DOCTOR reacts to CELLS AT WORK! // Episode 8 // "Blood Circulation"

Back by popular demand! I breakdown the scenes from the Blood Circulation (episode 8) of the fantastic Cells at Work (Hataraku Saibou) from a real doctor's perspective. I'll be reacting to scenes and explaining a little bit more about what's happening in the show and sharing some of my experiences as a doctor.
In this episode we cover; blood circulation (obvs), valves, what is a heart murmur, the portal system and a few other bits.
As with all these reviews I skim over a lot of medical terms, please leave a comment if you want any clarifications!
This is part of a series reviewing Cells at Work, you can find the whole playlist here:
• Doctor reacts to Cells...
You can watch Cells at Work! here:
crunchyroll.com...
This episode didn't have as much immunology as the last one, much more physiology but I tried to add in some insights where I could, so if you enjoyed this please check out my other reviews of Medical TV dramas; House MD, Scrubs, The Good Doctor, Grey’s Anatomy, The Resident and ER! And also I did a series on Marvel movies too, more on that soon.
Instagram: / drhopesicknotes
Twitter: / drhopesicknotes
FB: / drhopesicknotes
Clips used under fair use (education and review):
THANK YOU FOR NOT COPY STRIKING THIS VIDEO SO I CAN CONTINUE TO USE THESE GREAT SHOWS FOR EDUCATION AND REVIEW.
ALL Cells At Work! Clips owned by Kodansha / Kodansha USA and distributor Sony Music Entertainment (Japan) Inc.
Thank you to all the artists that make their music available for these videos:
Song 'Escapists' by The AutoDisko
Song 'First Day' by Huma-Huma
Song ‘Finding Me’ by Eveningland
#doctorreacts #doctorwatches #cellsatwork

[@DrHopeSickNotes]

Thank you for your patience everyone; I promised this video last week but only just got around to completing the edit... I was pleasantly surprised how Cells at Work handled general physiology rather than immunology, so looking forward to seeing what happens next! Hope everyone is having a super week! X

[@nipahnoob]

Dr Hope's Sick Notes I just recently started watching your channel and wow i love your videos. However, i still wonder how you have time to do KZbin. How do you have the time???

[@jasonrichardson1999]

@@nipahnoob he records in batches when he got free time which is rarely

[@richardlsp7670]

I like your explanation for CAW!!!! Thank you!! Hope to see more!

[@calebefalcao7997]

About the statues... they are just Onis. An Oni is a kind of demon, or ogre, of the japanese mythology, or they may be Kamis(gods). It's just a cultural reference, because the heart looks like a traditional japanese temple for the cells. I hope that you can understand what I meant to say, because I'm brazillian, and I had to learn english by myself, so, I still have some difficulties with the language... specially in terms of writing.

[@world4saker]

for the statues they are the Nio, are a pair of protectors who commonly stand guard outside the temple gate at Japanese Buddhist temples, one on either side of the entrance. The right statue is called Misshaku Kongōand has his mouth open, representing the vocalization of the first grapheme of Sanskrit Devanāgarī (अ) which is pronounced "a". The left statue is called Naraen Kongō and has his mouth closed, representing the vocalization of the last grapheme of Devanāgarī (ह [ɦ]) which is pronounced "ɦūṃ" (हूँ). These two characters together (a-hūṃ or a-un symbolize the birth and death of all things. So they represent in lay terms the deoxygenated blood cell are "dying" then they are "reborn" or become oxygenated blood cells

[@terrencekuruma3224]

_Anime characters being anime characters_ Dr Hope: This is exactly what happens in our body Heard here first folks anime is real

[@Tommy9834]

I guess this is what happens when you have anime in your veins.

[@dirichlettt]

We bleed best girl

[@benderossett1543]

Well, looks like Undyne will be happy to hear it!

[@eskreskao]

The real anime was inside us all along!

[@duddude321]

@@eskreskao Uryu Ryuunosuke coulda told ya that. Kiritsugu showed it to him with a bullet.

[@taura6960]

The gargoyle-like statues are likely a reference to Kaminarimon Gate in Asakusa, which leads to Sensoji temple. The gate is flanked by statues of the thunder and wind gods. It fits with the temple like depiction of the heart. Though I suppose the thunder god could reference the electrical impulses of the heart, and the wind god could reference the breath oxygenating the blood.

[@candacewhite9040]

Oh wow thanks for the info.

[@keremcantarhan]

Yeah definitely the same ones in Asakusa. They are also supposed to be guardians that separate what is impure from what is holy so it makes sense thematically that they stand between clean and impure blood.

[@MichaelBerthelsen]

Many Japanese temples and shrines have these, though, so probably a more general reference than that.

[@overthecounterbeanie]

They are called Raijin and Fuujin, and they are very common guardian deities found at the gates of many temples in Japan.

[@VampByDay]

I was going to make a similar comment but you summed it up better than I could have. I'll just add that the 'cramped passageway' that the Red Blood Cells go through on their de-oxygenated journey into the heart are called Torii Gates, and they are found outside of temples and shrines. Supposedly they form a sort of 'spiritual corridor' for people on a spiritual journey to said temple/shrine. Dunno why they chose to represent going through the heart as going through a shrine. It's . . . odd to say the least. I do like your idea that it has to deal with wind/Oxygen and Thunder/Electrical impulses.

[@jeremychan910]

Wait, did red blood cell _finally_ , legit, for once, navigate her way though the blood circulation system without losing her way? *Coagulations* !

[@sauravshrestha4951]

Jeremy Chan please see yourself out

[@8unnylover]

Do NOT see yourself out!!

[@randomsandwichian]

Platlet-chan: *someone called?* 😶

[@laurenceraran4027]

You will (not) circulate around the body.

[@jeremychan910]

@@laurenceraran4027 She (N)ierly did.

[@MrSzybciutki]

I thought it was funny for some reason that you memorized those virus depictions and are able to distinguish them now. "Hi I'm Dr Hope and I specialize in anime viruses taxonomy"

[@adrielpahati185]

This! There should be a degree for this! or at least a medical specialization! hahahaha!

[@HappyBeezerStudios]

tbh, they do look pretty close to how they actually look.

[@namjoonsdesciple5141]

They're bacteria 😅 right?

[@reeeec]

Ed Hope M.D Anime microbiology

[@immortalsun]

I’m Dr A. Nime, an animeologist.

[@Remls]

"... a process called the Krebs cycle ..." **shivers down my spine from the PTSD**

[@AnastasiaSilvi]

I thought I was the only one. Is anyone here hosting a support group?

[@theveganflower5135]

It makes more sense now why you crave sugars to get fast energy...this episode really broke down everyday things

[@SatishYadav-fo8yt]

It is amazing, the krebs cycle. Very easy if you associate it with something like a story

[@ley5532]

Satish Yadav isn’t Glycolysis the Linked Reaction and the Krebs Cycle easy processes to remember?

[@SatishYadav-fo8yt]

@@ley5532 that's what i said, they are easy but we need to concentrate and associate.

[@Box-O-Soldier]

*I legit turned pale when I heard "Krebs' Cycle"* The damn thing was the bane of all people studying for the metabolism exam, and I swear I had nightmares after that. Luckily, we all remembered that in the end of the day, *mitochondria is the powerhouse of the cell.*

[@DrHopeSickNotes]

Yeh I should have given a trigger warning ⚠️

[@nafri91]

i hate biochem.. all those cycles..nightmares..

[@Maric18]

Krebs is the german word for cancer ... so i guess have fun with that ;D

[@cincin366]

I had a nightmare after I learnt Kreb's Cycle. It was a struggle to remember all the reactions...😔

[@aggonzalezdc]

And of course, I have since forgotten basically all of the Krebs Cycle, in spite of memorizing every damn bit of it. Really makes all that suffering worth it doesnt it!

[@BananaAndAMonkey]

I've watched this anime twice and I never even noticed the jacket color detail! What a nice touch!!

[@Alpha0727]

Aniplex announced that they are releasing Cells at Work dubbed.

[@anna.owo.]

Same here

[@enforcerridley158]

Never noticed it in the anime myself, but the manga outright states that it happens.

[@TheEternalStarz]

their hats inflate and deflate too

[@thegoodkindofweirdo]

This situation was also shown in the manga on one page, explaining how their jackets work-although i forgot what chapter that came from lol

[@NuclearSharpShooter]

Oh my God Ed, when you said "you must say, it's the powerhouse of the cell", I lost it. I'm a biology teacher, and I feel like that's our motto

[@secondaryproductions9770]

*He got anime and medication on his side!* Edit: My highest liked comment ever. Thanks.

[@adt4864]

Mystic art of animedication.

[@GregAtlas]

Animedication no jutsu

[@senjougaharahitagi8310]

@@GregAtlas lol that made me laugh😂

[@LoreCatan]

nice vine usage xD

[@GregAtlas]

@@LoreCatan That's how we swing. **Tarzan yell**

[@kaylenvee8150]

I was talking about you with my friends and I was talking so fast I accidentally merged 'anime' with 'medication' and ended up saying: 'animedication' and we all laughed about it

[@mehmetgurdal]

Well it should be a term :D that's how I overcome my anxiety 2 years ago :D

[@AramatiPaz]

@@mehmetgurdal Thats how I overcome my first big depression crisis 12 years ago.

[@aegis_xo]

"Still doesn't stop them claiming my videos though :)" You've made my day, Ed😄

[@grandmask]

The man, The Myth THE DOCTOR is back at with the cells at work review!

[@cye2310]

I was expecting you to say 'The Legend' but 'The Doctor' is good too

[@RiuLenn]

Yeahh!

[@Rektlit]

Scoot sterling...

[@eskreskao]

@@cye2310 I'd go with "The Medic", but that's because I'm very fond of alliteration.

[@rfacproductions6552]

"THE DOCTOR" *_Dr. Who theme song plays_*

[@TriceeXO]

“The only artery that carries deoxygenated blood” Haha. Boy are med students happy every single time that questions pops up in the exams 😂

[@olahalyn4139]

This is a stretch, but this isn't strictly true. In fetuses, their arteries carry deoxygenated blood. I am sorry I have alevel bio exam in a few days and I cramming. Thought this was a good way to active learn. Apologies for being nit picky

[@Sauv_27]

Wow . They r so correct when they say biology is at its best when u can actually imagine whats going on n how it works n why. Never occurred that yea , featus also carries oxy n deoxy blood .

[@boeman6702]

The day that I realized arteries carried blood away from the heart not oxygenated blood blew my mind

[@UGNAvalon]

8:48 “This is exactly what you’d see!” Tiny bells and festival stands?

[@LazyLoonz]

Yes.

[@HibiyaPlays]

Would be nice~ xD But he was talking about those string things on the ceiling.

[@abingus8509]

The statues look like Raijin and Fuujin, gods of Lightning and Wind. Lightining = electrical impulses, wind = gas transfer.

[@gtf234]

They are because the area is modeled after the Kaminarimon (literally Thunder Gate), the outer gate of the Sensou-ji in Asakura. The gate is adorned with statues of Fuujin and Raijin, who spiritually separate what is impure from what is holy. In this imagery, they are separating the blood cells between dropping off and picking up.

[@goldenlion886]

This proves that they are living in a Japanese weeaboo

[@leirawhitehart1236]

To be honest, I thought the thunder deity represented the heart beat, cause when your heart beats, that means it's doing it's job right and blood is flowing properly throughout the body. Plus the guy is known for his drums, so I thought that was the connection. A deity to represent the air in the lungs and a deity to represent the beating of the heart.

[@ferretzim8694]

I just thought it was a red and a blue ogre, representing the artery and the vene. Maybe both?

[@Aozora210]

@@goldenlion886 This comment was too funny to pass but to inform you, Japanese weeaboo doesn't exist cause wee-a-boo is a term referring strictly to foreigners who are so into Japanese stuff and wants to be a Japanese to live on their fantasy about Japan, disregarding the other truths about the said country. Also this show and the original story were made by Japanese people. I think it's normal to want to put part of your nationality in your work.

[@jugapugz]

i wish they animate cells at work BLACK so you can review it... its same but in a perspective of a person that does not take care of his/her body...

[@helenc.romero65]

His. On V1 Ch3 the blood red cells try to get an erection.

[@ThatLaloBoy]

Ah, wonderful. I was wondering what that nightmare fuel would look like animated.

[@ImUnderYourFloorboards]

Helen C. Romero I'm going to say this to my friends if they try to convince me that anime doesn't have everything in it/ isn't that weird

[@yana_desu]

I hope it will be turned into anime bc I will make sure my friends who live in an unhealthy lifestyle will watch it.

[@_yeojo]

Jeannie Sakaguchi heard it's on the process

[@trigonometrisk]

Love this series! As a med student myself, there was one aspect in this episode that I was surprised that you did not comment on - namely, local differences in blood pressure! Like how the red blood cell is wandering aimlessly in the vena cava, but is getting a huge speed boost once inside the aorta.

[@nigelft]

If you really want to geek out, there is pressure differences within the aorta, starting from the valve face itself. Having done A&P myself, one of my textbooks (which is currently in storage ...), showed bp every 5cm from the valve face up the asending aorta through to the descending portion ... pretty cool diagram, although I often wondered how in the hell they produce results with that level of resolution ... strangly, I don't recall them doing that to the assending and descending vena cava, but then my memory ain't what it used to be ... [Edit:- forgot to add ... a dissecting aortic aneurysm is perhaps the most terrifying thing you may ever face if you are planning on surgical rather than medical. I once did six weeks in a haemotology lab/blood bank, and we had do a rapid type and cross match 10-12 units, minimum, whole blood, plus 3-4 units FFP, stat. Even though I was there as work experience, anyone not tied up with CBCs/FBCs or blood smears (depening on where you are ... here in the UK, we call them FBCs; US, CBCs, but they are the same thing ...), had to rush to help ... even dumpsky me ... talk about adrenaline dump ...

[@zeroday5441]

Also, remember the, old-school aesthetics of the heart Since its the first organ formed hence the justification

[@randomsandwichian]

I believe the speed also comes from gravity, ie. the force that helps blood travel under atmospheric pressure

[@trigonometrisk]

@@randomsandwichian Well, the pressure of the aorta is high also for parts of it that work counter to gravity, e.g.. carry blood to the head.

[@coltbolt6193]

by the time he finishes this season, the next season will be already out

[@TGNXAR]

Let's Hope. (ba DUM tss)

[@lunelilyonrunescape]

Oh, how I wish that were true :')

[@nekogamer2508]

It's not out yet

[@knightd8071]

It’s confirmed to be released in January 2021.

[@Bananaguy7]

One thing I loved about this episode is how Red Blood Cell was so determined to circulate by herself, and how White Blood Cell helped her and defended her when Killer T was putting down her efforts. Neutrophil spoke very kindly about how she may have this weakness of getting lost, but she is an extremely hard worker and determined to do it right; and besides, doesn’t everyone have areas of weakness? And then, even though he already knew about RBC’s entire journey, he sat down and listened to _her_ tell it with a pleasant smile on his face. I know it’s not related to medicine specifically, but I just love that. As someone with ADHD, it can be tough when, like our favorite RBC, you struggle to complete tasks that everyone else just does effortlessly. The world needs more people like Neutrophil U-1146, who listen patiently and appreciate the efforts of everyone, and RBC AE-3803, who give it their all despite the challenges they face.

[@privaterizk4936]

"Cool... so the Red Blood Cell is... lost again." I'm laughing so hard.

[@hunrahel]

Your commentary is uncontestably wholly transformative; don't let the copy claims get you down!

[@Curiousphy]

They break down the red blood cell *white blood cell incoming* BUT NOT TODAY This whole episode was so wholesome. Red blood cell was out here doin her best and wbc was keeping an eye on her from afar was the cutest thing I’ve ever watched

[@deltator6981]

This and the MCU medical analysis series are really enjoyable!

[@saimahramen]

6:17 It's so wholesome how he's bobbing his head to the music. 😭

[@RawbeardX]

Dr Hope is the Powerhouse of the Sick Notes!

[@brycevo]

Oh my goodness! I've been Hopeful that you'd continue. Thank you so much, Doc Hope

[@howtomedicate]

Me to! It is my favorite series!

[@RiuLenn]

Sameee!

[@jq3267]

was that an intended pun? XD

[@brycevo]

@@jq3267 Yes

[@asimplenarrator6771]

There's a pun right there

[@そけ-q7c]

I'm sorry if this has already been pointed out somewhere. It is said in the video that the mitral valve was not described in the video, but I think the two gargoyles pointed out in the video are the description of the mitral valve. By the way, those gargoyles are properly called Niou statues. They are there to protect the temple from the bad guys. The mitral valve is known as the "僧帽弁" in Japan. The Chinese character for "僧" in 僧帽弁 to a monk in a temple. I think that scene probably depicts the mitral valve in the form of a Niou statue, hooked to the kanji that refers to monks in temples. ... It might be hard to convey this feeling unless you're Japanese or have lived in Japan before. Being Japanese, I didn't understand English, so I relied on translation sites for everything. I'm sorry if there are any oddities. I apologize for the long text.

[@Т1000-м1и]

My life is a mess but feeling smart from learning new terms makes me happy, thanks for letting us watch that show for free.

[@HellGuardianAngel]

There's a manga called Cells at work Black It's in another body and shows smoking, drinking, etc. I remember it showing the macrophage in the liver degrading a eutrocyte

[@BoydOfPray]

I really hope they make this into a companion anime.

[@nicolealindogan]

That traumatised me man

[@Ember-Raine]

I want them to animate it so badly. Maybe it'll give me a push in the direction of not compulsively self-destructing every time something goes wrong in my life. I plan on going to med school at some point, and have a pretty good grasp of what exactly I'm doing to my body, but I just can't really bring myself to care. 😂😂

[@007.momochin]

I am a freshman student nurse and I couldn't be more proud that I understand all of this. Thank you so much for explaining some key points in the anime that I've failed to recognize. It really helped me especially during my term exams.

[@misstary13]

i presonally loved the detail of using a temple bell for the heartbeat itself, rather than reverberating the whole room

[@DarthMooglenator]

After watching these videos from episode 1 to now it absolutely blows my mind how our bodies are designed for so many different jobs, its incredible.

[@Penqu]

After watching these videos it's really cool to see how much the writers of this anime did their research even with the smallest and unnoticeable details like 1:08 and you manage to notice them and explain everything in a clear manner, i like the kind of reaction channels where i can leave with a medical degree pretty much.

[@bloodirose]

*the mangaka...

[@gtf234]

It's the managaka doing that, this is adapting a comic. What was left to visual details only those in the know would notice in the anime were often explicitly called out in the manga, generally on a bonus page after a chapter. The uniform difference for example is overtly pointed out as a bonus page in the manga went over in greater detail the standard issue equipment of the Erythrocytes; one such note pointed out the jackets are reversible depending on whether or not they are carrying oxygen.

[@poisonpotato3334]

There's a part where she and her other blood cells are walking through the inferior vena cava and above them is a large dark blue pipe. Very clever seeing as how veins are blue on the outside of the body, they made the pipes above the veins blue. It just goes to show you how much thought and detail they put into this anime.

[@suigenerisph]

Finally! 😂 Who else has been waiting for this? 😂

[@candacewhite9040]

Me!!!!!

[@suigenerisph]

@rihardo123 me too 😂😂 been waiting for ages 😂

[@UGNAvalon]

Your profile pic describes my elation!

[@suigenerisph]

@@UGNAvalon 😂

[@dorianwilde]

I honestly can't wait for the review of the last 2 episodes.

[@AznJsn82091]

I'm in EMT school and my class had a brief glimpse at the circulatory system. Watching this episode after that lesson was like a complete nerd-out moment for me! I was able to point out the major parts of the heart and trace out the path of the oxygen-depleted blood, oxygen-rich blood, and so on!

[@amadapittaluga1487]

When I get sick I rewatch Cells at Work to remind myself how hard my cells are working to keep me alive. This anime has inspired me to take better care of myself 💝💝

[@LoverMusic1014]

My dad is a consultant at a training hospital in my city and also the dean of our university medical school. I showed him some clips of this anime because I really love it and he found it cute. He also seems to approve some of the medical info they share. So if it's good enough for him, it's good enough for me to continue watching.

[@charliecharlie9042]

Somebody already mentioned this, you should review John wicks injuries. Love your Cells at Work series btw.

[@quietwyatt2873]

"Headshot, headshot, headshot, pencil through eye..."

[@acchery8910]

@@quietwyatt2873 recently killed a man with a book. Handing out KNOWLEDGE

[@zetsubouda]

That would be AWESOME.

[@alex53748]

Not even one minute in, and Dr. Hope already blew my mind. When I watched the episode back when it released I didn’t even notice they switched the Jacket’s color depending on it’s oxygenation!

[@mirane9803]

I really miss the series. Thank you for continuing them! Much love

[@lets_talkabout_anime]

There's gonna be a season 2!

[@mirane9803]

@@lets_talkabout_anime That's great! Would love to know more about the cells/characters, since I rarely read any mangas/ln nowadays. Thanks for the info!

[@anapaulapedro7025]

Chitaka06 Wait really?? When?

[@whotookmikey]

yaaaayy the moment weve all been waiting for! :D

[@howtomedicate]

Indeed 👌

[@FurosutoJouku]

Yaaaaay! A new one! It’s been a long time. ❤️

[@howtomedicate]

Way too long! But at last it is here 👍

[@4everRouya]

ive watched the anime and also read the manga and thought that those 2 statues were actually the bicuspid valves ahaha

[@rurii8682]

Learning about circulation makes my head spin but explained this way makes it easier to understand. Thanks for the video Dr. Hope!

[@ConnorLonergan]

It's both an education and a story as in this episode Red puts the effort to get her job done all on her own so you can't help but cheer her on

[@CRAVEN232]

Wait that collar switch on her jacket thats such a cool attention to detail im amazed you noticed that!

[@gtf234]

To be fair, it's been mentioned countless times in the comments of past videos and for what it's worth it's explicitly mentioned in a bonus page in the source manga.

[@LuizAlexPhoenix]

I must say, watching this again is making me feel really conscious of how I overwork my heart and cute little blood cells. Having a doctor explain the human body using an anime of the subject is a dream come true.

[@ericacamacho8080]

I can tell that you genuinely enjoy Cells at Work, and that makes me happy when I'm watching.

[@stephaniest.5336]

I've been hoping that you would review this light-hearted but very educational episode which has helped many pass their tests on circulation. And as always great review, love the way you describe what is happening and the various details. Regarding the two statues, if memory serves me correct these are two of gods found in the taoist pantheon relating to the beginning and the end. Quite fitting given the role of the heart.

[@CryingZombie666]

Taoist*

[@stephaniest.5336]

Apologies for error and point taken. :)

[@CryingZombie666]

@Stephanie St. Just fix it and everything will be fine :D

[@Chiasa7]

Doc Hope never fail as a hope, we have been granted a new episode of cells at work reactions/breakdowns. Grab your notes everyone!

[@redmuffler3186]

Broke- Doctor reacts to Cells at Work Woke- Cells at Work: Extended Doctor's Edition

[@somberflight]

But... go woke go broke.

[@ElizabethRivera-cy8oe]

That's literally how I'm treating this series lol

[@matthewbergdorf4108]

YAAAAAAAASSSSS!!! WEEB DOCTOR IS BACK!!!!

[@KINGKROSBYSKINGDOM]

Hes Mr. WEEB Doctor too you

[@thisjustathinghereyep9573]

I always love watching these. Pros: a anime worth checking out and also hearing someone passionately geek out on something they love. Cons: none at all

[@AMoniqueOcampo]

FIRST! This episode is one of my favorites! What I loved about this episode was how much White Blood Cell cared for Red. I was half expecting you to talk about some memories of doing rounds all on your own. The next episode will be interesting, giving insight on why Killer T cell needs to watch his salt intake.

[@pancaketime4827]

I know! I was hoping to see him talk about the white blood cell caring for the red one. It was so sweet!

[@avneetkaur254]

"the truth is the mitochondria is not the only way we produce energy" those 51 dislikes are all the mitochondria that got WiFi connection

[@foxymanaic5934]

Even though I know absolutely nothing about Cells at work I always enjoy your explanations of these medical terms it just brings a smile to my face every time I see a notification of yours. I learned something new in 1 minute in about the inferior and superior vein thing and that Deoxygenated. Im just so glad I found your channel I mean this just helps me out so much I can't thank you enough for all these videos. So once again Thank you Dr Hope.

[@ultru3525]

It keeps amazing me how mechanical bodies are, with the pumps, valves, electrical signals, etc., yet so intricate we're nowhere near fully replicating it.

[@Geejay412]

I actually am a heart parent who had a heart murmur which turned out to be my mitral valve never closing properly, never knew the actual word for the specific condition though!

[@alucozadebottle4423]

Patient do you mean?

[@cyan.-]

@@alucozadebottle4423 no they have a heart child /j

[@misse0077]

If I had to take a quiz after watching an episode of Cells at Work, I'd ace it. What an incredibly genius way to teach! And I learn even more from Dr. Hope. 🙏🏻💕

[@RubyChiang]

It's been a long time coming! Btw, a second season had been announced for this series! Thank you so much for all your detailed explanations! It's still a long way, but there was like an extra episode (Episode 13, essentially) after Episode 12, talking about colds and I was very confused by that episode so looking forward to hearing your explanations on the upcoming episodes!! Thank you so much!

[@CryingZombie666]

When and where was it announced?

[@bloodirose]

OMG! I clicked as soon as I saw it. I've been wondering if you would continue to do these. I am so happy.

[@LGalvan46]

I love your reactions, and i like learning all these things, especially from you doc, its a win win, continue to make great videos ❤!

[@rantuoftheshadows]

11:31 they are the guardian deities found infront of shrines in japan and one reprisents intake and the other reprisents release or outtake

[@asimplenarrator6771]

You are very helpful, I had a "systems of the body" pop quiz and I remembered this. Thank you😇

[@giboit.]

It was really cool to see you explain all the process showed in this episode. This definitely worth the wait.

[@howtomedicate]

Cells at work, my favorite series!

[@alijoc]

I just realised that in all of these Cells at work episodes Dr Hope keeps a very consistent wardrobe!!

[@mariadibondone9070]

It's been so long!!! I was missing your excellent reviews on this show. Thanks for getting back to it ^^

[@scatteredstraw]

Oh my god I didn't realise that you'd resumed this series!!!!! What an absolutely lovely surprise, thank you doctor!

[@kawaiizeraora8091]

Ohfuck, finally another Cells At Work episode, lol

[@CryingZombie666]

After forever, yeah.

[@0axis771]

Dr. Hope... what are you doing? Why are you doing this to me? WHY ARE YOU MAKING ME LEARN SO MUCH?! And you know the worst -best- part? I LOVE IT!!!

[@jvalentin55]

Glad you are picking this series back up! But sad to see that they have been claiming your videos. This must take more time editing since leaving any clip up too long could trigger KZbins' algorithm. Seeing your insight into the show and what you add with knowledge and wit really should be considered as transformative. Thank you for doing what you do, I really appreciate it, and by the looks of it so do many others.

[@DrHopeSickNotes]

Awww thanks. Comments like this make it all worth it!

[@zenagitana]

I'm a Cardiovascular ultrasound tech and this episode brought me back to my anatomy and physiology course. Loved it!

[@brini2439]

Thank you, Dr. Hope :D I reaaaaally have been waiting for this video - not only because I'm learning to understand English watching your content but also it brightens my day hearing your calming voice and looking at this funny entertainment. Keep up the good work but take your time. It's a lot of work producing these clips. I'm looking forward for your next video, greetings from Germany/Bavaria/UpperPalatinate

[@たごりん-w3i]

I'm japanese. The Gargoyle is 「阿吽像（AUN-zou）」. This mean is 「阿（A）＝born」「吽（UN）＝death」、set mean is 「the Life」. Because, in Heart scene is very near likeness,「浅草（Asakusa）」at「New Year's Eve pilgrimage（大晦日oomisoka）」. Bell, gate（鳥居tri-）, and congestion,very near！

[@k-l-in784]

I love how your videos are always well explained. It shows that you're not reacting at it just for views (because of its popularity), but rather because you find it good and want to share interesting points with us (that only you could explain so well!!)👍 You've got a new subscriber~

[@Hunttiger]

Been awhile, Doc! These videos really help to understand the show more while waiting for the second season.

[@Filbi]

I love how the heart is portrayed like a temple with a huge bell keeping time. It's a great visual metaphor.

[@SolitareHeartz]

It is always good to see you again no matter how long the wait. Awesome video as always.

[@Rajlinaa]

I love the way you explain things. I can actually understand stuff! This episode was especially interesting to me because I've had two valve replacements, an aneurysm and an aortic dissection. I read all the documents from my doctors and a bunch of stuff online and I didn't understand half of it. It's a bit frustrating when you don't know what went down in your own body and how exactly it's affecting your present and future. If you ever want to and have the time, it would be so cool if you did a miniseries or something about every system in the human body and how they work.

[@Lavie_Azure]

I love how you're so hyped when the anime makes clever analogies

[@Quonzer]

1:07 I never noticed the color change before! Good catch doc!

[@GDorky]

You being a doctor, you probably film these vids on your free time. Its understandable when you don't get them out right away BTW another great vid 👍

[@keybladewizard49]

The heart is depected as a Shinto-Buddhist temple, and the statues are common guardian statues at temples in Japan. They're there to decorate the gateway back into the heart and denote the "temple" as a holy place.

[@albertonishiyama1980]

About the heart and the statues, the heart itself is based on japanese shrines and temples (in Japan the two are slightly different, one word means budist and the other Shinto, a traditional japanese religion, but dont remember wich one). Japaneses are not really religious, but they have a strong tradition of going to a shrine / temple in January 1st and it always got HUGE amounts of people (imagine an entire city going to the same church at the same time, its crazy). That "somewhere where everyone goes in regular basis" and the drums / bells (representing heartbeats) makes that symbology really good, but hard to understand to non-japanese people. The two statues (and the big bell, and the Toriis in the scene where they're waiting in line) are traditional symbology of a shinto shrine/temple. That's not a medicine thing (except the bell and the drums, they are both religious symbolism and heartbeats).

[@candacewhite9040]

Cool thanks!

[@lordofuzkulak8308]

On the veins appearing blue through the skin factoid - not sure how true it is, but I've heard that this is the origin of the term 'blue blood' to refer to royalty/nobility; basically the peasants spent most of their time working outdoors so would develop tans and thus it'd be harder to see the veins while the nobs could afford to spend time out of the sun/be covered up, so tended to have paler skin, and thus it was easier to see the veins and because as you noted they look blue through the thinner layers of skin/tissue, people mistook that for them having blue blood.

[@AllTheArtsy]

HE'SSSSS BACCCKKKK And those statues out the lung is just some reference to certain temples that are guarded by different deities/kami (like a wind god or something) at certain gates

[@CryingZombie666]

He's back! He's the man - behind - the meds!

[@Ilicia16]

As many times as I've seen this episode, I never noticed the very minor detail of the blood vessels surrounding the alveoli. I'm actually glad for these reaction videos, because I still learn more things from this anime that I didn't catch before.

[@iravixian8833]

If I ever see you in real life, It would be weird to look into your eyes without seeing the RingLight Reflection

[@detectivesnickers6176]

Lol ikr. His pupils are almost never visible lol, just his irises

[@BlaxeFrost-X]

i never noticed the diference in color of the clothes of the red blood cell!! that's such a detail!

[@thevioletskull8158]

I see a hope cells at work reaction,I get to the video as quickly as possible!

[@MrKlausbaudelaire]

Upon watching the episode, I just loved how the heart was this crowded temple, as in many festivities, the temples do get incredibly crowded (and the overview shots just help us realize their berets are shaped like blood cells xD) and I actualy measured the sound of the drums to my own heartbeat, and in some scenes, the drum actualy matched my rate (which was at normal speed, I can assure you).

[@Ruffles2255]

This and a English Dub announced this has been a great week for cells at work content for me

[@veknus]

Learning something new everyday.

[@usurper4081]

Literally me when I saw the thumbnail: *GASP* FINALLY YEY

[@MrKlausbaudelaire]

I was like "ok, 5 in the morning, time to go to be- OMG NEW EPISODE!"

[@sussybaka6567]

1:08 Y'know I didn't notice that until you pointed it out, that's some neat details they added in

[@Alienerdz]

I've been waiting for this 😄✨

[@DoctorShroom]

My boy. It's been so long. You definitely, 100%, need to watch Episodes 11-13. Probably some of the best ones. Also, I never even noticed the inside-out jacket thing.