T Cell Activation and Control

Dr. John Looney reviews T cell activation contributors, T cell antigen recognition, and T cell "braking."This webcast is part of an interactive online series designed to bring you, the busy clinician, up to speed with the remarkable advances occurring every day in the field of basic and clinical immunology.
To learn more or to claim CME credit, visit www.ccfcme.org/TCell
This CME activity was produced by the Cleveland Clinic Foundation Center for Continuing Education and the R.J. Fasenmyer Center for Clinical Immunology.

[@romaissach497]

I just needed to link everything together and this lecture helped me with that, very simple and clear, thank you!!

[@frankieannholmes1892]

So very clear and WONDERFUL ANALOGIES--what better way to show antigen recognition and binding than lovers? And the tides in Nova Scotia representing the ebb and flow of the immune response. And all the incidental references to the diseases that are explained by immune overstimulation or exhaustion. What a brilliant and Renaissance man. I need to view this many more times. THANK YOU for making this available

[@marcelfab1657]

Very well explained. Helped me to study all these modern therapies like PD1 and CTLA Inhibitors. Thanks!

[@zhussipbekmukhatayev7225]

This video helps a lot! Thank you Dr.John Looney

[@magicuba]

dr. John is a real boss, respect

[@Mr22ogins]

Seriously well put together video. Top notch!

[@chrisli9685]

OMG, TY for this!!!! It summed up perfectly what I needed to understand!!!

[@GPanos22]

Amazing explanation. Clear and informative!

[@kenhayes9718]

Thank you for the time to explain this material so well.

[@johnsong7503]

Excellent lecture presentation! Thank you!!

[@chintomendoza]

What an ammazing topic.....This lecture ROCKS!!!

[@arinarakhteenko579]

Awesome summary and nice examples from culture or nature to keep some point in mind thank you!

[@spldrstudtom]

Very helpful, thank you very much!

[@jiayuho3459]

Thank you so much for the great lecture!

[@nope.13]

Excellent! Thank you so much!

[@0sama789]

A great lecture, thank you so much!

[@svetlanasoloviova2418]

You save my life tonight, so much thank you

[@rahelnyarko-morrison9354]

Lol

[@doctorrajeevkn3599]

This is a fantastic class. Everything explained. The secret of check point inhibitor in oncology revealed

[@RiDankulous]

I watch Twiv (This week in virology) podcast and these mechanisms are discussed a lot. This is very easy to watch, and interesting thanks.

[@billytheweasel]

TWIV is good too!

[@billytheweasel]

Thank you for this.

[@RiDankulous]

I wonder how Dr. Looney feels about having highest number of views of all channel videos, including more than Dr. Esselstyn (my hero!). I wish both the best.

[@MsAmour2009]

Great job, thank you very much!!

[@becizaistrup2920]

Very detailed and well explained

[@jeffreyleikachon1]

Thanks, it helps a lot.

[@faithfoi1303]

well done! thanks Dr!

[@MsAmour2009]

GREAT JOB! thanks a lot!

[@analasic1823]

Thnk you! Great repetition material!

[@limeroundup]

Great explanation!

[@oibal60]

Thanks for this.

[@mrsoluwaoseunti]

Thank you!

[@45th_is_47th]

This video really help out a lot

[@sapnayadav-rc1ym]

thanks a lot sir for explaining it all so nicely....

[@Macroautophagy]

Excellent talk

[@avinashselva9636]

It was a very good lecture. Thank you sir.

[@thyowen]

great video. really clear and moves really well into what it can mean for future developments. explains why its interesting haha, thanks

[@calebhaines3794]

Lasers can be used to identify materials that are coorelated with shredding and heating settings on recycling systems.

[@guillaume6373]

Awesome talk

[@jennamore5514]

Very good lecture, thank you !

[@zannatul23]

ayy ;)

[@chandybundy2667]

Ure so much better at explaining this than my lecturer was. Thank you so much

[@marymasterman7957]

thank you!

[@thesortsakis]

fantastic!

[@avisekdeyati6505]

Great Talk! Different components of innate and adaptive immunity have been put together in a clear and articulate manner!

[@tatendagucci3293]

this is really helful

[@rashmivinayak8377]

Excellent Talk..... Very very clear concepts..!!!

[@AlexanderKubik1993]

Rashmi Vinayak I thought it was very very very clear, not very very clear, didn’t give it enough credit

[@shreineraly1684]

It is primarily explanation but we need to connect that with the clinically associated explanation

[@yorkshin8901]

Nice talk

[@link2442]

I feel that I grasped this better and with ease than the lectures my professor gave through out the whole semester

[@drsharafathali4043]

Thankyu very much

[@user-rp1sg7ik7y]

Thanks😊

[@richardnevin]

Thanks

[@darkaction123]

beautiful

[@sivasankarnallapati]

Love it

[@kingpat345]

Nice video

[@claramarques5606]

amazing

[@gabrielbrill4782]

at 5:05 he mention how t cells get activated in the lymphatics, but a predominant amount of t cells get activated in the thymus and mTECs. I think some treg cells get activated in the periphery such as the lymphatics.

[@jiafengxu3126]

thanks

[@hildavalerolozano7752]

Gracias , me queda la idea de la complejidad del sistema inmune

[@jaggaiahnaidu4949]

Good lecturer

[@zethuandisiwe4188]

A very good explanation but how is a picture of a person indicating HIV

[@AlexanderKubik1993]

This dude has a stellar mustache though, props to him hahaha

[@theequaliser8026]

I wish you could help those with celiac disease surely

[@so-oo6ti]

I am curious about the radioactively contaminated water that Japan is trying to discharge.

[@claricecataldi7555]

I need the conctact with this doctor please.

[@vivekbhore8558]

Good

[@toulinma6916]

do activated t-cells PERMANENTLY release Cytokines even though no antigen binds to its T-Cell-receptor???

[@chrisli9685]

No, they don't permanently release cytokines. That is why you have CTLA-4 to down regulate the response along with IL-10 and TGF-beta. It is a HIGHLY regulated system. However, there are times it does go wrong.

[@solomondo3490]

How can I download these videos of interest??????? help!!!

[@AlexanderKubik1993]

Solomon Do you go on google and search how! You’re a smart one! (Sarcasm fully intended)

[@zakirzak1494]

💗

[@evagold5221]

what about infected Mph and DC? Can they make a presentation antigen for T CD8 ? Are there MHC I on DC and Mph or just only MHC II ? Thank you

[@evagold5221]

+Gukan Sakthivel Thank you for answer! Other one thing surprise me: is it really APC have CD4? For what it?

[@evagold5221]

+Eva Gold thank you ! but very often i read about the HIV infects all CD4+ cells =APC !

[@svoidkugan]

+Eva Gold No No CD4 cells are T cell CD8 cells are T cells too both are T cells ! HIV infects T cells!

[@evagold5221]

+kugan svoid Thank you! But why everywhere written about HIV 1 infects Mph by way CD 4 and CCR5?

[@evagold5221]

+Eva Gold This is from Robbins textbook: The requirement for CD4 binding explains the selective tropism of the virus for CD4+ T cells and other CD4+ cells, particularly monocytes/macrophages and dendritic cells. Binding to CD4 is not sufficient for infection, however.

[@caitlinriggs3433]

how do activated T cells know where to go after they have been activated in the lymph node?

[@slehbenhamida3689]

chemokines secreted by dendritics cells lead the way towards the infected tissue.

[@Enes-ld7gk]

by chemokines ofc

[@calebhaines3794]

Activation energy for any and every cell in the body needs to be monitored and controlled to prevent excessive photon and quantum radiation from passing through or onto the body.

[@davo3299]

chemokines!!

[@scottslomka240]

Creatine prevents exhaustion

[@vivekbhore8558]

Good