CHAPERONES AND MISFOLDED PROTEINS

[@martakadziolka7182]

Thank you for this really educational and user-friendly lecture on the role of chaperones. I have a family member with a disorder of glycosylation (CDG-SSR4), and understanding protein transport and folding is really important to me. Your lecture is the best I have found. My family and I would be happy to see more videos on the role of chaperones - especially the TRAP complex and the BiP - in protein folding. I understand that we are only on the edge of understanding the role of the TRAP complex, but recently, new research on TRAP in the human cell has emerged (i.e. Phoomak et al. 2021). I would love to be able to better understand and visualize how the TRAP complex preserves N-glycosylation under conditions of ER stress, for example. I would be happy to send you the relevant article, which is easily available online. I look forward to watching more of your lectures!!! Happy New Year '2022

[@sylviedumas3751]

THIS IS SO STRANGE. THANK YOU. Sincerely, A Biotech student

[@shubham_mahi]

Same Here, What kinda job You are doing now?

[@silkpharmacy5904]

nightmare fuel but thank you none the less

[@dandanthedandan7558]

This is a great video that's very easily understandable but man that mouth animation is right on the uncanny valley

[@superfantastic8481]

Omg thank you for dumbing this down 😍😍😍

[@kierahurlimann408]

Very good video, explains it so well and is very helpful. The animated talking human just makes me a little uncomfortable the way his mouth moves, might be less distracting without a moving mouth 😊

[@samuelfauteux6735]

HSP 60 and HSP 70 are misidentified at 2:20 of the video but correct the rest of the way. thank you for these lectures they're great.

[@I_DidntKnowThat]

I had to go back twice to double check.. So what are the correct forms though?

[@innate-videos]

This video is absolutely excellent - congratulations on the content, insights, clarity, and animation. It sets the standard!

[@zoea3474]

Love how you explained it!

[@bobby79]

Bro you are a genius, you covered the whole mechanism in just 4 mins. It took me almost an hour to understand it on my own by reading book and still I was in doubt, but you made me very clear about it now.

[@douglaswallace7680]

right click anywhere on the video . then click "loop" . click play . volume level very low . the best cure for insomnia !

[@hazossi1696]

Well, I know HSP60 is for polypeptide misfolded, but if I'm talking about HSP70, it's also with the same function? to misfolded polypeptides? Or is to help folding the polypeptide? I'm saying this because HSP70 take action at first moment, when the peptyde is getting out of traduction, right? Pdtt:. I'm not an English speaker, so my grammar could be bad, i'm sorry and thanks!

[@caseyandtoryshalloween1236]

It is crazy how a hamburger can cause these proteins to misfold

[@SophiaCundiff]

Okay seriously love this so much and love how you go so into depth!!!

[@iremasutkaloglu6968]

thank you so much. Finally, I understand this subject.

[@averagejoe8839]

So all these checks and balances simply came to be unintentionally and simply throwing massive amounts of time into the equation will make such a farcical proposition more believable? The reality of this system unintentionally coalescing over billions of years is absurd as the molecules and chemicals degenerate within hours under strick labratory controlled conditions thusly leaving a time frame for unthinking matter to flop iteslf into a information packed self replicating factory within hours and immediately start replicating over and over and over perfectly. You might as well claim a space shuttle could unintentionally swirl itself together in a sand storm as this would be a much simpler and believable unintentional manifestation. what a world! The truth is right there for all to see yet some still reject reality at all cost.

[@Hiyori___]

Awesome video! I'm a computer science engineer, but many years ago in high school I studied biochemistry and chaperones is one topic that I remember since. The whole concept is so mind-blowing to me!

[@hoobnbn___hooobnbn2453]

Blud says if you ENJOYED the video

[@gabrielacastillo9724]

But the hydrolysis of the ATP, do not expend energy but release energy

[@slurrpyy_7150]

yes but i believe this makes the hydrophobic regions hydrophilic. also it’s been two years so i hope you passes bio

[@nikiirulan]

lol I love this animation

[@marysmith3710]

When this process doesn't occur properly it seems to cause catracts. Can one shed some light on how this process can be restored to help the body eliminate eye catracts with non harmful medications & with out surgery.

[@MazharAli-yr8pe]

i want to know how does prion proteins develop resistance against the proteolytic process? secondly, how does prion protein misfold in the first place?

[@slurrpyy_7150]

Pov, Cramer sent you here

[@carsonneal]

omg YES, cramer is the best teacher haha

[@milindjagtap1897]

Which is best drug chaperon available in market for neurodegenerative disease

[@omaryahia]

wow , you are really talented and doing great great job, thaks for all that effort and Quality

[@BittuKumar-ov4ei]

very very much thanku for explaining very easy way

[@martinacoggiatti4438]

So… what about proteasome??

[@aakritiyadav4057]

Wow😍

[@roronoazoro3204]

such a genius youre both in explaining the subject and that amazing animation

[@salihasaeed6817]

Best lecture on chaperones💯 must say i was badly needing this type of video.

[@sudharshanampavankumar4992]

Hsp90 physiology

[@redwine8364]

He's too fast

[@brilliantfuture1841]

❤

[@dhabyaahmed8134]

THAT WAS AMAZIG. THANK YOU!

[@saijalsood]

An amazing explanation!

[@kashafhamdani8583]

Oh thank you thank you sir

[@Naikymomo]

Bro this helps sooooo much

[@asmaasaad922]

thank you for your effort on this video

[@sung-wookher4381]

THANK YOUUU

[@nikhilverma9034]

Interestingly explain...thnx

[@siddhartha7394]

Cover the topic mutations in your upcoming videos..#Requestedpls#Team Neural academy 🧐😄

[@NeuralAcademy]

It's on the list!! :-D Will make soon!

[@zainabqureshi9178]

Hie

[@MH-bw5jj]

Perfect

[@noursh6783]

Amazing 🙌 thank you Which program do you use to make this?

[@NeuralAcademy]

Thank you!! I used Adobe Illustrator/Photoshop/After Effects/Premiere/Audition!

[@noursh6783]

@@NeuralAcademy brilliant! thanks

[@kristenhale3022]

thank you

[@saragul6139]

WELL DONE

[@micamlla]

thankyouu 😭😭 you saved my reporting 🫰🏻🫰🏻

[@salihabekh6054]

Excellent!

[@tymarls]

This video is ultra creepy

[@tymarls]

but I also love it

[@eyymma99]

Holy shit, amazing work my man. Congrats

[@ummulbanin9845]

Thank you sir for such a lucid explanation