NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Lifespan with Dr. David Sinclair #4

[@LifespanOfficial]

Correction and clarification: At time point 1:07:37, I said I take 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. I apologize for the confusion.

[@brianruppert1071]

You mentioned physedin or fysadine, but I can’t seem to find the correct spelling. If you could spell that I can investigate. Thank you for your time.

[@ExbotHero]

@@brianruppert1071 Fisetin

[@brianruppert1071]

@@ExbotHero , thank you!! For some reason my computer couldn't track it down. I appreciate it, mate.

[@ExbotHero]

@@brianruppert1071 You're welcome my friend. 😊

[@HarveyCastroMD]

Can you share what brands he recommends

[@davidm1411]

The co host is great. He has a very effective way to be both a “layman” as he asks questions while at the same time, generally savvy on the topics. Also, I congratulate you both on not taking yourselves too seriously. We already get enough of that with certain scientists.

[@Eric-it4we]

I couldn’t agree more. Cohost totally makes this a next level podcast/conversation.

[@spindleblood]

Agreed 100% - you took the words out of my fingers. 😁

[@Thebusysuperhuman]

Yes I thought that too - big shout out to Matt

[@modelsupplies]

Agree. He’s lovely as Sinclair mentioned 🥰

[@scottk1525]

Technically he's the host, given that he's the one conducting the interview. But you're right. It's like nearly every time a question pops into my head, it's the very next question out of Matt's mouth.

[@jenneferwillard7758]

I’m obsessed. I’m so excited about this research. I’m 50yo. I haven’t had any living parents, grandparents etc in over 10 years. I’m determined to change this for my family!

[@w3w3w3]

cute pic

[@DoubtingThomas333]

My uncle was more educated than this man, and in the same field, and he died in his late 50s from cancer. I promise you none of this stuff has any real effect on your longevity. Live a healthy life, don't go taking a bunch of pills and potions and spending a load of money. Take care lovely.

[@lizzie2301]

@@DoubtingThomas333 what does your uncle being more educated have to do with this. How was his lifestyle???

[@tulparpusat]

You re so cute fem

[@TinyGiraffes]

@@lizzie2301Look up criticisms of David Sinclair. There is at least one drug he claims reduces aging that has been proven over and over does not.

[@Auronintheforest]

I’m a simple man. I see a new Video from Dr. Sinclair and I immediately hit “like”.

[@melayan9127]

This comment will age well, I predict

[@vladimirledenko8922]

Me also, like first😂

[@ericwiese7479]

As do I !

[@debrobinson857]

Me too!

[@NRNF1776]

This comment is great on the molecular level 🤐😅

[@juiianadebeers8230]

I just finished your incredible book Lifespan-for the third time. First reading was an audio version and I stopped every hour to cry hard. I read a lot for a leadership program that I teach for the Air Force and thank you btw for mentioning USA air supremacy. LITERALLY THE MOST INCREDIBLE INFORMATION!!!! I tried to relay it all to my own adult professional child and her husband and sounded like a blithering idiot bc I get so emotional. I am thrilled to find this podcast so I do not have to try. Your optimism is a leadership trait; you’re an educator, not merely a scientist. Your book’s messages were mostly about longevity, but also part existential, part environmental, and part economical. As a teacher myself a huge obstacle is keeping my students and coachees happy about humanity. I am as wound up at the end of your book as I am at the beginning. Thank you for your genius and your optimism.

[@mrLoftladder]

I'm taking a similar supplement regime myself and have been doing it for a couple of years now. 67 Y.O and feel more energetic and certainly fitter than any time since my early 50s. loving these podcasts learning so much from them, thank you.

[@edakovaci537]

Hi can you tell me please some names you take I need more to know the spelling , when he said Nmn quercetin and visetin or I don’t think writing right he mention desitin too, if I’m right. Thank you in advance

[@NicholasOdinson]

I aged a full week waiting for this podcast 🙃

[@fitafita7931]

Well, you can reverse it back now 🤣🤣

[@barbarafairbanks4578]

🤣😂😳

[@StarBoyyX]

double dose for a week and you will have gained an extra week ,im dreading the leap year I can't order enough

[@barbarafairbanks4578]

@@StarBoyyX you have some time...nxt L/Y 2024...🙃

[@barbarafairbanks4578]

@@fitafita7931 yup! Sinclair speaks and we're instantly younger😅

[@roberttorrie2651]

I HAVE BEEN ON NMN FOR 2. MONTHS AND HAVE NOTICED A DRAMATIC IMPROVEMENT IN MY ENERGY & A DECREASED NEED FOR SLEEP. THANKS FOR YOUR AMAZING CONTRIBUTION ❤❤❤❤❤❤❤❤❤❤

[@BlackPearlMona369]

Good for you 👍✌️. May i ask if you noticed any changes with your face skin? In terms of acnes and scar marks, if you have.... hopefully you don't have though....

[@roberttorrie2651]

Huge benefits for my face and skin

[@BlackPearlMona369]

@@roberttorrie2651 thanks a lot, appreciated 👍

[@reeshs9296]

Which Brand please?

[@618grow]

@Meem Aly wow I've been using it maybe 10 days and I swear my birthmark on my neck which is light in color is fading.

[@ashleyjwilliamshand]

I was so stoked when I saw you started this channel. Loved watching you as a guest on other podcasts, so this is a treat. Great job so far!

[@mixalis6168]

Why ?

[@ashleyjwilliamshand]

@@mixalis6168 Why what?

[@manolisworld]

@@ashleyjwilliamshand very good point!

[@bozorebebo9422]

@@ashleyjwilliamshand why, so you can grow a brain and ask better questions lol

[@ashleyjwilliamshand]

@@bozorebebo9422 I didn't ask a question in my original comment post on this video, I asked "why what?" to the person that commented "why?"

[@johnalbers8020]

I am a physicist by education. I used to think the biology was an easy subject. Not any more. Listening to this very interesting podcast, I marvel at the complexity of biological systems. This podcast is very informative and easy to understand. I plan to use some of the supplements outlined in this podcast. Excellent

[@EmperorFist323]

Wow exactly my thoughts. Physics and mathematics is very simple compared to biology. I came to the conclusion biology plays with physics the way we play with math, which makes it very difficult to predict and understand

[@EmperorFist323]

You should look up quantum biology.

[@creativesource3514]

@@EmperorFist323 This is incorrect. Physics and maths are not simple in comparison. They are the hardest subjects.

[@EmperorFist323]

@@creativesource3514 perhaps. But it is an elementary matter. I can explain to you the orbits of planets, their gravitational pull, their magnetic sphere. I can plot trajectories across the stars, how the stara form, hell i can make a star here on earth. I can tell you the age of the universe. In the same breath I cannot tell you in a fundamental level how a cell transcribes genes, I cannot tell you how the proteins are transported and constructed, I cannot tell you how a protein is folded, I cannot tell you how a cell structures it's self, I cannot tell you how all this produces consciousness, I cannot explain the quantum mechanical effects of biology and how cells utilize it. My point isn't that we don't know per se, as there are things we don't know about physics. But my point is more so to showcase that to understand how these biology systems fully function is nearly impossible due to the complexity. I can breakdown the solar system and its functions and interactions much more easily then I can explain a drop of blood.

[@creativesource3514]

@@EmperorFist323 I'm a head and neck cancer surgeon. I find what I do pretty basic compared to what you do, general relativity and quantum and what's going to be next. I study undergrad physics in those two in my free time and my mind boggles at the complexities.

[@akhisalaam]

I can't believe this is free content

[@katharineofarrogant7805]

Highlight of my week. As soon as I listened to these I started OMAD, changed my diet and exercise routine. I've sent this to all my friends and family. Pure gold!

[@cmsotube]

What is OMAD?

[@jazzisback]

@@cmsotube One Meal A Day = OMAD, IF = Intermittent Fasting. You're wellcome.

[@boydhooper4080]

Great that you go deep into dosage, timings and other details on the supplements. So frustrating when others don’t do that.

[@roadrunna.]

Finally an interviewer that makes good use of time by letting Dave talk without interrupting and pushing off tangent. Thanks

[@lindawalker2092]

Love this series of episodes. Very informative and hopeful for those of us in their 70s. Vanity would have driven my interest before, now it is quality of life. Especially cognitive function as I'm watching friends in their late 70s and 80s, mentally declining. Not all but so many.

[@urpgag2]

7-Oh and I drive a van full of handicapped and You and I both want my brains to work at capacity lol We could talk about Huperzine A

[@deboraheliseperrinwheeler9201]

Right behind you! 68 mother of two. Need to remain here as long as possible with healthy body and mind! My son passed during COVID. Being a mom of a 9 & 8 years of age need all help available!

[@uberandreman]

Second comment: I want to add that I am following much of your protocol and I have so much energy it is incredible! I am relatively young (33), but have been dealing with fatigue for a long time. Particularly the day after intense exercise (BJJ). I have trouble focusing and getting through the day even with heavily optimized sleep. I am currently alternating between 16 and 22 hour fasts. When I do eat, it is mostly a low protein, high carb, plant based food (with some junk thrown in because I'm human and still working on things). I am taking NMN, resveratrol and Metformin. And I feel like a million bucks! I am recovering well, focused, creativity is up. I am honestly shocked and hope this is able to sustain itself for the next few months (I do not plan on doing all of this indefinitely).

[@s3731711]

Same!! Wow

[@cmsotube]

What brand of NMN, reservatrol amd metaform are you taking?

[@coman349]

Where do you get those? Is there reliable source?

[@belkisrazai5380]

Brand name please

[@Steven-ze2zk]

You're fatigued AND spend your days doing "intense exercise?"

[@user-ud4do1hj5t]

Dr. Sinclair, hope you will discuss how NMN affects kidneys. Kidneys are crucial to life but are not discussed often. Thank you!

[@lasvegasplease]

How does it effect the kidneys?

[@pkstiever]

I really enjoy these two and how well they get along. I learn so much in each of their podcasts.

[@DalidaD]

People should look into the FDA nmn supplement ban and its connection with Sinclair.

[@peterellis4262]

I did. Nothing burger.

[@mbbrooks123]

I had heard of NMN on another podcast about a year ago. I then dud a little research and started taking NMN. I found out it that it has changed my life for the better. My anxiety had pretty much gone away. My energy is by far more focused, and for the most part, I feel great. I have other heath issues that dragged me down prio to NMN. I've tried many supplements and haven't had any luck, but NMN is doing wonders for me. I have bought a year supply since places have quit selling the product.

[@Dimer95]

The co-host is such a nice guy!!! Makes the podcast just perfect

[@sylvieasics6570]

I really like the chat/questions format with this super knowledgeable co-host that makes it so much more valuable than with a real layman! Thanks both

[@johnwilhelm]

Have been following David since the early Resveratrol days. Was super excited when this series started. Thank you for your continued efforts to expand our knowledge on this topic. You and Matt make a great duo and I hope this series continues beyond the current scope.

[@KyleMcDermott1]

@@johnf4680 what do you mean?

[@aaliyahlee1265]

My life has changed after taking NMN supplement... I was very sickly and weak years ago, but when I learned about this product, it gave me hope to progress all the things I stopped doing before, like gardening.. I feel so alive and well with vitruvin NMN and trans-resveratrol..

[@robynhope219]

You must be rich..I can’t afford these supplements ☹️

[@MJFUYT]

I discovered Dr. Sinclair from Dr. Andrew Huberman's youtube channel. This is amazing information from Dr. Sinclair. Thank you for sharing your knowledge!

[@jaihanjqx1140]

I have been taking resveratrol for several years now. Unfortunately I am confused. Many evidences suggest on the contrary. Why doesn't Dr. Sinclare clearly answer the question raised by Dr. Brad Stanfield. I think there are many worried people around the world who have been taking resveratrol waiting for Dr. Sinclair's response. Please!

[@usmanarshad6414]

@@jaihanjqx1140 take curcumin. It also activates Sert 🧬

[@EliasHossein799]

Biggest Salute to professor David Sinclair...

[@rapamycinnews]

Great to see David covering rapamycin a bit more than in the past.

[@redpilllense7125]

Thank you, Dr. Sinclair! I look forward so much to this podcast series. You truly are helping me 🙂

[@judipapendick2460]

This is all so very fascinating! Thank you for speaking to the public directly without the media filter! You are both of a lovely generous spirit

[@donotageteam]

Another excellent podcast David - we love your work!

[@nickl826]

A few drugs to add to your inventory list where possible ;)

[@donotageteam]

@@nickl826 We already have NMN, resveratrol, quercetin, fisetin, berberine & spermidine which he talks about here. Jump on our email list, we do the research so you don't have to 🙂

[@shcs2010]

@@donotageteam I don't see the email here. Should Berberine be taken in the morning too? What happens to traditional supplements, take them also or not?

[@ャンティオカ]

came here to post this

[@rosesolis2306]

Hello. Are these products refundable if we don't like them. The do not age..

[@thomasbiom]

I was hoping that you would discuss Methylation concerns and the use of TMG to mitigate. Also, I find the piece that’s often missing from Such discussions is for pregnant & breastfeeding mothers.

[@lelle9901]

Women in general are always missing from specific discussions. Because of hormones, women may respond to fasting differently than men, for example.

[@apocryphalsubfusion]

Thank you for another amazing podcast! The shows notes, the timestamps and the explanations were very digestible (pardon the pun). Seriously thank you David, Matthew, And the team at Harvard medical school working hard to bring us the best longevity science to date. I can't believe that this information is freely available for all of us

[@BurtWalker100]

David Sinclair and his Co author have produced one of the greatest blog for those managing their health. Bravo.

[@halnineooo136]

Any Q&A session some day on your channel? Thank you for the invaluable information.

[@triciamedora9274]

Lord David really does look younger and his Skin is glowing.. Gosh hopefully he will do a podcast in the near future regarding supplements that are effective and proven to be safe that we can consider using at this very moment .

[@danmustlearn]

Resveratrol, 1gram per day, in the morning with yogurt or olive oil,basil, and vinegar (needs fat to be absorbed) Nicotinamide mononucleotide(NMN), 1-2 grams, in the morning with same yogurt/olive oil Quercetin and fisetin, 500 mg each, once per day, in the morning Spermidine, 1-2 mg per day, in the morning Metformin (prescription drug), 800 mg, in the evening

[@rickemmet1104]

Tweets, "David just tell us what to take." LOL! I've already implemented a bunch of lifestyle changes. These interventions will change medicine (which many will be unhappy with) but you all better change what you're eating and get to the gym too. Thanks David for the awesome podcast!

[@goldgold4943]

Sinclar, the god of anti aging

[@therealtimray]

NR consistently raised my alt and ast liver enzymes during a year's worth of regular blood tests. NMN lowered my enzymes even lower than they were before taking NR in the first place.

[@larnapike6992]

Hi Tim :) given what Dr Sinclair said about Pancreatic Cancer and NMN, I’m wondering if you screened for that genetic propensity and if so what test you used? It’s my only concern regarding starting that supplement. Thanks!

[@therealtimray]

@@larnapike6992 under my 23 and me account, I don't see anything that would indicate a propensity for that or any other form of cancer. There are others who've had this issue with NR, since NR requires additional methyl groups in order to be converted into a usable form. To get these methyl groups, your body has to borrow them from other molecules in the body, taxing the liver more. Which by the way, I'm discussing the liver, not the pancreas. As far as my pancreas goes, all of those health numbers, such as A1C are optimal.

[@AmeliaLi-lz6kc]

Hey, are you still taking nmn?😊

[@therealtimray]

@@AmeliaLi-lz6kc yes, I stocked up a year or so ago when the FDA announced they were going to take it off the shelf for over the counter and rewarded a pharmaceutical company with the license to sell it as a drug

[@AmeliaLi-lz6kc]

@@therealtimray thanks for responding. Do you also fast? Have you slowed down or reversed aging? I've read and seen some some videos that Dr Sinclair is a fraud. What's your opinion on that?

[@jeremydavidevans]

Your partner contributes a lot to the interview! Excellent match, glad to see this information presented in an accessible way.

[@susette2024]

hello Dr. SInclair, are there any studies and recommendations especially for women regarding hormones, menopause and intake of bioidentical hormons or herbs, or supplements etc. and prevention of diseases related to decline of hormones. I would like to learn more especially about womens health (so rare in the school medicin). Thank you.

[@ewastykowska3460]

I also regret that there is no specific notion as to the women health. Men and women differs, however I found no studies on specific regime /supplements for woman at different age. Could any future podcast focus on this topic, please?

[@susette2024]

@@ewastykowska3460 yes, it's sad how gynecologists and general practinioners still react when you ask about hormons, according to the motto: “ You are a woman, you just have to go through it! “And such myths like bioidentical hormons cause cancer, what a bullshit and how many suffer every month on pmd or pmdd and all of the damage from the anti baby pills & Co. They just don't know how it all works together, even if you give them numbers

[@jeffmiddlebrook5251]

Agreed, a podcast on NCEs will be important.

[@radubetea5724]

Am inceput postul intermitent in ultimele zile ale anului trecut.După trei saptamani am facut o verificare si vârsta metabolica a scăzut cu 4 ani.fata de cat era anterior...inca mai am de recuperat,dar imi place foarte mult noul stil de viata.

[@suewade3970]

His voice for his sponsors soooo smoothing Ok David ill buy everyone of your sponsors products cause you said so

[@MarkDoesYoutube]

38:15 Best part of the podcast. You're welcome.

[@daventhegreat]

Thanks David & Matthew absolutely amazing series. I have a very important request: Can you do an episode on what molecules/drugs are safe if we already have cancer... some of the common cancers .. prostrate, breast, bowel, lung cancer .... that would b gr8.... if that's possible given the huge diversity that's present in these disease processes & stages. Are there any universals for particular molecules or types of cancer? Etc

[@winskypinsky]

Really looking forward to the Centennial podcast! brilliant podcast, you two are a great team!

[@yummimaus]

Thank u! Really appreciate you being so direct about how to supplement these ingredients. And David you look amazing for ur age and that make me believe you… and love the fact that u do so much in your own labs… instead of reading from others’ report only!

[@02ity]

Clarification: I am excited about your work. I am hungry to consume it all (pun). Just want to make sure everyone is on board with your findings and the results can not be corrupted.

[@kaylabryson1932]

Everyone is for sure NOT on board . Check out Ray Peat PHD work. Resveratrol for for beginners… so much science showing it’s Not a good supplement.

[@rdallas81]

@@kaylabryson1932 what is good? That depends on the perspective if a particular individual. What you may consider good I may not. What has a good benefit to you may have a bad consequence for me.

[@captainpike2468]

Important to emphasize ‘the threshold level’ as David discussed in his interview with Rhonda Patrick PhD , the ‘natural clearing process ‘ of the body that will eliminate NMN supplements , Resveratrol from the body - and David’s idea of ‘pulsing ‘ these supplements every other day , then fasting and exercising

[@jamesevans4781]

In that interview with Dr. Patrick he mentions that young mice lived longer if the protocol was pulsed rather than if they received the supplements daily, but he doesn't pulse his own protocol. Is that because he's middle aged and every day is more efficacious, or did you come away thinking that the pulsing is an emerging idea which he is still vetting before switching his own protocol

[@spirtfire6004]

What are your thoughts on apigenin? Especially in a post menopausal female on estrogen replacement-thank you for this terrific podcast and lending us your knowledge

[@winbalingit8502]

I saw Dr. Sinclair on a podcast giving a lecture on Resveratrol, it was for a wine convention, everyone, including Dr. Sinclair was drinking red wine!! The lecture was very educational and entertaining!!🤩👍🏽

[@jeffmiddlebrook5251]

I knew this podcast would change everything...I would need to know about my lifespan.

[@Josh-ev6nb]

Can you elaborate more on metformin and berberine for (aging) athletes? What is happening with glucose? Is the total amount of glucose storage in the body reduced? Are we excreting it? Or do the molecules just help glucose more effectively get into tissue? So let's say I have a big ride the next day and I'm trying to tank up on carbohydrates. What's happening if I take one of these molecules with my high carb dinner? THANK YOU!!! LOVE YOUR WORK!!!

[@thatchessguy7072]

Hi David! I’ve been implementing what you suggest (I haven’t yet implemented supplements yet) and I feel a lot better! One of the things I’ve done that’s helped a lot is actually something you haven’t mentioned in the podcast yet. I took a food sensitivity test and cut out the foods that tested positive for sensitivities. Milk was apparently causing me muscle and joint inflammation as well as stomach problems.

[@d3f34t]

How does one go about taking a test like this?

[@ChefGracesPlace]

@@d3f34t you can ask your doctor they usually refer you to an allergist/immunologist who does it.

[@joeanna1100]

do try metformin unless your doc says diabetes there's a risk

[@debralbungermd8804]

@@d3f34t find a functional medicine doctor.

[@soniaruiz2801]

Thank you both for this weekly series. Great job. Very informative. I just wish a could find a Dr who is willing to prescribe such molecules & drugs. Blessings🙏💙💙

[@lyndan438]

My biggest takeaway: the conversation about mice being predisposed to cancer (certain type(?)) and NMN stimulating cancer growth (as in the 2019 study that was discussed). It feels as though that wasn't given enough emphasis, should I be cancelling my order for NMN?

[@TheHorrorsPersistButSoDoI]

It stimulates it because if the body inside is younger cancer would also act as if it is in younger body, but then again, if you don't take nmn you will get older faster and chances to get cancer and other increse...

[@rdallas81]

People are not mice.

[@marcocoltelli5975]

I am marco from Italy, I have already read your book and I have found it fantastic! Naturally all your suggestion are focused on US market, I hope one day you'll have also some suggestion about italian or european provider for blood rest, dna test etc. Supplement are quite easy to find though.

[@ElectronicApocalypse]

Ciao Marco. Dove e quali hai preso di integratori se posso sapere?

[@marcocoltelli5975]

@@ElectronicApocalypse amazon

[@ElectronicApocalypse]

Nmn che compagnia l'hai preso?

[@vincentv5000]

Thank you for the information.. just joined the levels membership.. inam diabetes. But my doctor refused to prescribe CGM for me for two years ..I need this machine for supervising my intermittent diet . Finally got it ..

[@88Jenpal]

Thanks for this podcast, I appreciate all your work and I been trying to follow your regimen. I wish that you could tell or advise us which you think is the best choice NMN supplements. I been paying a lot for it and still not sure if they are true to their advertising or I pick the right one.

[@howardlui9943]

Fantastic co host! Great questions .. great balance of talking and allowing David sinclair to speak!

[@Paulsapartment]

Thanks!! But I wish you had mentioned something about Metformin and PCOS. I am 62 now and people often are shocked when I tell them that’s my age but I’ve been taking metaformin for PCOS since I was 25. I’ve now gone through menopause and my doctor said sure keep taking your thousand milligrams a day it won’t hurt yet so I am

[@CAwildflowers]

I’m interested in your comment. I am a diabetic and take insulin 70/30. I am prescribed metformin 1000mg but have not been consistent about taking it. I’ve just restarted. Have you had good results on metformin?

[@cindyradison8324]

My mom is 68 and never feeling old. Her retirement has been more fruitful and productive. My mom doesn’t have any age-linked issues even the minor ones. She still hikes with her friends. My grandma is 85, and still very strong and mentally alert. No medical issues except mild joint pains that come occasionally. They’re both very healthy and happy. Still can participate long family travels and visit one country a year. Thanks to NMN supplement by Vitruvin Nutrition. Age is just a number!

[@einosky]

If you take these supplements, does it reduce your body's capacity to produce them? (NMN etc)

[@cmsotube]

Very good question

[@jeffteer222]

Very good question. If you take Nad injections will your body stop making it then you need to take them for life?

[@nodap6449]

sharp

[@natashatelfer5778]

I'm guessing they don't know and that there is a ton still unknowed overall. Always risking taking anything especially something newly studied.

[@Thebusysuperhuman]

Thanks for this - I love the way you and Matt interact - All scientists need a Matt to help explain to lay people

[@espinozafn]

God Bless Joe Rogan for getting this guy's name out there. This is powerful information.

[@christinagior42]

I’m so grateful for having discovered you!! I hope to find the right manufacturers for these products.. 🙏🏼

[@puppygirlfm1483]

David, thank you for sharing your knowledge to help others! Question about Berberine- when should I take it? At night, the same as when you take Metformin?

[@GodofStories]

Cohost is great! Matthew great job explaining and discussing the finer details! Bravo senor!

[@geoffwelch5952]

Correction***- The study referenced for spermidine and cognitive decline was dosed 1.2(mg) not measured in grams. 1 gram has not been studied in humans and possibly be detrimental by over-activation of autophagy in some tissues and cell lines.

[@jeffteer222]

Is David taking 1 gram of spermidine?

[@geoffwelch5952]

@@jeffteer222 I believe he is taking wheat germ extract-800mg which equates to 1mg of spermidine. Most people aren't aware of the potential harm of suggesting 1 gram of spermidine, it is an irresponsible error that must be addressed.

[@migtowredpill6950]

I'm glad I read "Lifespan", thus I understand much better this conversation

[@LianaBuzea]

I can't wait for the episode on hair regrowth / regeneration. I know it was a topic announced for future episodes. 🙏

[@delaneyondreams]

Add to that hair regrowth issue: are the topicals used to increase eyebrow regrowth safe? I have used Beverly Hills Dr. Brow and in about 3 months it started to regrow , by 6 months even helper regrow the outer halves of my brows. So it works even if I don't, after 1.5 years, have the thick brows of my youth. Still, worth the bother. Amaz. Has much less expensive versions, but I do not know how to judge them nor have I found associated effectiveness studies.

[@rosiefoster713]

Im waiting for that too as a female that is losing her hair :(

[@PaLOmAFAiTh0]

Where did you heard this topic? Maybe one of the previous videos?

[@josephsiwek4324]

Yes plz

[@mattboscan]

Just go to More Plates More Dates for that. Derek and the channel Hairliciously are at the vanguard for KZbin hairloss content. Good luck! : )

[@JohnDeanMusic]

You guys are changing my life.

[@tobiasgerke9942]

Thanks David. Great podcast. Could you comment on the study that "Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults" from 2014 that found no possitive impact in humans (in JAMA Internal Medicine (2014; doi: 10.1001/jamainternmed.2014.1582)

[@StarBoyyX]

interesting , I thought the resveratrol steps on the gas for the nmn

[@davidashkanasy6718]

GlaxoSmithKline has to entirely drop all research and studies based off the company bought from Sinclair, as the results were not only bad, but in fact produced negative outcomes.

[@sanjaybhagtani9583]

Taking a supplement or injecting young plasma in a very old body would likely lead to rejuvenation in some tissues, but would also lead to rescue of some very damaged cells and since the all tissues and cells are not rejuvenated to the same extent can lead to undesirable outcomes such as cancer. For e.g. suppose a supplement rejuvenates the liver and does not rejuvenate the immune system to the same extent, some liver cells on the brink of senescence would be rescued, but with mutations or damaged DNA and the dysfunctional and aged immune system would not be able to eliminate them

[@ewastykowska3460]

As a person without any medical background I really wonder how to check my body response to the supplements recommended in this podcast🤷🏻‍♀️. I would like to know what blood parameters/blood tests I should check before taking the supplements and when to check out the results by retesting. My kind wish is to have the professor’s opinion whether the recommended supplements are safe for people with celiac disease? Could you also recommend supplements for people with serious problems with knees (deficiency of collagen and how to reverse that ?) Thank you for helping people understand what is going on with their own body❤️

[@lotfibouhedjeur]

I wait for these videos as if my life depends on them. Wait, it does!

[@partakith3673]

I truly appreciate everything you are working toward, even if much of it you have to hint at in over 40 hours of videos :). Who doesn't love a puzzle? You bring the thoughts and ideals of a future unlike any I would have thought to see in our lifetime. Thank you!

[@Bodzio1982]

What you said about NAD levels and alcohol just proved that my supplements are working. I’m not a drinker but when occasionally I have some alcohol I feel very bad next day. Last week I had few too many drinks and the next day I was feeling pretty well. Still had little hangover but wasn’t sick.

[@rdallas81]

Why drink? Who in their right mind drinks alcohol? Its not fun or good at all and everyone knows most people drink and do stupid things and feel stupid the next day- so WHY?

[@ordoabchao4202]

​@rdallas81 it is a lot of fun. not as much as in the teens or twenties but still. Uplifts the mood and relaxes.

[@tomwawersich809]

Love the podcast- great episode! I have heard I should be taking TMG with NMN - would love to hear if you do this. Thanks again for your work in the area of aging!

[@marinafoglietti9351]

Thank you Dr. Sinclair, for all these interesting informations. I'm taking 0,250 mg a day of resveratrolo in the morning from this week, with yogurt and a little bit of olive oil; I have ordered NMN for next week. In the meantwhile I am so excited❤❤

[@semaaral2498]

Who is your company can you pls share with me because I‘m having difficulty finding white trans Resveratrol at the moment. Alice by Science USA says they don't have it in stock until mid-March. NAD London lab said they have CIS brown ones which I didn't agree to use. So can someone helps me with a pure Resveratrol pls🙏🙏🙏 I’m desperate. And Stressed. Many thanks

[@marinafoglietti9351]

Sorry but on Amazone I have found only Resveratrol 0,250 mg but it is not white, it is brown. The company is WeigtWorld, it's English and next time I'll look for Transveratrol and not brown. Now I know that the one have had bought it is no good.

[@semaaral2498]

Yes definitely also you have to look at GMP and 3rd party test one. Alive by science US is one of the best & they use the same supplier from China we learned from youtube podcasters. But they don't have White trans one until Mid March they told me. Donotage is good and their prices are good as well. I will order from them this time my trans-resveratrol. I used from them many times and happy with the results 🤗 Take care. Thanks for replying to me very kind of you🌹

[@zaralushlush5903]

Prof. Elena Goun, a chemist at the University of Missouri: ,,High levels of NR can increase the risk of aggressive breast cancer and the likelihood of metastases, including to the brain" !!!😮☹😟

[@edwardpoppiti2258]

Hello, really liking the series so far. When talking carbohydrate there is a lot of talk about how many plants utilize certain chemicals to ward of predation, and that because of this they are harmful to humans and should be avoided, making the case for "primal"/keto. The question I have is: is it possible that these chemicals could actually be stimulating an "adversity" response and in fact be very beneficial to humans?

[@paulgennaro2001]

He addressed this in the previous episode or the one before I think. In short, the more stressed the plant, the better they are for you. Somebody correct if I’m wrong, btw.

[@edwardpoppiti2258]

@@paulgennaro2001 the question is not the fact that the plants were stressed, but whether the chemicals that were stressing the plants is actually harmful to humans or in the end beneficial. Many people in the low carb, keto camp feel that those chemicals are very harmful to humans, really getting into the weeds now.

[@francischen3819]

Thank you David - I am a huge fan of your work!

[@rosiesmallshaw]

Love your podcasts! The synergy is always courteous and encouraging. Keep up the great work 👏🏼👏🏼👏🏼

[@bozorebebo9422]

ya, you guys make a good team.

[@Oldmaninthestream]

Thanks for providing health and wellness on a massive scale!

[@uberandreman]

I love this podcast, and the format. However, I was wondering if there is room for special episodes where you have another researcher alongside you that might be able to add some criticism or another perspective to the research. I came across Dr Rhonda Patrick's video on Metformin for healthy people who exercise, and she seems less enthusiastic about the research. I finally found a review of the literature from last year that gave me a better understanding, but I was wondering if you could make this more efficient. My thought is, maybe you can have someone like Dr Rhonda Patrick on, and discuss a set topic that neither of you too fully agree on, like Metformin. Not to debate necessarily, but to get a more complete view and really flesh out the current state of the research from multiple angles. Matt can still be the moderator, he's great!

[@robertjleter]

Great idea, and Valter Longo. For the moment I tend to put my trust in David Sinclair but a discussion would be great

[@josepho5055]

To "Andre Salazar" the Master of metformin is Nir Barzilai, MD.

[@Dutchtraordinary_Living]

Great idea, was thinking the same!

[@bellehamilton3395]

It's difficult to evaluate something with no visible consequences, but the research points to a positive outcome. It's probably best to utilize while you're under physical duress. This product has met my expectations in that it has made me feel more energetic in the morning and throughout the day since I started using it. I'll keep taking Vitruvin Health Anti-aging supplement since it keeps me energetic throughout the day.

[@marwamite4024]

Hi! Thanks for all your work - When you were on Huberman's podcast, you briefly mentioned that taking Resveratrol on alternating days produced better results in mice based on a specific study, and that the beneficial effects could even be mitigated by daily intake. But I've also heard you talk about it being in your daily stack, as you've mentioned here. Could you elaborate/clarify whether you think a daily or alternating intake could produce a significant difference in potential effectiveness of Resveratrol ?

[@patrickflanagan949]

As a follow up - Dr Sinclair mentioned pulsing with exercise too. Does that mean one day on and one day off? Do you do the same thing with NAD boosters?

[@javadivawithdog]

Now I don't feel bad when I forget my resveratrol 🙄

[@stevedevlan4852]

Ditto. It also seemed like he was saying for supplements in general that alternating improves their effectiveness. He didn't make that direct statement but the way he mentioned every other day created that impression for me. What's up?

[@cristicons7362]

Thank you for asking this question, I’ve also noticed the same remark and wondered if the protocol is different depending on species, metabolism, weight etc. It would be great if Dr. Sinclair can clarify this.

[@zbridgjpxupzm]

"Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men" based on this study and some others, I am starting to think Resveratrol is nothing but snake oil.

[@lukejagodzinski]

Maybe, you should consider creating short clips out of those podcasts to bring more people to podcast? Most people don't have time to watch 1 hour long podcast to check if it's good or not. I think most people that watch your podcasts are already familiar with what you do and how good they are. But we should spread the world so more people are aware what you can do today to prolong your life. Keep doing the great work!

[@redart3005]

which supplement companies does he recommend? I know he said he doesnt endorse but which ones are trustworthy?

[@t8qvnr]

This is exceptionally interesting. I wonder if there are any studies addressing the additivity of the benefits of different supplements! If two different supplements increase the lifespan of mice by say 30% each, what is the combined effect of the two?

[@HooieBones]

David, I would be very interested in a video documenting your father’s use of these longevity products and how he is doing. I am a woman in her late 70s and am interested in how older people are responding to these supplements . KZbin videos seem to be posted by middle age men and much younger women. It appears as more a vanity thing than someone seriously interested in longevity.

[@paulaaquino5847]

Just randomly found you here on yt and into the world of longevity and I'm never going back!! About to buy your book as well! 🙌🙌

[@r.davidyoung7242]

Thank you! I appreciate your information and the sense of respect you seem to have for human kind and life in general. I wish both of you vibrant health and long life. 💚 I listened to your book on Audible. It's great.

[@theodorakisnik]

Ευχαριστούμε!

[@ottot3221]

I remember in the first episode we where promised information about brands of these additives that are safe to use. Is that still coming?

[@alicemaarouf3911]

Great question , would love to know the best brands .

[@adamloepker8057]

The 20 seconds of trolling starting at 38:07 is my favorite by far... this series is great!

[@dawnsutherland4834]

Hi Dr. Sinclair, what is your opinion on the reported adverse effects of NR/NMN on protein synthesis and hypertrophy?

[@dominiquejasperson900]

Dr Sinclair, I stopped taking Resveratrol because of the criticism out there. But when I stopped, I felt pain in my knees, which have stage 4 osteo arthritis. When I went back on Resveratrol, the pain went away. At least in my case, Resveratrol helps inflammation. There appears to be more to it than whether or not it activates SIRT1.

[@susanwoodward7485]

Any information on pros/cons of NAD+ boosters or infusions in non-diabetic ckd? Superb series Thank you.

[@jamesevans4781]

According to Dr. Sinclair NAD+ IV quickly raises NAD but it spikes and then returns to previous level. Unless you're going to do this several times a week he seems to favor supplements over IV