Intravascular Hemolysis

[@MedicosisPerfectionalis]

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[@deboraho7777]

For those who might wonder why G6PD deficiency was listed under both intravascular and extravascular hemolysis, it does in fact involve both. Extravascular hemolysis is primary for G6PD deficiency d/t Heinz bodies, but intravascular hemolysis can also occur.

[@MedicosisPerfectionalis]

You're correct!

[@rasterraster1728]

I'm here because I did the gym too intensely too often. I loved it. I never did the gym as intense as I did this year. Was doing weight lifting. I wasn't eating good enough with too much dairy.

[@paolo6424]

Great video, as always! Just one question about haptoglobin. Doesn’t haptoglobin bind to Hb only when released in blood, and therefore in intravascular hemolysis? And isn’t free haptoglobin low only in intravascular hemolysis? Thanks!

[@omershlez]

Love your videos!!!! I think there is an error that continues through the hemolysis videos, reticulocyte index in acute blood loss is Hypreproliferative, i.e. above 2~2.5., in the videos (1:20 mark) it states that it's hypoproliferative.

[@suramohamed3499]

This is really fantastic ☹️☹️ thank you very much 🌷🌷

[@MedicosisPerfectionalis]

My pleasure 😇

[@TheYASSERASD]

My favorite channel ❤️❤️❤️❤️❤️❤️

[@MedicosisPerfectionalis]

Thank you so much 😊

[@clowie299]

Helpful in visualizing the information

[@MedicosisPerfectionalis]

Thanks a lot!

[@ElSequenceDelHelio]

Real life Question for you: what do you make of elevated bilirubin (has been in range of 1.8 to 3.7), low haptoglobin, normal LDH, and CBC totally within normal limits? Would this fit the picture of Gilbert Syndrome?

[@dr.doaaageez2233]

Very easy and clear! Thank you

[@MedicosisPerfectionalis]

You’re very welcome! Thanks for watching!

[@Medical_Sciences]

Lovely explanation

[@MedicosisPerfectionalis]

Thanks a million!

[@bruryrosally]

Excuse me professor, 02:45 Is it lymphnodes or lymphocytes? Thanks professor

[@MedicosisPerfectionalis]

Lymph nodes.

[@bruryrosally]

@@MedicosisPerfectionalis thank you professor

[@habibaagk9361]

thank you so much that really helped a lot

[@MedicosisPerfectionalis]

My pleasure 😇

[@gail7347]

This is amazing 😍

[@MedicosisPerfectionalis]

Great...glad to have you as “Medicosis” :)

[@aytakchichak7456]

thank you...great and complete

[@MedicosisPerfectionalis]

My pleasure 😇

[@nehalbeyari292]

Thank you too much ✨

[@MedicosisPerfectionalis]

Of course..You’re are welcome!

[@CristianoRaashid77]

Greetings good sir, At 5:58, isn’t protoporphyrin involved in the heme synthesis pathway and not the heme breakdown pathway?

[@MedicosisPerfectionalis]

Both

[@Abdul-Rahman3207]

Thanks alot for your vids, I actually appreciate the amount of effort you make to collect such information in such way makes it very easy to understand and memorize However I have one small note: I have read robbins and essential hematology and they did not mention Uunconjigated billirubin as a part of Intra vascular hemolysis Actually, does blood stream contain macrophages in it? If answer is no, then protoprohryn can't be digested into bellirubin, it will just get execreted as it is (as hemoglobin in urin) So ... are you sure that intravascular hemolysis induces bellirubin?

[@leenalsader8476]

Thanks!

[@MedicosisPerfectionalis]

My pleasure 😇

[@abhishekr987]

Can anyone explain why haptoglobin decreased in intravascular hemolysis?

[@mohamedreda3518]

When coagulation Consumed.. Coagulation study will be abnormal as in DIC and normal in HUS and TTP... Why?

[@bhaveshgarg8142]

i could not understand why hemoblobin level INCREASES in blood ... the Hb that was initailly present in the RBCs are now just in free form in blood their is no overproduction of hb . instead their is even loss of Hb in urine plzz explain!

[@beautyblossoms1879]

Before that Hb was in the RBC so it wouldn't be counted as hemoglobinemia right? But after the destruction, they lie freee in the blood so hemoglobinemia....

[@swarangeechavan3515]

​@@beautyblossoms1879 it's not overproduction, just the mchc values increase because the free hb is still counted while the pcv reduces

[@kumar6557]

My ZEHK ❤

[@sharonfellner4255]

Doesn't enzyme deficiency such as G6PD cause extravascular hemolysis?

[@starflysevtae7850]

It causes both extra as well as intra

[@sonorahmastura3816]

Thanks

[@MedicosisPerfectionalis]

Of course!

[@faezehs6258]

Tnx so much😍👌👌

[@MedicosisPerfectionalis]

My pleasure 😇

[@aya2217]

LoL 🌹❤️😍,,, very helpful. 👏👏👏 Go ahead.

[@MedicosisPerfectionalis]

Thank you so much 😊

[@mahmoudelabd7035]

Perfect

[@glorystar4318]

G6PD is it extra or intravascular hemolysis??? Plz answer me

[@masumrabbani9996]

Awesome bro...just awesome

[@deepakkumargupta9511]

increase LDH, decrease haptoglobin are seen in intravascular hemolysis. NOT IN EXTRAVASCULAR HEMOLYSIS

[@deepakkumargupta9511]

CHECK OUT

[@شيخةأحمد-ت2ش]

yes Indeed

[@drhamadaryad7761]

Good lectures😍😍 And very useful

[@MedicosisPerfectionalis]

Thanks :)

[@MedicosisPerfectionalis]

@@drhamadaryad7761 Thank you so much!

[@megaprincepk]

May I know your name sir... Wondering explanation with lovely accent

[@MedicosisPerfectionalis]

Call me Medicosis:)

[@9032290952]

Is maha explanation is correct?

[@huzaifasiddiqui9703]

You are awesome

[@MedicosisPerfectionalis]

Thank you so much 😊

[@samrat8258]

How patients can. be saved from this fatal deasís

[@xacxoc423]

Tnx

[@MedicosisPerfectionalis]

My pleasure 😇

[@xacxoc423]

R u a doctor!

[@animecrazyxyz4040]

Is intravascular hemolysis normal like extravascular hemolysis?

[@MedicosisPerfectionalis]

I am afraid I didn’t understand your question.

[@animecrazyxyz4040]

@@MedicosisPerfectionalis I mean RBC gets old and hemolysis occur extravascularly. So in normal conditions is intravascular hemolysis occurs or it happens in abnormal conditions ?

[@esraakhalil9978]

5:41

[@tuhazzip8716]

Can b12 & folate Deficiency cause extravascular/intra hemolysis?

[@MedicosisPerfectionalis]

It’s the other way around, hemolytic anemia for a long time will consume iron, folate and B12...provided that you are not eating enough folate, B12 and iron.

[@brittophone6219]

I love uu❤️🥺🥺😭

[@MedicosisPerfectionalis]

Thank you!

[@jyotiprokash7450]

I have one question...when rbc is being destroyed.....hemoglobin that going to kidney through renal artery are intact? Or it breaks down into heme and globin there...globin is being absorbed as protein? And iron is being stored as hemosiderin??? Please explain these....

[@MedicosisPerfectionalis]

Good question! Both processes happen! Whole hemoglobin can be found in the urine. Hemosiderin is present as well.

[@heba6746]

I should’ve came here first. Raise your hand if you have terrible professores.

[@suezz5296]

why u r sleeping ?

[@MedicosisPerfectionalis]

That's a good question!