David Baker (U. Washington / HHMI) Part 2: Design of New Protein Functions

[@scicommlab]

Congrats to David Baker who just won the #nobelprize2024 "for computational protein design" with Demis Hassabis and John M. Jumper "for protein structure prediction!" We have several #iBiology talks by David Baker in addition to this one. Check them out on our website: www.ibiology.org/speakers/david-baker/

[@amirsafari7140]

It's been 4 years that I'm studying mechanical engineering,but now I've fallen in love with proteins and dna and etc,

[@josephcoon5809]

It’s the same thing, only on a smaller scale.

[@elliemartin6503]

This guy is so cool!! Always appreciate talented researchers who know how to communicate their work clearly!

[@tessalittle6244]

LOL love the climbing analogy - am one myself and loved my days as a protein folding functional scientist that went into redox systems biology

[@TheZenytram]

this so fucking cool, i wonder how much this topic has advanced since then

[@dc33333]

Wow this is a fantastic lecture. Everyone should see this.

[@alimobedi1399]

Wow!!! I am just truly fascinated by the amount of work and research that has been invested here! Thank you for the great lecture!

[@yarkkharkov]

The 3d shape on 19th min is actually a dodecahedron, not icosahedron :)

[@StewartChaimson]

So fascinating! Thank you for making this lecture!

[@MolecularAnimationsoftheCell]

I really want to create new proteins xD

[@pratibham4154]

Hi, I am Pratibha from IITH. I am curious to learn nano cage protein designing. Can you share some information about this.

[@lumpyspaceprincess6335]

Let's assume i designed a protein with alphafold2 that recognizes a specific ligand, how to check it if it's working?

[@TheBiotechInvestor]

Very interesting challenge

[@Leyshire]

Incredible!

[@CristalMediumBlue]

Amazing

[@yapunijo4925]

Genius David Baker xoxo .. I wish to work with him

[@0xoRial]

5 years later doctors keep telling me there is no treatment for flu...

[@TheHuesSciTech]

From concept to commercial pharmaceutical can take 20 years. (And before you say, "what about the coronavirus vaccine?", that had billions of dollars poured into it, and was built on research that had been happening for years before.)

[@pieterduplessis6632]

Wow!

[@oberguga]

Did they research this new materials for it electrical, thermostability, chemical activity, optical and mechanical characteristics? Maybe it can be usefull for some nonbiological application? For example lubricants, fiber, flexible electronic, electrodes for implants, micromechanical systems and so on. Looks like potentially very useful things even today. Give the samples to physics))

[@quintonwilson8565]

Designing materials with certain physical properties would probably be even more difficult I'm guessing--although protein structure is already insane.

[@hubijohn7451]

'Viral epidemics' WHAT DID YOU KNOW haha

[@josephcoon5809]

7:30 What if you designed a single protein that docks and goes through a conformational change once docked that creates the same dock on it. The new dock would attract another of the same protein which would go through the same conformational change creating another dock. This would reduce the number of proteins required to one while allowing you to modify the dock and proto-dock while keeping the mechanism binding the two intact. 23:30 “Not for bad purposes…” If only intent were enough. 23:00 How about a nanocage that encloses an E. Coli bacteria modified to create insulin? The cage would allow resources to reach the bacteria cells, but would restrict the space in which the E. Coli can multiply within.

[@vigneshs5286]

Wowwwww

[@christophiano10]

1:54 well..................