David Sinclair at ARDD2023: Epigenetic stabilization and reprogramming: an update

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Күн бұрын

David Sinclair , Harvard Medical School, USA presents at the 10th Aging Research and Drug Discovery conference: Epigenetic stabilization and reprogramming: an update.

Пікірлер: 111

@MichaelMerritt 5 ай бұрын

They should work with Michael Levin’s lab who has shown there’s an electrical interface inside cells and the human body which controls the programming of cells and biological substrates. Like you can see the formation of biological formations like a face as electrical energy before a face is created for example.

@rigaleb 5 ай бұрын

They will never do that, because they're obssesed with control and micromanaging and pushing new expensive wonder molecules and procedures to the market from which they profit. Michael & Josh's work is a hundred levels past that. Sinclair is still in the NMN - vegan - protein war and obssesed about single gene activations like sirtuins and yamanaka factors which he desperately wants to control, instead of letting the body control the process. Very primitive, just like computers in the 50s.

@helicalactual 4 ай бұрын

I love dr Levins work. yes that cancer can show electrophysiologically before anything, xenobots etc. please cite your sources as his work is amazing and everyone here would benefit from watching.

@chrisyu1024 5 ай бұрын

I am particularly intrigued by your experiments involving the optic nerves of mice, where you have demonstrated the potential of these factors to repair and possibly rejuvenate damaged nerve cells. However, I have a couple of questions regarding the specifics of these experiments: Distinction Between Nerve Regeneration and Repair: In your studies, how do you ascertain that the observed improvements in the optic nerves of mice are the result of the repair of originally damaged nerves, and not the regeneration of new nerve pathways? Since the reconstruction of neural pathways might lead to memory loss or other issues. Direct Aging vs. Induced Damage: Your experiments involve inducing physical damage to the optic nerves before applying the Yamanaka factors. I am curious to know why this approach was chosen over directly inducing aging or degeneration in the nerve cells themselves. Would the latter not provide a more direct model of age-related neural degeneration? Experiments on Naturally Aged Cells: Have there been any experiments where you applied Oct4, Sox2, and Klf4 to naturally aged cells, particularly in the context of nerve cells, to observe whether similar rejuvenation or repair effects are noted?

@Geroscientist 4 ай бұрын

The 1st author Dr Ryan Lu basically answers the 1st two Qs in the LEAF journal club on their nature paper on the lifespan youtube channel: "Partial Cellular Reprogramming Restores Vision in Aged Mice"

@-Brendon- 5 ай бұрын

Amazing and very in depth explanations. So excited for Dr. Sinclair's work on chemicals that will be cheap.

@joshlocher71 3 ай бұрын

hi brendon i am fan of david sinclair i know about these chemical combos too

@DCGreenZone 5 ай бұрын

Thank you for this video series. ❤

@SilverFan21k 5 ай бұрын

Wow. Awesome event + attendance + David is rad

@peterm5554 5 ай бұрын

I would like to hear more from David Sinclair on recent progress on ageing

@peterm5554 5 ай бұрын

I like to hear David Sinclair talking about ageing because it is such a hopeful topic.

@elliottrubenstein1746 5 ай бұрын

Thanks for the info.

@Thaythichgiachanh262 4 ай бұрын

Thank you very much for your valuable information ♥👍👍

@sergenzali9252 4 ай бұрын

Une video tres riche !!! Thanks

@armankilic 5 ай бұрын

Thank you. Waiting for 2024 talks.

@joeblow1748 4 ай бұрын

Goes on. "Hey everybody, its been 10 years" looks exacty the same as last time XD

@georgiaparaskevopoulou7425 2 ай бұрын

That is amazing!! I will like to hear more...l would like also read the book Lifespan!!😊by David!!

@DCGreenZone 5 ай бұрын

I have read that L Carnosine may reverse cellular senescence. That can't be a bad thing, can it?

@Jessica-kk1cz 5 ай бұрын

20 years is too long. These labs need funding, now, in the 100s of billions of dollars, and for “regulatory” agencies to get out of the way and stop interfering

@Inanothertimeandspace 5 ай бұрын

Exactly. If a patient is informed of risks and chooses to take that risk, they should have the opportunity to access these technologies.

@nomvonglismerced4311 5 ай бұрын

Yeah. No one but me must be allowed to enjoy my millions. I must become immortal now.

@JZGreengo 5 ай бұрын

@@Inanothertimeandspacethey aren’t fully developed, there has to be clinical trials to determine efficacy and even if you want to dismiss safety no point in approving something that ain’t gonna work unless it’s proven through clinical trials

@Inanothertimeandspace 5 ай бұрын

⁠@@JZGreengoThe point I’m making is that it takes far too long to get to a clinical trial at all. If a patient is dying of aging (as we all are) we should have the right to assume risk to test efficacy. There are gene therapies available in Colombia, for example that are currently increasing telomere length. These therapies are being utilized by the ultra wealthy to demonstrated safety and efficacy, yet are unavailable here for even a simple clinical trial. We have a right to our bodies or we don’t. The last thing we need is another mouse model. For those who are willing to test these drugs they are legally provided for under Helsinki Protocol.

@DaniilDimitrov 5 ай бұрын

Sure

@andrewwalker8985 4 ай бұрын

Sinclair is a very gifted communicator. My only gripe is that one would be for given thinking that he invented partial cellular reprogramming. Needs to give a better nod to those coming before him IMO.

@markrobert2146 4 ай бұрын

There is no reason whatsoever to ignore the resvertrol scandal and move forward forming companies selling false hope

@christian-schubert 4 ай бұрын

"And the answer that we came up with was: PROBABLY" - weirdly enough the most scientific remark I've ever heard 😂

@Dailyblu 2 ай бұрын

I've read his book lifespan couple weeks ago.. and thereafter I'm looking for his interviews

@tserenchimedaltangerel7498 4 ай бұрын

He is getting younger and younger,means that he already got that how to stop aging ❤❤❤

@kiwiingrid 4 ай бұрын

Haven't researched but my bet is BlackRock, Vanguard and Statestreet own all those companies.

@frv6610 4 ай бұрын

Why do you think so?

@Jenny-fv6go 4 ай бұрын

When was this conference taking palce?

@harmankardon478 5 ай бұрын

WHY CONSTRAIN THE TIME SO MUCH?????

@joeschmoe5583 5 ай бұрын

FINALLY - FOR THE LOVE OF GOD - 3 MONTHS LATER.

@brandonrincon1208 5 ай бұрын

lol seriously iv'e been waiting for this one too lol

@Izakokomarixyz 4 ай бұрын

still talking about mice and rushed thru the monkey part which didn’t even sound promising because he said that he didn’t know if monkeys vision improved or not

@lanlebozec8228 3 ай бұрын

Prof David Sinclair is Gods gift to humanity I am so glad that we make good strides in understanding the miracle of Life

@74HOLLE 5 ай бұрын

Thank you for taking Homo sapiens closer to relative immortality.

@520cuban 4 ай бұрын

Has anyone considered POMC and Leptin modulation in Ageing?

@markhedger6378 3 ай бұрын

Work done by Dr. Jack kruse may be of interest to you

@LondonSoundSystem 2 ай бұрын

AA very joined up thinker.@@markhedger6378

@CraigHocker 4 ай бұрын

There are so many companies he is financially mixed up in (16+) that the title slide doesn't even keep track of them and lists Tally Health twice. LOL. Skepticism deserved. 10 years crazy hype, the progress now is that it's just "mostly" crazy hype. Sinclair remains part of the hype problem. His yeast work was debunked after only a few years, crazy that he still ignores the literature that followed. It really should be called the Information Hypothesis of Aging. It's far from a scientific theory at this point.

@squamish4244 3 ай бұрын

Sure. He has still done a lot to raise the profile of the field. There are other, more promising lines of research than his, but he has brought attention to a lot of things. I've benefitted a great deal from intravenous NAD for a bunch of medical conditions, including a devastating benzo addiction. Ironically, Dr. Sinclair is down on IV NAD, when it is WAY more powerful than NAD in tablet form.

@user-qb9od7pu3c 4 ай бұрын

What is the mechanism to revert age by applying four Yamanaka factors?

@user-qb9od7pu3c 4 ай бұрын

It's important to know basic underlying mechaminism resetting epigenetic setting cell. This will be found by some genius.

@jordanong5114 2 ай бұрын

If he becomes my teacher, I’d be honored.

@EdT.-xt6yv 5 ай бұрын

13:00 🎯 21:00 epigenetic damage by certain institutions 🤔

@CAMIDRCS 4 ай бұрын

👏👏👏🤟!

@Melanie____ 4 ай бұрын

In the meantime you can effectively enhance your epigenetic expression and prevent dna damage with a whole food plant based vegan diet. (Ref pub med)

@newpro93 4 ай бұрын

Can you share the link to this study?

@timothygrey-nn4od 4 ай бұрын

na-ah, we need meat, collagens and proteins to function.

@mowthpeece1 4 ай бұрын

Fact*. Too many studies to post here. And protein is in everything. Do your research objectively, without bias.

@mowthpeece1 4 ай бұрын

@@timothygrey-nn4odWe don't need meat to function. The 7th Day adventists have long since proven that. You just want it. That's a different story and far from scientific.

@startedat36yearsold33 4 ай бұрын

@@timothygrey-nn4odHow do you KNOW we need meat? 🐑

@videovitae 4 ай бұрын

Thanks ICE mouse , we think our girl’s need to focus on these treatment’s to make it cheaper as colaborators’, organisers’, early learner and learning teacher’s. So in David word’s “don’t quit”.

@lubnaahmed1299 4 ай бұрын

♥️♥️♥️♥️♥️♥️♥️♥️♥️♥️♥️♥️

@antoniobortoni 4 ай бұрын

There is no backup information the universe has the good information right know everywhere, like the brain is just a antenna to another dimension field that create the reality itself, so just low stress and good nutrition slow aging, some activities activate mechanism of rejuvenation like fasting, hot yoga meditation in a hot sauna, extreme cold meditation, extreme cold, high oxigante, low oxygenate, and those substances that we create doing those activities can be found in nature and more and ingest them and become some young again, but become like a teenager?? so the elixir of young is on those chemicals?? we need them now here, all people young again, better than bejore young ja. Cool.

@dalevandenheuvel3927 3 ай бұрын

I would like to know you said this company is going to make NMN Into a drug, how is that going to affect the rest of the people that you are educating on his benefits, to me that would limit it greatly as to who can get it?

@jip3443 4 ай бұрын

Bus drive surely could have waited one more question, you have David Sinclair on stage. Come on!

@charlessavoie2367 3 ай бұрын

Did I hear him claim to have dead lifted almost 1,000 pounds?? If so can't he hold a stationary Iron Cross on still rings with 100 extra pounds strapped around his waist?

@SquatFull 5 ай бұрын

Have your studies been reviewed and confirmed by other scientists given the history of resveratrol?

@Inanothertimeandspace 4 ай бұрын

This ❤

@andreasstuermer4946 4 ай бұрын

Who wants to put money into confirming results? Professors won't put their PhD students on projects to confirm other people's results because then they won't be able to have groundbreaking papers. The system is broken

@helicalactual 4 ай бұрын

nice analogy, they are collecting all the tennis balls and so no one is playing tennis anymore, Ie the enzymes and etc. are so worried about repairing old stuff they can't expend resources on new stuff.

@vlogkitsune6785 4 ай бұрын

Is the mouse immortal now ?

@Rafa-pf7kz 4 ай бұрын

yes... super mouse

@timothygrey-nn4od 4 ай бұрын

Now he is saying 20 years? He said 10 years in some another video

@vivian3371 3 ай бұрын

Big pharmacy stoped his work. And we all know why...no profit for them...

@Izakokomarixyz 5 ай бұрын

… monkey part was not very convincing…

@klianino6559 4 ай бұрын

and how is it you can't tell if monkey sees again or not? Sounds fishy

@DavidL-wd5pu 4 ай бұрын

Can't wait to live to 150 years old so I can sleep all day. That would be epic.

@jaappesman7899 4 ай бұрын

Wait...funeral? I thought the idea was to avoid that one...

@danielmccarthyy 4 ай бұрын

Is this research as valid as Claudine Gay’s PhD?

@dinomiles7999 5 ай бұрын

Light ,water, magnetism and oxygen. Any questions.

@bornatona3954 5 ай бұрын

What?

@presence5426 4 ай бұрын

Yes.

@Izakokomarixyz 4 ай бұрын

what about gravity

@Rafa-pf7kz 4 ай бұрын

yes

@jimwilliams3333 4 ай бұрын

Besides myself, and I'm about 80 from a family both sides live long, someone needs to talk to Elon Musk and convince him to talk to David Sinclair. He seems to be aging too fast and I would like him staying around creating and inventing...ha ha!

@user-jy2sz1jr9p 5 ай бұрын

Time constraints for Dr. David Sinclair. Joe Biden can go on with his rambling nonsense for as long as he wants! Good job, America!

@domino6434 4 ай бұрын

Jesus why does everything have to be connected with either trump or biden

@presence5426 4 ай бұрын

Lame

@miroslavparvanov 4 ай бұрын

Such an important topic and they didn't let the man answer more questions. Obviously the bus was more important than living healthy life

@rigaleb 5 ай бұрын

Micromanaging is never gonna work.

@jujjuj7676 3 ай бұрын

really the one person to ask a question was some girl who wanted to know what to study...great way to waste it...🙄

@dmitrikonnov922 4 ай бұрын

Are there anybody here who’s at least made the smallest attempt to figure out what happened to Dr. Sinclair’s previous project? :D the guy sold a not working piece of bullshit for millions of $$$.