said CAMKIV is active in associative pathways, where as calmodulin dependant adenylyl cyclase is activated in the Mossy Fiber Pathway, could you clarify?

[@sciencewithtal]

What your professor is saying is that although LTP happens in both the CA3 to CA1 synapse (I am assuming this is the associative pathway your prof is referring to which is also called Schaffer collateral) & the mossy fiber pathway from MF to CA3 (see at 1:41 for reference for the pathways), the two pathways use different mechanisms to achieve potentiation. In the associative/Schaffer collateral pathway, LTP is achieved in the postsynaptic cell via CAMKIV (2:11 to 8:19); whereas, in the mossy fiber pathway, LTP is achieved presynaptically via de calmodulin dependant adenylyl cyclase (12:39 to 13:58). Hopefully that clarifies your question. Let me know if I can help further!

[@neurosciencegirl]

great video :)

[@sciencewithtal]

Thank you!

[@soundarya.k5374]

Where can i find short term plasticity

[@sciencewithtal]

In my full discussion about properties of CNS neurons (kzbin.info/www/bejne/mH3LlH6ejt6rq9k), there is a segment that covers short term plasticity concepts between 1:41:53 and 1:55:31.

[@soundarya.k5374]

Thank you so much