Creutzfeldt-Jakob Disease (CJD): An Overview of Symptoms, Causes, & Diagnosis

Creutzfeldt-Jakob Disease (CJD) is a rare and fatal neurodegenerative disorder caused by the abnormal folding of proteins, known as prions. I made an animated overview of the Symptoms, Causes, Diagnosis, Pathophysiology & management. All four types of CJD are discussed in the video.
Thank you for watching! Please let me know what you think in the comments section.
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References:
1) UpToDate: www.uptodate.com/contents/cre...

[@sarairodriguez1254]

My dad is in the hospital now fighting for his life with CJD. This video helped me understand what’s happening with my dad. However, I’m broken right now seeing that there is no cure. I can’t lose my dad.

[@nikhilthakur1518]

I can understand the pain u are going through

[@kassidydavis5565]

My grandma is in the process of getting a diagnosis the neurologist is pretty sure this is what she has but they need a spinal tap to confirm. It’s been 10 months and she is in such a depressing state. Breaks my heart to think this is her future

[@Maardinli]

İ am in same situation like you :(

[@nickolespears]

Hope youre ok

[@judyr5011]

Give your pain and sadness to God. He is with you every step of the way. So is your dad.❤

[@exploding_asteroid]

This and CWD (Chronic Wasting Disease) seem to be caused by the same issue. Even a single prion misfold can cause your entire nervous system to turn on you.

[@mollymc2912]

Exactly. I have an educated guess that the development and spread of these prions through the brain works in an exponential growth pattern. From that first molecule misfolding, the spread of the disease prion is slow, but this rate will increase with the presence of more prions. Once there are enough prions to cause symptoms, the disease is able to progress rapidly, therefore the patient declines rapidly. The rate of progression then continues to increase. I need to do more research, but this is my guess as to how it works based on what I’ve learned so far.

[@ihateeverything9137]

my grand pa died of this disease. He was a vegan and this video helped me understand what are the other causes

[@TinyMedicine]

I'm sorry to hear about it. Glad you found this helpful.

[@stefchris2067]

Did he take other medications?

[@joeysmith7296]

It might have been becuase he had it from genetics or his had it from a protein misfolding

[@Aqui-em-casa-e-assim]

Did he take any vaccine before ? Especially tick born vaccine ?

[@user-pp1bq7pc2d]

is grandpa bad?

[@chrismoore43]

My mother was just diagnosed today with CJD. She is in the final stage of this disease. Thank you for this video!

[@SErdm-ed6bn]

Hello. My mom has just diagnosed by 14-3-3 test was positive😢 what is the final stage? Mine can only see i think and barely open her eyes. She only has her breath and the first symptom was 2 months ago and was dementia😢 may God give peace all ppl with CJD

[@PIFEIGENBAUM.]

@@SErdm-ed6bn is she still alive?

[@geniesis481]

@@SErdm-ed6bnthe final stage is sadly, death my friend. 😞

[@Aqui-em-casa-e-assim]

Did she take Ticovac vaccine ? The one for tick encefalites ?

[@ron3557]

​@@Aqui-em-casa-e-assimvaccines cannot give you prions

[@roku401]

Prionic diseases are the most terrifying diseases... CJD, Kuru, and FFI, possibly others are most terrifying...

[@mook_butt8037]

There are only three transmissable disease groups that actually scare me: prion diseases, hemorrhagic fevers, and lyssaviruses.

[@gabrielsfilms2086]

eh kuru isn't that scary cause you have to do cannabilism to get it so pretty avoidable

[@guysumpthin2974]

Aids , cwd , cjd , all “prions”, prions were “weaponized” long ago

[@guysumpthin2974]

@@gabrielsfilms2086 no, thats just one of the many ways it is transmitted (not the only way)

[@gabrielsfilms2086]

@@guysumpthin2974 im talking about JUST kuru, all the other ones are also not that scary cause its rare (assuming you don't have a family history of it) but they are still scarier than kuru

[@polarskye]

My psychologist died from this cruel disease. So did an ex partners father. Thank you for the video.

[@billybones6463]

I used to be totally terrified pf prions and their concept but their seemingly very very rare incidence rate keeps them sequestered in the book of 'regular' curses and how they can be placed upon you

[@TodosLocosOfficial]

My grandma died from this when I was 10. It was like watching dementia in hyper speed. She was in a wheelchair within only a few months, and only a few months after that she became mute. It only took about nine months for the disease to kill her, and we could only watch as she lost more and more of herself.

[@fallmar05]

It appears my sister has this. Can't get movement specialist appt. No sooner than late next month so technically undiagnosed. Watching her declining every week. Body and mind failing and helpless to stop it. I am mentally preparing for the worst. Heartbreaking. 😢Anyone else going thru this at this moment your not alone. I feel this too. Be strong.

[@cameronfrantz4971]

I hope one day we can find a solution to this awful prion problem

[@shubhsharma7367]

Hopefully

[@arthurnaut-1]

Hopefully.

[@sigiligus]

I hate to be the bearer of bad news, but it’s not going to be cured. Not for at least hundreds of years. Modern civilisation is in the twilight years. Even mainstream sources are now openly discussing the “competency crisis” and the fact that as of Gen Z, the so called “Flynn effect” has gone into reverse and IQ scores are now declining relative to prior generations. Once the boomers and gen x-ers die off, even currently treatable diseases will see massive rises in fatality rates.

[@NyaMartin-db9gj]

They should stop using fetal bovine serum

[@defixnts]

some people have immunity to it mostly the people that were around kuru

[@BigDaddySlightt]

My mother Kim Lockrey just passed away in Petrolia Ontario Canada on Monday September 04th 2023, we just got word from the special autopsy team that this is what she died of 😢 This is two people in my life time that I've watched fade away in The most brutal way, my mom's ex husband's brother Adam Cataldo died of this when I was like 10 or 11.

[@ihaveallergies]

man I’m so sorry for your loss :( yes i can agree that it’s the most brutal way to pass don’t worry bro, you can just remember that your mama and his brother are watchin’ ya in heaven

[@ThePolerbearproducts]

Knew someone who died from this. He had arm weakness so he initially thought it was a stroke. But further testing confirmed it was CJD. He was gone within a month. RIP Jeff.

[@seal1237]

My close aunt sadly passed away from CJD. It was shocking to see how quickly it progressed and how quickly it debilitated her. After her passing, we got a call from the Ministry of Health stating that we had absolutely no choice but to cremate her, which neither we nor most importantly my late aunt wanted. After a lot of begging, they finally gave us the option to bury her as long as she was bolted into a certain metal box that they were going to bring and place her in following the funeral that was instructed to be completed the very next day. It was extremely difficult to plan and negotiate all this in literally an hour of her passing. She's definitely missed 😢

[@Term-0]

I don't know why I got so attached to the fictional character that is Anthony, but I felt really sad for him.

[@ricovelas]

You’re an empath. Research and guard your gift carefully.

[@arunnukala]

My dad was diagnoised with CJB on Nov 8th last year and he passed away on Feb 1st this year. Just 60 days and he was done. Miss him a lot. he was travelling to US to visit my brorther. He was all fine before boarding flight and that was the last conversation we had. 30 minutes before his landing in Chicago , he lost his memories and he doesn't even remember i existed.

[@chsandstrom]

❤❤

[@onefromfuture6913]

Wtf thats brutal

[@onefromfuture6913]

Does it run in the family?

[@arunnukala]

@@onefromfuture6913 no , first time

[@krish-ut9de]

rip

[@lilhomiebro7539]

My dad died from this and he was only 48 😢

[@gen.arnavpoe4633]

I died from cjd ....

[@giovannibarbagallo7723]

Sorry for your los man

[@marcika]

Liar. CJD doesn't exist.

[@suchabadkitty1293]

​@@marcika 👈🤡

[@suchabadkitty1293]

I'm so sorry. Such an awful illness.

[@watermelonineasterhay]

I like that "subjected to an mri" having had one, i can say its very apt!

[@Gsngsngs]

I'm 31 and I'm sick of this crap. First there was a 2-year depression from 2020-2022, and then a bunch of symptoms began. In 2022 the beginning of seeing double. The dizziness that did not go away for weeks gurgled in my ears in the morning. Later, the left half of my face and left thigh became numb. Then I started to lose coordination and strength. In the Romberg pose with my eyes closed, I sway like a spring in different directions. Well, and most importantly, I lose control over my body, as if they are trying to separate my head. It's been 20 months since the onset of symptoms, but I'm still on my feet. As I understand it, young people live longer, but the result is the same. There were difficulties in making a diagnosis, but then neurologists held a consultation and found cortical atrophy on MRI. Everything fell into place. Sorry for Google translator

[@iskra7602]

Years and you think you have CJD???? By the sentences you form, there is no way this is what you have. Do you understand how debilitating this disease is

[@iskra7602]

The dementia is so bad that you might not remember words. In 20 months is too much even for w young person you would be bed bound on ventilator. Look into more common diseases like young onset als, Kennedy disease, chronic ataxia, chronic demyelinating disease, and ecs

[@Gsngsngs]

The disease can progress in different ways. It all depends on the type of disease. I don't know which one I have. It may be sporadic, iatrogenic or genetic. All this determines the duration of the disease. Having studied more than 100 clinical cases from open sources, I came to the conclusion that in young people it lasts longer, with dementia developing in later stages. Neurologists, having studied my MRI, determined cortical atrophy and, taking into account the symptoms that coincide with the course of the disease, they unambiguously identified the disease. This is cjd 100%.@@iskra7602

[@Gsngsngs]

I am aware that most cases of the disease occur in old people. Ataxia, rapidly progressing dementia and akinetic mutism at the end of the disease. In young people, the onset of the disease often occurs without dementia and with sensory symptoms. I even found several cases similar to mine.@@iskra7602

[@Gsngsngs]

I will write all the symptoms in the order they appear. Chronic fatigue, depression, panic attacks, chronic dizziness, diplopia, hearing problems and fear of loud noises, restless leg syndrome. Rigidity of the abdominal muscles (even with an empty stomach it seems like I ate a huge amount of food) Numbness in parts of the body (first the thigh on the left, then the face on the left, later almost everywhere) Ataxia (gradually develops, at the moment I can’t stand on my feet at all with my eyes closed) I don’t know what the correct name for this syndrome is, but I’ll describe it. With severe anxiety, convulsions appear throughout the body, starting from the face and hands. Later it spreads to the entire body. Then gradually control returns. It looks like epilepsy, but I don’t lose consciousness. If you know what it is, write it down. At such moments, I can’t even speak normally because my face is distorted, my muscles harden and contract involuntarily. After sleep I feel better, by the end of the day I feel as if I don’t remember what’s happening around me. I also began to notice that if I see some complex object or if it is far away, it is not easy to quickly determine what it is, you need to look closely and peer, this has never happened before. Well, in the end I will say that my endurance tends to zero. If I used to work 6 days a week and also go to the gym. Now even a walk causes huge problems. After a little physical activity I feel unwell and need rest.@@iskra7602

[@dacisky]

Excellent video. Could you do Lewey Body dementia? My cousin has this and parkingsons. So heartbreaking.

[@TinyMedicine]

Thank you Deci! I'm sorry about your cousin. Will make a video about it. Thank you for the suggestion.

[@visionvixxen]

🙏🙏🙏

[@miggybalba1328]

"If you enjoy this video,..." 💀

[@alishalee1766]

Me: 😭waaaaaahhh!!💀

[@D.Martyr]

This animation is amazing

[@SuperSherwoodfan]

I see great potential here! Great video. A Kurzgesagt style of video and animation, clear and concise narration, good vulgarization. I would have liked to see extra sources, though! CJD is still a very nebulous topic, and medical opinions on specifics differ. Multiple sources and confronting these oppositions in a short and synthesized manner would greatly improve this. Very educational and enjoyable video. Keep them coming!

[@grizzlycmmg9578]

I have a family friend who had a strange case recently. He woke up one morning and couldn’t feel half of his body, normally a sign of a severe stroke, but it ended up not being a stroke. He was hospitalized and shortly after fell into a Coma, since then he’s undergone every test you could possibly imagine, seen specialists, ect and for the life of them they could not figure out what was going on he came out of his coma for a bit but lost his ability to speak and walk,and shortly after fell back into a Coma. Finally, doctors came to a conclusion that he had spongiform encephalopathy and was going to die very soon. As far as I am aware he is still on Life Support to allow his direct family to see him before he goes. What an absolutely brutal disease.

[@patkzy]

ik how u feel i lost mu twin sis to this but she had fatal sporadic insomnia where the prion attack the thalamus

[@user-jd1cg9tv5c]

hi, how old was your sister? how long she was sick

[@sheogorath2721]

I liked the video I’m surprised your channel isn’t bigger

[@aimanadil1317]

Amazing video for medical students

[@bindasschacha370]

On point video for medicos!!

[@AKA_CYBORG]

Best explanation ever

[@jackzimmer6553]

I was informed by the NIHS, back in the 1980’s that some patients who received HGH from pituitary donors (like myself) were diagnosed with CJD due to contaminated storage of those glands. Unfortunately it was reported by a minute percentage of patients worldwide. Luckily I was not in that affected lot but it probably took them several years to pin it down.

[@ganrimmonim]

Being in the UK we got to learn quite a bit about vCJD after BSE jumped the spiecse barrier.

[@monicagonzalez2920]

And apparently about one in every two thousand British people are carriers of the abnormal prions from the beef scandal to this day. And that was found out from appendicitis surgery.

[@DrRoton-ln5br]

Really amazing video! It will help the Medical students more than thousands time read.

[@marinavignjevic9370]

Moja mama je umrla od ove uzasne bolesti. Bila je potpuno zdrava uvek, umrla je sa 67.godina nakon tačno mesec dana od dijagnostikovanja ove bolesti. Oslepela je 10dana u bolnici, bila je u pelenama. Bolest je stravicna. Na kraju je bila u nekoj vrsti kome, hranu je primala kroz nos, nije bila pokretna uopste. Na kraju je umrla bas kao u ovom videu od upale pluća. Svakoj osobi koja ovo prolazi sa bliskom osobom šaljem jedan zagrljaj ❤️

[@ayseerten285]

Was she crying at the last stage?

[@Dragons445]

So i saw an article of a naturally occurring prion anti-body and it's found in four people and they were testing it in a lab with some other phages i hope they find a cure real soon 🔜 don't want to see anyone else suffer😢

[@mahmoodmirza3301]

Thank you dear!

[@sandyjamjom2716]

Thank you very much

[@kristenzuck5134]

I've had so many family members pass of the familial form (23 people spanning 7 generations). I haven't done the genetic testing yet, very nervous to learn of the answers and how that will not only impact my thoughts of the future but also how it may impact my health insurance. Some of my family had huge regrets when learning they carried the mutation and their insurance dropped them. I am so sorry to hear of everyone's loss and experiences in the comments.

[@lucianaromulus1408]

I wonder if preventing procreation even helps, because looks like much of it is sporadic ? There's GOTTA be a source for this.

[@onefromfuture6913]

Why would the insurance drop you?

[@lucianaromulus1408]

@@onefromfuture6913 because of more of a guarantee of needing serious medical attention later in life. It's like if you're a smoker and you have higher insurance than a non smoker

[@onefromfuture6913]

@lucianaromulus1408 fawk that, what scum bags. At worst case they should increase ur premiums not leave you without insurance

[@-SpaceFrog-]

My dad had a patient with this disease and they had to burn all of the equipment that came in contact with it

[@OneManOnFire]

In 2001 my Mom is 51 years old and starts to become weird and would argue with my family. We see a neurologist who diagnose my Mom as having CJD some time in 2007. I'll give you a timeline as i fall into the 1% group who did everything possible. 2002 medical retirement and no longer driving. 2003 staying at home acting weird. 2004 arguments at home 2005 Walking but leaning forward. Able to put on a seatbelt. Ability to ride a subway with me supervising. Fly to another country. Taking medication. 2006 Walking around at night pooping and peeing on the ground. Last time she said she loved me. 2007 More aggressive. Pooping and peeing on the ground. Yelling. Walking skills are not good. Currently using dippers 2008. Same thing but more issues. By late 2008 the first seizure happened and she hit her head on the dresser. No meds for this yet as we didn't know. 2009. She's sitting in a chair as her walking skills are bad. Her ability to swallow food is lost. Multiple chocking events. Feeding tube is placed. Her weight has decreased. 2010. Transitioned from sitting in a chair all day to being in bed but the ability to sit up. Her weight picks up thanks to strictly tube feeding. More seizures are happening. Her eyes are open and she's alert. 2011 Her weight gained back but still the same issues. 2012 Mom is stable but she's showing signs of Alzheimer's as we expected from the beginning. Spent 2 months in a nursing home due to pneumonia. Goes back home 2013 Mom is stable, alert with eyes open, unable to communicate verbally, or comprehend correctly whats going on. She can still laugh and give me a kiss on my check if i ask for it. 2014 Stable but the feeding tube routinely needs to get replaced. Seizure meds need to get bumped up to a higher amount. Lab work comes out fine. 2015 stable but we start to get more of a sleepyhead state. 2016 Stable but the progress downward is showing. Her weight is picking up. 2017 same as above. But now a care giver is brought in to assist. My father has open heart surgery and doing dialysis 2018 same as above but progressively showing a lack of alertness or reacting/flinching to a light 2019 hospital visit for uti 2020 In a sleepy state more often eyes closed. Sometimes wakes up with eyes open and goes to sleep. 2021 progress downward 2022 survivors covid +. We as a family agree to not replace the feeding tube if it falls out. After we replaced it May of 2022. 2023. Sleepy state with eys closed nearly all day. I can still get her to kiss my cheek if i let her lips touch it. May I transitioned to a night shift for work 2pm to 10:30pm resulting in no help from anyone to change her diaper. Yes it was all me picking her up out of bed putting her on a bedside kamode to clean her bottom. I took extra care to ensure she couldn't touch her feeding tube. October 2023 My dad has liver seriouses and ascites. As im changing my mom on Sunday night October 15 she starting leaning forward and the tube fell out. We agreed to not put the tube back. October 29 my Dad throws up dark colored stuff that looks like coffee beans. He goes to the ER well aware my Mom hasn't eaten in 14 days. October 29th 9pm Mom passes away and my Dad wasn't home. Very painful to see my Mom pass away. Despite the Alzheimer's/cjd she started crying at the end. After 20 years of caring for my Mom I had a lot of time to think about what would happen if she's gone. Every situation in my head. I never gave the funeral or burial any thoughts. That was difficult. It cost $30,000 to bury her including the ceremony service. Stressful coming up with money needed, arrangements, life, and everything else. Hopefully this brings some help to someone. Please make your home 911 compatible. You'll thank me later.

[@LyriMetacurl]

Definitely not CJD. Seems like Alzheimers though.

[@terg8472]

@@LyriMetacurl uh huh argue with the neurologist

[@krish-ut9de]

thank you very much

[@patkzy]

I lost my twin sis to this she had prion which went bad she had fatal sporadic insomnia she did not sleep for 5 months

[@ArifulIslam-yt5df]

nice explanation

[@BoyKhongklai]

Awesome stuff

[@imeann...]

00:32 🧠 Creutzfeldt-Jakob Disease (CJD) is a rare neurodegenerative disorder characterized by rapidly progressive dementia, myoclonus, and ataxia. 01:28 🧪 Prions, misfolded proteins, play a central role in CJD. They self-replicate and convert normal proteins into abnormal ones, leading to cell death and disease progression. 02:27 📊 CJD can be sporadic, familial, iatrogenic, or variant, with different causes and risk factors. Variant CJD is associated with Mad Cow Disease and can be transmitted through contaminated food. 03:52 🩺 Diagnosis of CJD involves EEG, MRI scans, lumbar puncture, and the detection of specific proteins in cerebrospinal fluid. Brain biopsies are rarely performed in living patients. 04:49 💊 Unfortunately, there is no cure for CJD, and most patients with the disease die within a year of symptom onset. Autopsy confirms the diagnosis after death. Harpa AI

[@ni_wink84]

You have way too much time on your hands to make a comment like this, maybe out that effort into something worth while

[@John-bv2ft]

Well made

[@ContextSwitch]

underrated video

[@gluonic]

it's a good explaination. I wonder how many people came from the project called "vCJD".

[@alepherrorcode404]

This. Needs. More. Views.

[@rebeccawspanogle4275]

We just found out my brother has CJD I AM so heartbroken right now.

[@Jaysen6740]

So sorry to hear it.

[@McWheeler93030]

My dad died of this at 56 but we saw symptoms 10 years earlier

[@Kajimityphoon]

im sorry for your loss.

[@McWheeler93030]

@@Kajimityphoon thank you

[@jonashjelm6804]

Sorry for your loss. I note thats an exceptionally long period of time cause people usually die within a year.

[@sarairodriguez1254]

My dad just passed away a little over a month ago but I saw symptoms years before also. There has to be a way to detect it sooner.

[@ayushkumarjha9921]

​@@sarairodriguez1254 That's sad. How he got CJD.?? Is there any family history ?

[@user-jp4tl9zd8n]

This is in my sister late husband families members had this happen to him. Deadly 🤢⚡ condition.

[@drashtysatani8200]

Amaazingggggggg explainationnnn❤

[@michelleoraboni8474]

My brother passed at 62 of this horrendous disease

[@vincentm.7462]

Sorry for your loss my friend’s father passed of this at 62 as well. He was gone in three months so sad

[@nabilajama9561]

Do you have the script for this video

[@marppramthegodofdestruction]

It’s strange that this got recommended to me after I listened to the Vcjd album

[@P.H691]

My aunt might be diagnosed with CJD. I hope it isn’t this disease, but if the worse thing we fear, we will all do our best to let her last time here be the best.

[@fallmar05]

I hope your aunt is spared from this villainous disease but should she be not you have my absolute empathy. My sister just passed from almost certain CJD yesterday and I know your journey that lays ahead of you. Give her all the love and happiness you can for the "emotional" trial ahead will heartbreaking. Be strong. I am still raw in my loss but know that someone truly understands your fears. Embrace her throughout this journey.

[@mattgray666]

What membrane proteins are specifically being misfolded?

[@geeteevee7667]

I found this by searching its name “vCJD” when I was looking for videos on the album from The Patients

[@Lukesharmofficial]

Same!

[@Oshic1273]

The funni prion album

[@The_Variables]

@@Oshic1273 The Protein infection album

[@Sophicals.]

My mum just got diagnosed with this.

[@Mac-tz4wn]

Can you prion disease be transmitted through working with cadavers? If your handling a cadaver brain and dont take the proper precautions in hand washing or not touching other surfaces

[@theholysynopsis5100]

Prions can only be transmitted through ingestion. If you ate the brain you’d be at risk.

[@Eosinophyllis]

Yes* *you would have to make a lot of mistakes to do it, but it’s theoretically possible

[@theholysynopsis5100]

@@Eosinophyllis damit what kind of mistakes? I am pre med and I don’t want to keep stressing about these things.

[@Eosinophyllis]

@@theholysynopsis5100 basically just don’t lick your surgical equipment or reuse it, you should be fine.

[@aluminiumknight4038]

@@Eosinophyllis it's hard to not taste all the brains

[@p.vamshikrishna8144]

My dad is in KIMS hospital ICU diagnosed with CJD Pneumonia is attacked😢

[@Game-dx3cc]

Any idea which variant he has?

[@kellypawspa]

I had watched another video on the topic of fasting, they claimed that after three days of not eating food, your body will begin to eat the improperly folded proteins in your body that are cancerous or may cause it. I wonder if it would cure this as well, since the pathology of it is to cause your proteins to improperly fold similarly?

[@Kibinishi]

That’s misleading.

[@joelmartindominguez8273]

Why? Sounds logical ​@@Kibinishi

[@dragonfire3727]

​@@joelmartindominguez8273they are basically immortal

[@addictedtocheese3688]

Prion disease is scary and very interesting at the Same Time.

[@prostatecancergaming9531]

New kurzgesagt just dropped

[@heavenburke]

I thankfully will never have this none of my surgeons had it

[@gyanrahashya6416]

Earlier I used to think that prion disease only occurs when cannabilism is practised or someone eats prion infected meat

[@khushimyway]

My father is suffering from this problem & at that time he is not able to open his mouth for food.. he is permanently on the bed 😢

[@Aqui-em-casa-e-assim]

Did he take any vaccine for ticks ? Prior to that ?

[@Hi22213]

What symptoms your father had? My father is also admitted and doctors think that he also have CJD.

[@terg8472]

@@Aqui-em-casa-e-assim what does that have to do with cjd? if you're an antivaxxer, prions and the way that vaccines work have nothing to with eachother

[@busraersoy7638]

@@Hi22213can we speak this situation? My dads same situation

[@Teja0._]

Permanently means for how much yrs or Month they will stay on bed

[@alepherrorcode404]

50K views to 90K views? Thats even more quick.

[@simplyharkonnen]

Fantastic video! Odd question from a layperson, but could it be argued that Alzheimer’s Dementia could be considered a prional disease because of the self-replicating behaviours of Amyloid Beta and Tau Protein, or is the prional classification specific to malformed PrP variants?

[@simplyharkonnen]

And an additional question, if you’ll indulge me- do you consider “Kuru” a separate illness from CJD? I don’t see any real valid reason to do so, but I’d love to hear your thoughts.

[@monkeybundi]

I'm not the video creator but I believe a disease has to be specifically caused by malformed PrP to be considered a prion disease, otherwise it's just a disease caused by protein misfolding (e.g. Alzheimer's).

[@violet4481]

@@simplyharkonnen I did research on this topic around a year ago and wrote a paper for my college publication. Your argument for Kuru being similar to CJD has weight. The Kuru prions PRPsc are the same as the ones in CJD, however this is different from vCJD. As for Alzheimers, while we do have promising data to consider it a prional disease, we can not confidently declare prions as the causative agent for it just yet. More research is being done as we speak on relating prions with alzhemiers, lewy body dementia, parkinson's disease, and some other neurodegenerative disorders.

[@stefanostokatlidis4861]

Most forms of neurodegenerative disease are in a way prion diseases. They just have a slower progression and low transmissibility. Still, they have been transmitted by extreme methods, like intracerebral inoculation of test animals. Researchers on this field is slow, and I believe that the implications are too severe and funding is restricted due this. Kuru is a traditional term for CJD and it is believed to have started from a single case of sporadic CJD.

[@monkeybundi]

kuru has different clinical presentation to classical cjd i believe. also misfolding protein =/ prion disease. prion disease involves the specific prion protein.@@stefanostokatlidis4861

[@prototype795]

There's some silver lining though, a breakthrough has been made to extend the life of mice infected with with prion diseases similar to CJD. They now just have to figure out how to make this treatment work on humans.

[@BlissBee]

4:49 bro looks way too happy about it

[@cynical-4649]

why are prions so difficult to "kill"? I read its because its stable but what makes them stable? Also i really wonder how spontaneous cjd can just form from no where? And how does eating it make it end up in your brain?

[@lonelyelectron5283]

our cells actually capable to deal with misfolding protein like prion even if they are pretty stable, so yes our cells capable to destroy prions, but reason why it isnt is multifactor, mostly its because our cells doesnt recognize this harmfull protein as a threat or our immune system not responsive to it, immune cells usually not respon or triggered to many type of neuronal proteins like tau protein, etc, but theres still atempt and onging research to cure it This one as example and it sound promising kzbin.info/www/bejne/r3bRfGx3nJeLl9ksi=Z-yHOYOMitkQPa43

[@wagoni3505]

I am by no means an expert but I believe it's their geometric shape, the same thing that makes spider silk stronger than kevlar, despite also being just a mesh of proteins. Prions have a unique 3d shape which makes them exceptionally durable and stable. The PrP protein has two forms, the regular non-pathogenic one is the form that the body manufactures. But unfortunately, it isn't the most stable one (lowest energy state). It has a second, more stable form which it can acquire spontaneously, the prion. My interpretation of why this happens is because the process of manufacturing proteins by the ribosomes isn't perfect and generates defective, misfolded proteins all the time, and due to probability it only takes one off chance for them to misfold a prion into existence while creating a PrP protein. What makes it stand out from other defective proteins is that it's stability allows it survive the enzymes that the cells use to dispose of such proteins. How it "infects" other PrP proteins is mostly speculation. But, the key thing to remember is that prions only convert/misfold other PrP proteins, which is why I believe it's again due to their stability, prions can somehow incite them into also acquiring the lowest energy state like themselves, because everything "wants" to be in it's lowest energy state. This is kinda similar to strange matter. Notice the use of the word "fold" so far, this is important because in proteins, the way they are folded determines their functions. If they aren't folded correctly, it may hinder their ability to function or make them harmful to the cell. Sickle cell disease is also caused by a misfolded hemoglobin protein that binds together in large chunks, deforming the cell. Misfolded PrP protein has similar origins but its abilities to convert other PrP proteins and immunity to enzymes makes it very dangerous. When ingested, stomach acids fail to break down prion back into amino acid due to their durability. After this, prions just linger within a person's circulatory system, as PrP proteins are mostly found within the brain and the nervous system, floating freely without much to infect. It's once they breach the blood-brain barrier that they begin to cause a lot of harm all at once, this is possible because of their small size, as individual prion proteins tend to be smaller than even viruses. In the brain, they misfold regular PrP proteins and form large aggregates that disrupt essential functions and trigger an immune response which isn't able to achieve anything and merely cause more harm. The only enzyme that I know of that can destroy prions is keratinase, from a bacteria. Humans and other animals got nothing to get rid of the aggregates and can just wait for death at that point.

[@fannyalbi9040]

@@wagoni3505can this keratinase pass bbb?

[@supimkfc]

well the prions go into ur bloodstream when u eat it and it reaches ur brain. idk if I'm right or wrong, this is just what I heard

[@terg8472]

i assume they rarely are deformed when they are formed kind of like a cancer

[@WhatWouldVillainsDo]

I just found.out there have been cases of this being spread by wholw blood transfusions Im not a doctor but I am a meat cutter-butcher and this scares the hell out of me. It use to be just the brain and spinal tissue we had to worry about but if its in whole blood its going be in other tissues.

[@user-bs1dk3tz8g]

interesting 🤔

[@nightshadeaudios]

Omg my dad's friend just died of this 😢

[@zingerman11259]

Wait what about not being mobile gives you pneumonia???

[@hmgrraarrpffrzz9763]

Well, if you don't move you take more shallow breaths for a long term. That means that mucus isn't cleared that easily from the lungs and that increases the risk of infections. Coughing while lying is also difficult.

[@darkgodxyt1182]

My dad have this disease at age of 52

[@nikhilthakur1518]

My mother died at the age of 49yrs 10 months

[@noorlita]

Sorry for your loss man

[@soniaghosh601]

She is too young.. 😢 Hey .. which year she died ?

[@nikhilthakur1518]

@@soniaghosh601 May 2022

[@soniaghosh601]

@@nikhilthakur1518 I think you are also young now ?

[@nikhilthakur1518]

@@soniaghosh601yes i am 28

[@fezza4k]

Lost my sister to nv cjd at 18 years old :(

[@winske6093]

I’m so sorry❤

[@user-jd1cg9tv5c]

please tell me how long she was sick?

[@otam700]

What does nv mean in your comment

[@fezza4k]

It's all gravy boat...been a looong time... I believe v cjd is variant cjd and nv cjd is new variant... But I could be off.. essentially cjd hits older generation the vcjd is for middle age and nv cjd is for 16 up

[@otam700]

@@fezza4k ok thank you

[@thylacine622]

Can’t you get this via cannibalism alao??

[@stan3449]

if you eat the spine or brain of someone infected then yes

[@agentepolaris4914]

Yes

[@Himeko-astral]

You could. With also Kuru.

[@agentepolaris4914]

@@Himeko-astral only if you eat the brain or nerves

[@akadnb4592]

Not really. That would be kuru.

[@MonicaPinto-ic6cb]

Mi padre tiene esta enfermedad hay cura si o no

[@Mau365PP]

No

[@Aqui-em-casa-e-assim]

Yes it is possible to cure . Search for dr Jose Nasser in Brazil.

[@Lodada]

Aot when they hear spinal fluid

[@keerongill7310]

I ate a fresh spawn and im looking on how to cure my curo , hahahahaha

[@UrLoCaLWeIrD_GiRl]

Free

[@tom-ke7lb]

hillary clinton has similar symptoms.

[@leemin3243]

اهلا لقد اصبت بهذا المرض منذ شهرين .حيت عضني قط وذهبت لاخذ لقاحات عديدة لعدها بعشرون يوم اصيب نصف جسدي بتقل وتنمل عملت اشعة مقطعية ولا يوجد جلطة تم بعدها بيومين في الليل احسست بشيء يهجم على جهازي العصبي افقدني النوم نهائيا تم احسست كان كتلة خلف راسي تتحرك مع تحريك راسي وتصيبني بقلق شديد لا يحتمل اصيح وامزق ملابسي من القلق والهلع اخذت ادوية نفسية للنوم ولاكن تلك الكتلة المشلولة في منطقة المخيخ لا زالت انهض في الصباح مشلولة وا قلقة جدا اصيح وابكي اصبحت لا استطيع مغادرة فراشي ولا اكل لان عند الاكل تسوء حالتي واثاب بالقلق وايضا اصلحت انسى كتيرا وفقدت الوزن انا حرفيا اختظر . لم اشخص بعد لان في بلدي المستشفيات بالواسطة . العن اليوم الدي اخذت فيه اللقاح انا اعيش الجحيم كل يوم كاني في كابوس ولاكن لا اصحى منه الا بموتي😢. وانا متاكدة بان اللقاحات فيها بريونات وان كل بروتين دخيل على الجسم يصبح بريون لان ليس له انزيمات تحلله ويلتسق بالدماغ مما يسبب كل هذ العذاب 😢 انا اسفة لانه رغم التطور التكنلوجي الا ان الطب لم يتطور بل الادوية واللقاحات هي من امرضتنا .

[@INVALIDZEROTheTitSucker69]

إنتي حالتك إيه دلوقتي؟ و مشكلتك أكيد هي نفسها المشروح فالفيديو؟ غلط إني بحاول أسئل؟

[@eua4808]

So just like caner but 100% more harder to live

[@TANSZ548]

tso this how u get familial fatal insomnia?? so scary

[@include-bit]

No. You can get it any second Even now ehile ur reading this

[@TANSZ548]

@@include-bit😦😦😦😦😦😦😦

[@Oshic1273]

​@@include-bithang on I remember you from the minute earth comment sections... Hello fellow troll

[@infinityzer054]

Rebellion who?, for who?

[@jazz-sn5np]

So is CJD dementia but 100% uncurable

[@user-xr4jk6oe4g]

Dementia is uncurable too

[@ramimohammed3132]

If you enjoyed the video.... 🤣🤣🤣🤣

[@sislertx]

Man..i been complaining of these symtoms for a out three weeks...its just got worse...

[@ieatmoney]

Go to a doctor

[@ndownman]

I'm a doctor, I recommend seeing a doctor

[@serialpablo]

update?

[@patkzy]

@@serialpablo its to late!

[@Hi22213]

Any update?

[@lizichell2]

A most putrid of maladies

[@TheZeyon]

and here I thought rabies was the most terrifying disease 😧

[@yeoweehuathuat8926]

It come from meat beef

[@scatdog1]

Did I notice any abnormalities ?? Well yeah the whole thing look’s completely abnormal.

[@animefan3320]

I came here cuz of Batman Arkham knight

[@Lladz171]

👀🫁

[@9x177]

I cannot watch this my name is Anthony bruh 😂😂😂

[@ndownman]

Damn that ataxia walk fly. Bet it would look good in some baggy pants

[@Webkins9009]

😭😭😭 bruhhh

[@ni_wink84]

Mad cow disease blame the UK for this

[@aysnov]

This disease really is a multifold problem

[@Stayhappy25]

5:12 NO I did not ENJOY this video as My dad passed away. A lot of people here are the patients or the families of patients who are watching this with tears in their eyes. So no I didn't enjoy and from next time change your script for such videos. And be aware of what you are posting and writing for such fatal or any diseases because no body and I mean NOBODY enjoyes these kind of videos not even medical students and not even pharmacists. Some people can watch it for information purpose but they also get sad seeing how fatal the diseases are. This is not the place or channel which can be ENJOYED, watched while eating chips or made fun of. I hope the creator can understand what I mean. Do change your script for next videos. Only the families that have seen the death of their loved ones can understand what pain I have gone through.

[@terg8472]

i understand you're upset about your dads death. but what he means by "enjoying it" is if it was informative and was helpful

[@azzounefella6259]

Only people living the same situation can understand how hard is this disease, seeing your mother dieing but you can do anything or even help her I am actually living that and just still can't believe or figure out the whole situation 😢😢 may Allah gives us the strength to continue...

[@happyundertaker6255]

Mad cow disease

[@TinyMedicine]

CJD is not madcow disease. But they are both prion diseases.

[@adailyfact]

We have found that there is a strong link between vCJD and BSE, so perhaps the prions that cause BSE when ingested and in the blood stream of humans cause vCJD in us.

[@General_shit_sound_effect]

Mad cow disease is called vcjd and it's when you eat an animal which suffered from CJD transfering it to you

[@roku401]

It's technical name is Bovine Spongiform Encephalitis...

[@ruvanefriebus-cv6td]

Don't eat raw brains shellfish or engage in cannibalism