Long-Term Plasticity In The Hippocampus (LTP, LTD, STDP) | Clip

[@Pumiki]

"From the perspective of the weak pathway..." - 12:35 - *heterosynapic* plasticity DID happen. right?

[@sciencewithtal]

Oh, right! Sorry about that, I just verified my narration and my example should be about the case of input specificity. In that case (input specificity), there is no heterosynaptic plasticity in the weak pathway. In the case of associativity, there is heterosynaptic plasticity. Again, sorry for the confusion and thanks for picking up on that!

[@Pumiki]

thank YOU@@sciencewithtal

[@parimehr88]

OMG!!! you covered all fundamentals of my PhD project in the simplest and best-organized way! Thank you!

[@sciencewithtal]

I am glad it could help, thanks for the feedback!

[@michael3226]

great explanation. I understood every part of it 100%. Thank you so much

[@alzbetahojsikova]

Thank you for this video! My professors explained it in such a chaotic way that I did not understand anything, but your explanation gave me the much needed clarity on this topic ❤

[@sciencewithtal]

I am glad you found the video helpful! Thank you very much.

[@jiaxisun9064]

Thank you so much for this video. I've asked my prof 3 times about how STDP happens cuz I don't understand how AP can go backward. My prof never explained this as clearly as your video. This video saved my life. Please keep on doing more videos related to neuroscience. Thank you very much !!!!

[@sciencewithtal]

Thank you for the comment!! I am glad the video was helpful!

[@oblomov4580]

I can not describe how grateful I am for this video. Before watching, I spent hours learning the ltd and ltp which i did but COULD NOT grasp the stdp fpr the life of me but after this video I FİNALLY understood it all. Thank you thank you thnak you

[@sciencewithtal]

Awesome! I'm glad the video could help you make sense of that !!

[@neurosciencegirl]

Okay you definitely gave me an Ah-ha moment with STDP and backpropagation, you are the first person to mention this! Makes so much sense now

[@sciencewithtal]

My pleasure!

[@camkillam2437]

So fascinating!!! Im taking behavioral neuroscience right now and this was very easy to follow

[@sciencewithtal]

Thanks a lot, glad it was helpful!!

[@rabihanasir315]

this is the best video ... I really understand what LTP, LTD and STDP is Thank you

[@sciencewithtal]

My pleasure to help, thanks for the feedback!!

[@giteins7481]

Dude thanks for all yours videos.

[@sciencewithtal]

Thank you !! Im glad you enjoyed!

[@sarahzerrouki1948]

May Gob bless you

[@TristanLozito]

Anyone know where camkIV is involved? I know that that kinase is calmodulin Activates it, where it Phosphorylates CREB and MAPK causing Ubiqipuitin hydrolase synthesis/PKA R subunit degredation, and CREB to alter gene activation for synaptic growth. But my professor has said CAMKIV is active in associative pathways, where as calmodulin dependant adenylyl cyclase is activated in the Mossy Fiber Pathway, could you clarify?

[@sciencewithtal]

What your professor is saying is that although LTP happens in both the CA3 to CA1 synapse (I am assuming this is the associative pathway your prof is referring to which is also called Schaffer collateral) & the mossy fiber pathway from MF to CA3 (see at 1:41 for reference for the pathways), the two pathways use different mechanisms to achieve potentiation. In the associative/Schaffer collateral pathway, LTP is achieved in the postsynaptic cell via CAMKIV (2:11 to 8:19); whereas, in the mossy fiber pathway, LTP is achieved presynaptically via de calmodulin dependant adenylyl cyclase (12:39 to 13:58). Hopefully that clarifies your question. Let me know if I can help further!

[@neurosciencegirl]

great video :)

[@sciencewithtal]

Thank you!

[@soundarya.k5374]

Where can i find short term plasticity

[@sciencewithtal]

In my full discussion about properties of CNS neurons (kzbin.info/www/bejne/mH3LlH6ejt6rq9k), there is a segment that covers short term plasticity concepts between 1:41:53 and 1:55:31.

[@soundarya.k5374]

Thank you so much