Lifespan: Why We Age-and Why We Don’t Have To

Lifespan: Why We Age-and Why We Don’t Have To
Featuring Dr. David Sinclair, professor of genetics at Harvard Medical School and author of “Lifespan: Why We Age-and Why We Don’t Have To.” Dr. Sinclair explores the research that is pushing the boundaries of our perceived scientific limitations, revealing incredible breakthroughs that demonstrate how we can slow down, or even reverse, aging. He also delves into emerging technologies and simple lifestyle changes that have been shown to help us live younger and healthier for longer. Presented as part of the Murdock Mind, Body, Spirit Series.
About the Aspen Institute:
The Aspen Institute is a global nonprofit organization whose purpose is to ignite human potential to build understanding and create new possibilities for a better world. Founded in 1949, the Institute drives change through dialogue, leadership, and action to help solve society’s greatest challenges. It is headquartered in Washington, DC and has a campus in Aspen, Colorado, as well as an international network of partners. For more information, visit www.aspeninstitute.org.
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[@xuxiaohong888]

I have followed Dr. SinClear’s protocols over 6 years which turned my health span around. I am 61 now, but my appearance & energy back to my youthful form of myself 👍

[@joeschnur4632]

Saying the world was round sounded crazy. Saying we can turn back aging sounds crazy. Someone has to lead. The future will thank David

[@079Francvs]

the future will thank yamanaka, he's the root of that discovery and many, and then to the sinclair work and its students... but yes is crazy to listen that. Start planning your life from now to 300 years old lol

[@henvest3491]

Steven Hawkins said in a space documenty he beilved humans will extended life span a must for space travel. So absolutely beileve it is possible. I also beileve AI is essential in speeding up the discoveries.

[@robertt7002]

And yet.... he keeps hedging and downplaying the arrival of an actual age reversal treatment? Is this all just flim-flammery? I agree that the treatments for specific ailments are great, but let's face it. An extra five years? I'm not here for that. I'm waiting for full body regeneration. Otherwise, even with treatments for the ailments of aging, it's still suffering. I hope the governments/corporations aren't slowing this down. Hope I'm wrong here. Fingers crossed. If David is looking for volunteers for total body regeneration, I'm here dude!

[@bhvnraju8493]

Brilliant talk on longevity, we are glued to your insights Mr David, Hoping every positive change happens soon for the betterment of the Humankind in curing disease 👏👍

[@mikeghafoori8227]

Thank you David for your service it’s the best work you’ve done

[@sinagtalamalaya5392]

David Sinclair is heaven sent.This world needs people like him.🙏🙏🙏

[@jds02153]

The world already has way too many fraudsters. We don't need more like him

[@JackZhou-ix9um]

You are a victim. What a shame

[@PoliticsLost]

I think David could reframe his aging car analogy to say "aging is similar to the wear and tear on cars, except the mechanic tasked with repairing it gets progressively worse at keeping it running." Another way you might frame it is "aging is like having a car where wear and tear outpaces the ability of the mechanic to repair all the problems."

[@kimpedersen7780]

Thank you so much for the great info! I'm always glued to every single video that I can find with you. Always looking to get more educated on longevity and improving health . Even though we know what is best, it always helps to hear different perspectives and insight

[@chanyh8643]

When I hear the article reveals the optic nerve regeneration at 2020, now 2024 nothing is in progress.

[@clearpupil]

At last the update on modern longevity research we have been waiting for. David proves time and again that he is at the cutting edge of a dynamic area of science and technology. I’ve had some of my best years since starting nmn and Resveratrol but still cannot say whether they had any effect at all. Maybe it was my will to live and enjoy life that made the difference. I do notice how many commentators are citing religious ideas which is quite interesting to me as a clinician. Placebo is a powerful medicine and even to ranking medical advances struggle to compete against the placebo effect.

[@markusheimerl]

These are the conversations that we need to have. Thank you for inviting Dr. David Sinclair.

[@shinkurt]

Stop inviting scammers

[@markusheimerl]

@@shinkurt What makes you say that? I am honestly interested in your experience here.

[@Jessica-kk1cz]

People who say he is a scammer clearly are not Biologists, let alone geneticists. I don’t take medical advice from my plumber either.

[@Len1977gt]

@@shinkurt you are just mad because he looks better than you

[@Rafa-pf7kz]

@@Jessica-kk1cz Isso não tem relação alguma com conhecimento em biologia, mas com indicações e escolhas dele que mostraram, acima de tudo, um absurdo interesse econômico. Basta pesquisar um pouco. Não se deixe cegar por exageros ou generalizações. Ele tem suas qualidades e méritos, mas já fez escolhas extremamente estranhas...

[@hasdrubanapal]

THE BEAUTIFUL OF KZbin IS THAT HUMANS CAN TELL...WHO HAS THE MIND TO SEE...IT WILL BE HELPFULL. BY THE WAY....PHARMA.. SYSTEM...WILL NEVER ALLOW KNOWLEDGE....IT IS ABOUT MONEY...

[@1timbarrett]

As I watch this video I will look for robust evidence to support the notion that we don’t need to age, from which it should follow that we don’t ultimately need to die.

[@msplateaugal]

I am intrigued by your current work, Dr. Sinclair. You have survived controversy before and can do it again! My mathematics PhD adviser Christopher Zeeman taught us that you need 17 ideas before you get one that works.

[@xuxiaohong888]

Thank you Dr. SinClear for the insights

[@goodphone156]

David I am your fan !

[@senaitmebrahtu848]

Believe it or not , science has limitations. But breakthroughs do happen ( electricity, insulin , etc ). With diligence we may solve alot of situations we were once challenged with. I hope so!

[@Den-c5d]

I'm grateful to David for drawing my attention to longevity field, although he is full of BS ;)

[@ottobrito1352]

This was Great! Thank You!!!

[@mbtmlawyers7903]

❤ Thank you David for your work, you are a great being.

[@fakhraddinghahremani9272]

❤🎉

[@msplateaugal]

NMN has improved my vision, solved my congestion problem at night, and given me more energy. Others should know that my chronic congestion vanishes for the night if and only if I take ½ gram of NMN before sleeping. So I take ½ g sublingually in the morning, ½ g 7 hours later and another ½ g 7 hours after that. This has greatly improved my sleep!

[@JICKY2.0]

placebo

[@JackZhou-ix9um]

who knows if you are telling lies?

[@craigrobinson4526]

If I'm taking some supplements recommended to work by one study, is there any point in adding others recommended by other studies or would there be diminishing returns to adding things which probably act on the same pathways?

[@clearpupil]

Good question. And I think you’re correct. Some of these supplements rapidly reverse biological age by 5-10 years. But there are factors like illness, stress and prolonged bed rest for any reason that will increase biological age by up to 30 years. So it is an equilibrium not a one way arrow backwards and as you say, diminishing returns.

[@capgains]

What happen to Sinclairs reputation lately?

[@JICKY2.0]

that in the end they only sell useless or harmful supplements and die like the others, Musk is right about it Sinclair has today only a "social" reputation

[@jeffersonveloso112]

Dr. David, parabéns pelo seu trabalho e pela sua coragem em enfrentar a bigfarma. Eu acredito em você e tenho seguido o seu protocolo.

[@travisjewell8607]

He is great.

[@vickybiagini8623]

Can't believe it has been eleven years I have been listening to David, and nothing has come to fruition. Now my whole family has died, and at almost fifty I am next. Our lives are literally a blink, then we are gone. It is amazing how fast we all die. God rest all the souls that have passed.

[@silence8806]

"God"?! If there is any hope for what you describe in the future, then it definately is not to be found in religion. "Religion poisons everything" - Christopher Hitchens

[@vickybiagini8623]

@@silence8806 , Are you sure that man doesn't poison everything? God most certainly exists, but we can't fault him too much for not stopping at animals, and creating humans. David will never save you, but Jesus Christ dying in the cross most certainly will

[@silence8806]

@@vickybiagini8623 Have you ever thought about the possibility, that ideas can poison the mind? Is that so far fetched? And is that "man" or is that the ideas that poison "man"? There is zero evidence for any of the thousands and thousands of gods than humans invented for all kinds of reasons. And the ancient idea of the blood sacrifice, which is only one of several bad ideas in your religion, is deeply harmful. I suggest to seriously look into the arguments against religion.

[@lamb-in-Christ]

Amen

[@silence8806]

@@vickybiagini8623 The very fact, that you even ask this question, shows that you have not the slightest idea, what Christopher was talking about. "Man" is the host of ideas and can therefore never be the poison. And Christopher even talked about the ethical problem with the religious idea, that an all knowing God creates a flawed being to then punish it generation after generation, for that very error. Only religious people don't get it.

[@betterstanding5186]

Aging disturbances run riot if lifestyle allows for it. Behavioral changes = ‘rebooting’.

[@longevity-gene]

We all want to live long, healthy lives, and most of us can. But some of us have genetic hurdles to overcome. I found out through GBinsight’s Longevity100 test that I have high Lp(a), which significantly increases my risk for heart disease. Knowing this, along with a family history of heart attacks, means I need to do everything I can to stay healthy, like not smoking, staying active, and eating well. I've talked to my doctor, and now we have a better understanding of my risk so we can take extra steps to keep my heart healthy.

[@megan_kal]

I had this test done too and my doctor found a genetic mutation causing me to hyper-absorb cholesterol. It means my body isn't clearing the cholesterol I ingest from my diet, so it was accumulating in my blood. I found out I could easily change a few things in my diet and reduce my cholesterol levels significantly. Didn't have to be on meds. This probably added years to my life since I am in my 20s and making big changes.

[@brians5088]

Q: How to help the poor with equal ability for aging healthy? A: Do not take available molecules like MNM and try to restrict it with a trademark for your own profit...David.

[@MubarikSaleem-tz5ez]

I think he is a fraudster. I am listening to him for many years now. He keeps on changing his story and making millions for himself

[@Len1977gt]

you are just mad because he looks better than you

[@sandybayes]

I don't have any symptoms for a prescription so what do I do to get something for my aging? I'm 82.

[@darwinmonzingo9738]

we don't age and loose cellular energy we loose cellular energy and age. repairing mitochondria damage the metabolic disfunction from oxidation is essential for reversing the signs and disease of aging

[@susymay7831]

Timestamps would help your nice videos ❤

[@hugoq4335]

He looks his age.

[@TheDeadSpeaking]

Yeah 5 years younger at best

[@ronaldrt]

Majority of those near his age are grey!

[@ThinkingDN]

Yeah age caught up.

[@SilverFan21k]

Was this recent?

[@SoulRoh]

He somehow looks not healthy and like he feels physically uncomfortable.

[@Len1977gt]

you are just mad because he look's better than you

[@jds02153]

known side effect of combining botox and NMN

[@GeorgiosAndreasIoannou]

seize the day

[@Telecom515]

He looks pretty good for a 55 year old… he is doing experiment on himself and we wouldn’t know if he lives to a 100 because we are normal people and eat a normal diet, and exercise like a normal person and become an average life expectancy statistic…

[@tullyendicott6700]

MAYA - Where can I get the hat? You could fund the research just from hat and tee-shirt sales.

[@romescala_aban3125]

Pls review Dr Brad Stanfield's opinion on this .you will know more ..it's an eye opener...

[@danielgranath2348]

Stanfield is a fake with a huge ego

[@romescala_aban3125]

@@danielgranath2348 even then there's a lot that Dr Sinclair claims to be verified ...he's not a medical doctor , his claims based mostly experiments with rats , were humans ..& his anomalies with a drug company ...raking millions of dollars , etc ...

[@romescala_aban3125]

@@danielgranath2348 he's not a medical doctor..you have to have a well rounded investigative inquiry about certain Dr Sinclair's credibility ..search for other people's opinion on Dr Sinclair's claims ...

[@romescala_aban3125]

Also read Scott Carney's review on Dr Sinclair case with glaxo drug company

[@nesdi6653]

regenerative medicine operates at the macro level not at the DNA level

[@gqas1247]

Okay so what's the solution to the longevity that Sinclair is talking about?

[@LuciousKage]

This Guy is all talk, no peer review, no proof. ... Show me mouse that lives 5 years, thats when i get interested.

[@EmreSenSecrectOfMusic]

Dont rush him..He seems to be on the right track

[@LuciousKage]

​@@EmreSenSecrectOfMusic I actually remember him from his first tv appearances like 15 years ago ? ... There is NOTHING that he actually put out there that moved a needle i would even say. look into his 2010 resveratrol backlash and other claims of amaaazing molecules. and what... where are the Mice that live 5 years ? or ANY extension proof ? He never cleared any peer review, and stays aways from anyone who can challenge his methodology from what ive seen,

[@EmreSenSecrectOfMusic]

@@LuciousKage he sort of mentions his precvious claims on red wine, etc.. but I hear what youre saying. Still, he strikes me as someone who is up to something good.. may be im wrong, guess we shall see:)

[@LuciousKage]

@@EmreSenSecrectOfMusic well, im not saying im dont want him to succeed, but everything he came up with so far is just snake oil. :/

[@jds02153]

@@EmreSenSecrectOfMusic This is the same guy who said red wine was the cure to aging 15 years ago

[@BraveNewWorld5404]

By definition, if cells can regenerate, life should be able to live forever. So it is reasonable to assume that the aging process is not primordial rather it is added later to deliberately sabotage the life during early years of evolution. In other words, it is more likely than not that the initial life forms were long lived because in a self-regenerated life form, the aging process is not trivial and intrinsically unnecessary for the life form. The reason that all living beings have aging process is because the "natural selection" prefers short lived generational life forms over the long lived life forms for obvious reason: better adaptation for environmental changes and faster evolution due to exponential genetic mutations from generational offsprings. Today, human have evolved into a highly advanced creature, we no longer depend on biological evolution, we evolve ourselves through sciences and lab experiments. Without natural evolution, the aging process has no more biological usefulness, it is time to stop it ! Or is it ? in fact, we are not really sure if there are other critical roles played by the aging process. Living forever may create many issues to a society, which cannot be overcome. It also may create issues for the individuals who seemingly benefit from it, living the same life again and again and you know there is no ending, all hell may break loose.

[@blitzd21]

why would all hell break lose? if we can live forever we can explore the universe and more wth

[@ilyab.5127]

David UnThinkClear been saying same nonsense for decades. We are soon in 2025 and have nothing available!

[@ThinkingDN]

Yeah. He seems quite muddled.

[@vvvoda]

Finally a video where there s no face filter that makes him look 10 years younger. Yeah he shows his age at some things, like posture and a little lag when moving his limbs, but he still looks amazing for 55.

[@jeffgadbois1707]

Trump needs to talk with David 💯💯💯💯💯💯💯💯💯🤝

[@079Francvs]

It would be wonderful if you left this topic in the scientific field instead of politicizing it.

[@jds02153]

They certainly have a lot in common when it comes to telling the truth

[@UnsaltedCashew38]

All his company has learned is that nuking the cells of mice makes them age much faster, not how to reverse or stop aging. All his interviews are hype and stories, keep talking about your grandma, sleep and alcohol bud.

[@lwalt7120]

Can't wait to read your research. I'll wait...

[@UnsaltedCashew38]

@@lwalt7120 Did I claim I found the fountain of youth like this charlatan? Go watch a bunch more of his videos and check his tweets, he just makes media rounds to get more funding, they haven't discovered anything useful to humans.

[@brucewayne5554]

@@lwalt7120 he has a point thou

[@SuperDodoe]

Comes off a bit like the snake-oil salesman from the movie the Outlaw Josey Wales

[@Len1977gt]

you are just mad because he look's better than you

[@nadinejoyce1203]

He doesn't exude health or enthusiasm either.

[@Len1977gt]

Yes he does and besides what do you know about anything?

[@ThinkingDN]

He used to but not anymore

[@albardo08]

Geez, people are still listening to this con artist?

[@ronaldrt]

Why is he a con artist?

[@SuperDodoe]

I'm sticking to my low fat whole food plant based diet and daily exercise for a long and healthy life.

[@In-N-Out333]

Maybe you can live as long as Dr. John McDougall-who also followed a low-fat, whole food plant-based diet, but died at the age of 77.

[@hawaiirealestateorg]

Carnivore with fruit and high fat is the only way. Add Celtic sea salt, selenium and iodineto RO water or distilled

[@jadeatlakegrotonvt]

He nearly died as a young person. And it is phenomenal that he lived as long as he did.​@@In-N-Out333

[@vkreeger]

@@In-N-Out333 McDougall had a massive stroke when he was 18 so he is lucky to live he has lived as he did. I do believe he put too much emphasis on starch relative to nutritionally dense food sources such as greens and berries. He also downplayed the risk of too much sodium.

[@EMedNation]

David Sinclair is a grifter and should be held to account

[@shinkurt]

Stop inviting scammers

[@Len1977gt]

you are just mad because he look's better than you

[@starfox300]

You listened to Stanfield or whatever his name was

[@jds02153]

@@Len1977gt Len has a crush on David

[@ThinkingDN]

I can easily see the face lift

[@姜萍萍-d9f]

Dead poet society! Was popular in 1990, what a great era. Seize the day!

[@ShaneHarveyMusic]

I bet you this blabbermouth has the same amount of gray hair as the interviewer. 😂

[@jamesjohn2537]

Hi, there, can anyone recognized humans design economy, economy isn't the problem, humans are the problem due to luck of good managements of taking in large population accommodation but we can learnt and adopts as the same ways at molecular level how this colonies of spaces shares space holding trillion of trillion of microorganisms. we cannot limited human capacities ability. we are not longer at the level of stone age, the only limits is what we cannot thinks of but we have our partner AI next to us. the only question exist is when do we need to change the whole world forever and stop harming ourselves fighting over natural recourses and political differences!!

[@rg-cb2wd]

Dude is scammer

[@gqas1247]

Please expound 🤔

[@KlingbergWingMkII]

For such an interesting topic, he is really boring.

[@Jessica-kk1cz]

Try watching his interview with Peter Diamandis.

[@shinkurt]

He is a scammer

[@GraceDurrani]

Why​@@shinkurt

[@Jessica-kk1cz]

People who say he is a scammer clearly are not Biologists, let alone geneticists. I don’t take medical advice from my plumber either.

[@crowdancer5]

@@Jessica-kk1cz and.....most doctors have no clue about HEALTH care.....by their own admission if honest.......they do SICK care

[@jaykraft9523]

Sinclair is a disgrace. See video on his $720,000,000 train wreck

[@dinomiles7999]

Junk research 😢❤.

[@1nterpretThis]

He's gained weight! Bye

[@berndwildner6341]

Sorry but he doesn’t look very young…my brother is 60 and looks younger 🤷🏼

[@rdallas81]

Yeah. Sure your brother does.

[@jujjuj7676]

I'm getting tired of Sinclair saying same crap.. Nothing new here.. What happened to those mice years ago he claimed reversed aging..and got there grey coat back and starting running around..hummm the story just faded away didn't it..😂

[@Radosworld]

He looks like a scammer.

[@AvatarMakusan]

ALL LIFE has a BEGINNING...a MIDDLE...and an END. We are No different. FUNNY enough this also applies to the rest of the UNIVERSE! Yes... this spinning dirt ball will end at some point. Probably not before the 'smart' chimps completely destroy ALL LIFE and the environment that makes life possible. -namaskaram

[@craigrobinson4526]

Even with the fountain of youth you can still die to an accident, murder or suicide

[@drzavahercegbosnaponosna5974]

sinclair sells snake oil, as always.

[@IWantToDieFRFR]

He talks about fasting. Fasting is amazing

[@drzavahercegbosnaponosna5974]

@@IWantToDieFRFR fasting is fasting, sinclair is sinclair. he didn't invent fasting...

[@nicolewolfeceo8]

Partner collab nwcinc.