Cellular Respiration Part 1: Glycolysis

You need energy to do literally anything, even just lay still and think. Where does this energy come from? Well, food, right? But how? This is one of the most miraculous biological processes, and it happens in our bodies every moment of every day. It's quite complicated, so let's check it out in three sections. First up, glycolysis!
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[@alanmunoz5621]

sooo basically, Glucose (6C) splits into 2 (3C) Pyruvate 1. 1 phosphate added to 1 side (-1 ATP) 2. 1 phosphate other to 1 side (-1 ATP) 3. 6C splits into 2 C3 4. Hydride (H-) removed from each, reducing 2 NAD+ to NADH (or FAD+ -> FADH2?) . 5. Hydrides are replaced with an inorganic phosphate on both (not from ATP) Now, 2 P’s on either side of both GP3’s) 6. Phosphates on either side of both molecules then split and go to ADP to create 4 ATP, becoming 2 Pyruvates (3C) NET = 2 ATP & 2 NADH

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so what is the difference between the 2 C3 (step number three) and the 2 pyruvates?

[@flamesblades]

@@maysk.5998 I’m learning this myself, but I think it’s the fact that the pyruvates get phosphorylated in step 3 by phosphofructokinase 1, and they get dephosphorylated, or lose a phosphate group, to replinish the ADP’s into ATP again.

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Thank you for making that very easy to understand. I've been struggling with this concept lately, and now I understand it. Thanks!

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Thanks Professor Dave, by showing the molecules as they change through the process I finally get it!

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Thank you for simplifying this complex process...helped a ton with studies!

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Fantastic, clear explanation of a complex biochemical process. Thank you, Prof. Dave!

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Cool, I am a DNA chemist, so I never learned about metabolism but I also new ATP was involved. Now I can see how are food is used to generate ATP through this cycle :) I heard we make 80 kg of ATP a day, pretty crazy synthesis scale!

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A lot of videos repeat things "atp stores energy" and "you get energy when a phosphate group is released" but they don't explain it and probably they themselves don't know what it means. Professor dace does a good job at explaining it

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my pleasure!

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i don't have any such notes unfortunately!

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tnq professor Dave, u made me easy 2 understand glycolysis

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[@ahmadhegazy7811]

1. Any glucose can enter glycolysis either beta or alpha right ? 2. I think the net overall equals 8 atp ( 2 ATP + 2 NADH ) Because starting from step 6 or after producing 2 GADP we will double every nad or atp So from step 6 to step 10 we will have 10 atp Minus 2 atp from the first 5 steps the net overall equal 8 atp What do you think?

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