Diabetes & Mitochondria: How Nutrition Connects the Two. [Study 32]

[@Physionic]

Previous Video: kzbin.info/www/bejne/gYKlnqewiZmJirc Hope you enjoy, guys. I'm off to lab.

[@61651092]

Hey Nick, It would be great public service if you could debunk all the crazy things that this guy is spreading. I mean his crusade against plants because they steal your minerals is absurd. kzbin.info/www/bejne/hGK0qn18h85ghNk Thanks to you Nick for doing a great job digging in to the papers in order to guide the rest of us through the jungle of good and bad science. Best regards Thomas.

[@Stoney-g1o]

I always enjoy any reviews of papers that include mitochondrion. Thank you 😊

[@wolfrahmphosphoros5808]

since insulin is required in order to clear glucose from the blood by pushing it into the cells, how does glucose enter the pancreatic beta-cell to initiate the process in the 1st place? regards.

[@Stoney-g1o]

@@wolfrahmphosphoros5808 The GLUT4, GLUT5, GLUT2 glucose transporters facilitate transport of glucose through the cell membrane. Insulin signals through the surface protein to IRS pathway and results in the cell transporting GLUTs via Clathryn vesicles to the cell membrane. The pancreas beta langerhan cells have GLUT2 which sense the milli equivalents of glucose in the blood vessels. This can trigger glucagon when glucose levels are low. I need to go back and refresh my memory

[@wolfrahmphosphoros5808]

@@Stoney-g1o thank You so much for this Information. so I'm guessing GLUT2s don't require Insulin. I need to learn Biochemistry. best regards, and I hope You have a wonderful week.

[@youssefraby7647]

It’s a shame this video has only 42k views. Thank you for the enormous effort

[@KoiRun50]

Your illustrations make a world of difference for me in terms of learning.

[@Physionic]

That’s great to hear, I put a lot of thought into how I make them and present them. Thank you for letting me know, KR. Hope you’ve been well, of late.

[@westcoastswingmusic]

Thank you! I love intermittent fasting! I fast about 20 hours a day on average. It has done wonders for every aspect of my health. I use the free Zero app. I discovered this lifestyle this summer and have been doing it for a little over 3 months now. I am so grateful for all the health problems it is improving for me. I'm 47 and have been struggling with some of these issues since my early 20s. If only I had known about intermittent fasting back then, I could have had such a better life! I just try to focus on gratitude that people like you are making this valuable information available to people like me. Thanks so much! I'm fascinated by mitochondria and insulin. It is so awesome that you share your knowledge with us! 🙌🏼

[@adelepartridge9484]

Not only are you the genuine deal, super intelligent, passionate and beyond talented at science communication. Your so kind to stop and say this system will not fail if you have a holiday. Constantly thinking of your fellow humans. A lot of respect. So many fake PhD's not you. You are the role model. You earn everything. 😊😊😊

[@hitmusicworldwide]

Hand raised. Homeless electrons having nowhere to go, get radicalized and then proceed to destabilize and tear down the structures that surround them but will not accept them and makes no productive role for them. Boy does this sound like a history lesson or a lesson in sociology. But I digress, do go on.

[@jmc8076]

Love when insights and patterns in nature and life recognized. As above so below. What happens in our body can be seen in rest of world and universe on macro and micro levels. Thx for posting. Best comment of the day for me. And yes I’m that person who needs to get out more.😉✌️

[@edwhite2255]

What would antioxidants be in that situation? Social networks that donate to the radicals or law enforcement who lock up those radicals?

[@hitmusicworldwide]

@@edwhite2255 "An antioxidant is a molecule stable enough to donate an electron to a rampaging free radical and neutralize it, thus reducing its capacity to damage. " ( From the NIHarticle "Free radicals, antioxidants and functional foods: Impact on human health" ) In our macro world that would mean stabilizing and restoring balance so that the energy is no longer destructive, allowing for constructive and restorative activity to once again be the normal state .

[@stephx9759]

Powers of 10 comes to mind. It seems everything is relative. Ying yang

[@stephx9759]

@@hitmusicworldwidesounds like welfare lol

[@WholeCosmos]

I do intermittent fasting 16 to 20 hours a day. I was type 2 and fasting has helped me lose weight and keep my blood sugar in more normal ranges. I don't get hungry or the jitters anymore when I fast like I did in the beginning of fasting. At first I would feel hungry and shaky like I had low blood sugar but my sugar was high(insulin resistance). A slight amount of exercise or caffeine at this point to burn off the extra sugar turns my body to fat burn mode. I can tell when I am in fat burn mode because my body gets hot and sweaty and the hunger and jitters goes away. Fat burning is more thermogenic in my opinion. when I was younger(not diabetic) I was used to this feeling playing sports and doing cardio. I found fasting can do the same thing as cardio to go into fat burn mode. Runners that constantly drink sugar water never let themselves be fat adapted and they "bonk" or hit a wall when they run out of sugar. Perhaps very low body fat % contributes to this metabolic inflexibility. Type 2 runs on both sides of my family. Although I am technically not diabetic anymore I still take metformin for longevity. Also I think I am just managing my default genetics of insulin resistance and my physiology is inherently skewed to fatty acid oxidation. Interestingly when I learned Fructose doesn't require insulin to be taken up by cells I realized that the copious high fructose in our modern western food products is driving insulin resistance because with plenty of fructose in the blood the cells don't need to use glucose or insulin so they build up and the insulin receptors are, I believe down regulated. I think it's a similar thing to going nose blind to any smell after the stimulus is saturating. The cells are like "hey too much insulin.." so they express less receptors on the membrane to compensate. meanwhile the poor beta cells are being exhausted. Let me know if you think I'm wrong and your opinion regarding fructose

[@zekeriasvarg530]

Nature have put sugas in fruits by a reason. Fructose in small ammounts say 50 grams a day will probably be good for health (if exercising).

[@AngieLyke]

Thank you. The does give me some hope for my diabetis. I've totally changed my diet. 9000 steps a day. Started intermittent fasting 2 weeks ago and seeing results. I had a feeling that this was to be a lifestyle change of eating in a 6 to 7 hour window. And if I go back to eating too much or badly I'll get the same result as before. This may not reverse it, but I do feel better already. Thank you for doing this important research. I've always been told once overweight your metabolism will slow down forever. And you always have to work out twice as hard as. somebody who is never overweight. I hope that's not true but if I have too while maintaining proper diet and portions so be it.

[@philunderhill8382]

Regarding low carb diets and insulin resistance - as I type 1 diabetic I have one benefit, knowing exactly how much insulin my body is using. I've experimented with various diet strategies, I did very low carb for a couple of years and despite maintaining a constant 'ideal' weight over time my insulin needs rose significantly. More recently I've tried a high carb, very low fat approach and have found that my basal insulin requirements have dropped significantly and sensitivity to mealtime insulin greatly improved. There are many others who have found this to be the case - so it seems as though fat drives insulin resistance to a greater degree than carbs. Thanks for the content - I'm learning plenty from it

[@glennlockwood7608]

keep in mind therapeutic formulations of insulin behave differently than that produced by a normal pancreas. and the liver is also involved in glucose maintenance. i think you have to be careful with diet experiments to keep calories constant. dietary fiber is converted to short chain saturated fat in the gut so this is another uncontrolled and arguably uncontrollable variable.

[@philunderhill8382]

@@glennlockwood7608 agree, that there are some differences on the insulin side. I believe though that when comparing different diets it is more important to maintain a constant body composition than have the two diets equal in calories (gluconeogenesis is an expensive process!)

[@jasonhowarth6789]

I've been doing a ketogenic diet for close to 6 months and doing OMAD for 5 months. Been taking D3/K2 as well as allithiamine as supplements. I also started fermenting my own purple cabbage sauerkraut and garlic cloves in raw honey to take as pre/probiotics. I can't believe how much better I feel! Been watching a bunch of different channels about keto and gut biome. I stumbled across your first video in this 2 part segment and was really happy with your coherent explanation of the more in-depth physiology of mitochondrial function. I took human anatomy in high school and college and was able to digest your information very well. Thank you very much, and I wish you the best in your pursuit of your PhD! I just subscribed.

[@Dank_Engine]

Single-handedly justified my use of this platform. I almost cancelled my Premium, but I found your info and I'll hang onto it for a bit longer so I listen while I work :)

[@Physionic]

Dang, thanks!

[@billtrudell1636]

I think the problem with carbs is they tend to result in over consumption where as fat doesn't. I do wonder about the effects of keytones on the cells I read a study where keto had a repairing affect on nerves damaged by over consumption which is probably why a lot of people with neuropathy see improvement on the keto diet. I found after 6 months the feeling in the base of my feet returned then after 2 years I finally have feeling back in my toes.

[@sammay1540]

Thank you for producing quality work! Even at the expense of remaking the video to add energy.

[@lyndobla]

I've been wanting to learn more about mitochondria and I'm glad I found your channel. I am rather late but I am now a follower. Thank you for sharing your valuable knowledge. Blessings!❤

[@Physionic]

Welcome aboard!

[@thirdworldperspective2409]

what a spectacular explanation ... im looking forward on sharing some results from a patient of mine whom I've submitted to IF and his diabetic profile got significantly better his fasting insulin dropped 50% by the 3rd month, his glucose tolerance test also showed a great improvement and of course his weigh also improved, I stumbled upon a study that suggested that most of this alterations during fasting were caused by the stabilization on the levels of adiponectin and leptin resistance. ill forward the lab results on your DM . keep it up Nick

[@Physionic]

Thank you, Richard. Good to hear from you.

[@wisconsinfarmer4742]

Good work, Doc. I hope your patient feels moved to tell his story and plant the positive seed for others to consider making the change.

[@jeanjaz]

I stumbled on your first video and then had to watch this second video. Thank you for producing these videos! My own situation is actually the opposite - I struggle with hypoglycemia, and have since I was 17 (I'm 63 now) when I was started on Prednisone. I have to be very careful what combination of foods I eat. If I eat something easily digested (simple carbs), I will very quickly have a bad hypoglycemic crisis. This will happen also, if I haven't eaten for 6 or more hours and then I eat protein without some complex carbs. I know that you are only addressing normal cell functions and not body functions put into unnatural states by drugs, but I'm hoping that watching your videos might help me understand what is going on. I know that prednisone causes my body to catabolize muscle tissue to fuel what it thinks is an adrenaline spike. Diabetes is supposed to be a long term side-effect. (And yes, I still take Prednisone, but I'm down to 5mg/d and have been for years - I can't seem to get lower) I understand a little better, how Prednisone therapy can cause diabetes, but I don't understand why it has caused hypoglycemia in me instead. I'm hoping I'll be able to figure this out as I educate myself. 🤣

[@dipdor1]

This was awesome. My wife has CFS/ME and from what I've found, it's a mitochondrial dysfunction condition. This has helped me get a better understanding of what's going on when functioning normally. And gives me some further avenues to research 😁 Thanks for all your great work!

[@joeboxter3635]

Found any answers?

[@dipdor1]

@@joeboxter3635 look into glynac (videos on this channel) and megadosing b1/thiamine, with a b stack, vitamin d and magnesium. I think it depends on the root cause of the CFS. If it's a nutritional deficiency those could help. But many believe that CFS is the result of the body holding on to past trauma. So there, a psychological approach could be better? 🤷 For that you could research neural retraining

[@johnrhodes3350]

Thanks for your helpful answer. I have Complex PTSD and diagnosed Fibromyalgia... Any pointers for neural retraining

[@dipdor1]

@@johnrhodes3350 there's a fella on KZbin called Dr Gupta who does neural retraining. There's also a lady who has a product called DNRS. But they are all selling courses. I think Dr Gupta has some free content though. A lot of it focuses on getting the limbic system out of the fight or flight mechanism. Essentially taking control of your mind. Think of it like this, your brain learned a program and subsequently it keeps running it in an endless loop. You need to delete and replace that program. But I would add that having no micronutrient deficiencies will also help your body immensely in the healing process. My anxiety almost evaporated when I started getting healthier. (Though I appreciate PTSD will be harder to treat) Good luck my friend.

[@lindabirmingham603]

@@johnrhodes3350 I had fibro for 30 years. It went away completely after going Carnivore. Could have been from dumping oxalates. I can't believe I can turn my neck without pain! Lifelong depression has lifted too. I have read comments from others who said that Carnivore WOE helped with PTSD. I hope you find your way to heal from both.

[@melt7891]

Thanks for your video, especially as you’re so tired. Hope you feel better, soon

[@Physionic]

My pleasure, Mel. Hope your travels are going well.

[@melt7891]

@@Physionic I haven’t left yet, but getting very excited :)

[@tonnymuller6791]

EXCELLENT. EXCELLENT. EXCELLENT. I agree with you every single statement in this speech even though nothing proved in spectacular right now. I think in the cyto environment in case of telomere shorting disasters the same mechanism seems effecting particularly in mammals. Under extreme stress conditions surprisingly telomeres were elongated and cells preserved with longer mitochondrial structures.

[@elhombreloco3680]

Thanks for a great lesson on the biochemistry of cellular metabolism. I'm really enjoying your content. It's so clear that you are very well read and educated. I know a wrote you an essay, but please at least read the first point of the first paragraph, I'd really like to know what you think. I generally agree with you that overconsumption is the problem, however I'd like to suggest that low carb even at an unchanged caloric total intake is much much better for someone with really stubborn insulin resistance. Here's my reasoning - assuming the only solution for fixing insulin resistance is to lower insulin levels overall over a longer period of time so that the peripheral cells have a chance to decide that creating more insulin receptors might be a good idea (and I'm open to other suggestions), then having a high carb meal (even when below maintenance calories) will increase the blood glucose by a shit ton (please excuse the non-technical jargon), which will lead to a ton of insulin release through the primary insulin release pathway, but because glucose remains high (due to high insulin resistance) the activation of insulin release is persistent and very long lasting, which is not the case with dietary fats since they do not increase blood glucose that much and the fat dependent insulin release is not as effective as glucose dependent insulin release (as you said). In addition, keep in mind that normal blood sugar levels represent only 2-3g of glucose total in your entire blood stream. Then what is a diabetic supposed to do with 200+g (like 100x more than blood can safely handle) of carbs a day? I do understand that bioavailability of it is not 100% and might actually be quite low based on exact diet, but still! So it's all about how bad your insulin resistance is and recommendations should change based on that. In my personal experience I was able to go from 13.9% A1c to 8.5% by switching to low carb and intermittent fasting in just three months- and I'll tell you my insulin resistance is really really bad. In addition I would say that switching to low carb is easier than reducing calories. Maintaining a caloric deficit or staying at maintenance is at best magic guessery, not to mention that maintaining a caloric deficit for longer than a couple of weeks leads to metabolic adaptations that result in lower BMR. However, for healthy people I'm a strong proponent of maintaining metabolic flexibility for maintaining health, i.e. Don't fast all the time, don't eat carbs all the time, don't do keto all the time. Keep changing it up. Flexibility is key, just like heart rate variability keeps your heart healthy. And btw, most diabetes drugs (at least the ones I'm familiar with) do not address the issue of high insulin, often time make the situation worse, in fact (with the exception of metformin, but even metformin can't do magic) and also the recommendation for someone with obviously really bad insulin resistance is insulin injections? In what world did that make sense? Did you know that type 1 diabetics can develop type 2 as well, because they eat too many carbs and therefore have to use too much insulin to keep their blood glucose in check? Sorry for this last rant, that's just a personal issue of mine. What do you think about this line of reasoning?

[@Physionic]

Thank you - I've been trying to find time to respond to all your comments (I'm thankful you're this interested - clearly you *do* have a scientific mindset, which I appreciate). First paragraph - I largely agree with you. I do think a lower carbohydrate diet has added benefits for the reasons you mentioned. However, I don't think I'd jump to the conclusion that carbohydrates stimulating insulin is the only driver of insulin resistance. I think there's more to it, and therefor different ways of attacking the problem, although a low carbohydrate diet is a great way. Second paragraph - congrats on treating your insulin resistance, and as for your points about flexibility and following IF and low carb - I can't disagree. Third - the reason they tell people to start taking insulin is because people are entering later stages of diabetes where their pancreas physically cannot produce enough insulin to control blood sugar within normal levels, which implies less sugar is going into the cells, and the cells are relying more on ketones - which can lead to ketoacidosis (there's nothing inherently wrong with ketones, but this is in a pathologic situation, not physiological). If these people don't administer more insulin to supplement what their body produces, they end up in a coma. Is it a great solution? Absolutely not - it sucks, but it's the best available at the end of the line if a person can't or won't correct it through lifestyle adjustments.

[@karenohanlon4183]

I over consumed yesterday. With honey comb chocolate and salted caramel ice cream. So low carb working up to fasting for a 3 day.

[@carmenslee6234]

Wow! This is so good. I usually can’t be caught up in science stuff but this was so clear and fascinating!

[@Physionic]

Thanks, Carmen.

[@fyrerayne8882]

Thank you

[@Andrew-W]

20:03 ~ thank you for clarifying on Calcium channels and how it controls beta cells' insulin release. So it appears that beyond dietary calcium intake, many other factors PTH and possibly ~ vitamin d status are involved in the health and state of the beta cells. BTW - excellent and informative underrated channel.

[@Physionic]

My pleasure, Andrew - and thank you.

[@ausmiku]

Great video. How much "quantity and quality" of anything over the year and over 24 hours is what counts. "Quantity and quality" of food, exercise, rest etc. It's simple but not easy and requires motivation. There is no magic pill.

[@hazzah3104]

You should try relate this to ketogenic, high fat, carnivore diet

[@beataprus8585]

Excellent work. i've watched only two of your videos and i am already addicted. You explain everything so clearly and make it all sound simple and understandable. Thank you VERY much for sharing your knowledge.

[@tangimjoo3090]

I think in this topic you should also explain how high insulin & insulin resistance, the real problem of diabetes, affecting mitochondria.

[@RayBrown-j2g]

Very motivating, excellent work!

[@StockTraderClassLive]

Nick, awesome content, when you do your research, can you incorporate “water” because it’s obvious but we have not really quantified it yet. Drinking plenty of water helps your kidneys flush out excess sugar. One study found that people who drink more water lower their risk for developing high blood sugar levels. Another thing, since you talked about prolonged fasting, you probably want to talk about measuring ketones levels do not to get adverse effects. Many people suggest that drinking more water when fasting, this is because the body expels more ketones in urine rather than as a breath. By drinking water, people will produce more urine, which will help expel many of the ketones from the body. I am interested in accurate measuring this processing and at the rate we do it for different age groups!

[@karenohanlon4183]

I agree whole heartedly about fasting. I think a fast once per month say 5 days. Then only eat real good nutrients dense. With the odd indulgence of the sugary rubbish a few times per year. Sounds like a plan.

[@brendasmith9076]

Thanks for the great videos and explanation of the mitochondria beta cell. My husband is type 2 diabetic and try as I may to get him to reduce simple carbs or a little intermittent fasting for reducing his diabetes, I fail. He wears a CGM and turns off the volume of the alarm so he doesn’t get the quoted “the look” from me.🤷‍♀️ I ask him why he even wears it if he doesn’t learn from it? He tells me he is learning from it… again “the look”. I have a hard time understanding why he is comfortable having a morning reading above 130+ and then goes up to 200 throughout the day? Blows my mind. Thank you again for sharing your great knowledge!

[@patiakreles]

Your husband sounds like a charm 😂

[@Technichian462]

I’m a bit disappointed you didn’t cover the Randel Cycle in this video. That in itself explains what insulin resistance is, how it works, and why.

[@Physionic]

I'll be covering it soon.

[@Technichian462]

@@Physionic Excellent!

[@jamesgordon8867]

Direct correlation between insulin resistance and carb levels, lower carbs until insulin level below 5

[@mehr-sepehr]

All the best for your research. YOU ARE IN THE RIGHT PATH

[@humbertonajera6561]

Thanks!

[@Physionic]

Wow, thank you so much - that's incredibly generous of you.

[@hannesforster1845]

Excellent. Thank you!

[@HenIchaer]

Could be the ROS responsible for blood vessel damage in coronary heart disease? I'd be interested in the exact mechanism of the relationship between high glucose levels and vascular complications. Do you have any videos about that?

[@bunberrier]

Why does this channel not have more views... idk. Contrast this with these "body positivity" people.... basically a kind of faith based outlook, that claim they can be as huge as they want without consequences. *

[@MeHere650]

Thank you. I need to cut out some calories! I can see why overeating contributes to cancer, since old cells can’t be removed and they have the potential to turn cancerous. Makes complete sense.

[@NanetteNette]

Alright!!! One of the topics i have been eagerly awaiting! Downloaded and will listen to tonight

[@Physionic]

Wonderful - let me know if you have questions, Nanette.

[@NanetteNette]

@@Physionic will do. These videos make working midnights go by faster ♥️

[@Physionic]

I'm glad. :)

[@nishachauhan2343]

This was a really helpful explanation of ROS. Thanks.

[@MrDasart]

Excellent explanation!!

[@doblofiber992]

I, as a Type 1 Diabetic, has to insist. Using low carb as a driver against insulin resistants is way to simplified. When I consume just raw fruits, I should have problems, because of high carbs. But the opposite is the case. I have to use less insulin. I know, that the secretion of insulin is different, than giving it with a pen/pump, but the insulin resistants is less high.

[@clarksims54]

Great content. Thanks for posting.

[@Neur0z]

Thank you for the video; this is topic is what I research

[@Physionic]

Glad I could help, Andrew.

[@davethe-bear9923]

Good stuff. I’m now following and want to learn more about mitochondria.

[@ReadingDave]

Is there a way to measure how much exercise/ energy expenditure will put cells in overnutrition, undernutrition and starvation?

[@draconisdragonheart4248]

I get it. Glucose effects it faster, but fats also effect it. Over consumption is the main point.

[@madhuvantipatil4708]

Thank you for this very informative video about mitochondria. How often should I take an anti oxidant such as alpha lipoic acid? Will ALA flush out ROS from mitochondria?

[@tony538]

good stuff, great teacher, thank you

[@Physionic]

Kind of you, Tony.

[@Rene-uz3eb]

11:40 i think you are describing mitochondrial uncoupling (electron slippage), but that is not proven to be an outcome of too much incoming glucose or fatty acids. I think the whole premise here that overconsumption is causing diabetes is oversimplified. Diabetes and metabolic syndrome go together, the latter is a lack of energy production, not an excess. The excess is fat deposits that is not being used.

[@charlespark490]

will taking large doses of Niacin create electron slippage? what effect does niacin have on mitochondrial morphology, lysomes and atp efficiency?

[@MorrisLess]

This is great content. I like intermittent fasting, but controlling intake while not fasting is always an issue. You mentioned low carbs, and that's helpful, but do you have any other strategies for intake control? Counting calories? Thx.

[@davidjohns5236]

Good presentation- Not too complex!

[@Physionic]

Thank you, David.

[@bobcocampo]

Please discuss research on Keto Diet vs Dash Diet

[@alexanderohanlon8825]

So a period of over eating primes them, then followed buy under eatting activates clear up.

[@darekcituk491]

Great content,thx a bunch;)

[@markwiegard8384]

I have had good results with taking calcium supplements when I have leg pain, not cramping. I am overweight (Marine Corp weight when I left 235lbs and was running 3 miles a week) I weigh 305 at age 65. That said, other than certain vegetables calcium is gained from dairy. Humans are the only species, I’m told, that still drinks milk. Do other mammals react to calcium, releasing insulin, with calcium? Note that I 16/8 during the week and 12/10 on weekends, snacking.

[@ChangchubLhamo]

I noticed I developed a craving for sweets after recovering from covid. 2 months after, the sugar craving became more obvious and unstoppable so I went for a testing for blood sugar and glucose tolerance. The result showed I am in the category of pre-diabetic. Though my Fasting Plasma Glucose was normal as I have been following 168 intermittent fasting for a couple of years, my 2-hour blood sugar and insulin were off the chart. The doctor was not sure if it was just a long covid symptoms and might go away eventually. Nevertheless, I have been put on a treatment program since. Wonder if you have any suggestions for people in my situation? I don't have a family history of diabetic and have been a healthy eater. Thank you so much

[@lisahannah3175]

Check out the med cram channel. He’s a doctor not a scientist but it’s similar format looking at hard science studies. He has one on long Covid and several on the use of light as medicine. From what I gather, the spike proteins produced in Covid, and to a certain degree vaccination, can be problematic in cells and red light can be helpful. He’s suggesting it’s just getting out in the sun a lot more, I would say if your work doesn’t allow that look at a near infrared/red light. Idk, check out the studies he cites and good luck.

[@yaronmosheezer4580]

Wow what presentations and what clear molecular explanations Spectacular and fascinating! University height in popular approach ... Champion, still wondering why you do not have at least a million followers ...

[@Physionic]

That means a lot to me, Yaron - thank you. Maybe one day we'll reach that milestone, but until then, I'll keep chugging along.

[@naijaman6639]

Honestly. I ask myself the same question anytime I watch his videos.

[@MarcMallary]

What about this methylene blue stuff? Do you think it helps mitochondria?

[@hugotolentino4348]

Again! Great insights for my masters! Thank youu

[@Physionic]

Wonderful to hear, Hugo - hope you've been well.

[@abigaila7341]

Do you have any videos on how pharmaceuticals can affect the mitochondria? SSRIs, antacids, heart meds, cholesterol meds etc

[@Stringandsealingwax]

Can you do a short version?

[@sarahgirard1405]

If you want to make more „pulling“ content. Might I suggest a collaboration with scishow. Love their format.

[@Physionic]

Oh no, please no. I would hate for this channel to turn into a pop science channel. Consider it the “anti-SciShow”

[@joshuabowman7210]

I try and study the Mitochondria and hope i can ask some questions ? One is about ROS and weather it is possible to test and calculate a persons total ATP, ADP. AMP, ROS and SOS ? either in the Whole body or area of illness ?

[@mshengaout]

Thanks!

[@Physionic]

Thank you - I appreciate it, M.

[@tony538]

any supplement you recommend to help with this process, i use to be type 2diabetic but not any more, i did low carb and still do

[@bre3756]

If I understood correctly. Majority of the time I should eat just enough and do intermittent fasting. And ocasionally do some prolonged fasting. And maybe a few times a year overeat. But what about eating less calories. If I chose to have a few days where I purposely eat less calories than required. By how much can I decrease the calories and how many days?

[@MickFutz]

So what type of diet does a person like you change to, since you mentioned you are starting a “diet”.

[@applebobbingfore6221]

Interesting, but I find it incomplete. The use of the term nutrition I believe is misleading. First: this work is one step in the middle of the complete staircase that is assuming nutrition is either sugar or fat. However being a skinny man that got fat eating nutritionally poor food, I can attest that sugar isn't nutrition. Nutrition is the 76 essential minerals, 18 essential vitamins, 12 essential amino acids, 3 essential fatty acids, with at least 5 enzymes, 26 live probiotics, and 3 prebiotics we;re not eating anymore. So far I've found 144+ nutrients and not one is sugar. Second: I lost 200 lbs in 4 weeks fasting (in hospital with stage 4 congestive heart failure while protesting my cardiologists' stand on salt and stomach acid). I learned that I could heal from CHF without drugs. I learned that inflammation is used to buffer against illness. I learned how easy it was to turn on my adipose cell's mitochondria. But, I needed 93 nutrients to do it before the fast. (the others nutrients are involved in maintaining the path to good digestion).

[@jamesgordon8867]

Need to learn Fructose metabolism

[@ovoxochris88]

What would overproduction of ATP, or an unnatural excess availability of ATP, do to a cell? I'm assuming this would be a much different environment than overnutrition.

[@dwdwone]

I really enjoyed your skilled direction in Total Recall. Oh wait..

[@shaunnasworkshop]

Heh. You *did* anticipate my questions. Good work as always, Nic!

[@Physionic]

Great, Shaunna :)

[@Leonidas-eu9bb]

But insulin is Not needed to lower blood glucose. From what I know insulin just speeds up the process. This was seen in type1 diabetics. Their cells use glucose pretty well without any insulin. The problem was the constant gluconeogenesis from the liver. Insulin works as a catalyst and as a inhibitor. But it's the inhibiting actions that are crucial. I read this is from James Krueger (weightology).

[@paulasawyer1392]

Can you connect this process with how a person with a BMI of less than 18 for 10 yrs struggles with prediabetes? It's not over consumption. Anything short of whole food, grain & sugar free, low-carb, and small plate meals sets off the CGM. What causes this? Demand of running half marathon training helps, but not completely, and isn't really sustainable. What else could be driving the glucose production.

[@tyrussteinman7491]

One year late. Finding you recently and deep diving. Can you clarify a point you made for me? Or anyone here... When the outlet for K+ gets shut and the charge gradient shift positive why does Ca2+ suddenly go into the positive area? Seems counter intuitive from a physics perspective. What is the mechanism overriding the gradient and pulling the Ca2+ into the cell? I get that insulin is likely positively charged or somehow removed K+ from the cell to balance it out in response. But what pulls Ca2+ into the cell?

[@Sunnydaisy1987]

Great EDUCATION ❤🎉

[@Physionic]

Thank you!

[@WholeCosmos]

good video, great content for this bio nerd.

[@susanbeever5708]

Check out how trpv1, trpa1 and trpv4 play in this scenario both on beta cells and peripheral cells such as skeletal muscle cells.

[@aldifortuner278]

What is your opinion on mytheline blue?

[@FamiliaritasClinicaMédica]

Thank you for this grate video. I would like to listen some more about vitamins and mineral suplementacion, sould we or should we not? What about the higher need of vitamin B complex in overfeeding? Maybe another podcast? Thank you for the lesson.

[@NuLiForm]

Love the Zoolander Magnum look! you pull it off Perfectly (better than he does, actually)..Great video, enjoyed it Very Much, Thank You. ....& abt the Mitochondria...of course it does.. We Are what we eat....is True. (& Terrifying, considering what Mega farms & processing plants put into it especially lately. Between the Medications, the Water supply, & the Food supply..even the Air... We are...mostly chemicals.

[@alexmcclure6545]

What about the role of deuterium in mitochondrial health?

[@curiousminds357]

How about those who are not obese and yet develop type 2 diabetes? I understand the concept of overconsuming which leads to the processes u mentioned. But I am at a loss when it comes to seeing people who are not fat or obese yet develop type 2 diabetes. Can it be that eating ultraprocesssed foods somehow resulted in mitochondrial dysfunction despite no constant overconsumption and somehow also affected the cells involved in secreting metabolic hormones resulting in dysregulation? Coz if it was just overconsumption, would it also mean that if my daily diet is mainly table sugar without overconsumption of total energy supply (meaning 80 percent table sugar, 10 fats and 10 percent protein but enough to supply my total daily energy needs) , then i will still remain healthy? Kinda hard to imagine that.

[@anngodfrey612]

I am a skinny 48 kilo pre-diabetic (used diet to get back from fully diabetic at mid 50 kilo mark) so have difficulty in balancing my supply and demand which as a relatively sedentary 68 year old I try and achieve by intermittent fasting. Is this th3 right tack to take?

[@tizzlekizzle]

Do exercise and eat only things that can spoil. You'll be awesome.

[@Jake-is1ud]

I think you should define over-consumption better. Maybe you explained it but it didn’t stick with me. It’s so important for this topic I would like to have it better highlighted.

[@Physionic]

I'll keep that in mind for the future - thanks, Jake. I plan on re-making this video.

[@Jake-is1ud]

@Physionic , I look forward to the re-make!

[@lumierdusoleil]

When I see all this research’s about how our body works the more I praise God ! What a God we have ! And all this information, and intelligence comes from the God’s love from humanity. He gives you this brilliant brain to help us live a better life. Thank you and keep doing the good work! God bless you!

[@blahblah2779]

Love of humanity? 😆 So where does famine, war, despair and death come from? Because if we were do to a pro/con of being alive...

[@lumierdusoleil]

Comes from our enemy Satan, and all people that don’t know the character of God how his design Law works say that He is to blame , or better , blames God for the work of the Devil and also for the wrong choices that they do.

[@jhaduvala]

The ads that ran as I watched this were for Dominos pizza and Coca Cola. What kind of algorithm is that?

[@Physionic]

😂

[@nicholasfleischhauer191]

Do you tend to go on tangents? I mean to ask this in a sincere way.

[@saliksayyar9793]

Mn SOD in the matrix takes care of the superoxide produced by electron leak and the hydrogen peroxide by glutathione peroxidase

[@jamesgordon8867]

Glucose Goddess: glucose stability

[@willheyward]

How to cultivate optimum autophagy?

[@wefoiwefeoiiwefw]

Plug for Tim Ferriss's slow carb diet.

[@KKMultes]

the best thanks!

[@Physionic]

Thanks, KK. :)

[@wheelofcheese100]

😂 I’m watching this on my phone at an angle across my desk. Point is, I can’t see the screen well. I look over and it looks like you’re shirtless. I grabbed my phone and looked closer. You’re wearing a tan shirt lol

[@jamesgordon8867]

Photobiomodulation blunts ROS

[@daviddaygame]

So basically a long scientific complicated way to confirm the simple truths that we kinda knew already lol: 1. Avoid overconsumption 2. Ideally reduce carbs 3. Fast regularly, e.g. on a weekly/monthly basis. 1 x per week, or 1 x per month etc. 4. Use some form of IF as a basis 5. Bonus: never eat later than 4h before bed, which will blunt deep sleep + GH etc.

[@michaelbond4609]

Why do you have such long commercials at beginning? You get more kickbacks.

[@Physionic]

I don't control what commercial show up on my videos.