Cyclodextrin | Inclusion Complex

[@GurcharanGarcha]

Can you take cyclodextrin for plaque removal in coronary artery disease

[@prajnadutta4065]

👍 full of information... great 👍

[@PikaiPharmacy]

Thank you 🐰

[@luckspell]

Can you take Cyclodedextrin for cholesterol?

[@Rushesweet1]

Big thank you sir.....i needed this for a food chem course lol.....

[@justingibson8788]

great explanation! ive been doing research on cyclodextrins because i intend to try and complex beta ecdysterone. would you mind a question on easy methods of achieving this? would simply mixing both at a 1:1 ratio in water suffice?

[@laststandns5373]

According to a 2018 study (and mainstream ecdysteroids) all the efficacious ratios are 1:1. Furthermore, all methods of mixing (manual, solution) are shown to be effective. However, the only process so far that actually forms a complex is by mixing ten compounds in water, and then freeze drying the solution. Hope this helps!

[@ojpimpson3343]

Did you ever figure this out???

[@larrytate1657]

@@ojpimpson3343 is hydroxy propyl cyclodextrin safe orally? Cause I saw a study showing when injected it caused permanent hearing loss.

[@ojpimpson3343]

@@larrytate1657 Yes its shown to he orally safe in humans. In mice is where that hearing loss study occurred but present day b cyclodextrin is in a lot of medicines.

[@larrytate1657]

@@ojpimpson3343 thanks it was shown In cats too but I think it was high doses and injected.

[@somesumm2501]

Great explanation about CD's!

[@alphagonist4748]

After a long time❤️🔥

[@PikaiPharmacy]

Yes

[@alphagonist4748]

@@PikaiPharmacy I was watching your videos from 1st sem...now I'm in 5th semester

[@PikaiPharmacy]

Thanks a lot bro, it's means a lot to me. ♥️

[@АняВасютина-т8ч]

Hi! Can you please explain why beta is less water soluble then alpha?

[@exvlica5150]

it's because of the intramolecular hydrogen bonds between secondary hydroxyls, reducing the possibility of hydration with the surrounding water molecules.

[@exvlica5150]

BREWSTER, M. E.; LOFTSSON, T. Pharmaceutical Applications of Cyclodextrins . 1 . Drug Solubilization and Stabilization. Journal of Pharmaceutical Sciences, v. 85, n. 10, p. 1017-1025, 1996.

[@АняВасютина-т8ч]

@@exvlica5150 But those bonds exist between all cyclodextrins? Not only beta.

[@exvlica5150]

​@@АняВасютина-т8ч Hi friend! Please read this article, will help you to understand. It's because of the conformation of the structure too. Have a nice day! SAOKHAM, P. et al. Solubility of cyclodextrins and drug/cyclodextrin complexes. Molecules, v. 23, n. 5, p. 1-15, 2018.

[@pallabidutta940]

Will be very helpful. Thank you 😊

[@PikaiPharmacy]

Thank you 😊

[@kalpanakumari5027]

Thankyou sir

[@krane15]

You accent made it a challenge (I'm not a scientist). But the information was so useful I stuck with it and made it through. Thank you.

[@kollibalakrishna314]

Thank you sir

[@shavyboy3450]

bhai ye video hamare zoom clas me play hua