Control of Gene Expression | Transcription Factors, Enhancers, Promotor, Acetylation vs Methylation

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MerylMayGregory]

I'm here just to learn a simple gene regulation in eukaryotic cell, I can follow everything. If you are looking for simple explanation definitely not this. I laugh so many times watching this. I feel like I'll do the same tutorial to be honest. I am that detailed oriented person when it comes to learning. Thumbs up.

[@waelfadlallah8939]

Medicosis is a legend 🙌

[@MedicosisPerfectionalis]

Thank you!

[@Startpixie12]

enhancers are not proteins!!!! why did you say that? was that a mistake!!

[@pj.m5145]

Enhancers are not protein.. They are the regions where activator can bind!!

[@prachipant2355]

Thankyou so much medicosis this is really very very helpful ... Sometimes i feel if u had taught it in my language too then it would have been very great but then also ur english i understand and find lectures very useful😊😊 from india..

[@MedicosisPerfectionalis]

I appreciate you, Prachi!

[@prachipant2355]

@@MedicosisPerfectionalis thankyou so so much sir and thanks for replying...😊👍

[@MedicosisPerfectionalis]

My pleasure!

[@Mgsogs]

Yesssssssss my mdr research will love you today

[@MedicosisPerfectionalis]

Good luck!

[@waelfadlallah8939]

Also cortisol is dose dependent when it comes to activation or inhibition of a particular gene. That's why high dose causes immune suppression (in cases of prolonged stress, for example) and at low doses causes immune enhancement. Similar to TATA box there are GC islands that participate in gene expression (although i can't recall by which mechanism)

[@allthingszany1489]

This guy is funny and interesting 😭😭

[@MedicosisPerfectionalis]

Thank you!

[@MR-DD-qw8qr]

A million thanks for such ultimately comprehensive conceptual video.

[@MedicosisPerfectionalis]

I appreciate you!

[@amlomer8132]

thank you very much. your vidoes are amazying, clear explination within short time, and most important I don't sleep while watching them ❤❤❤❤🎉

[@MedicosisPerfectionalis]

Thank you so much!

[@Mol2412w3]

i love ur teachings!!!!!!!!!!

[@MedicosisPerfectionalis]

Thank you so much!

[@noorkholif5040]

THAT is sooo helpful, thank you very much🥺❤️❤️❤️

[@MedicosisPerfectionalis]

You’re so welcome!

[@noorelbackush9824]

this is the first video you have ever posted that I didnt fully understand :( I @7:04 when that table got pulled out. It was the first time I got exposed to enhancers and I dont fully understand the table that you created. The Response elements are under the enhancers tab but then they are talked about as if they should have their own tab. and at the end of the table, there was a section where it says promotors vs enhancers and it says in that little section that promotors are supposed to be very close to the start of the gene and enhancers are as far as 1000 bp but then the top table says that enhancers are cis regulators and that they are very close tot he gene that they regulate and that trans regulators are farther away than the genes that they regulate but promotors are at the top of the trans regulator side. I am very confused

[@HarryCoot-ro3yt]

yea I think Mr. Medicosis didn't fully understand this subject. seems like he's just posting content for the clicks now. I can promise you that you're not the only one who feels that way about this video. there's really nothing about this video that makes this subject more understandable. conversely to what this video states, it is actually true that enhancers are trans regulators and transcription factors are cis regulators. Medicosis, if you're reading this, please stop posting 'teaching videos' on information that you're not capable of teaching/don't understand. instead, please produce videos that simplifies science content instead of making it harder to understand. use multiple resources if you need to. thanks.

[@NanditaJali]

Omg same

[@jacktravers5049]

Trancsription factor acts far away, promoter is close. Enhancers are far away from the start of the gene(not really) in terms of how many nucleotides are between its sequence and the beginning of the gene sequence, however, enhancers are brought into proximity of the gene they control via dna looping. In that way, in the vs part, transncription factors act from far away, and enhancer act from proximity, the sequence for enhancers are not connected to the sewuence of the gene but are further upstream but still act locally. Does that make sense? Confused me for a second there too because of how he organised the boxes. I confused the promotoer for trancsription factor and that confused me as if it was conparing transcription factors vs enhancers both times. Hes not wrong. Transcription factors are products of sequences that act on sequences, by their nature free floating in the nucleus in fluctuating proportions. It is the binding of a trans acting transcription factor to a cis acting regulatory element like an enhancer that affects regulation of genetic expression. Theres two layers of abstraction from the dna that coded the transcription factor to its action which causes an effect. Enhancers directly cause an effect through recruitment. Hope that helpsm Good luck in your future studies. The struggle is what the process of learning feels like. All the best to you.

[@jacktravers5049]

​@@HarryCoot-ro3ytYou're wrong buddy. Very wrong.

[@jacktravers5049]

​@@HarryCoot-ro3yt you're wrong buddy. This is simplified, and a great overview, actually. I'm impressed with it. It would've been very useful to me back in 1st year biomed. Now I'm using it as a quick refresher before I go into minute details at this stage.

[@ketolomics]

This is video #40 in the Biochem set… the rest of the videos (from ‘biological membranes’ forward) on the playlist appear to require a $60+ per month subscription. Is that right? If so, can people just purchase the video package rather than the subscription? If a student were to pay for the subscription, can they download the content they need? Or do they only have access as long as they keep paying the subscription? Just trying to figure out how this works as a potential student resource!

[@MedicosisPerfectionalis]

If you just need biochemistry videos, I have a package available for you for a lower price...Please send me an email: [e-mail]

[@cristobalvalenzuela238]

Aren`t enhancers DNA sequences?

[@Nora-dx9cy]

OMG I WAS JUST MEMORIZING IT CUZ I DIDNT MAKE SENSE

[@Nora-dx9cy]

this man saved me so many times

[@MedicosisPerfectionalis]

I am honored!

[@asurvivor3846]

Answer is D ?

[@ManizzakousarKousar]

Idk im not getting it this is extremly confusinh

[@fareedfarah1495]

Hi Medicosis, whtat's the difference between postive and negative sense mRNA?

[@MedicosisPerfectionalis]

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[@animedattebayo802]

can someone tell me why the rest of the videos on the playlists don't work ?

[@MedicosisPerfectionalis]

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[@guestmyname5446]

Do you offer discounts? I've been watching this playlist since the start of the semester. How would I survive if I can't watch your video. I'm pretty broke college student. 😭😭🫤

[@BourasInesRacha]

7:02

[@antodecasa]

tysm

[@MedicosisPerfectionalis]

Thank you!

[@gabrielamaral3167]

Transcription, baby

[@MedicosisPerfectionalis]

:)

[@عمادزيتاوي-و1ف]

Big like 🌹

[@MedicosisPerfectionalis]

Big thanks!

[@sofiasheveleva5534]

This is a misleading video and not very well organized. I would delete it if I were you. Enhancers are not proteins, they are stretches of DNA. They can be located megabases away from the transcription start site (TSS). They are called cis-regulators because they are located on the same chromosome as the gene they regulate, unlike transcription factors, which may or may not be located on the same chromosome.