David Sinclair’s 2023 UPDATED Supplement Protocol | And WHY He Takes It

If you’ve been following Dr David Sinclair, you know he updates his supplement protocol from time to time.
And in each interview, he gives one piece of explanation to what he does.
And certain supplements that appear in one interview, he does not mention them in other interviews.
Sometimes it’s hard to follow his protocol today.
Since, I know Sinclair’s work since 2007, before he went public in 2019.
Here, I have collected for you from a variety of sources, including Sinclair’s book, trying to figure out EVERYTHING he takes today and how much from each supplement.
And, you’ll find a very spicy comment from Sinclair about resveratrol.
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✅ Brad Stanfield vs David Sinclair on RESVERATROL
• David Sinclair VS Brad...
✅ David Sinclair's Original RESVERATROL Study: Amazing Discovery & Analysis
• David Sinclair Study o...
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Copyright Disclaimer under section 107 of the Copyright Act 1976, allowance is made for “fair use” for purposes such as criticism, comment, news reporting, teaching, scholarship, education and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use.
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Credits: Scott Buckley
Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.
Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities.
Statements made, or solutions suggested in this video and/or at this channel are not intended to diagnose, treat, cure, or prevent any disease.
The statements are not contradictory to first following authorities' guidelines of social distancing and hygiene.

[@WellnessMessiah]

This video is obsolete. Watch the UPDATEd video: kzbin.info/www/bejne/bnzZqZKIi7x6atU

[@henrikmadsen2176]

is TMG = Glycine ???

[@roba.8907]

@@henrikmadsen2176 TMG consists of glycine with three attached methyl groups. It’s naturally produced in the body, found in certain foods like beets, and available as a supplement. It’s involved in a process known as methylation and can help lower levels of homocysteine - which improves cardiovascular health and protects against dementia. It’s a very safe and well studied supplement that also may increase athletic performance and improve insulin resistance.

[@henrikmadsen2176]

@@roba.8907 Thankyou for your great answer. I have seen Dr. Sinclair advise taking Glycine and NAC together (GylNAC). I assume for that I can then use both ordinary Glycine or TMG? I think I have seen Dr. Sinclair recommending taking NMN with TMG, because of the tri-methyl gruops), but now NMN is banned by FDA, I assume it's not sold any longer, and maybe also not safe to take? So is Glycine is cheaper than TMG, I might just go with the Glycine-NAC combo. Best regards, Henrik, Denmark.

[@narsreenjohnson4966]

i saw a show he said about telemores in skin and what he applies on skin like tyme oil etc can u find out for us?

[@SD-SD-SD]

Many thanks for creating these videos :-)

[@awc4t]

Thank you for doing the leg work for the rest of us in putting this together. It is very much appreciated.

[@andrewgigliotti315]

O. Obo obb bobo oo o bbo obobo o o. O. Oo obo o o o ob bobhbobobboboboo ob no o. O o BBC. O o. Obo o o o Vvvv v vvv. Vvv. V. C. V C c. C v v C. V. C C c C cc😊

[@roseward16]

Read an article awhile ago that man who had calcification of heart valve and was due to have a valve replacement. He started to take higher doses of K2-7 and asked for tests after taking this high dose of K2-7 and his valve showed significant decrease in calcification. He opted out of replacement valve surgery and continued to take Mk2-7

[@sandrasamuels9828]

What's MK2

[@ukaszuminski1559]

@@sandrasamuels9828 he meant vitamin K2 - Mk7

[@evanlerman5447]

Thanks your response may have saved me a valve replacement. I take D3 and K MK7

[@BobSmith-ke4jg]

I've never seen MK-2 in the vitamin section at the store

[@evanlerman5447]

D3 and the mk7 form of K2, you won't find it if its spelled wrong. Join consumer labs instead of following Dr Sinclair

[@Sarah-gm8zy]

Just wanted to thank you for putting this video together, it's definitely required a lot of effort on your side. Thank you and thank you!

[@santiagogold446]

Thanks for organizing these videos and data. It makes things much easier to reference Sinclair

[@Always-xl9db]

I would really like to clarify about Quercetin - it’s not safe to take it every day, it can damage healthy celks, and I dont think Sinclair is doing it everyday either….the study that he brings up (and I can look it up) used quercetin in hit-and-run fashion meaning 3 days in a row then 6 weeks break. Because there is no point to keep taking it everyday - once u remove senescent cells.

[@WellnessMessiah]

Yes, he said in his podcast - recorded in late 2021- every day. Maybe he has changed that since. I'm with you on this question and expand on that in the resveratrol research series which includes touching on Quercetin. Currently 2 videos are out of many in this series of research :)

[@Always-xl9db]

From Dr Kirkland, the “father” of senolytics research: “Since new senescent cells take 10 days to 6 weeks to form, these senolytic agents can be administered in a hit and run manner - once or twice if there is an insult like radiation that’s not repeated, and do that periodically as new cells form. In those experimental situations the drugs can be given once every two weeks or once in a month and that has the same effects as giving these agents continuously. We are not trying to occupy a receptor or inhibit an enzyme, not looking for a steady state of the compound in blood, we’re trying to get rid of a cell type, allow these cells to kill themselves.”

[@Always-xl9db]

There was also something about the role of the senescent cells in wound healing and other processes, so there can be downside in their complete removal. Let me look it up, it was an interesting argument and reasoning behind not taking quercetin and other senolytics continuously but in that pulsating manner

[@GibaGouvea]

Quercetin doesn't kill senescence cell alone. It is necessary to use together with other drug to have this effect.

[@cheetahbrfc9016]

I currently take 375mg of quercetin with 500 mg resveratrol with olive oil 5x a week. Not sure if its good or not. I am eating way more vegetables now than before so maybe I don't really need to have it as often. :/

[@beautylover8138]

Interesting- If I remember correctly, apples have fisetin and quercetin - pretty much the same amount as in most senolytic activators - I guess the old adage is true- an apple a day keeps the doctor away😊

[@auriellenazro2516]

I do not have a prescription for metformin. So I decided to substitute it with Berberine since it is very effective in reducing blood sugar. I would like your opinion on this….

[@Quixote1818]

Same here.

[@WellnessMessiah]

Hi, Berberine has a wide array of impacts. It's more complicated - from my research - than metformin (3-pronged effect, metformin just 1). But one of its mechanisms indeed overlaps with metformin. Personally, I do not take it at the moment and have more personal experience with metformin. I can tell you that I've seen a massive reduction in cholesterol with my clients, so I suggest tracking that too. Dr. Peter Attia is very smart on Berberine and uses it in his clinic, so I'd go to check his recommendation. The brand here matters and I know Attia is using Thorne research, albeit it quite expensive.

[@damianbachul3599]

@@WellnessMessiah metformin has a great impact on Testosterone level.. i dont want to play with too much. ;) what about berberine

[@majaber1]

@@WellnessMessiah All Thorne supplements are over priced by yards.

[@henrikmadsen2176]

Great to watch your summary!! Sinclair is pretty sloppy when he reports on his protocol. Fantastic to have you to sum it up. Great work. Thanks a lot.

[@eugeniebreida1583]

That's politely stated, I might say obfuscation was a little more Sinclair's style, regarding a straight-up recitation of supps & drugs & dosage concerning his current protocol.

[@Shiv1971]

I used to take 20 100 MG K2 MK7 (liposomal pills - 2 gm all at roughly the same time....) for 21 days to reduce calcification in the arteries. It made me feel better and I followed up with more normal doses. Also used boron (9 mg), fish oil, and full multivitamins/multiminerals - it all reduced arthritic stiffness as well. High doses of magnesium and potassium also were helpful, and so were liposomal pills. Whenever I take significant doses of calcium, I try to take Vitamin K2 (complex - both MK2 and MK7). NMN (liposmal - 1 gm) or Niagen (300 mg) should be taken with quercetin (500 MG) and TIMG (1000 MG) for better results.

[@MsOrangeknickers]

Thanks for this great summary! Can you advise if using Berberine instead of Metformin will be effective. If it will be, what dosage? Thank you.

[@vanessagregory8835]

Thank you for this concise account. I take 1gm NMN daily sub lingually. I have ordered 100 gm resveratrol and Fisetin on line and am in a quandary about dosage. I take Vitamin D 10,000 and Vitamin K2 90 micrograms daily. At 81 I want to stay on track. I read Lifespan and Super Human and have used NMN since 2018. I purchased a NMN Resveratrol mix on line for my son which he takes sublingually. This was because one supplement was easier for him to remember. My GP prescribed Metformin 1gm when I asked to keep my Blood sugar under control and it coincidentally reduces my blood pressure. Give my son 250gm Metformin. Advised him to ask his GP for a script. He has high BP and my father had diabetes so reasonable request. He My GP said he has been taking Metformin for years as preventative health measures. His father too had diabetes. It is a cheap drug and very safe.

[@zbridgjpxupzm]

resveratrol is proven complete scam. It is actually harmful. Search the investigation by DrBradStanfield

[@felicisimomalinao1981]

Dr. Stanfield reviewed a research showing that quercetin and fisetin are not assimilated in the blood.

[@WellnessMessiah]

Hi Vanessa sounds like you're very active and smart. Keep up thinking for yourself, track the results, and based on that adapt the dosage.

[@vanessagregory8835]

@@WellnessMessiah I found I was using 2mg which is overkill. Also taking 5gm Creatine Monohydrate for muscle strength and balance. For older women it helps the bladder to stay functional. I put it in my fizzy multi vitamin and Vitamin C (5gm) drink. There is no substitute for ageing well.

[@markfischer3626]

He did mot mention apigenin to block CD38. He could have added R alphalipoic acid to quercetin to boost NAMPT. TMG good. All three are required to assure the salvage pathway for NAD+. He vould have added NAC when combined with glycine in TMG creates glutathione, the master antioxidant. There's so much more to know.

[@samanthazone7128]

13:11 for summary thanks again

[@antonystringfellow5152]

I'm a little surprised David takes so much of so many of these compounds. Most of them are synergistic to the point of actually amplifying the effects of one another. The effects of Metformin and Aspirin, taken together, is more than the sum of each taken alone. The effects of Metformin and Resveratrol, taken together, is more than the sum of each taken alone. Metformin, Aspirin, Resveratrol and Quercetin are all synergistic, with many overlapping effects. I have taken all of these, and in similar doses (but 1 g Metformin per day) but only for 4 weeks, as a purge. I wouldn't want to risk doing this long-term. The only one I take every day is Metformin and that's because it's the only one of these compounds that has been proven to extend human life and has an excellent safety profile. On the other hand, one study on rats showed that Quercetin increased the occurrence of tumours. Starting Monday, I'll be taking the polyphenol, Pterostilbene together with NR as they seem to have a powerful anti-cancer effect when taken together. Pterostibene has 4X the bioavailability of Resveratrol so I'll only be taking 100 mg per day. I'll also be starting with sulforaphane and eating much more broccoli together with mustard seeds (trying looking that one up). When I was taking Resveratrol and Quercetin (my purge) I mixed them together with soya lecithin, on a slice of wholemeal bread. Both the lecithin and the wholemeal bread boost absorption, especially the lecithin, which has a strong affinty with water. I also mixed in 500 mg of VitC which I had in paste form, in capsules. The Vit C and lecithin help to protect the Quercetin, the lecithin in the stomach and the Vit C in the bloodstream, so it has more time in your system before being metabolised. Anyway, thanks for keeping us up to date.... really appreciate your videos!

[@iconoclast1399]

Thats all very interesting but also confusing as just when I think you have found someone that knows what they are talking about you come across information that is rather conflicting. Wondering if Rimon has contacted you, oh and thanks for the post.

[@mattsmith1440]

I just had a look on Pubmed and all the papers I can find suggest Quercetin tends to have anti-cancer effects, both preventative and also therapeutic. I'm not saying there are no papers to the contrary (couldn't find your rat one!) but I would go rather with the weight of the evidence if I were taking the supplement. That doesn't mean the studies I found were any good of course. Do you have a link to the study you mentioned?

[@gregl2249]

everyone I know (diabetic) who is on metformin have bad side effects

[@dude861]

Look deeper into that rat study. These rats already had tumors and they didn't grow from Quercetin.

[@mattsmith1440]

@@dude861 Which study? Got a link?

[@miracoli16]

Great video! Thank you!!! After having watched all your videos I'm still insecure about how much resveratrol to take (30-50mg or 500mg or even 1g like Sinclair does??)....Hopefully your forthcoming videos will help finding the right dosage... As far as i know wheatgerms contain much more spermidine than the sources you mentioned.

[@WellnessMessiah]

Thank you, Otto. Yes, you're right about wheatgerms, the study hasn't checked that for some reason. That's how they make the supplement from, too.

[@timmyschannel5]

Resveratrol will wreck testosterone levels. It has no benefit

[@sonson5jadamshuzu111]

2 grams is best

[@speedseekers]

Hi, thanks for the great info. Do you know the anwers to the following questions? 1. do you have to keep NMN refrigerated 2. how could I take NMN when I travel (refrigeration not possible) 3. how can I see if NMN is still good 4. when I get NMN delivered it is not refrigerated, how can I make sure it is still good 5. is NMN really harmful once it changes due to not being refrigerated?

[@youthlabile]

Im waiting for the answer

[@kikilynn1167]

Amazon is banning sales of NMN products in its store because of an FDA letter stating that NMN is not considered a dietary supplement as of November 2023. This is a reversal of FDA's previous decision. Their stated reason is to protect a pharmaceutical drug development application for a patented version of NMN.

[@miamimartin2195]

Shocker!!! That's what I said right when I heard is being banned, drug companies want their piece of the pie.

[@christopherellis2663]

Have been aware of D3K2 since learning that my mother died from Aortic Stenosis: calcification of the heart. Thank you, margarine. Res and quercetin are in my protocol

[@WellnessMessiah]

Sorry to hear about your mother Christopher. Yes, K2 is very important especially over 60 for the reasons you said and Sinclair mentioned.

[@christopherellis2663]

@@WellnessMessiah Thank you. She was 96, would have been a hundred, next January.

[@bernhardwalther]

Really sorry about your mother. There is no words for this kind of loss. I am a bit lost at the moment on K2 since I saw a video of Brad Stanfield with desapointing results of a K2 study. I keep on taking it but it was unsettling.

[@charlesrichards5389]

@@WellnessMessiah I recently switched from K2 to K2+D3, but while the K2 were liquid-filled gel caps, the K2+D3 are powder-filled capsules. They're both the same brand (let's say, with the initials SV from Wally World). Is this OK?

[@ArtDesignHobby]

@@christopherellis2663 God - I would know her diet and lifestyle... 😄

[@bogse]

12:50 so we can conclude that he exercises only 1 day in a week. Just adding more exercise days to his week would probably benefit him much more than all those supplements.

[@walterscott2286]

I agree wholeheartedly! And, I honestly don't think he looks all that young for age 52. Especially considering the fact that he's been taking Resveratrol daily for nearly 20 years!!

[@JWV_]

Thank you for your honest work! 👍

[@WellnessMessiah]

You're very kind Jean!

[@johnnymurray6275]

Thank You for the video. It's quite informative! I appreciate it 👍

[@user-wr3gy7el2h]

Thank You for this amazing channel!!! 👍🤗I subscribed

[@jefftezos]

Thanks for all your hard work! You're one of the best longevity streamers.

[@gif24gt60]

Is trans resveretrol better than regular resveretrol?

[@anthonyrude]

You left out the most important part... Where does he get his supplements? I think a company was mentioned in a clip but I didn't catch it. Do you have a company name or link? Thanks

[@WellnessMessiah]

Hi Anthony, he stated he gets NMN and resveratrol with material bought for his lab. The spermidine, he consults the company (conflict of interest, you can say). The rest - IDK. Please check the new resveratrol series in this channel, it's eye-opening and includes SInclair's work. This is episode 1: kzbin.info/www/bejne/e16ldqBpgdyif9U

[@riteshnayak80]

What about Astaxanthin, which is known to be 3000 times more antioxidative than Resveratrol?? What about ayurvedic Shilajit (asphaltum/mineral pitch) ?

[@melindawolfUS]

The book goes into detail about why antioxidants don't reverse aging like science thought they would 10 or 15 years ago. The reserveratrol is working to reverse aging using a different mechanism, so you can't just replace it with an antioxidant

[@jeffreeOH]

I saw a video by Dr. Berg where he stated that you can take 10,000 IU's of vitamin D3 with 100mg of vitamin K2 (MK-7 form only due to it's increased bioavailability) and not be concerned with calcium build up in the arteries, therefor you might be safe doing that.

[@charlesrichards5389]

100mg of vitamin K2 or 100mcg of vitamin K2?

[@vlad4512]

Dr. Berg is a scam sorry!

[@MaxLofi7]

Very well done sir. I am now a fan after this video. Keep the viewers updated. I want to know if sinclair changes anything. But also, what happens if nmn is removed from the market? What to take if that happens. Would love to hear a video on that

[@WellnessMessiah]

Hi Sorry for the late response. Frankly, I'm waiting with serious NMN research now until we going to know the absolute FDA stance. I speculate smart consumers could get NMN from other countries if it is banned. I hope the governments wouldn't care so much about importations for an un-risky supplement such as NMN.

[@KirstiCheetahh]

Great video! Just one thing: Taking drugs like Metformin is not natural and not healthy, it has side effects. If you do not eat sugar, you do not need Metformin! I do low carb - high fat - medium protein and IF and most days OMAD. Do sports in a fasted state. Take Pterostilbene on my resting days, not when doing sports.

[@WellnessMessiah]

Hi Kristi, I would add the original molecule from Metformin is actually created by plants, not humans. They used the plant which has had some nausea effects, for many decades. It seems that any useful drug comes from plants after all. It is a drug, as you said, today.

[@KirstiCheetahh]

@@WellnessMessiah Hi Rimon! Yes most molecules in medications come from plants, mushrooms, bacteria or animals. That does not make them harmless. Metformin has bad side effects. Not eating sugar and carbs has no side effects and is the most natural way to get healthy. And is not expensive.

[@stevenbrown3035]

What about rapamycin? Some are saying it is the most effective, but no mention of it here.

[@birgittadevlin4206]

How about this study concerning A-HgM (Metformin f.ex.) exposure in patients with T2D was associated with reduced risk of MS in patients younger than 45 whereas in patients older than 45, exposure to A-HgM was associated with an increased risk of newly diagnosed MS, particularly in women. Would this then also apply to Berberine?

[@deb1000001]

Just started resveratrol (for 1st time) at night after a meal, with coffee with the 2 tsp of olive oil and coconut milk. Not as bad as thought it might be. (after watching one of Sinclair's videos, ad lib.) Have to wait and see literally, results. Read about coffee as antioxidant. Also have read that it stops vitamin absorption. (Hopefully just slows time of absorption.)

[@gabebabe1]

You shouldn’t- you should do some research on his resveratrol bullshit

[@jajarounette95]

Please plus you share your thoughts?

[@tonywong8134]

Dr Sinclair is a fraud. Every video he is in is filtered to make him look younger. But unfiltered video shows every bit his age. From the receded hair line to the crow's feet and deep nasallabial folds. For someone who has studied aging for decades it hasn't worked. Now that his company got NMN banned, even though it's a substance the body produces, because he wants to profit off of it. I wouldn't listen to anything the guy says. His resveratrol controversy is enough to shed light on his scam...but then to get NMN banned? Right.

[@jft8994]

@@jajarounette95 quackwatch says it all

[@tanyamironova5466]

Helpful video, thanks! What about the statins he mentioned he've taken?

[@WellnessMessiah]

Hi Tanya, he said he had high cholesterol ("I have bad ashkenzi genes" his words). So it sounds like a medical thing, and indeed he doesn't mention that often to not confuse with longevity. Hence, I didn't want to confuse people either.

[@markfischer3626]

I have enough different kinds of supplements to start a health food store. After seeing your presentation on resveratrol I stopped. It appears to me that in high doses used continuously it might be dangerous. I'll stick to red wine and berries.

[@WellnessMessiah]

Good luck Mark, I think this Saturday episode 3 will help you a lot with what to focus and WHEN,

[@markfischer3626]

@Wellness Messiah with Rimon I just saw a video on three precautions you need to take if you are going to take NMN. I'm also looking into synthesizing it from Niacin or NR and P-5-P. I had my long overdue annual physical Monday and my lab reports look good. Triglycerides are a little high. A1C was 6.3. She gave me no advice on supplements I haven't taken except to say don't. Very disappointed. However nobody knows everything. Maybe she's too busy working to follow research on all of these supplements. I'm trying maqui berry extract to see what it does to my blood sugar.

[@TriangleDancing]

This is another very informative video. I just recently found your channel and really enjoy the content, especially when you dive into the details of Sinclair's comments and the studies. Since this one is about supplements, have you considered doing some videos on liposomal supplements? A lot of these longevity substances have very poor bioavailability. Using a liposomal delivery system dramatically increases the amount that gets into the bloodstream (almost all of it from what I've heard) and also facilitates entry into the cells where it is needed. I'm in the process of switching to liposomal (or phytosomes, which is very similar and does pretty much the same thing as liposomes) supplements where they are available for the stuff I take. One last thing, Metformin is mentioned in this video, and that is not typically available to people. You've also mentioned Rapamycin on your channel I believe as a longevity molecule. It turns out there are natural mimetics of those substances. On that reasoning I added ashwagandha, EGCG, and ginseng to my stack. See the study below for scientific support: www.ncbi.nlm.nih.gov/pmc/articles/PMC5723685/

[@WellnessMessiah]

Thanks for your comment Jason. There is no doubt that liposomes are a superior delivery method. However, from my research, the company has to make them right and it makes it more expensive than most people can afford - including myself at the moment. But yes, there is no doubt, that if there is an effective liposome supplement, it will increase absorption pretty significantly. The cheapest way to do so, so I heard, is to mix the supplement in a mixer with something like sunflower lecithin, hoping it will form a liposome.

[@bernhardwalther]

Hello, I would be interested as well on your look over some liposomal supplements. I looked on Internet to make it myself (mixer, ice, emulsifier) nonetheless I don't know how important is the size of the liposome in the delivery method. Homemade liposome might be pretty big.? Home blender might not have enough shear force? Further emulsifier might not be very healthy as some of them might weaken the gut barrier ? If the supplement is in a liposome, maybe it is not helping oher parts of the body that would need it as well? Anyway lots of questions 😊

[@miracoli16]

the studies were carried out with non-liposomal active substances. If these substances were to be replaced by liposomal substances, which are much better absorbed, the dose would probably have to be greatly reduced. The only question is how much the dose should be reduced. A manufacturer indicates a 6-fold better absorption of its liposomal NMN (250mg thus correspond to 1500mg). Can this be true?

[@misterpizzaman3581]

@@WellnessMessiah No such study to support that at all. It seem to be marketing and higher prices, nothing else.

[@martinepeters9891]

Just drink sugar and then visit the lab. Your doctor will then prescribe it. I did it like that

[@brbubba]

Vitamin D Vitamin K2 Resveratrol w/ Coconut Yogurt Quercitin Fisetin NMN Spermidine TMG (Trimethylglycine) Metformin Aspirin

[@maz.6525]

Thanks for the overview. You mentioned coconut yoghurt a couple of times. He states sever times that he is vegan and uses plantbased (coconut) yoghurt. Also I think he said in one of his podcast he takes 5000ui vit d3 a day.

[@rudolphpitterman3202]

Dr. Sinclair is a scientist/experimenter. At a point in time he'll tell you what he's taking but that can change anytime because sometimes he carries out these experiments on himself.

[@fvw53]

I am surprised that Dr Sinclair speaks this month about new protocols including ONLY 0.5g of NMN on KZbin (Business To-day) "Exclusive conversation with geneticist & Harvard Professor David Sinclair"

[@antcam007]

He says in an interview that the resveratrol he takes is "the white stuff, not the brown one" . I thought you would like to mention it in your update.

[@WellnessMessiah]

Yes you're right. Good observation. Check the new resveratrol series, it's eye-opening and includes SInclair's work

[@scottishfoldmocha5875]

2:17 the question for vit D is NOT about dosage, but what blood level he achieves, is his blood level 50-60 or is it 70-80 - this is an important point to ask

[@WellnessMessiah]

True, because blood levels represent convertions to 25 hydroxy vitamin D. Thank you and happy new year, full of youth and love

[@ClassicalLiberalWarrior]

I just ran across this channel today (Feb. 6, 2023) and it seems pretty good. I'm a fan of Dr. David Sinclair and Dr. Brad Stanfield, and I've attended two high-quality international conferences on longevity. Almost all this stuff is quackery and snake oil, but perhaps Rimon's content is not.

[@dg7438]

There seems to be a contradiction b/n the two of what to take :/

[@WellnessMessiah]

the fish oil works much better than snake oil for longevity :)

[@ClassicalLiberalWarrior]

​@@WellnessMessiah Witty and good spirited. But probably false. Fish alone is likely superior. Just as olives are likely superior to olive oil in obtaining oleic acid for longevity. But seemingly NO ONE discusses this. Nor anything else important. A really obvious point -- but braindead scumbag mankind NEVER mentions it. Instead, there's endless discussion about getting cold-pressed, extra virgin, Italian or Greek only, very fresh olive oil. But I feel bad for you too, Rimon. 99% of all the people in the comment section are pure-bred morons and scumbags themselves. 95% agree with you in whatever you recommend. If you recommended eating rat poison for longevity, 94% would agree too.

[@majaber1]

@@WellnessMessiah We are told now that most fish oils are rancid!

[@roscopeco2000]

i take resveratrol in a 1g tablet, i am dubious about ordering tablets off amazon but cant see any other good sources.

[@roblangsworld]

In the photo of resveratrol it appears the capsules contain a brown substance?!? Dr Sinclair says if its not white or gray its off and you should throw it out? Thoughts?

[@AndroidSamsung-qz9pl]

What about replacing Metformin with Chromium Picolinate and Bitter Gourd?

[@michaelberman3648]

I am aware of the resveratrol you are taking which is a water soluble molecule I believe. What do you think about Pteristilbene which appears to look like resveratrol but is more lipid soluble? Would taking both the water soluble & lipid soluble form be more beneficial in your opinion? And does pteristillbene work under the same or similar mechanism as resveratrol?

[@WellnessMessiah]

Hi Michael, I need to do a complete video on Pterostilbene. Every molecule is a whole new world. This is important when we want to take it every day, for life possibly.

[@evanlerman5447]

Pteristilibene is in Elysium Basis .

[@cheetahbrfc9016]

Do you think you can take berberine at night instead of metformin? Whay dose would you take if yes?

[@WellnessMessiah]

Hi Cheetah, Berberine has wide array of impacts. It's more complicated - from my research - than metformin. But one of its mechanism indeed overlaps with metformin. Personally, I do not take it at the moment and have more personal experience with metformin. But Dr Peter Attia is very smart on Berberine and use it in his clinic, so I'd go to check his recommendation.

[@damien4266]

My understanding is that berberine is very effective at flattening a glucose response in the body, but you also want to use it very sparingly. i.e. only take it before a carb heavy meal, such as the rare time you go for pizza and ice cream. I would not recommend using it in a routine manner.

[@lynnrussell1641]

​@@damien4266 A friend reversed Diabetes Type 2 with 500 mg. Berberine 3x a day and meat and veggies diet.

[@damien4266]

@Lynn Russell Fantastic that your friend reversed type 2 diabetes, but I would primarily attribute it to meat and veges diet not the berberine 3x a day. Cutting out processed food, refined sugars and sticking to whole foods such as meat and vegetables is all that is required, berberine is on the margin.

[@lynnrussell1641]

@@damien4266 Diet alone didn't do it.Berberine plus diet did.

[@michellelouise8865]

Wow, this was so good, thank-you

[@stubbler1969]

Hi Rimon, Do you address, or can you address, Berberine as an alternative to Metformin? My doctor is not really up on longevity research, and she refused to prescribe Metformin to me. However, Berberine is touted as a natural alternative to Metformin, with many of the same benefits, plus others. Of course, I purchase Berberine online, so it's more accessible. Thanks in advance, Chris

[@WellnessMessiah]

Hi Christopher, Berberine has a wide array of impacts. It's more complicated - from my research - than metformin. But one of its mechanisms indeed overlaps with metformin. Personally, I do not take it at the moment and have more personal experience with metformin. I can tell you that I've seen a massive reduction in cholesterol with my clients, so I suggest tracking that too. Dr. Peter Attia is very smart on Berberine and uses it in his clinic, so I'd go to check his recommendation. The brand here matters and I know Attia is using Thorne research, albeit it quite expensive.

[@arpandutta1344]

Glycine is the best...but remember it lowers libido but highly beneficial for health

[@stubbler1969]

@@WellnessMessiah Thank you. I ask this because many of us do not have access to Metformin because we can't acquire a prescription, but I've heard several additioanl benefits of Berberine, in addition to this overlap that you mention. I'll check out Peter's recommendation on berberine. I am still very much taking it now, but not Thorne. I'll look into that as well.

[@juanloprada]

Dr Attia takes berberine

[@bernhardwalther]

Great video as usual now. Thanks not to take holidays on that this summer 👌👍

[@WellnessMessiah]

haha thank you for noticing. Well, all the tourists are bombarding London now, so I try to be a tourist in my own city in the meantime & preserve my youthfulness until they leave haha

[@the_kingd0m]

David talked about DHEA somewhere and I cannot find it. He spoke negatively of it for some reason, it may have been on the J.Rogan podcast

[@WellnessMessiah]

find where it is, and comment in a new video . I usually check out comment only in new videos, hope to see more from you :)

[@JayP7.62]

When talking about vitamin K2 supplement dosage it’s important to be more specific on the type. I believe he was talking about MK-7 K2. You also have MK-4 which in most supplements is dosed higher than MK-7.

[@WellnessMessiah]

Hi Jay both of them are important. MK-7 stays in the body for 3 day, MK-4 for an hour. Please check the new resveratrol series in this channel, it's eye-opening and includes SInclair's work. This is episode 1: kzbin.info/www/bejne/e16ldqBpgdyif9U

[@eraalta449]

I am trying to buy NMN but cannot decide which brand. Should I buy from Hello 100 or Prohealth?

[@BK-dy8jk]

Make sure they do third-party testing for purity and strength. Also are very many things that are fake. so buy from a good company like I did from DONOTAGE, pro longevity, etc

[@youtubeok9228]

Can u pls list out the supplements in an order of giving high results to longevity..

[@letadeley8724]

Thank you for this summary and clearing up some of the confusion! I follow Dr Sinclair and find it hard to know exactly what he does. I was totally against metformin before following him, but I have learned so much from him and his ongoing longevity studies

[@anbrugm]

So where do you get these products? I do one search for either supplement an I get 10 different suppliers and bottles. And the prices makes no sense, 100x pills of 500mg for half the price of 50 pills of 250mg etc. I'm struggeling to sort all the information....

[@abdinajibisaak2186]

What are the supplements that will I take every day please I need the least?

[@cj-sp8ed]

Ill just stick with d3 k2 zinc and creatine, I eat a good amount of meats and low carb veggies that help me to function very well.

[@DingusCirc]

Its not needed to skip Metformin before exercise.... Especially if you are using TRT.

[@pabf2745]

Si, revesterol o arándanos (uvas negras, vino tinto)

[@gloriagolemboski4515]

Do you have any advice on strontium . I have it but don’t want to use calcium with it as calcium with Prolia shots went to my arteries instead of bones. Caused calcium in aorta.

[@DragonRyderNyx]

How helpful - thank you so much!!

[@soyivalu]

Very good summarize. Thanks!

[@WellnessMessiah]

Good to meet you :)

[@ryandoherty9696]

So am I to understand just to be clear that he takes virtually all of these supplements at the same time or around the same time in the morning? I don't hear him or yourself mentioning that he takes anything later on in the afternoon or evening. (I heard him mention some people take NMN at night time). Just curious, is he taking D, K2, Resveratrol, Quercetin, Fisetin, NMN, Spermedine, and Tri methyl glycine all in the morning? Thank you!

[@WellnessMessiah]

Hi Ryan, I can only know what he says. he know Vitamin k2 needs fat, so I think he takes with meal in the evening. He is doing intermittent fasting and skp breakfast. Fiseting and quercetin, NMN, RES, spermidine, he takes in the morning. TMG - I mentioned he stopped mentioning this. Metformin, he say in dec 2021 he takes at night.

[@ryandoherty9696]

@@WellnessMessiah Ty!

[@Anna-antiaging]

Really good question This is what I want to know. How does it work out with the liver ???

[@Anna-antiaging]

So he mix it all together

[@xochitlmorales6217]

thank you for the information, NMN and Resveratol = NAD+?

[@roslechte]

Good question 🤔

[@trnqwl]

Having read this far into the comments I am ashamed to ask, what does NMN stand for? What does it mean? Not at all savvy,,,,just trying to learn.

[@ginacardarella]

I enjoying the way you break down the video

[@WellnessMessiah]

Thank you. Check the new resveratrol series in this channel, it's eye-opening and includes SInclair's work. This is episode 1: kzbin.info/www/bejne/e16ldqBpgdyif9U

[@garynapolitano1270]

GREAT video!

[@telugufunnymoji5564]

Pls tell which supplement gives more percentage of longevity

[@emceeanders]

Sinclair said on Huberman lab that he pulses resveratrol, but does not go into detail.

[@edrock4605]

The fact that he is updating them means he doesn't really know. And we are all going to die.

[@miracoli16]

Today i saw a new video where he says that he recently only takes 500 mg NMN.

[@peterpau283]

Do you know Vitamin K2 and Vitamin D3 are fat soluble. So if you do not have a good Liver and Gallbladder. You can not properly breakdown and hence cannot absorb these vitamins properly meaning you do not know how much of Your daily intakes

[@LeaveAsItIs]

Why doesn’t Dr. Sinclair have made the supplement and and market it and letting others to do that and make business out of that? As far as I know pioneer in this reverse aging, is Sinclair. But I don’t see any supplement/product has come out of him other than free guidance, while others make business out of it. Which is not fair in my opinion.

[@phily8020-u8x]

Good research mate

[@bondjane007]

What is best to help memory loss of things U R taking Dr. Sinclair?

[@Synkronized7]

I thought he is also taking alpha Lipoic acid? Did he stop taking it?

[@livefromberlin2327]

I have heard that nmn should be kept in the mouth until it is absorbed, so it can pass the lever and intestinal in order to be absorbed.

[@cfpup]

Thank you. Well done.

[@AlexLondon]

what about the new nmn controversy that it never goes past the blood stream? Has sinclair responded?

[@EarthGen]

Thanks for summary of information!

[@WellnessMessiah]

nice to meet you hear. Check the new resveratrol series, it's eye-opening and includes SInclair's work

[@BryanDalleStelleOfficial]

I think he updated the way he takes resveretrol. I heard ( I don't remember the interview) he now dissolves resveretrol in olive oil and a little bit of apple cider vinegar.

[@WellnessMessiah]

Hi Bryan, you're right. I used to do that. But in the interview I put, he said what you said, and he said that he stopped using it.

[@BryanDalleStelleOfficial]

@@WellnessMessiah oh ok, thanks for clarifying that! I used to mix it with olive oil and put it in my chicken rice. I was wondering it a problem if the rice is hot? I guess unless you cook resveretrol it should be fine🤔

[@WellnessMessiah]

@@BryanDalleStelleOfficial Honestly, a great question! I'm not sure. If you put it immediately, it should be fine. But for many hours, heat increases oxidation. It can turn trans resveratrol into cis resveratrol, which doesn't work at all. But immediately, again, - seems fine to me! I have a video on absorption studies of resveratrol and its family member (quercetin): kzbin.info/www/bejne/raS9YoCgZpqZd7M

[@BryanDalleStelleOfficial]

@@WellnessMessiah thanks a lot, you are helping me a lot. Awesome channel 👌✨

[@roqclimber]

Rimon, thanks for completing my homework for me! Where were you when I was actually in school?

[@aaradhikachopra]

Anybody know how many months to take without a break..? And how many days in a week..?

[@nmc2049]

What would be the recipe for a homemade quality coconut yogurt ?

[@minyukova]

which brand has 1000 nmn capsules? i can't find anything online.

[@josephcollins6033]

What do Sarceno ...what ? do to our bodies? Is that cancer? thanks!

[@Anna-antiaging]

Ok the real question does he take it all at once. Like how much suppliment can you take at teh same time??

[@peterpau283]

Is NMN just a derivative of Vitamin B3

[@elenirum2020]

I take a grammar of NMN and a gram of TMG. It seems that TMG creates problems to my sleep. Is there any other alternative as a Methyl Donor?

[@lisamarierosso2713]

Have you tried DMG?

[@scottishfoldmocha5875]

12:13 Rimon, how are you taking it before bed time, an hour or 30 min before bed time with a few sips of water?

[@WellnessMessiah]

it doesn't matter. it enters my blood in 20 minutes. generally 1 our before with little water to avoid peeing.

[@popelgruner595]

May I add to the Spermidine question that you find HIGH concentrations of it in wheat germ. It is up to three times the concentration of mushrooms. At least that is what the web says.

[@WellnessMessiah]

Yes, you're right. The study hasn't checked wheatgerms for some reason,. That's how they make the supplement, too. Kudos for your comment

[@henvest3491]

I add wheatgerm to my tinned tomatoes in my regular salad. Tastes ok. So pleased I can now eat less of it I was trying to get close to 1gram which isn't really possible. Great source of vegetable protein too

[@WellnessMessiah]

@@henvest3491 sounds like a great way to add spermidine, good idea :)

[@palden4579]

All the Resveratrol I ordered until now was always brown and not white in color like Dr. Sinclair says it should be. Anybody knows a Resveratrol supplement in which actually the powder is white?

[@Batony]

Toniiq

[@palden4579]

@@Batony Thanks! :)

[@denisemaryheatherington5820]

It can be white or light grey not brown

[@scroolewse7733]

PlantPills.

[@tonycastani1560]

Why does Dr Sinclair still take such large doses of Resveratrol even though in his own studies low doses worked better for longevity? In one of his recent interviews he mentioned that he now takes Resveratrol every other day.

[@WellnessMessiah]

Hi Tony, can you share the video where he transitioned to taking every other day? And please check the new resveratrol series in this channel, it's eye-opening and includes SInclair's work. This is episode 1: kzbin.info/www/bejne/e16ldqBpgdyif9U

[@hrhtreeoflife4815]

Q Just think about the cost of these vitamins Sinclair received them free Does he have to pay out of pocket for these now? Probably. That would explain having to skip, change doses, or how often. Because the cost becomes exorbitant. Q ❤️

[@tonycastani1560]

@@hrhtreeoflife4815 He became rich after selling Resveratrol to GSK. Unsure how much of that money he re-invested in his research.

[@hrhtreeoflife4815]

@Tony Castani if he is cutting back on what he is taking, I guarantee 💯 that he isn't rich...but you imagine that he is. I was trying to figure out what he takes and how much, but I can't come close because of the COST. For me to pay my bills and add this to it is extremely expensive and cost prohibitive.

[@gavinmurray4505]

Guys, I live in Ireland,where can I get metphormin in Europe please?

[@janaskopec6033]

Can TMG help people who don't MTFHR gene mutation?

[@cesarvillalobos5183]

Thaaaaaank you because you speak clearly!

[@dagoelius]

"Metformin enhances and mimics the benefits of fasting"..so why not just do fasting.

[@tarekelias463]

Shit is hard my dude

[@saxmafia]

He has stated that both is better.

[@Sirblader11]

Fasting shutdowns Mtor

[@jwscheuerman]

"Enhances"

[@gaetanozorzi2055]

Taking both has a synergistic effect, and correct me if I’m wrong but I think I remember seeing that fasting can cause some muscle loss with athletes and other highly physically active people which may be undesirable for some

[@markferris3674]

What do think about L CARNOSINE ?

[@annethomas4112]

I'm vegan and was wondering if iI still need b12 as I'm taken nmn and tmg

[@WellnessMessiah]

Hi Anne, nice to meet you on this platform. Vitamin B12, when taken in "methyl cobalamin" only form, will contribute methyl groups to your body. This is covered by TMG supplement. However, TMG doesn't cover the B12 part. In other words, TMG won't increase your B12 in a blood test. The opposite makes more sense: giving up on TMG because you already get methyl via B12 - if it's methylcobalamin.

[@amitloutube]

I need to know which multi vitamins(which brands) especially B complex are best without any side effects

[@evanlerman5447]

With water soluable vitamins take all you want, be care with fat soluable

[@kboy4120]

Methyl b complex - I take biocare