Cold Agglutinin Disease (CAD)

[@MedicosisPerfectionalis]

💊🦠 Antibiotics Course: www.medicosisperfectionalis.com/ 🧠 Autonomic Pharmacology Course: www.medicosisperfectionalis.com/

[@andriqukamanahan3208]

1-C: Direct Coombs Test 2-B: keep the patient warm

[@juliennegrace4155]

Diagnosis :b direct coombs test Treatment : b keep the patient warm

[@MedicosisPerfectionalis]

You’re absolutely correct 👏

[@katmeow95]

Hematology makes more sense when I watch your videos before reading Harrison's! Thanks!! 🌻

[@MedicosisPerfectionalis]

My pleasure 😇 Can you please help me by sharing?

[@emanalashmony3347]

1. Direct comb`s test. 2. Keep the patient warm. Thank you dear

[@catherineedwards8460]

I was Diagnosed with CAD - Autoimmune Hemolytic Anemia in October 2020. Very interesting diagnosis to have!

[@MedicosisPerfectionalis]

I am so sorry to hear that!

[@dianasousa356]

Hematology makes so much sense after i found your channel... I don´t know what i would do without your videos. Thank you so much!

[@MedicosisPerfectionalis]

Thank you so much, dear...I am so happy right now...Can you-please-help me by sharing my videos with others?

[@ahmedabd3191]

Thx for explanation, 1-direct coombs test 2-keep the patient warm

[@My-m1x]

I watch your videos from Iraq and I would like to thank you for your efforts.💙

[@nishagahlot8472]

Ans. 1 - direct climbs test Ans. 2 - keep the patient warm

[@salisumuhammadmukhtar6585]

Direct coombs test. Keep the patient warm.

[@yinkus100]

Answer to questions - 1. direct coombs test 2. keep patient warm

[@MedicosisPerfectionalis]

Excellent as always!

[@andriqukamanahan3208]

1)Direct Coombs test. 2)keepthe patient warm

[@shafiaabbasi732]

1.direct coombs test 2.keep patient warm

[@alizehgheewala3345]

these videos are so helpful! Also are the answers, direct coombs test and keeping the patient warm?

[@MedicosisPerfectionalis]

Awesome 😎

[@shahabuddin6149]

Thanks alote sir, direct comb test,management avoid cold

[@karlaloyolamoreno9799]

1C - 2B . Thank you for all your videos , you rock !!!! 🇵🇪

[@cindyhansen7681]

What’s your take on having both warm and cold antibodies?

[@زهراء-غ8ت1ض]

Great doctor 👏

[@MedicosisPerfectionalis]

Thank you 🙏

[@evankim2158]

In terms of onset, according to Harrison's p.719, CAD is characteristically a chronic disease. For me this arises a question since you mentioned polyclonal antibodies are related to acute onset, and the patient in this vid's case presented acute onset as well. I agree with what you mentioned by polyclonal antibodies show in acute situations as in infections, but this might not be case. I'd appreciate it if you could clarify if CAD is chronic or acute. Thanks!! I really love your videos :)

[@نورالهدىعباس-س5ك]

Direct Coombs test Warm the patient

[@chantaleusebio9315]

you are THE best, thank you for your videos

[@MedicosisPerfectionalis]

My pleasure 😇

[@tahiransari3917]

Direct coombs test keep the pt warm

[@MedicosisPerfectionalis]

Haha 😂

[@tahiransari3917]

@@MedicosisPerfectionalis 😁😁😁😁😁😁😁😁😁😁😁

[@Tilr701]

My 14 years old daughter's hands and feet are cold. She is low on iron and vitamin d. Which doctor do I even go to see?

[@aminpakdaman4676]

thanks for the great video can you tell me the difference between CAD and cryoglobulinemia?

[@saikat179]

Cryoglobulins - Cryoglobulins are antibodies that form immune complexes in the cold; they generally do not interact with RBCs.So no hemolysis.

[@MedicosisPerfectionalis]

50 hematology 💉 *cases* - written by me - are NOW available on www.patreon.com/medicosis/

[@georgenaratadam3803]

Your videos are great

[@MedicosisPerfectionalis]

Appreciate it, brother!

[@shafiaabbasi732]

Sir can u make a video on hemoglobin electrophrosis bands?

[@MedicosisPerfectionalis]

Great idea...It’s on my list!

[@shafiaabbasi732]

if u can make it early i will b thankful to u

[@MedicosisPerfectionalis]

I will try my best

[@ATA-wi2lh]

why is acute monoclonal whereas chronic is polyclonal?

[@karlaloyolamoreno9799]

Love your videos ❤️🇵🇪 Thank you for do medicine much easier 🔝🔝🔝

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@faizaadbaiba9400]

think you very much for all these lactures and I would ask you about a case of patient with Sickle cell disease came for blood transfusion but all the blood are incompetible and the coomb's test is positive .what is cause of this combination and how can treat this case(HB=5.0g/dl)

[@MedicosisPerfectionalis]

Is it a real patient or an exam question?

[@faizaadbaiba9400]

@@MedicosisPerfectionalis of course its real patient 7yr aged and its stable for long time with Hb between 7_and 8g/dl suddenly his HB dropped to 5g/dl. blood film show marked agglutination,sikle cells ++ and few sphercyes. reticulocyte more than10%

[@rashidkhan9079]

@@faizaadbaiba9400 brother the case is simple in this vase there’s vaso occlusion can occur so better you should keep the person hydrated give pain medicine nd also antibiotics for infection and the last one HYDROXYUrea😄

[@rashidkhan9079]

Better you should don’t do it any transfusion that can create many problem

[@jeanpierresanchezsanchez7931]

U re amazing, man

[@MedicosisPerfectionalis]

Thanks a bunch 👍

[@bijahmswazi4843]

C and B

[@alaanabil6364]

Any videos for cryoglobulinaemia?

[@MedicosisPerfectionalis]

I don’t have it yet!

[@alaanabil6364]

@@MedicosisPerfectionalis never mind 🌸

[@jynxy866]

no offence. love the video

[@MedicosisPerfectionalis]

Thank you 🙏

[@jynxy866]

Watching this a week before my final degree exam

[@MedicosisPerfectionalis]

Good luck 🍀

[@arwinraj861]

What’s the difference between the direct and indirect Coombs test ?

[@MedicosisPerfectionalis]

I am literally preparing that video right now 😁😊...In brief, the direct Coombs test detects antibodies (or complement) bound to the RBCs surface, while the indirect Coombs test detects antibodies that are free in the plasma. In cases of warm or cold autoimmune hemolysis, the antibodies (IgG or IgM respectively) are bound to the surface of RBCs, that’s why we use the direct Coombs test...Hope it helps!

[@arwinraj861]

Medicosis Perfectionalis thanks you’re the best man

[@MedicosisPerfectionalis]

Don’t mention it...Thanks for nothing...I really appreciate that and wish you the best of luck...Please let me know if you want a specific video to be made.

[@pashaghorashy9292]

Why is it important not to treat with Steroids, Reason I ask is that my Mother has CAD and was on 80mg Prednisone and was lowered to 40mg. She is having issues with her O2 sat and the cause is presumed to be from the Prednisone. We have asked to be taken off of this but were told she needs to stay on it.

[@yashasvigupta9914]

Why arent steroids given? Even in cold type like warm,there are antibodies attached to the rbc,then why not?

[@ThatsWhy-]

It will inhibit immune system

[@bayooo100]

Thanks

[@MedicosisPerfectionalis]

My pleasure 😇

[@palakarya4179]

Love your videos, it makes everything so easy to learn👌

[@MedicosisPerfectionalis]

Thanks 🙏

[@majadbassam1032]

what is the difference from warm type

[@MedicosisPerfectionalis]

Here is my video on warm subtype: Autoimmune Hemolytic Anemia; warm autoantibodies kzbin.info/www/bejne/iXmnfZmQrrqnqKs

[@chathuanushki6331]

Why t is important to keep samples at 37 degree celcius

[@MedicosisPerfectionalis]

That’s your body temperature.

[@chathuanushki6331]

@@MedicosisPerfectionalis I know but why.is it to prevent false negative results

[@palakarya4179]

Why is Direct Coomb's test preferred than indirect?

[@MedicosisPerfectionalis]

Have you watched my videos on Direct and Indirect Coombs test?

[@palakarya4179]

@@MedicosisPerfectionalis I didn't know, I'll watch it asap. Thanks..

[@MedicosisPerfectionalis]

You’re welcome! If you want the links, I can send them to you. Please let me know!

[@palakarya4179]

@@MedicosisPerfectionalis I've got them now, can't thank you enough for these lifesaving videos.

[@srikantkumarbehera4143]

i think cold agglutinin disease causes extravascular hemolysis. its cold hemolysin disease(PCH) that cause intravascular hemolysis

[@MedicosisPerfectionalis]

Thanks for your comment...Actually, cold agglutinin disease causes intravascular hemolysis, check “Goljan rapid review of pathology 4th edition” page 369...The link to the book is in the description of the video!

[@sokamoustafa5407]

Why can't we use steroids here?

[@MedicosisPerfectionalis]

Honestly, I don’t know why, but Harrison’s mentions that using steroids here is not advisable.

[@sokamoustafa5407]

Thanks alot ...and we badly need more and more videos like this

[@MedicosisPerfectionalis]

Thanks a million!

[@ThatsWhy-]

@@MedicosisPerfectionalis because thyroid wants to raise warmth into the body , steroid will inhibits it

[@ItsMe-jr6kd]

👏 😍😍 great

[@MedicosisPerfectionalis]

Thanks 🙏

[@majadbassam1032]

c,b

[@cielphantomhive2128]

So cold disease does exist 👀so my mum care about me👀🙇🏻‍♂️

[@fistikcisahap7268]

Looks like there are diseases cold showers won't fix. :P

[@dipakkharate.]

Cold like you

[@MedicosisPerfectionalis]

So funny!

[@dipakkharate.]

I was kidding dude ...I love you ❤️

[@aishakernazi9776]

🤍

[@MedicosisPerfectionalis]

:)

[@karlaloyolamoreno9799]

Love your videos ❤️🇵🇪 Thank you for do medicine much easier 🔝🔝🔝

[@MedicosisPerfectionalis]

Thanks a million!