David Sinclair: Living to 120

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David Sinclair is a professor of genetics at Harvard Medical School and the founder of the Sinclair Lab. He’s the author of the bestselling book Lifespan: Why We Age-and Why We Don’t Have To, as well as a founder of several biotech companies. #bestsellingbook #biotechnology #genetics
Auren and David discuss the potential to expand the average human lifespan by decades. David challenges traditional notions of aging and emphasizes the need to embrace new technologies. They also discuss the benefits and drawbacks of standard anti-aging practices like interval training, fasting, and stress reduction.
David shares his thoughts on what longevity medicines and supplements are most beneficial, and how to talk to your doctor about them. He breaks down which health metrics to monitor in treating and preventing aging. Overall, David offers an incredibly optimistic vision for what the future of aging could look like, and the science it will take to get there.
0:00 Intro
00:48 Do we have to age?
15:00 Why modern life is aging us
18:07 Biology of interval training
20:46 NMN + anti aging supplements + side effects
35:05 Why people have a negative reaction to life extension
36:55 Key health metrics
40:27 Starting biotech companies
47:28 David’s take for common bad advice
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You can find Auren Hoffman on Twitter at @auren and David Sinclair on Twitter at @davidasinclair.

[@worldofdaas]

Which *Health Metrics* do you actually need to track? We tried to answer this in our latest call Sam Corcos of LevelsHealth Catch it here kzbin.info/www/bejne/mKOTe6SEip2InNUsi=SYcbVf3iWSIrwLKz and let us know your thoughts

[@lisedumais2030]

David you look amazingly young. I can see myself aging backwards at 62. I will get myself checked for my biological age a year from i started intermittent fasting. I am presently on a 72 hour fasting. I was on a meal a day for 2 months, back on 20/4 fasting/eating. I go to the gym daily and do strength exercises. I just started to do hot/cold/hot therapy . I see some of my loose fat disappear, I lost 38 pounds, 5:2, weight 114 pounds. I am off several medications, I am regular naturally; after suffering with constipation forever. I am on the Mediterranean lifestyle diet . I owe this all to you and other scientists, Doctors, on KZbin. You have given me my life back, a much better one, THANK YOU

[@worldofdaas]

This is awesome! Mediterranean diet for the win 🍅

[@a.d.7922]

did you watch his earlier videos? He has aged so much and I am so disappointed. If David cannot slow the aging, then who? We are all doomed. so sad.

[@melkor321]

David Sinclair is a true hero for me, and have inspired me to live healthy

[@worldofdaas]

Glad to read that.

[@aurenh]

me too!!

[@annabergmann3603]

Indeed, me too. ❤️

[@semaaral2498]

Same here🙏💯 Bu😢 this podcast isn't new, is it?💻💿 Worth to listen again🙏💙💊 Thanks to our Scientist, As always⭐️✨💫💯 Wish His Father A Healthy Happy Life🙏💙💯

[@semaaral2498]

But... Correction🤗

[@SilverFan21k]

Thanks for having on David Sinclair, this is awesome.

[@omittapir5986]

I never ever get tired of listening to Dr Sinclair. I have been listening to each and every podcast, interviews for the last two years and follow what he suggested for longevity as far as I can.. well saving coffee money for nmn and others 😊. Each time i learn something new and my determination grows. Though he might tell the same thing but each time i understand it better but to my advantage. Thank you for getting him for this interview and asking the right queries which we the viewers wanted to know. One great thing about you... you don't interrupt him after asking the question and let his answer flow without break.. And one thing you look as if you are in your late 30s actually.

[@worldofdaas]

Thank you so much! We're glad you enjoyed the video! We release new interviews every Tuesday with the best people in Tech and innovation. Follow to never miss a show!

[@Derby08]

You are being lied to! DYOR

[@aclearlight]

@@worldofdaas This guy is nobody's friend. He has now succeeded in getting NMN, a naturally-occuring molecule, withdrawn from public access so that he can become FABULOUSLY WEALTHY as gatekeeper of his own propietary version. Someday, years from now, a tiny sliver of our ruling class may have access through boutiques dedicated to our ultra-rich "betters", but the public health? Who cares about the tacky public when there are millions to be made in a cornered market!

[@aclearlight]

@@worldofdaas This guy is nobody's friend. He has now succeeded in getting NMN, a naturally-occuring molecule with great promise to benefit the public health, CYNICALLY withdrawn from public access so that he can become FABULOUSLY WEALTHY as gatekeeper of his own propietary, slightly tweaked "drug" version of this basic molecule. Someday, years from now, a tiny sliver of our ruling class may have access to his drug through boutique centers dedicated to our ultra-rich "betters", but the public health? Ha! Who cares about the tacky public when there are tens of millions to be made in a carefully cornered, strangled market! This guy is a POSTER CHILD for what's wrong with our medical-industrial complex. Please do some laborious digging, look under the hood and wake up to who this weasel is.

[@Adam-nw1vy]

I've been doing this since 2016. Almost 7 years. However, I gotta say the whole NMN supplement ban made me somewhat skeptical.

[@jessicapetrick283]

i just ordered the book! I'm so intrigued.

[@frv6610]

Sinclar, Aubrey de Grey, Bryan and all the other smart longevitists should create a conference group or 'parliament' and advance like an undefeatable super think-tank on the question of what really and actually forces the body to retain youthfulness

[@2020debz]

Thank u, David Sinclair

[@SilverFan21k]

Deserves more views. Ty for this and having David on 🎉

[@worldofdaas]

Glad you liked it, David was a great guest!

[@Derby08]

He’s a horrible guest out to line his own pockets. My opinion only. Why all the makeup if he is so cutting edge? He is as pale as a ghost - makeup!!

[@hevechvy]

Been watching this guy for a while. HE IS AGEING like everyone else.

[@ten10_ten10]

Just started following him and his work. He could be a massive fraud and everything he is saying is purely for money, but also you have to realize that if he is ACTUALLY working on a cure for aging then that'd probably be a very stress filled task. Stress ages people more than time ever can. Assuming he is following good protocol, he shouldn't be doing any age reversal that he's studying on himself until it's proven relatively safe for humans. So assuming it's all real, he should still be aging because reversing age hasn't been confirmed as safe yet. Not saying to just blindly trust him and his word, if anything you shouldn't believe anything he says until you can see first-hand that it is proven true. But there can also be a logical explanation for these confusing and seemingly contradictory things.

[@DanielRaymondQuebec]

That was a great interview with a lot of topics.

[@worldofdaas]

Thank you! We post new videos every Tuesday 🌩

[@Derby08]

Do you ever ask yourself why Mr Sinclair wears so much pancake makeup and look at his neck it’s there to and if it’s not why is he so freaking pale? When he gets red you can barely see it through the makeup. I worked in the industry and he has lots of makeup but you don’t have to be in the industry to see he’s loaded with it. People wake up. He’s not who he says he is.. My opinion only do your own research ask him why he’s trying to take NMN off the market ask him why NOW is behind him and many other advertisers if you mix money and “supplements” you get lies

[@Ali-gl8ql]

It is so interesting to listen David Sinclair. Amazing podcast, thank you!

[@worldofdaas]

Glad you enjoyed it!

[@WilliamPeterGloege]

David, can you please say once & for all, will you publish a SECond BOOK discussing recent life extending information.

[@Greyfoxdbz18]

any tips on how to make it to 35?

[@gettingyounger]

A great straightforward interview with David Sinclair. Inspired me to start looking into Metforman, in addition to all the supplements that I already take for longevity

[@Derby08]

Wake up your being lied to. Why does he wear sooo much pancake makeup. If you can’t see it your blind. I believe he started out trying to do good but now is living large and needs YOUR funds and you all think he’s a hero. YOU WILL FIND OUT. But back to the pancake makeup. If he is doing so well with anti aging why does he hide what his real skin look like and why is he so freaking pale.. use your brain people Just one persons opinion. DYOR

[@gettingyounger]

@@Derby08 can I ask you a question? Have you tried any of the things that David Sinclair talks about? If you haven't, then maybe put aside all that you believe about lies just for a while and try for yourself. If I can be bold here and suggest, I would recommend 1. Fasting 16:8 every single day, 2. Take 1gm NMN, 3. Take 1gm Resveratrol (mixed with small amount of yogurt so u don't break the fast) both previous first thing in the morning, 4. Excercise more a few times a week (weights and cardio), 5. Cold shower every morning (stay in for 1 min at least). Then see how you feel after 1 month and then let me know if you think it's still all lies. I'm talking from experience, not from looking if the guy is wearing make up. I wish you all the best.

[@emh8861]

Metformin has a black box warning.

[@pjaworek6793]

​@@gettingyoungerYou might want to switch to 50mg resveratrol unless you have cancer. Look it up. David doesn't acknowledge the more recent findings. "Wellness Messiah" dies the best explanation of resveratrol that i have found.

[@SalaKahle]

​​@@Derby08 i haven't even seen the make up. I was completely taken aback by the hair dye. 🙄

[@paoladegennaro204]

Nice interviews❤️ please go on following doc. Sinclair, he Is a great scientist ❤️

[@01maggie]

Any thoughts on the benefits of a Power Plate?? Good or Bad for Health??

[@orbitia662]

ppl r dying from aging every moment ! tthkx for doing as fast as you can

[@YongMingPor]

The thing to remember about screening tests, eg for certain cancers, is that there is an incidence of false positives. The idea behind ‘targeted’ screening is to minimise these, and so minimise unnecessary further tests such as biopsies with the possible complications.

[@aerotuc]

yes but i would insist ,probably the Dr. as well,to have tests which would confirm or at least hint toward a false or negative result /.there would be many tests prior to haveing a biopsy..especially if its in the brain .therfore i would agree dr. sinclairs views are the right way to go ...having an mri as a general screening is best choice,regardless.But as a dr ...im sure your government doesbn't want YOU to request mris on everybody...,thats the main reason against screening this way.

[@br6768]

Thank you for making NMN illegal to purchase in the United States, David Sinclair.

[@Sweetp520]

NOT !!!

[@nielp91]

Please explain

[@ivana6141]

Love the research in this space, but there seems to be few resilts so far that give clear instructions to follow.

[@willcook403]

Fasting - avoid sugar and gluten mostly, great quality water, good salt, load bearing regular strength training ..

[@stephaniefronkkonneker9614]

David Sinclair's book Lifespan has a lot of specifics in it: *avoid DNA damage- (don't smoke, if your work around xrays dont be lax about your personal protections, don't microwave on plastic containers/plates, limit your exposure to exhaust fumes if possible, do not get sunburned) *exercise- (get 7k+ steps a day, do resistance training which is more important the older you are so you keep your muscle mass that drops off perciptiously post 60 and 2-3x a week do 15 minutes of sprint trainint or HIIT ) *diet- (avoid cured meats/sausages entirelu, stick to fish and poultry if you eat meat, try to limit it to a few times per week because your body repairs DNA in times when protein is low - and to that end its worthwhile to try fasting in whatever way you can tolerate it. Even one 24hr fast per month is probably beneficial. Or doing time restricted fasting like 16:8) FWIW- Vegetarians do live longer in observational studies. *Supplements: resveratrol and NMN . prescription Metformin is great if you can get a prescription for it.

[@mitubogoogle]

very smart questions by a very well prepared host

[@worldofdaas]

Thank you! Subscribe for new videos every Tuesday

[@onlinecall5284]

Before people call someone a hero or smart, look at this guy's history and Harvard's.

[@ildevaniosoares]

wonderful video and Dr. David Sinclar ! thank you ! Brazil!

[@dongrey8975]

I do take NAD, Tru Niagen, in fact it's sitting right here on my desk.....I remember when I started on it an few years go. I ran across my very large estate yard, at full speed.

[@dongrey8975]

I said to myself, what did you just do, what the hell, did you just do.......70's

[@michaelvanelsberg5051]

Good interview

[@worldofdaas]

Thanks for watching! We release new interviews every Tuesday. Follow for the latest in innovation and tech!

[@danielsanzvoice]

i love this guy...my hero :)

[@Derby08]

Wake up He is a phoney that wears pancake makeup can’t you see it. If not you need glasses ( no offense) DYOR don’t believe me look on the internet it’s all there. My opinion back by thousands of others .

[@madgoatspaddling]

Lets go David!!

[@Elonsovich]

very good and smart man! but the question is: when will you be able to really reverse aging, not just talking about it. for example, when will you be able you reset the epigynum information, "clean the scratches" ?

[@victoriasun3729]

Handsome David… great man🎈

[@Derby08]

Are you kidding he’s got more pancake make up on than a fully loaded brothel! He must pay loads to have that done. Look at old podcasts as well as new ones. It’s getting heavier and heavier. He is as pale( unhealthy) as a ghost. Don’t believe me open your eyes. He’s just selling a product or products. Start questioning start reading do your own research don’t believe me. I did my own and know the real story!

[@dongrey8975]

I tried the 300 an scrip thing, before long I was broke as hell. My Doc was living large and well. He just loved, to see me, though ~!!

[@thaidomain]

It is very interesting to listen to David SInclair. However, his purpose seems to be to develop products to sell. As such, this shines a darkened light on whatever he is saying. This may be the American way, but it has to be taken into account when listening to his comments.

[@KingRockets]

Agree 100%, I'm surprised not many others see through all that. I take his advice with a grain of salt and make sure to look at the research myself.

[@Derby08]

@@KingRocketsi totally agree. I’ve been trying to get people to WTF up but the people who are true believers are cultists and can’t see the pancake makeup is getting heavier and heavier as the years go by. You just have to look. He is as unnaturally pale as a ghost even his neck!! He’s not healthy he’s faking it. Just my opinion.

[@AlexandreSa1]

Excelent video

[@conniegreenamyer6636]

Invest in your health yes 🙌

[@marikacartwright2548]

So this is (metformin) ,so you should take it @ 67 yrs or more ? DR David Sinclair may you let me know ? What about Pure Creatine for rebuilding muscles as the results are not the same when doing weight training ? I love the knowledge & research, am all for antiaging ,you are amazing a true Luminary. M

[@jamesnewsom5899]

Easy to declare that you’re going to live to be 120 years old. Time will tell. The expected lifespan for this epoch of history is around 100 years give or take. I am all for anything that will improve quality of life for sure!

[@ginacardarella]

Would love to see David s. Dave asprey, dr Humbert and Bryan Johnson in a discussion

[@worldofdaas]

Totally agree!

[@manjunathaa.m9242]

I've been taking NMN (1g) and trans-resveratrol (500mg) supplements for 6 months, and I've noticed increased hair loss. My hair is thinning, and my scalp is showing. If I stop taking these supplements, I notice that the hair fall halts. Has anyone experienced this? Any advice?

[@alexandernapapi3433]

Thanks for such an educational video Can anyone tell me where I can find more information about life extension?

[@golgipogo]

Do you have a computer?

[@gsferreira3048]

E so acompanhar a medicina integrativa como um todo;dr Himan tem varios estudos sobre magnesio blueberry etc dr.Arnoldo de souza afirma que magnesio injetavel combate a dor os peroxidos de hidrogenio(vitamina cvinjetavel e peroxido-agua oxigenada)estao enfrentando de câncer a reversao demortes por septcetmia passando por combates de virus como a deng;se vc ver uma materia que dr.David Fez a BBC entenderá o "que Esta em jogo";chama se economia em saude publica Que realmente nao interessa a medicina tradicional(leia se Indústria farmaceutica);sao dezenas de bilhoes ou mesmo Centenas;quebrar o paradgmas destes ",bunckers" Nao e coisa para amadores... Bil Gates, Elon Musk Silício valey Harvarr warren buffet E tantos outros que "estao pensando em escala" ou "fora Da caixa"mas veja bem que se Nao haver uma transformação Nesta magnetude ou em voltz ou IA pro educação e ter em mente que varias destas moleculas podem entrar ja em Protocolos mundo afora nós Seres humanos não temos sentido de existencia e temos conselhos Espirituais e a maioria dos "grandes" sabe 'o que está acontecendo neste campo mas nao conectou"... Mas nao sabem que as "solucoes" vem da educação? Para mim o Espiritual esta abarcando todos estes assuntos e nao queremos acelerar a educacao?yann Lecun afirmou que nao podemos guardar a IA a "sete chaves" e Geofrey Hinton afirmou que nunca viu uma aceleração da ciencia como Nos ultimos cinco anos. "Escolham as armas"...

[@georgesoong4149]

I am quite curious, how about putting our bodies without air conditioning?

[@da3ki]

if you take something like public health into account, it becomes clear that it makes sense that not everybody can get health care in the sense that everything gets measured and checked, if the risk is very low. If you have limited resources as a society you have to properly allocate them. we humans get very self centered sometimes.

[@AviationPilot91]

I'm confused. Are you saying humans are self-centered for wanting preventative care for everyone?

[@da3ki]

@@AviationPilot91 no it would be great if everyone had all the prevention there is, but a doctor is always making a risk reward assessment, for example a doctor is not performing a full blood panel and mri of the brain with every patient that has a mild headache, he is trying to be resourceful, because otherwise healthcare would get too expensive, if everyone got the best treatment there is all the time....

[@AviationPilot91]

@@da3ki Then find more creative and affordable ways to assess the patient. I think this is where AI will excel. Then, physicians will complain that they're losing jobs or are underpaid.

[@da3ki]

@@AviationPilot91 yeah many physician will probably revolut against ai, because their egos und wallets feel threatened, but it will be a great tool for patients that's for sure!

[@ShahidKhan-qw8yk]

Love listening Dr Sinchiler , He is always wonderful to listen and watch, A hope for millions of people. Thank you so much.

[@worldofdaas]

Thanks for tuning in! More exciting videos coming soon!!!

[@dongrey8975]

No mention of the Hayflick limit ~?

[@VietYork]

Crafted by Viet York from Mollyverse 00:07 Aging is not inevitable and can be reversed. 03:13 Advancements in aging research are leading to the possibility of extended human longevity. 08:58 Doctors are now focusing on treating aging itself, starting early to prolong healthspan. 11:40 Monitoring biomarkers is key to staying ahead of disease. 17:20 Hormesis concept promotes intermittent stress for health benefits 20:05 NAD levels play a crucial role in aging and health 25:25 Starting preventive medications in your 30s is reasonable under doctor supervision. 28:03 Ensure the science and data are true before making health decisions. 33:25 Fasting and longevity 36:04 Life appreciation is not limited by lifespan 41:44 Encouraging more scientists to start companies and commercialize their discoveries 44:41 Prevention is key to reducing healthcare costs by detecting diseases early. 50:13 David Sinclair's second book is expected to release in 2024 with co-author Met LaPlante.

[@johnpatterson4718]

David Sinclair you need to have an interview with Brian Johnson the "Blueprint" Inventor. You need to check every marker he has and compare your results! The True test of what you are talking about. Let the Data prove who is Right. ❤

[@bottymcbotface007]

We don't really know if those markers have any real effect on longevity yet, just that it changes them. It's a bet like anything else being tried. The fact that Brian has to take testosterone as a direct result of his program is a major red flag in my opinion.

[@gordonchung6348]

David Sinclair The Brainiac Of Knowledge Is Power!

[@user-uo7wo6ii5q]

Hi Auren Hofman and Dr Sinclair thank you for your great work I'm big fan . very important question: is NAD booster boost tumer and cancer ? 😢 if someone has cancer or tumer . Or don't have . Go get check before getting NAD booster MNM ??? Thank you very much I'm waiting for your answers

[@msnewmind328]

Hello, I’m only responding is because I don’t know if David Sinclair or the host will answer you back. I just want to let you know that I’ve listen to a lot of videos on NAD & NMN and I have heard in videos-& read in the comments that they said that taking NMN can grow cancer tumors, if there is cancer so you may want to do more research, but I would probably not take it until that tumor or cancer is replicated.

[@Derby08]

Don’t trust DS he is a wolf in sheep clothing. Please DYOR don’t believe me but please be careful if you have cancer. He is not an authority on cancer, far from it! Can’t you see his pancake makeup he’s putting it on heavily now more than the old podcasts. Please talk to real scientist he’s a podcast scientist all about the color green $$. Please this is my opinion but what is not is you don’t get cancer treatment from DS. Please open your eyes he is not who you think he is.

[@ChessMasterNate]

I am thankful to Sinclair. I was taking too much niacinamide, and he pointed out in a video that it can impair collagen creation. That is exactly what was happening to me, and I was in very bad shape. I am now fully recovered, though some accelerated face aging does appear to be permanent. Nonetheless, I have to call him on his claims. Claims, in fact, that shift the burden of proof inappropriately, as he should know as a scientist. Still, I will play along. 2:05 So tell me how you are undoing DNA damage, and I don't mean methylation. He knows as well as I, there is no fixing DNA, short of Science Fiction. We accumulate DNA damage that is carried on to the next generation of cell and the next. This is caused because our DNA breaks 10,000 to 100,000 times in EACH cell EVERY day. Most of this is repaired correctly, a small fraction is not. These breaks are caused by ionizing radiation from the sun, outer space, radiation in the ground, radiation in your food (potassium and carbon mostly). It is also damaged by chemicals. And lastly, it is damaged by quantum tunneling as a function of body temperature. Heat is in quanta, and by chance a bunch of these quanta can bounce into the same area and act like it is a higher temperature. Just being a few degrees lower extends lives dramatically. This is the reason bowhead whales live 200+ years. And the same reason naked mole rats live very long for rats. The rats are effectively coldblooded. That is why they don't need hair. We can't just tweak stuff and get cold and hope to live longer. Our enzymes have a very tight temperature tolerance, which is why you feel terrible if you get too hot or too cold. When the enzymes stop working, essential processes are disrupted and you die. Some people do have a partial cheat. There is a gene variant that improves the odds of a good repair. But errors will still be made. Good levels of the right antioxidants can also decrease DNA damage events. But if it is fixed and fixed wrong, there is no repairing it. There is no rational hypothetical path to repairing it. We have 4 far-fetched fantasies: 1. Whole genome genetic modification. That is absurdly far-fetched. Genetic modification does not look for a problem and fix it. A specific change...sure...not any random thing that just happened to that cell. 2. Whole genome swap. You find some undamaged DNA, multiply it without errors a few trillion times, then have it transported to every cell where the original DNA in that cell is destroyed, and then this new DNA inserted. There are only about 100 things absurdly challenging about this like every tissue has a different selection of DNA that is activated, methylation must be right, so it knows how old you are supposed to be, transporting that much DNA, without it being damaged won't be easy. Can you actually dispose of the old DNA without killing the cell before the new stuff is inserted?... 3. Nanites who know what your DNA is supposed to look like enter each cell and make all the repairs. Maybe in 200 years. 4. Something enters the cell and if damage is found on anything that is active, the cell is destroyed. Other cells have telomere extended, so they can replace the cells, and lots of stem cells are introduced to help. The problem with this is that some cells are irreplaceable, like most neurons. And there is no guarantee a person could even endure this, as they could be replacing nearly all the cells. It would probably feel worse than bone cancer. They probably would have to induce coma for months while this was undergone, if possible. And there is a bunch of other stuff we accumulate. We accumulate Advanced Glycation End-products (AGEs) especially glucosepane. You can reduce the accumulation using some supplements reducing the creation, but diet must change dramatically to have a very low AGE diet. No pan-frying. No deep-frying. No "air frying." No roasting. No grilling. No broiling. No poaching eggs, only boiling or scrambling. Low fat. Very limited oil choices. Even olive oil is out. Most cold pressed seed oils are okay in moderation: flax, sunflower, chia seed, and sesame. Pistachio, and avocado are also good. No roasted oils. Never heated above boiling water. No BUTTER. Only unfermented cheeses: Mozerella, Ricotta, Cottage cheeses. Parmesan is the worst, but most fermented cheeses are high in AGEs. No roasted nuts, except pistachios. No roasted nut butters, which is virtually every kind unless you make it yourself. Many things blended at high speeds have high AGEs. If it is only carbohydrate or only protein or only fat, it is not an issue. You can make a smoothie that is almost entirely carbohydrate, and that is fine, just don't put in seeds, nuts, oils or protein powders and such. Some dressings are okay, others are more dubious. If it is acidic, it is probably okay. If it is "Low Fat," it is probably okay. Only "Low Fat" mayonnaise is okay. Any sauce made with lots of tomatoes is probably fine. Anything acidic is probably fine. Protein or oil can be stirred in; you just don't want to blend with a powerful machine. For meat, you want soups, stews, chilies, meat cooked in spaghetti sauce, or other tomato based sauce at fairly low temperatures. Steamed fish, fish or other meat boiled in just a little water. Various crock pot stuff. And no cheating, cooking meat in those unacceptable ways and then putting it in a stew or chili or whatever. Of course, most vegetables and grains are much lower in AGEs than meat, so they should take center stage a lot. Then there are other accumulations. Age spots are made of Lipofuscin. If you have age spots on your skin, you probably have them in your muscle, heart, brain, and other organs. The main problem with this one is just obstruction. Though, that can be a problem in the brain, especially. Speculatively, new accumulations may be minimized by HIIT exercise and supplements and other activities that promote mitochondria recycling (mitophagy). Some people inherited better mitochondria in the first place. Another thing that accumulates is amyloid. There are about 30 different kinds because different proteins can misfold. Once this starts, it can be next to impossible to stop. Though, some of the tech that has been applied to Alzheimer's may allow other amyloid to also be removed. We also have the accumulation of scar tissue. This quick fix repair solution is good short term, not so good long term. Scar tissue does not perform the functions of the organs it is in. The more of it you get, the less function those organs have. And there are likely many other substances that accumulate in the blood. This may be why plasmaphereses seems to have health benefits. None of this means people can't live for several centuries. But it does mean it will likely require organ replacement, whole body replacement, or head transplant. That will not be cheap. And it will likely be limited to a small percentage that can afford that. And whatever tissue is not replaced will eventually die, most likely. Even if they could print your exact neural pattern...would that be you or just a copy? There is another way. We can engineer future generations to age far slower. No one wants to talk about this option because we want to be the ones living very long or our children that are already born. But this is by far the most cost-effective method, and likely the only one that will allow everyone at least of that generation and in the future to share in the gift of a long healthy life.

[@I-Dophler]

Living longer without becoming elderly is the goal.

[@worldofdaas]

Totally agree 🙏

[@I-Dophler]

@@worldofdaas 🙏🙏🙏🙏

[@I-Dophler]

@@edoardo.. Wow, your perspective is thought-provoking! You've highlighted some intriguing ideas about ageing and energy. It's great to see someone questioning conventional beliefs and exploring new possibilities. Keep sharing your unique insights!

[@I-Dophler]

@@edoardo.. I appreciate your perspective on this topic. It's interesting how people's attitudes towards life and mortality vary widely. You've brought up an intriguing paradox - the idea that not loving life might lead to a cycle of returning. It sounds like you're looking at this from a scientific standpoint rather than a religious one, which adds another layer to the discussion. It's thought-provoking to consider the concept of resonance and its potential impact on our experiences. While not everyone agrees, exploring these ideas can lead to fascinating conversations.

[@I-Dophler]

@@edoardo.. I appreciate your perspective on physical immortality and the connection between energy and eternity. It's fascinating how you emphasise that energy is information and how our perceptions can influence ageing. Your thoughts on ageing as a programmed outcome based on our beliefs are thought-provoking, linking our mental outlook to physical experiences. The idea of reincarnation and multiple dreams adds an intriguing layer to this discussion, suggesting that life, death, and beyond are all states of consciousness. It's a unique and contemplative take on existence. Thank you for sharing your insights!

[@vulcan4d]

The man is a hero but with plastics in our blood, chemicals in our food, and smoke in our air, do you really think this generation will make it to retirement?

[@SternTube]

Thank you, David! Where can I find the “results of monkeys” please?

[@venkybabu8140]

What use living in a room of 120.

[@LarryHable]

6 minutes in. Curing blindness !!! No followup question !!! When you say people eating well can live to be 95 do you mean people born this year of people who are already old? Consulting an Actuarial Life Table, a person aged 92 can expect to live to be 95.

[@robertferguson7800]

So can someone tell me the recipe that David is saying to give me long geverty I’m 74 would love to think I can get another 20 years

[@adriantrela]

In nutshell: intermitent fasting, hiit training, weight training, low carb high fat diet, cold exposure, lot of supplements, lot of extra food like herbs, spices.

[@sandybayes]

Auron Hoffman most of the meat studies are paid for by the meat industry as are dairy studies (also paid by dairy industry) and likewise the egg studies. Unsure how well researched you were for this interview.

[@marikacartwright2548]

I do Hyberbaric chamber ,a pure oxygen capsule in a professional clinic ,athletes use it ,excellent for recovery, clarity of our brain ,our cells turn around ,any joint pains etc .M

[@MarkZiegler]

If you could grow gills then you could still breath with the increasing levels of humidity. Have the genetics dept. look into it.

[@dongrey8975]

I've seen mice on NAD compared to those of not. Big difference.

[@Joshukend]

His age is starting to show

[@joparr4081]

Exercise for your cells. Micro like Macro. Exercise your cells. They need it like you do!

[@21EC]

7:51 - Would these age reset pills be available everywhere possible or just the USA at first ?

[@Rorscach]

It'd presumably only be in the US and then come out in other 1st world countries a couple months later, then the rest of the world. And it'll be SUPER expensive at first.

[@21EC]

@@Rorscach Ok, thanks for info, but where did you get your info from? how do you know that for sure? I'd imagine they might sell these pills for people around the world and would ship them to people so there won't be a need to come to USA to buy it, hopefully it would get cheap enough down the line afterwards, I don't see a reason for it not to be since the whole world would want to buy these pills and then that means quite a lot of money..even for a relatively cheap price, but by super expensive what do you mean? like 5000$ or even 100000$ ?

[@Rorscach]

@@21EC I said "presumably" but idk anything i'm just a 13yr old thats interested in these topics. And for the price as I think david has said before will be quite expensive like 50 thousand but in a couple months probably drop to around a couple thousand, but who knows what the future holds.

[@alphamale5802]

Realistically nothing could reset aging. Look at all those doctors giving anti aging advises, do any of them looks younger than their age?

[@Rorscach]

@@alphamale5802 That is the dumbest logic... no one said it's todays news. it could become reality in 10 years, 50 years or 100. And they aren't giving anti aging advices, at least not yet. there giving longevity (long life) advices, literally look at the title "living to 120". as i am going to reinstate anti aging could happen whenever.

[@camarosspr]

Mental health important, stress. Pain suffering is coming like a train into you when you reach old age. Inevitable. Everybody close to you died, or is dying or very sick. Money problems. Most morbidly obese. Family, Parents, friends.

[@Jcombetta]

Really! Taking a few pills, sleeping 6 hours a night and eating one meal a day and I will live to 120. WOW!

[@waynerichardson1051]

Ya reckon? Really?

[@Derby08]

It’s all BS .. Do you see how much pancake makeup he wears ( he’s as white as a ghost and look at older podcasts it’s getting much heavier).. why do people believe this fraud….

[@mm669]

You need to have $$$$ to buy the supplements.

[@jenxsj3902]

I am not being shady okay? just the facts. Sinclair is losing bone and collagen on his face at a normal rate. He has jowling, diminishing of his facial fat pads, deep groves in his tear throughs, wrinkles (despite the make up, professional lighting and filters). He dyes his hair. I cannot see his “protocol” working on the outside. I hope it is working on the inside.

[@dlg5485]

Appearance is subjective and is a terrible way to determine one's age. Checking bio markers of aging is the only way to know one's biological age.

[@sgprox021]

Ok, give him growth hormones ! assured life reduction with a good look

[@gatakaas8586]

His forehead doesn’t move which suggests Botox injections.

[@jaimeballester840]

What really matters is preventing disease. He is looking at the metabolic process inside the body, doing something about it, and researching.

[@whiskerske3218]

Where is your “factual information “ coming from about him dying his hair?

[@planetmuskvlog3047]

The host looks a little like Luke Wilson, am I wrong?

[@squamish4244]

At least the filter Sinclair uses isn't so harsh in this video and looks more like he actually is, 54. If anti-aging technology is coming, and it seems pretty obvious now that it is, quickly, I'm sure he can look a youthful version of his actual age for awhile. After all, he's still only 54.

[@juliettailor1616]

Yeah to me he doesn't even look a youthful 54.

[@RECOVER361]

@@juliettailor1616 he has aged a lot in the last 2-3 years.. maybe it's his vegan diet. Or aging just hits different after 50.

[@juliettailor1616]

@@RECOVER361 or his divorce, as someone pointed out.

[@golgipogo]

He may have reasons to look as old as he does

[@katekleinsteuber7652]

I don't think he looks 54.

[@barbaraolson6783]

Why ? To live incarcerated in nursing homes. As a very young 70 year young human, paralyzed by radiation, I suffer incarceration in a nursing home that doesn’t permit travel outside the facility. I wish I had taken more risks and possibly avoided this incarceration.

[@pjaworek6793]

No. "Why?"? For the specific purpose of avoiding your situation. You, like any incarcerated person has only the power of the pen to help you out now. Best of luck!!

[@timothykowalewski3943]

I so want to believe what David is selling. Who wouldn't. What he's selling is attractive to just about everybody. But no human studies on his claims, and many of his peers are really backing off his theories

[@Erictraiven]

You cant defeat death he forgot that here is accidentally death too not only the natural one by age...

[@eddieworkman5855]

be nice to live forever to stay same age 30 32

[@camarosspr]

If you're not stopping on its track arterial inflammation, Artherosclerosis. You're wide open for death, full incapacity Forget anti aging, you won't reach elder age.

[@Codydoggy]

Pity NMN is so expensive in other countries

[@anngray9171]

Wish this bloke would stop chipping in with something banal, while Dr. Sinclair is saying something interesting .

[@Bilge-Tekin]

When someone recommends people to see their doctors for so called "early detection" without deciphering between mainstream doctors who are controlled by Big Pharma, FDA, i.e. those pushing lethal therapies like Chemo, Radiation, etc versus non mainstream doctors, who are genuinely interested in getting patients wellI with natural means, like sound, using frequency machines, etc. I take their advise cautiously.

[@Tate-Trump-Fan]

There is this dude, bryan johnson who's apparently reversing his age

[@worldofdaas]

We love Bryan!

[@I-Dophler]

Edoardo replied: "I-Dophler 🤣🤣🤣🤣"

[@I-Dophler]

Yes, lol.

[@thoughtsfromathenasreality]

Our bodys are designed to last to 160 years. and in some countrys many people do live that long.

[@roslechte]

Humans do not live to be 160 anywhere in the world. The oldest verified age to which any human has ever lived is 122 years and 164 days by Jeanne Calment of France. There have been claims of longer lifespans in various parts of the world, but these have not been independently verified and are often viewed with scepticism by experts in the field of gerontology. Many factors contribute to longevity, including genetics, diet, access to healthcare, and lifestyle, but even in the most favourable conditions, the human body has biological limits. Research into aging aims to understand these limits and, potentially, how to extend them, but as of now, a lifespan of 160 years remains beyond our reach.

[@katekleinsteuber7652]

​@@roslechtein biblical days it was well onto the hundreds.

[@Stanley_Baby]

Not 160 🤣🤣

[@whiteninja9481]

I wonder what David's speaking fee for this 50 minutes was.

[@waqarrasheedalvi2899]

No question about doctor because you are doctor Patient said that metformin created constipation and weight loss upto 14kg last four years

[@Porstile]

19:29

[@ronnie5966]

And David takes Metformin at night?

[@x1magalhaes]

Aquele rícino parece mamona que é venenoso. Em doses pequenas o óleo de rícino parece ser homeopático então.

[@cheesypotat0es]

Why the hell would anyone want to live to 120 most people are ready to hang the gloves up by their 70s

[@OASH2023]

And there be part of the problem , the psychology of giving up, you will if that’s what your inner voice tells you

[@lu77xiaojun37]

Anyone else notice Dave's hairline is receding fast n Lake Mead?

[@Stanley_Baby]

I mean he’s 54 what age are you?

[@alexandrina...966]

David you look great😉👍👍👍our retirement homes will be empty if all will get younger

[@barryth]

Cmon David, a coffee is $2 @ McDs . A CT scan is still $1000. That’s no coffee for @ year and 1 1/2

[@Lulu-kt6gr]

Resveratrol is getting a bad rap lately and I need to know the truth. Why did I have a very obvious, repeatable result from taking resveratrol?… I never expected any visible results from taking it but I began to see that it was indeed responsible for increased endurance in a strenuous “ yoga with weights” class during which we increased heart rate and worked our muscles to their limit. I tested it over and over again. I stopped taking resveratrol because of the negativity around it, but I also had to stop taking the class!

[@pjaworek6793]

Confusing. Go back to res and yoga, duh

[@kuakilyissombroguwi]

Michael Levin is the only person doing any sort of real longevity science, and even his stuff is decades away from having any practical applications. Don't hold your breath.

[@squamish4244]

If we live to 120, we're probably going to live a lot longer than that. Hell, that will take me to 2100. My niece and nephew will be 90 years old, which is amusing to think about. The idea of generational gaps starts to become meaningless.

[@worldofdaas]

Love this take!

[@squamish4244]

@@haveagreatlife3973 Uhhh...not all of us are Muslims...

[@camarosspr]

Of course, lots of money helps.

[@longevitycoach1573]

To live 150 0r 200 ;you need strong teeth but for that you have to eat a lot of meat.

[@conniegreenamyer6636]

The best is not arrive to those sad negligence nursing dead homes

[@chaneliza6075]

If age can be reset, then we are talking about the possibility of immortality?!

[@GubekochiGoury]

We don know but it is not not on the table.

[@gizlibilgi2265]

No, there is no immortality but living longer and healthier.

[@dongrey8975]

yes when one is 50, they want to live to at least 70, then when 70, to at least 90, then....

[@shinkurt]

Grifters gonna grift

[@KorisnickoIme84]

The problem would be the overpopulation if everyone lived to 120..People will still be having children and others would live an extra 40-50 years and where would you put all those care homes and who would work there? Logistical nightmare..

[@edytatehrani3934]

With the demographic crisis that is already happening, we need people to stay healthy for ad long as possible. I am surprised that Elon Mask is against natural life extension as he is aware of demographic woes we are experiencing.

[@bouchaibzaraguit1241]

Nobody can control agging... probably stay healthier all over the rest of life by considering those advices... what About genetic disease....

[@ijojan]

David is DILF 🔥🔥🔥