Colchicine

Colchicine remains one of the traditional medicines used to treat acute flares of gout. The current preferred treatment involves a low dose of 2 tablets at the first twinge of joint pain followed by one additional pill 60 minutes later. At this dose many of the unwanted side effects of previously popular higher dose therapy with colchicine may be avoided.
While gout remains the most common indication for colchicine, recent investigations shed light on its potential to prevent heart attacks, stroke and other cardiovascular disease. A study of colchicine presented at the American Heart Association meeting in 2013 demonstrated dramatic improvement in these conditions. Another larger study published in late 2019 revealed a 74% reduction in stroke and a 50% decrease in urgent hospitalizations for chest pain requiring revascularization in a population at elevated risk.
Colchicine also seems to provide significant protection against recurrent atrial fibrillation following radiofrequency ablation. Another benefit of colchicine involves prevention of inflammation of the sac around the heart or pericarditis.
Unfortunately colchicine may be associated with a wide range of adverse effects even including an occasional death. Careful consideration of kidney and liver function is mandatory along with evaluation of any drugs that may increase the risk of colchicine's
side effects.

[@georgemeyer2487]

I havr been on practice for 40 years. You 22:29 are still teaching old dogs new tricks. Thank you very much.

[@mistyblue5312]

Thanks for this informative “lecture” on colchicine which you made simple and easy to understand - especially with regards to dosage. Surprised to know that it has an impact on cardiac issues. Much appreciated. Now on to listen to your other “lecturers”.... and glean more info.

[@mrgreenjeansgenetics]

PLEASE MAKE A VIDEO ON THE DETAILS OF THE MEDICATION PROPOFOL!! THANKS IN ADVANCE DOC.! 👍😎

[@riz8462]

i enjoy your videos, please keep making them! i'm a pharmacy undergraduate student, and i'm not very bright but somehow your videos stick, so thank you!

[@wellnowdoctor5976]

Glad you like them!

[@priestbuddha2990]

i'm the 1st,i'll use this chance to tell you how much I grow familiar to your face Doc...

[@heyfernando6293]

super informative, I enjoy your content very much. I hope you continue posting whatever interests you as your knowledge and the passion you have surrounding the topic is rather engaging

[@oldguy8078]

Impressed by the drug, but you are quoting relative risk reduction rather than the absolute risk reduction. Death was 0.8% in the Colchicine group compared to 1.0% in the placebo. An absolute risk reduction of 0.2%.

[@johnarmstrong8694]

Colchicine after 3 tablets for severe attack of gout within 12 hours caused extremely severe diarrhoea. Really really unpleasant. Up all night, could not believe the body contained so much fluid. Stopped colchicine as had no effect on gout attack. Took 180mg of Arcoxia, immediate improvement in reducing gout related pain and swelling.

[@wilma-gv9ff]

Great video...well researched and presented. You have a great personality for film. Would you consider a future video on oxalates and how they affect joints. I'm researching causes of spinal stenosis and mechanisms of ischial tuberosity inflammation.

[@Mark_Ocain]

WOW..In Australia, I paid 13.00 AUD for 30 x 500 mic tablets..why so expensive in the US??

[@Vsp712]

United States loves to make money

[@MrBlister808]

It's because of the deal the Australian government made with Big Pharma to secure the medicine for the national Healthcare system here. Americans are forced to by the 'reformulated' version which costs a fortune, and the old formulation has been taken off the shelf Iike the good doctor here has said. I know this from personal experience, and with speaking with both doctors and pharmacist while over there with a gout attack. I had good insurance, but because I went to Intensive Care, was charged $20 USD for three, that's 3, pills! A year prior I bought a bottle of 30 pills for less than $6 AUD while living in Aus! Us Americans get fleeced for health care...it's ridiculous.

[@volatilechemicals-wo2yh]

@@MrBlister808 but why are they doing that? why would they deliberately make medication less accessible and affordable?

[@mwj5368]

Thanks Wellnowdoctor for a very informative video! I was prescribed by my rheumatologist .6 mg a day permanently and I have non alcoholic fatty liver disease, and my creat and urine albumin haven't been good either but in March my egfr was 88 but usually around 50 if I remember correctly. Is that an incorrect prescription? I also take allopurinol 400 mg a day. I'm 68 and have had gout attacks so it is for my gout and a 12 day prednisone taper to take when I feel gout starting. I had a cardiac and carotid cat scan in about 2017 and the carotids about in 2019 that showed all arteries clear I think with my being vegetarian for 32 years. Should I stop colchicine? On 6-24-22 I started the carnivore diet at 280lbs and so far 90 days later lost 17 lbs at 263 lbs and hope to lose 100. I had my first gout attack while on carnivore diet 3 days ago. I had eaten ground beef and now switched to just chicken. Does chicken count as "red meat" and contribute to gout? Also pork is not red meat but would rather not eat pork if I don't have to for reasons similar to I think why Jewish people don't eat it.

[@volatilechemicals-wo2yh]

good question!

[@ndayishimiyenabilisraeldav1238]

From 1961 nothing else have been developped so far.Colchicine is not working anymore to many people with acute pericardtis.many people still getting back attacks from pericarditis

[@mehmetcanmsrcoglu2781]

Hi. I have FmF and Coronary artery spasm. i have to take colchicine and diltiazem. i take colchicine 0.5 x 2, diltiazem 120x2 and now Rosuvastatin 5 mg x 1. normal liver , kidney function(although eGfR was higher than 121 with normal creatinine levels) should i discuss other treatment options with my cardiologist?

[@larceraymann5263]

Hello Doctor, I'm in South Africa, my brother died at the age of 32, and we did not know he was taking Colchicine. Could he have died from Colchicine poisoning?

[@BlackMamba-lt8oe]

How he died

[@cjbrown8245]

I’m sorry about your brother. Colchicine is dangerous if accidentally overdose

[@elevatedemotions4548]

@@cjbrown8245 how much it takes to overdose in adults...being that study shows people taking it daily

[@Vsp712]

It was 260$ at CVS cash

[@Lachmangyawaly]

Thank

[@milindjagtap1897]

Is it safe for cns disease which is caused by over stabilization of microtubule

[@MyMuzzamil]

Very good information for old is new again I. e. Colchicine

[@robertturner1959]

Why is the medication $200 for 20 tablets

[@krubbek5135]

Because of the drug companies know people with gout will pay for it. in europe I pay 5 euros for 20 tablets without insurance. the US has the worst healthcare system in the world. Colchicine actually predates the FDA and was before 1961 sold over the counter and cost only pennies.

[@volatilechemicals-wo2yh]

@@krubbek5135 yeah but its a first world country

[@cjbrown8245]

You made this med sound real good. Hmmmm, overdose is 8//9 death rate. It goes through the body ripping it all up and all the diarrhea doesn’t eliminate but 10 percent maybe then, if you live through organ failure, your hair falls out……. My opinion

[@thelandsavior402]

My pee color changes to tea color after get poisoned from colchicine. May i know will my condition be cured?

[@cjbrown8245]

No

[@JoseRubio-xq4ub]

You had liver injury. How much did you take?

[@thelandsavior402]

@@JoseRubio-xq4ub hi, i already cured from carnivore diet. No more gout. I consume 4tablet daily for 4 days whenever i experience inflammation by that time.

[@elizabethwinsor-strumpetqueen]

I get it for free in Scotland

[@cjbrown8245]

😮

[@observerev3166]

Q- IF I TAKE 500 MCG HOW MANY TABLET I TAKE IN ONE DAY..THANK YOU .

[@salimalturfe8861]

الترجمة للعربية

[@ahmedahm1]

Please post about gene therapy

[@stannisbarracuda5693]

doctor can i drink Alcohol after taking colchicine ? im taking it for pericarditis

[@volatilechemicals-wo2yh]

no

[@stannisbarracuda5693]

@@volatilechemicals-wo2yhdamn you 2 years late bro lol

[@nizar7576]

Cocichine wizard