Do You Know What Coffee Does to Your Brain? | Institute of Human Anatomy

[@LauraDeVasconcelos]

I don't drink coffee to wake up, I wake up to drink coffee

[@esra_erimez]

*This*

[@Window4503]

If this isn’t a T-shirt yet, make it one

[@judasthepious1499]

oh no.. strawbucks gonna steal this quick, patent it!

[@dzymslizzy3641]

🤣🤣 Sounds like a friend of ours!

[@shravp769]

Textbook definition of addiction

[@classic.cameras]

I am always shocked at how gross, informative and amazing this channel is. Never had an interest in Medicine but I am always fascinated when I watch one of your videos. Keep up the great work. You guys actually are a quality learning channel on YT and that is saying a lot with all the junk out there.

[@nancyaustin9516]

That was sort of my reaction when I took an anatomy and physiology course. I think it’s the content you’re reacting to, moreso than the presentation. The human body is fascinating.

[@SPS-u5w]

Family member ?

[@creeperfan2734]

Short answer it makes brain happy

[@dl3472]

Yeah because they are addicted to it

[@lordmo3416]

Simple!!!

[@nickbuis3307]

​@@dl3472We are naturally wired for addiction. The key is to harness our addictions so as to be addicted to things that are good for and always in balance. I strive to be addicted to whole food, exercise, good relationship and community. Coffee and mate are great compliments.

[@SanxxChevalier]

@@dl3472 okay 😂 and people are addicted to weed and we don’t bat an eye.

[@LisaLove-m4l]

@@SanxxChevalier exactly! And weed has been known to change brain chemistry in some individuals and bring out underlying mental illnesses. But ppl make a big deal out of coffee.

[@alphabeta8403]

3:00 Adenosine 9:00 Improving reaction time 11:00 Tolerance; up-regulation 13:00 Diuretic; Agitation 14:50 Caffeine addiction 17:00 Intermittent caffeine use

[@thomasLivesInANewCountryNow]

Your title summation time stamps are actually not accurate. There are better terms for what is being said.

[@HeartlessKnave]

I use caffeine very sparingly, rather than daily or weekly. For pain relief as an "analgesic stack" Caffeine (60mg - 120mg) synergizes with Acetaminophen (1000mg) and Ibuprofen (400mg - 1200mg) for AMAZING pain relief. For tests and exams, especially early morning, when I need a bit of an extra stimulant to focus and not go ADHD. For competitions or tests for certifications when I need a physical performance boost. Otherwise, I completely avoid the stuff as much as I can.

[@rj-xe1cv]

😂

[@thomasLivesInANewCountryNow]

Analgesic stack?? Are you still alive? Those dosages you give are deadly, they close to daily allowed maximum . Mixing chemicals like that is totally bad for your organs. You definitely should never mix coffee with recovery or trying to recover from pain. Horrible advice.

[@fesalvehbi6511]

Can’t live without coffee. I love the mental alertness it gives me and I love doin puzzles when I feel alert.

[@pkus8437]

One thing that's i like about your channel that you also give your personal views on any subject you make video about rather than leave it on the viewer's .

[@jimmytimmy3680]

We need a whole video on ATP and its biochemistry.

[@WackyWaffle0123]

He has videos on metabolism, or search up videos on Krebs cycle

[@DbiPro]

He’s gonna make one soon.

[@levidiaz3074]

And the difference in effects of truth and lies on the brain

[@ozzstars_cars]

Drinking coffee while I'm watching this. Enjoying every sip.

[@DrMilesBennettDyson]

Your'e an addict.

[@heistruth2865]

❤😂

[@laurag7295]

Me too!

[@leslieiris7093]

It's very good. The . Caramel. Flavoring.❤

[@leslieiris7093]

Have fun drinking it. Life is short.❤

[@Maryland-Man-Son]

I'm 34 now. I found out 2 years ago I've had ADHD my whole life. I started drinking coffee pretty frequently right around college, where focus is needed to the utmost. From then on, I just drank coffee just to center my focus on a daily basis. I didn't realize there was an underlying reason for my desire for coffee.

[@terriberrens2144]

Same here 😊

[@dewayneoverton466]

Same here..without coffee my mood and brain function is terribly off.

[@friedrichjunzt]

My coffee and I are glad that we can stay friends ❤

[@leslieiris7093]

I'm.very good friends with my coffee too. We know each other pretty well . Were. Lovers.❤❤❤

[@dawntowe5799]

When I was 8 in 1976, my family doctor told my parents to give me coffee to counteract my hyperactivity. I used to drink six pots of coffee for years until about six years ago, when I slowly lowered my coffee intake to two or three cups a day now. Coffee never woke me up; it made me sleepy, and it still does. so is something wired differently in my brain? I always wondered why it had that effect on me.

[@wmdkitty]

Get tested for ADHD, that's a classic sign.

[@olgaiushkova2454]

Caffeine helped to stimulate your prefrontal lobes cortex, presumably. It's adhders' problem. The same type of brain - I can drink coffee and go to bed. Yet a cup of strong espresso orders my thoughts, disciplines them and slows down their wandering around

[@dawntowe5799]

@olgaiushkova2454 cool.

[@kuyab9122]

some people experience a paradoxical calming or sedating effect especially if they’re naturally high energy or have certain types of neurodivergence like ADHD. In ADHD for example caffeine can sometimes help regulate attention and reduce hyperactivity by providing mild stimulation that counters the brain's natural under-stimulation

[@alex-x1u7p]

Same

[@firehog]

I was depressed to 11. Caffeine made me handle the day. Turns out that therapy worked better than 2000mg of caffeine a day. Yes, I was THAT tollerant. My doctor joke that my bloodtype was 100% arabica. I should cut down since the nurces wanted to take a shot since my blood was stronger than the coffee at work. He joked yes, but it drove the point to it's mark. After a looooooong time of therapy, I drink a cup, perhaps 2 every day. No bad health effects either. My doctor ran a bunch of test on me to see but found nothing. Sadly, he retired after that. Dang it. Loved the guy. My new one is cool. Reminds me of you, but european

[@liamwaters5451]

Caffeine does not make me happy anymore. Found once i hit 28 it started giving me servere anxiety all the time, i couldnt sleep at all and i was freaking out over the most insignificant of things. So i had to stop. once i got past the horrible withdrawals my brain was relatively back to normal.

[@gdawg51]

Exact same experience, starting at a similar age.

[@omerd5147]

Same thing happened to me. Thank you for sharing.

[@Strugglingsportsman]

Same happened to me at 35. I need to quit it

[@RoseGold1224]

Same I haven't drank coffee in a few weeks

[@dolcemaddalena]

I had heart palpitations and agitations a couple of years ago and mind you I only drink one cup per day. I switched to decaf and the heart palpitations and agitation gone. I still drink one cup of decaf a day. I love the taste and the aroma of coffee. I never drank it for the buzz. If you get good quality decaf beans you won't notice the difference in the taste. But if you're solely drinking it for the buzz might be a different matter.

[@SanxxChevalier]

Watching this while I’m drinking coffee and my brain is like hell yeah!!! Coffee!! ☕️

[@SanxxChevalier]

8:23 lolol the joke 😂

[@sofiamalheiro]

2 questions: - why do we get rid off adenosine while sleeping? Doesn't our brain spend ATP as well? Shouldn't there be a constant build-up then? - how long does it take for an average person to downregulate the adenosine receptors after quitting caffeine? Do you have any idea? Great video btw; excellent work! 😊

[@Honour57]

yes yes yes!! check out the glymph system....the brain gets washed whilst we sleep using cerebrospinal fluid.....research shows that lack of sleep can cause neuronal damage because this washing process is hindered... lack of sleep, therefore, can lead to all sorts of problems long term...

[@nealesmith1873]

Coffee lowers my blood pressure and lowers my heart rate. Drinking coffee helps me relax!

[@Kasiek2011]

Caffeine works exactly the other way round, Jonathan even explained it in the video. So if coffee really lowers your blood pressure and heart rate, you should be concerned.

[@Arnot-r7u]

@@Kasiek2011 It depends like the amount of caffeine is the persons coffee other additive like cream sugar milk and its ratio to coffee also tolerance place a good role since if you are tolerated to it you will feel the alert effect lower it happens to me occasionally when I develop a tolerance caffeine helps me sleep better but in most cases its totally different

[@n539rv]

I’ve used 2 extra strength Excedrin just before exams or other mentally challenging activities to get the mental acuity boost without having to run to the bathroom in the middle of an exam! It really does make a big difference.

[@joshuacastleberry1431]

A video of how a pre workout supplement works in the body would be pretty awesome. How the different ingredients function in the body during a workout.

[@allfusionx]

Thank you for the great information. One key thing you didn’t mention is the half life of caffeine (or how long does it stay in our system); this is helpful to understand to minimize the adverse effect caffeine might have on sleep

[@Honour57]

It depends on the dose but typical half-life 3-7 hours! So a 2pm coffee could still be supplying adenosine blocking at 9pm...I am writing an essay on sleep v stress!

[@InGratitudeIam]

This is helpful information. There are studies out there that show that consuming more than two or three cups of coffee per day (>32 mg of caffeine), an increase in Osteoarthritis has been known to occur for those dealing with that type of degenerative arthritic condition. Accordingly, I've cut back to 2 cups/day and silently weep.

[@macemoneta]

It helps with gout too, as long as you keep up your water intake as well.

[@Jessica-l2o7j]

治療 氣喘 也很有幫助 適量飲用咖啡☕️ 對身體是有益的👍🏻

[@GCBH0402]

I have 1 espresso in the morning. Not to wake up, I just really enjoy it as part of my morning ritual which includes meditation and yoga. But if we don’t have fresh beans, it’s no biggy. I don’t drink alcohol, fruit juice, fizzy drinks or energy drinks. Only 3L of water, every single day. I don’t smoke, I don’t use sugar and I don’t have sleep or waking up problems (thank g-d)

[@Michael-ud5og]

Oh gee, your such a super hero. Oh how God's should bow, bless and wash your feet.. so special

[@SPS-u5w]

Take care of your teeth , if somebody digs you out after few mill years , you want to make good impression , now , won't you ?

[@Godswill247always]

@@Michael-ud5ogwhich god is that, after “meditation and yoga”?

[@user-ds4tr9kw3n]

​@Godswill247always I like 👍🏾 comments, our God is a jealous God and doesn't mingle with yoga nor meditation. Yoga is satanic.

[@SunShine_sublime]

​@@SPS-u5wI found out baking soda is really good for my oral health. I've been using it for a few years.😊

[@martinsedivy4594]

As someone who often quits caffeine only to get back into it out hod habit, i find the caffeine effects to be one big lie. It may work for the first and second time, maybe third and fourth. But once you're in a daily habit of drinking coffee, you only feel worse overall, and the caffeine makes you feel slightly less bad..

[@graciegrey4049]

Rarely, mostly never, hear someone speak this truth that I also believe to be true!!!!! Thank you. Couldn't have said it better. I think there might be mold in coffee but I'm not sure. Whatever, it is absolutely addictive physically and psychologically immediately. And it's a big lie, makes me sick. The next time I quit so be for good. Never say one cup.

[@martinsedivy4594]

@@graciegrey4049 Good luck! I hope we both manage to kick it for good 😁

[@johnnywilson7799]

It makes me feel good all day been drinking it for 65 years

[@johnnywilson7799]

Nothing wrong with with a cup of coffee

[@martinsedivy4594]

@@johnnywilson7799 stop for months and you'll feel better. Though at this age, just don't worry about it. I'm in my 20s, I want to optimize my health.

[@StopTheRot]

Recently gave up coffee (have one cup of tea in the morning, then no more caffeine) and it has been my most significant decision in a battle with anxiety. My anxiety has gone from overwhelming and immobilising, to practically non-existent, all in matter of three weeks. The effects were almost instant. It’s left me feeling there must be a pretty forceful caffeine lobby.

[@Trike.]

Even decaf coffee gives you a reaction? I cannot drink a 1/4 can of pepsi in a hour or it will spin up my anxiety then adrenaline kicks in and i go supernova , When i go to the dentist i tell them no epinephrine cause that starts a chain reaction . I find the best way to recover from a caffeine overdose is drink lots of water and flush your body out of it . If i ever do drink a pepsi which has 55mg of caffeine i can only drink it over a 12 hr period , but not all at once

[@thomasLivesInANewCountryNow]

Well said my friend, I had been under the illusion of benefits because there is a mountain of propaganda for coffee and it's all industry driven. Just another nail in the coffin of humanity , that destroys the earth and our bodies, like so much else of industrial capitalism. We perish in ignorance.

[@CarnivoreOma]

Outstanding and perfect timing. Needed to evaluate my use of coffee at this time. Easy to make my decision and define the process I will take. THANKS

[@TheSnackWrap]

I loved the explanation of physiological basis of caffeine and adenosine interplay! I was finally able to understand the general idea of it, thank you! I would be very interested in a video where you'd talk about possible neuroprotective effects of caffeine on the brain. I think it's a topic worth exploring, though I personally find the literature confusing. :x

[@turtletom8383]

It's likely as harmful or more harmful but you'll never hear it as long as it's an addictive money maker

[@AndrewBlucher]

Interested in caffeine and athletic performance. My current understanding is that it aids performance in multiple ways, one of which is pain tolerance.

[@aimzzz9382]

18 hours till this airs ? I’ll go make a coffee 😂

[@Jessica-l2o7j]

😆

[@DanielVance]

I cut out caffeine from my diet nearly 25-years ago due to it giving me extreme pain. Each time I accidently ingest it now, I am utterly amazed that people can function on it.

[@BuiltInBrooklyn]

If I drink caffeinated coffee I feel like I’ve been hit by a train the next morning. It also makes me very anxious and jittery!

[@omgrapist]

The placebo effect is a hell of a drug

[@Loyannelima]

The perks of DNA ❤ Tk God I'm on the side that caffeine does wonders ❤☕️❤️

[@terriberrens2144]

Maybe it's the mold in coffee. I had to find one that I could tolerate. We are all so different.

[@aaronamponsahasiamah1220]

The headaches caused by caffeine are due to its mild diuretic properties that would in turn cause dehydration. Dehydration causes headaches.

[@Brievel]

There's got to be more to it than that because I drink water plenty but a single cup of caffeinated tea gives me a headache that lasts for three days.

[@aaronamponsahasiamah1220]

@ perhaps your tolerance to caffeine is less than how much of it you ingest in your tea. Have you considered that?

[@Brievel]

@@aaronamponsahasiamah1220 That would be difficult, considering what a low dose of it is in the tea.

[@aaronamponsahasiamah1220]

@ You're perhaps Caffeine intolerant. Have you considered?

[@i2iFX_Colleen]

Is there any chance you can investigate the effects of caffeine on an ADHD brain? I find this video fascinating but it works the opposite was on me, I began taking caffeine tablets to counteract the effects of strong pain killers in the morning, I also drink 2 cups of strong coffee in the morning too! (Yes, my doctor did tell me that it would be fine to take it). I can go to bed right after consuming all that caffeine and sleep well..... So why, Whats so different about MY receptors? Thanks for this video, I am sharing it with very intelligent friends who drink a lot of coffee :)

[@olgaiushkova2454]

I'm afraid they're still no proper researcher of ADHD+coffee. But it's too common for adhders to have this relationship with caffeine to be coincidence))

[@thekawaiislartibartfast42]

It helps me function in a somewhat human way

[@BuiltInBrooklyn]

Because you’re dependent on it, if you quit for long enough you’ll realize that you never really needed it and that you actually feel better without it!

[@timm_Rudiger]

@@BuiltInBrooklyn no. i'm so tired of that cr%p. I quitted sugar for 2 monthes, i was ok. But I definitely did not feel better than when i consume sugar. So no. Sugar makes me happy, just consume it moderately. The same with coffee, it makes me happy. I drink it moderately.

[@nickbuis3307]

​@@timm_Rudiger Sugar and coffee are different "beasts". I wouldn't lump them together even though people literally do it on a daily but that's not really what I mean. What I mean is sugar is way easier to over do and the detriment is evident in the chronic and metabolic disease epidemic and coffee on the other hand while still addictive it's way harder to over do and much less harmful than sugar if you do find yourself in the upper limit of what is ideal to use on the daily. For most people 1 or 3 cups of coffee is fine however as for sugar 20 to 40 teaspoon of sugar per day is probably not OK for most people and this is what the average american consumes on the daily of both of these.

[@matsu5223]

@@timm_Rudigerhow many cups is moderate for you?

[@belugaflying]

​@@timm_RudigerRay Peat wrote on why your experien e checks out. Coffee and sugar are good

[@vishalnihal2101]

You are doing really great and respectful job. Keep going.

[@adambellesheim5706]

Drinking your 1st cup of coffee after going caffeine free for almost a year was the most euphoric experience. I used to drink upwards of 500 mg a day for years and years, and I had built up a tolerance. Stopping at the gas station a few times a day to get an energy drink and it almost making me sleepy instead of giving me energy, I knew I needed to Completely take a break from caffeine. I’m about two years in drinking coffee again and caffeine, now 1 cappuccino in the morning, really puts me in an incredible mood.

[@lorraineyanez4301]

Why do we always get conflicting answers . One day, coffee is ok. Another day, it isn't.

[@markrobby7136]

Just do what makes you feel good. Reseachers are confused. Many years they told us that fat was 3vil and that carbohydrates are way to go, but decades later, they flipped it and say the opposite- fats are great, carbohydrates are sugar

[@francinemiranda8409]

Possibly related to new information, based on further studies???

[@lorraineyanez4301]

@francinemiranda8409 possibly but then everything should be taken with a grain of salt , science and research is always constantly changing

[@Anonymous------]

​@@markrobby7136 Science only discovered vitamins a century ago!

[@CHSCxp]

i dont think its the coffee. its the day. 😅

[@SkepticalCaveman]

Decaf coffe also have health benefits, although less than regular coffee, so I drink both, reserving caffinated coffee to workouts or times when I'm tired.

[@chifylube]

Doesn't decaf still have caffeine?

[@cargoraygaming9274]

​@@chifylubeyes just not much

[@HasanAhmed-ex6jv]

One of the very first coffee drinks was made in a town called Mocha in Yemen.

[@johnstraley9057]

There was a time I didn't care for the taste of coffee, then started drinking it just to be social. Over time I realized the caffeine was having a positive effect on my asthma and the rest is history.

[@ladel2o1a48]

IDK, but it's exam week so I hope it does magic

[@LV4ALL]

Good luck

[@ILLEGALSINMASS]

I recently realized im totally addicted to coffee. It took me 40 years to realize this. Im from Boston- dunkin doughnuts on every corner- a staple in my childhood and my life

[@Bruce.-Wayne]

Lol....I was in the Brockton area last year and I realized I didn't need GPS help to help me find a dunkin donut...

[@ILLEGALSINMASS]

@Bruce.-Wayne omg! Dunks at every corner!💗

[@SunShine_sublime]

Or, you might be addicted to sugar and not caffeine?

[@mikaelajasonnn3]

Anything the Government say to eat i just do the opposite. I recommend reading “Health and Beauty Mastery” by Julian Bannett that book is a real eye opener about shocking stuff health industry is doing! I completely changed my habits

[@jasontree33]

totally agree

[@manojtr7203]

This comment is a scam.

[@DrMilesBennettDyson]

So you eat fast food and sugar?

[@blessnorthamerica7919]

Does Coffee make you sleepless?

[@thegrilayz3283]

Where can I get?

[@the.yashsingh]

can you make a detailed video on acne scaring or scaring on skin. why do the occur ? why our skin cannot overcomes it?

[@redpill8274]

توقفي عن السكر

[@xblackchristmas]

so interesting. i have high tolerance to caffeine - can't tell if it's working. i thought i'm adding energy to my system when in fact caffeine is blocking adenosine from attaching to its receptor!

[@williamkazak469]

I have not been drinking coffee for any effect except that it tastes good. I have it down to one cup each morning. That don't sound right. Does it? There must be an effect or I would not be doing that. I drink tea throughout the day. I am going to cut that down to three cups per day and totally eliminate coffee. I have been sluggish, urinate frequently and sleep poorly, waking up throughout the night. Thank you for this video. A lot to think about. I will share this

[@susear5939]

Tea has L-theanine in addition to caffeine. The effects of both together is what makes drinking tea a more pleasant experience. L-theanine produces a calming/relaxing and more focused state. Lowers blood pressure. This balances the effects of caffeine. I suppose this is why a mild cup of green tea is often suggested at night.

[@mdw6793]

Another good vid, thanks. Caffeine also increases CSF production in the brain, so is a treatment for cranial and spinal CSF leaks.

[@Xander_Park]

I drank an entire pot of coffee every day for decades. I suffer from panic disorder, and now that I'm older the caffeine would trigger my panic attacks. I stopped drinking coffee cold turkey last August and replaced my morning beverage with a healthy fruit smoothie & 16 oz of water. I feel so much better, and healthier.

[@Mauitaoist]

Having a high fructose smoothie is very bad for your health so is the caffeine so you didn't really benefit by giving up one poison for another

[@easyhomeremedies]

7:13 As a coffee lover, I found this video incredibly informative. It's given me a better understanding of how my morning cup of joe impacts my brain function. Thank you for sharing! 😀

[@davidtwchan4925]

Thank you for your video! I do consume coffee everyday after lunch, and this one elevates my focus in the afternoon. Any extra bit won’t do the trick, so 1 cup per day for me (and must be after lunch) is the optimal amount to me. At this amount I won’t feel anxiety or other adverse effects but just calm and calamity, and hence can focus on the afternoon work.

[@CrispyKyle8]

So I'm epileptic and I have found caffeine to be a trigger at times but not always. I assume adenosine is kind of needed for someone like myself to help suppress the electrical activity on the individual cells to avoid the potential for misfiring? So any interruption of this process can cause issues I can only assume (makes sense to me) Nonetheless, I love the video

[@NuKim-ld1tw]

I love love coffee and tea. On days I am sluggish I drink Celsius. 200mg per can. I have become so used to it, it doesn’t hit like the first few times. So now I drink 2-3 per week instead of every day

[@LisaLove-m4l]

I’m not addicted to coffee. Coffee is addicted to me ☕️

[@damarisrodriguez4244]

😂🤣😂🤣

[@crazylarrywatson9248]

Dear Jonathon ~ Thanks for making this wonderful insightful channel of CURRENT knowledge and educational comparisons that great enhance our movement forward to understand the human body. How it works? Great analogies. I love them! Please reach out to me I would like to talk to you regarding changing the lives of thousands of kids whom I'm associated with already. I would love for you to be a part of the glory. Sir. GOOD stuff GOOD efforts buddy!

[@kjetilrohde4370]

Can the number of adenosine receptors decrease again if someone stop ingesting caffeine?

[@SizakeleTwal]

I'm watching this in awe, but I'm not quiting it,... Not in this lifetime

[@kam1583]

Right there with you😊

[@darnelllacan6904]

Are you open to trying some new coffee? 👀

[@donneverae3050]

Would love a video on ATP. I was heavily addicted to caffeine and had to go off it cold turkey. The withdrawal headache was excruciating, lasted 3 days, and OTC pain killers did nothing.

[@JoaoVictor-dw2ci]

always such a pleasure to learn more about physiology with jonathan !!! Keep up the good work guys !!! ❤❤❤

[@kelsierussell7965]

I had a baby 4 months early and she’s in the NICU and they give her caffeine to stimulate her brain & gets it going like it needs to. It benefits them and I thought that was so crazy!!

[@thethoughtfulpeanut6662]

So---does that mean it's okay, or even potentially beneficial for prenatal neuro-development, to drink coffee in moderation while pregnant?

[@thomasLivesInANewCountryNow]

Caffeine for a premature baby? Are you mad? Please see a doctor. Crazy.

[@yvettejanice]

I used to drink coffee like it was water, there was one time I was abroad for work, it was all tea and water! I felt sick after a long day, and my boss said it was caffeine withdrawal. My doctor recommended cutting back, last year replaced it with hot chocolate. This year I returned to coffee but only 3 cups, 1 in the morning, a white coffee in the afternoon, and 1 at night. When I have a headache, I take medication with coffee to speed up the effects.

[@SquatchWatcher]

6:15 - The ad for AG1 supplement says the year "2022" 😮 Regurgitated reruns 😂

[@markkcrosby6109]

I feel like I watched the video about caffeine used by athletes as well

[@arcan762]

I legit thought this was some kind of reupload, this confirms it lol

[@xerzac]

This may be a result when they got hacked

[@gabrielstarlight9003]

4:52 please do a whole video on ATP

[@sheepwshotguns42]

yeah, im definitely addicted, but i do try to make it work for me. i love coffee as an artificial mood enhancer. even on a terrible day it can make bad things glide off me. i wont drink it every day, it tends to dehydrate me and i'll cut back harder if i can feel the effects waning. i also prefer to drink coffee when im already well rested, when im tired it just makes me jittery and tired.

[@kentspeigner8738]

Hey. Like your name. I get it.

[@sheepwshotguns42]

@@kentspeigner8738 in todays world its important for a sheep like me to be well armed.

[@nixniemand4802]

I recently saw a video by Layne Norton about a study that implies creatine can reduce the effects of the mental fatigue caused by lack of sleep and this helps explain those results.

[@cococreates26]

Would be interesting to learn about the differences between how neurodivergent and neurotypical brains react to caffeine! I take caffeine in order to sleep, as it has the opposite effect.

[@Blamcomacncheese]

Same! I have adhd and had to give up coffee because it either makes me sleepy, or gives me horrible anxiety and jitters.

[@edgarmartinez6980]

I want to share a pitfall if caffeine. I have been taking pre workout drinks for about 20yrs. So much that now I have acid reflux. In my case it was “silent” reflux where it wasn’t heartburn but it demonstrated as a cough. The acid reflux ended up causing a small growth on my throat from irritation. I know share my story with young kids at the gym to not even start. Save your health and money.

[@weszehm3588]

Thanks for the information I've been very interested in learning more about the brain it's such an incredibly interesting subject ☺️

[@EzraMable]

Does upregulation affect how tired one feels, the rate of absorption of adenosine, or the maximum amount of adenosine that can be absorbed? Or, is the rate at which ATP is broken down more significant?

[@GeoffryGifari]

Is the effect of caffeine on the cardiovascular system also directly related to adenosine receptor blocking?

[@turbyoulance]

I had Supra Ventricular Tachycardia . Eventually having an RF Ablation. I am no stranger to ADENOSINE pushes intraveinously to "snap my heart rate back form 180 beats /minute to normal. Can you explain why ADENOSINE pushes are so dramatic to the patient and why only ambulance paramedics are allowed to carry it or the Emergency ward ? Plus why do they administer Adenosine ? Cheers.

[@karenmcneill2602]

i love both tea and coffee. Coffee has no effect on me that I can tell. It will not keep me awake at all. I drink it because I love the taste. But Im happy for just one a day. Tea, though, is my great love. Still no effects but utter delight for my first cup LOL. This video was interesting!

[@nancyaustin9516]

And my reaction is exactly the opposite-tea is blah to me, and coffee is much better. I can’t understand why anyone would drink tea.

[@RSE-2020]

As a bodybuilder I use caffeine mixed with creatine in my morning coffee it's brilliant❤

[@levidiaz3074]

Caffeine is also a thermogenic

[@cartist5523]

I try to warn people not to drink super caffeinated energy drinks, because it can cause a heart attack. But nobody listens to me. I drink a cup of coffee every day but after seeing this I am going to go down on my caffeine intake.

[@cordfuller]

So with it making the heart beat more frequently and possibly more forcefully, does this cause the heart to deteriorate or have future problems in the long run?

[@jesscorbin5981]

Quite the opposite. Watch out for pesticides though

[@DbiPro]

Im happy to put myself up for an experiment. Building up ATP Stores and brain productivity

[@jaydenfurler6601]

Amazing informative video👏🏻👏🏻

[@margaritanaranjo8089]

It activates my brain in the morning, I love it

[@PeakWellness-m7l]

I didn’t know this before! Thanks for making it so easy to understand.

[@bonnielundholm5535]

How does all this relate to people who get a calming effect from caffeine? For example: Caffeine used to put me to sleep when I was an occasional user. Now that I use it when I have a migraine (I have chronic migraine,) it doesn't put me to sleep, but it still has a calming effect on me.

[@b64771]

hot liquid is the comfort, not the stimulant caffeine. Caffeine can help migraines though. Separate things going on.

[@bonnielundholm5535]

@@b64771 I drink cold Coka Cola for my caffeine. I'm also not talking about comfort. Calming and comfort are very different.

[@manishadudi6142]

Message from India, sir you videos are amazing but can add subtitles features in your video. So it's easy to understand.

[@gissmats7065]

The only anxiety I have is when I wake up and I don't find coffee. 😂

[@Mashmans]

Interesting about how those adenosine receptors increase. How long is it until they get removed naturally? Would you make a video about how cinnamon and nutmeg work in the body because you're able to explain things clearly.

[@stevewhalen6973]

Thanks!

[@xykszz77]

hello

[@myvotedontcount20]

I love my coffee! And I am never stopping. Medicine, first responders, and military.. thrive on our coffee!

[@pwalk4160]

1 to 2 cups and I feel like I have adjusted to the universe 😁But more than that or at the wrong time and my sleep is ruined. I also suffer from anxiety so I take supplements for it like ashwagandha which really helps offset the bad effects of caffeine.

[@Golth1502]

I always need to go 1 or 2 weeks without coffee from time to time to enjoy caffeine again.

[@Ohmanwhyyourfeelingshurt]

Anything could be addictive of you tell yourself you need it but your body doesnt

[@cargoraygaming9274]

IM ADDICTED TO MONEY IM ADDICTED TO MONEY IM ADDICTED TO MONEY just manifesting don't mind me

[@LegendFromWoW]

I try to keep my caffeine intake to the morning. This way at night I can get to sleep without much trouble. If you have it anywhere near mid-day it can cause issues if you go to bed at a reasonable hour.

[@susear5939]

It does take about 12hrs for caffeine to fully exit the system. That's why it is suggested to limit your caffeine intake to max 8hrs before sleep. The minor caffeine content in some teas has been shown to be fine for me if I consume it at night.

[@dkarbaev]

Why does it cause anxiety? What’s the mechanism of that effect? I once had four double-shot espressos in a day, and the last one caused pretty noticeable anxiety, so that I couldn’t even focus on my work.

[@jillnichols2467]

I happily discovered drinking coffee can get rid of a headache quite quickly & effectively. For me it works every time, I've had occasion to use it.

[@mariettestabel275]

True 👋

[@stevegrady5451]

It would be very interesting at the cellular level to look at the caffeine effect on GABA receptors(an inhibitory neurotransmitter).

[@davidcarbone3385]

i drink white tea every day and occassionally caffeinated coffee. When I drink coffee, I'll usually drink it 3 or 4 days in a row and then not all for a couple or more weeks. The biggest thing I notice is that when I am tired and in need of sleep, drinking coffee, the few times I've done so when tired, makes me even more tired. Instead of a "rush" I'll get just the opposite. Strange.

[@stevewhalen6973]

I take AG1 every morning and it gIves me an energized but not hyped like caffeine can do , feeling. This way I'm more vital without the nervous energy of a stimulant. I'm on my 4th month of the supplement getting it monthly on autoship.

[@juliemarkham4332]

How cool. Great explanation of the caffeine effect.

[@Yupppi]

AG1 is a great thing if you don't eat any food and want to supplement everything for a way to spend a lot of money.

[@Matt_from_Florida]

_"Beer is proof that God loves us "_ -Homer Simpson

[@SanxxChevalier]

Well Christian Catholics Monks made it 😂 and so did the nuns

[@jesscorbin5981]

Since Babylon

[@Royalchess1]

Well Done Presentation! I was hoping you would've mentioned esspresso.

[@cateclism316]

A day without caffeine gives me a headache, and a foggy mind.

[@ag135i]

Caffeine is business for millions of people around the globe and many people got married had a family also got beaten up murdered because of caffeine socialising.

[@jesscorbin5981]

Like at Starbucks?

[@thomasLivesInANewCountryNow]

Coffee is bad my friend. Shut it all down now. Kills our bodies kills our earth. Forget millions blah blah , it's all lies for business. Make them stop killing our lives

[@elwachiman22]

Soy taxista, sin cafe seria muy pesado el trabajo, amo el cafe.

[@DianaM-sr3yh]

☕👍❤

[@PlutosMoon22]

No bebo el café todo los días pero mi encanta🥰

[@theanatomylab]

No podemos argumentar contra eso 😅

[@jacquelinepianto5087]

I exfoliate with coffee grounds every single shower. Very stimulating!