Countercurrent Multiplier Mechanism of Urine Concentration in Kidney | Countercurrent Mechanism

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Countercurrent Multiplier Mechanism of Urine Concentration in Kidney | Countercurrent Mechanism Animation:
There are two components of the countercurrent mechanism. One is hard work, and the other is smart work. The hard work is done by the ascending limb. He generates a concentration gradient. However, at a time, he can generate a gradient of 200 only. So alone, he cannot make the interstitium very hyperosmolar. The descending limb provides a smart solution to this. She picks up the higher osmolarity (generated during previous cycles) and feeds it to the ascending limb again. So now the ascending limb can generate even higher concentration, with the same capacity of 200. Thus, the countercurrent flow, allows the ascending limb to work on the same gradient, multiple times. That's why this mechanism, is called the countercurrent multiplier.
Chapters:
00:00 Intro
00:31 Coritcomedullar Osmolarity Gradient,
01:30 Anatomy of Countercurrent Flow
02:00 Role of Ascending Limb (Generating Gradient)
03:25 Role of Descending Limb
05:18 Interstitium & Descending Limb
06:15 Countercurrent Mechanism of Medullary Hyperosmolarity
09:55 Simplified Model of Countercurrent Mechanism
12:15 Summary
13:12 Bonus Point
Dr Vipul Navadiya
Nonstop Neuron
Medical Animation
Medical Animation Videos
Physiology
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.

[@solace8773]

Why does CCM stop when the inner medullary interstitial osmolarity reaches 1200 mOsm/L (or 2400 in camels) instead of going on continuously to result in even greater osmolarity?

[@NonstopNeuron]

Look at it this way: A dilute filtrate is continuously entering from the top of the descending limb. It keeps getting concerned as it descends. The deeper it goes the more concerned it gets. Based on depth in humans, it reaches up to 1200. Then it starts ascending, and the concentration starts falling. I hope it helps.

[@solace8773]

@@NonstopNeuron I understand that, but when the fluid at the thin descending limb reaches 1200 osmolarity, wouldn't the thick ascending limb continue to pump out solutes to make the surrounding interstitium even more concentrated than 1200 mOsm? How does the loop of Henle length affect this process?

[@NonstopNeuron]

No. Because simultaneously dilute fluid from the top keeps moving down and keeps diluting the fluid on the lower side.

[@NonstopNeuron]

Both things are happening simultaneously. Concentration by ascending limb, and dilution by fluid from top. Final concentration at any level depends on the equilibrium of two.

[@solace8773]

​@@NonstopNeuron Thanks for the explanation!

[@muqtarjamaegal6071]

Waiting long time this is treasure to me self study 📖 is better than what ever✋️ ❤

[@adrianpurcea8453]

Thank you very much for this video!❤❤. I have physiology exam (cardiovascular, respiratory and urinary systems) on Monday and urinary lecture was the last! You've really saved me!🎉

[@NonstopNeuron]

Most welcome

[@SKANDA295]

Sir If possible Please explain Route of drug administration theory+ objective wise and Enzyme induction and inhibition topic....

[@aliakgun3237]

at minute 8 must the equilibrium be 350.... why is it 400 mosm/l

[@NonstopNeuron]

Please don't isolate any step from others. If you do so, the confusion is bound to happen. To give you a conceptual model, I have to mention them one by one. There is no other way of explaining. But in reality everything is happening simultaneously.

[@aliakgun3237]

thank you very much