DNA Replication: Helicase and Unwinding

Donate here: www.aklectures....
Website video link: www.aklectures....
Facebook link: / aklectures
Website link: www.aklectures.com

[@arianacisneros1477]

no joke, I prefer your lectures over Khan Academy. And I REALLY like Khan Academy. Thank you for being so wonderfully thorough.

[@sammyedarling8316]

I second this strongly.

[@77mayanksingh45]

Me too

[@plamenferdinandov5083]

AK lectures, Khan Academy, Prof Dave and Dr. Najeeb = Life savers

[@XstrioX]

oof hot take xD

[@sylviasamboko7291]

I agree... I loved khan until him....

[@juliageaghan-breiner4202]

when I am a doctor it will be because of you and I will donate all my $ thank you thank you ur the best

[@vezashjee2629]

your voice and style is so impressive.

[@wilburash8315]

You are good. I understood everything clearly the first go-round. But I'mma watch it again anyway.

[@gentianviolet2785]

Handwriting - brilliant. Lecture - amazing. Me - Super Happy Overall - Thanks a lot for your effort

[@annacaroline9424]

Man, you should now that all your lectures have helpme out so many times... No thanks will be enough!

[@thecasualfront7432]

This is the level of detail I need. Love this guy.

[@SoumilSahu]

your beautiful diagrams illustrate an incredibly complex process in a way that even my dog could understand them and i don't have a dog!

[@velis0246]

Amazing, I'm glad I found this, going into cellular development and genetics . All of these lectures will be very beneficial thank you so much for making these.

[@DiegoDiego1989]

This guy is incredibly good.

[@radio146]

This is just amazing. Keep doing what you are doing! I hope someone realizes your potential and invest in you.

[@angelina976]

Thank you for your lectures! You are very very good! I am studying with your videos for my medical exams and have exelent results !

[@malembelamfungo2223]

Hello dear friend.

[@Nasirhussain-vc8yp]

Execellent work i understand more your lecture than any other

[@orewaswordda2928]

This is the best explanation I've ever seen so far .. now i can refresh my memory at anytime thanks to you!

[@janeijama8564]

your lectures re almost perfect..great diagram nd easy to understand.. thank u plenty!!!

[@martinstubbs7974]

Thank you so very much. I am literally very new to neuroscience and have been working very hard to make sense of it. I find your lectures so very helpful and informative. Absolutely brilliant!!! Best wishes from the UK.

[@michaelfreilich6930]

You are unbelievable my friend

[@mohammedal-hammadi5085]

It's so great lecture, I love your lectures so much really! Thank you so much

[@jyotimittal7362]

Thanku so much sir for explaining the topic in very simple form 🙏

[@mallicksayeedmahbub5637]

i'm really glad I subscribed ur channel u really r great ............ keep up the good work........... 😊😊😊😊

[@ayushshende4290]

Thank you for the videos. They are awesome.

[@ufonekalat2135]

Best lectures thank u for being a great teacher

[@Mpumzar]

No one can explain like you I can bet my last 5c for this statement

[@William17lil]

Am having good time here, he breaks everything down👏🏽 ❤ I also need medical physics lecture if someone knows it plzz tell

[@sammyedarling8316]

One thing I do wish you could do is post a link below your description of the next video in the sequence. :)

[@sammyedarling8316]

You say following lecture and I am not sure the following lecture that pops up for me is actually the one after this one.

[@hagerel_mhashhash9369]

thank you for this explanation

[@SebastianGomez-bx6fb]

my professor flips his figures to have 5'-3' strand on to of his diagrams and 3'-5' on the bottom. Im having a hard time picturing this when referencing the book websites and these videos.. Any suggestions on how to tackle this?

[@babuakhil8520]

May god bless you.

[@MaryDavidson911]

Proof aliens exist!! 2 thumbs down....they aren't from this planet! AK lectures, you have explained these concepts, in multiple subjects, better than the textbook authors and instructors teaching them! Thank you!

[@brucebancanesibanda5269]

thank you well explained, i like this

[@malembelamfungo2223]

I suggest that how if you could create the application consting of all you lectures? .

[@michaelolafitness9491]

Instead of using helicase couldn’t the cell just cool the dna which will make it come apart for replication to occur?

[@umeshjinamaste]

bidirectional replication doe's not mean that the replication occurs on both the complimentary strands but the replication occurs in both the direction form origin of replication site, on DNA double strand.

[@Xollo9874]

Really enjoying many of your lectures!! Sometimes (like in this one) I would like to have a deeper going version :) Sorry, my english is very bad :D

[@juliette7776]

Thank you thank you thank you 💃😭😭😭

[@shanesavage484]

good lecture but you made an error dna gyrase is only in bacterial organisms topoisomerase II is what relieves the supercoiling stress in mammalian organisms

[@gunfighter3890]

Shane Savage I'm gonna double check that. If you are correct, you deserve a medal.

[@mrinaliniroy6221]

Yes,gyrase in prokaryotes..its called nick n seal enzymes for a reason

[@md.tanjilurrahman5949]

what is the role of gyrase???

[@rajagopal4927]

thank u sir...👍👍👏👏☺

[@eget4144]

thank you

[@patient3841]

Thx

[@mrinaliniroy6221]

I have a question.. please can anyone answer me?? When 2 strands unwind & replication bubble forms, does the replication proceed in 2 forks together simultaneously?? Or after unzipping replication happens through only 1 fork ??

[@TIM-721]

I hope you have already found your answer. BUt, It works in two direction. It is not just a Y shaped thing. It is more like -()- this one.

[@dohaeliwa9551]

What is meant by supercoil?

[@steverob123]

its super and its coiled

[@shreyasrao905]

Basically means an extremely high amount of coiling

[@richardshane2080]

doha eliwa if you look at your Elementary particles periodic table using electron Band Theory you will realize particles share outer electrons to create molecules while the DNA is created by elementary particles called hydrogen oxygen carbon nitrogen which form to create the nucleotides which are the atcg of the genetic code as purines and pyrimidines Using a phosphodiester sugar backbone as a structural lattice to house these particles with the hydrogen bonding of the two molecules there's a place for the lattice to twist or Torque in theory it seems pretty evident that the hydrogen bonding is allowing that torsional twerk that coiling positively so when the helicase breaks the DNA lattice to make it into RNA so It can be synthesized as a protein The Divided lattice now has positive supercoiling because it's trying to compensate for the other half that has been removed from by the helicase enzyme and the gyrase comes into play negatively coils it against the positive coiling at the elementary particle level which is really a Layman's way of saying we really don't know all the mechanisms but that's the gist of it although Ak knows)

[@richardshane2080]

doha eliwa DNA has it in an electrical characteristics at the elementary particle level as electrons influenced by neighboring electrons called atoms DNA it's protected because the information the "nucleotides made of hydrogen carbon nitrogen oxygen" are kept on a sugar backbone (phosphorusdiestor) we call the whole linear polymer a DNA It is when replication begins by separating the DNA strands that supercoiling becomes a dangerous problem for the process to continue ( convey genetic information correctly ) as the DNA is separated with the helicase enzyme the nucleotides in "lack of better terms has to be capped off or they want to regroup to its original configuration as a double-stranded helical DNA the gyrase enzyme is used to cap off the nucleotides as the DNA is being separated in the 3/5 Direction only so that they do not rejoin as DNA and remain as a RNA single strand lattice without the complementary pair as a hydrogen bond the hydrogen bond is removed by the helicase enzyme the gyrase enzyme helps minimize positive supercoiling by introducing negative supercoiling and capping off the nucleotides from rejoining as a double stranded helix so the process can continue This is when the supercoiling happened they call it positive supercoiling because you only have one half of the double-stranded lattice structurally intact To counter the positive supercoiling they process of cell division introduces gyrase enzyme which is a negative coiling enzyme in layman's terms to counter the positive quote of the separated DNA lattice as 1/2 now called the RNA

[@richardshane2080]

doha eliwa here is a better answer I hope this helps good day kzbin.info/www/bejne/enm1g51ma92XoaM

[@jdoedelyewing6711]

Is it possible to get the.background notes?

[@amruthamavily]

take screen shot😃

[@lokeshkumarsanepalli9016]

Sir Can u please sujjest me books for physics and chemistry

[@muyambiseith4264]

I like it

[@faheemislam8166]

U have written R SSB in dig 2 why ?????

[@gkwithbalvir]

usefull

[@bhagyashreekavyashree9530]

Sir plzzz share this slide to me sir

[@TheDuvee6]

you look like a nurse

[@Matt-re4et]

I'd be willing to bet that this guy is from Yonkers.

[@AKLECTURES]

Nope.

[@yagmurcamd]

Progress,

[@astro8149]

thank youuuu